CA2909581A1 - Stable, protracted glp-1/glucagon receptor co-agonists for medical use - Google Patents
Stable, protracted glp-1/glucagon receptor co-agonists for medical useInfo
- Publication number
- CA2909581A1 CA2909581A1 CA2909581A CA2909581A CA2909581A1 CA 2909581 A1 CA2909581 A1 CA 2909581A1 CA 2909581 A CA2909581 A CA 2909581A CA 2909581 A CA2909581 A CA 2909581A CA 2909581 A1 CA2909581 A1 CA 2909581A1
- Authority
- CA
- Canada
- Prior art keywords
- amino
- carboxy
- butanoyl
- ethoxy
- leu27
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13164272 | 2013-04-18 | ||
| EP13164272.0 | 2013-04-18 | ||
| US201361814969P | 2013-04-23 | 2013-04-23 | |
| US61/814,969 | 2013-04-23 | ||
| EP13196656 | 2013-12-11 | ||
| EP13196656.6 | 2013-12-11 | ||
| PCT/EP2014/058084 WO2014170496A1 (en) | 2013-04-18 | 2014-04-22 | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2909581A1 true CA2909581A1 (en) | 2014-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2909581A Withdrawn CA2909581A1 (en) | 2013-04-18 | 2014-04-22 | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
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| Country | Link |
|---|---|
| US (3) | US9474790B2 (enExample) |
| EP (1) | EP2986313B1 (enExample) |
| JP (1) | JP6594856B2 (enExample) |
| KR (1) | KR20160021758A (enExample) |
| CN (1) | CN105307672B (enExample) |
| AU (1) | AU2014255608B2 (enExample) |
| BR (1) | BR112015025464A2 (enExample) |
| CA (1) | CA2909581A1 (enExample) |
| MX (1) | MX362275B (enExample) |
| MY (1) | MY174727A (enExample) |
| PL (1) | PL2986313T3 (enExample) |
| RS (1) | RS59124B1 (enExample) |
| RU (1) | RU2683039C2 (enExample) |
| SI (1) | SI2986313T1 (enExample) |
| WO (1) | WO2014170496A1 (enExample) |
| ZA (1) | ZA201507010B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI596110B (zh) | 2011-09-23 | 2017-08-21 | 諾佛 儂迪克股份有限公司 | 新穎升糖素類似物 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| WO2014096149A1 (en) | 2012-12-21 | 2014-06-26 | Sanofi | Exendin-4 Derivatives |
| EP2986313B1 (en) | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| PT2986313T (pt) * | 2013-04-18 | 2019-09-10 | Novo Nordisk As | Co agonistas do recetor de glp-1/glucagon estáveis e prolongados para uso médico |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| PL3155017T3 (pl) * | 2014-05-28 | 2024-06-17 | Mederis Diabetes, Llc | Ulepszone farmaceutyki peptydowe dla insulinooporności |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| SG11201705376SA (en) * | 2014-12-30 | 2017-08-30 | Hanmi Pharm Ind Co Ltd | Glucagon derivative having improved stability |
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| KR20140043793A (ko) * | 2011-06-22 | 2014-04-10 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-작용물질 |
| TWI596110B (zh) * | 2011-09-23 | 2017-08-21 | 諾佛 儂迪克股份有限公司 | 新穎升糖素類似物 |
| EP2986313B1 (en) | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| WO2015086733A1 (en) * | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
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2014
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- 2014-04-22 RU RU2015146600A patent/RU2683039C2/ru active
- 2014-04-22 WO PCT/EP2014/058084 patent/WO2014170496A1/en not_active Ceased
- 2014-04-22 SI SI201431291T patent/SI2986313T1/sl unknown
- 2014-04-22 JP JP2016508190A patent/JP6594856B2/ja active Active
- 2014-04-22 KR KR1020157032329A patent/KR20160021758A/ko not_active Withdrawn
- 2014-04-22 RS RS20191031A patent/RS59124B1/sr unknown
- 2014-04-22 PL PL14719715T patent/PL2986313T3/pl unknown
- 2014-04-22 BR BR112015025464A patent/BR112015025464A2/pt not_active IP Right Cessation
- 2014-04-22 CA CA2909581A patent/CA2909581A1/en not_active Withdrawn
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2015
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2016
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2017
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| RU2015146600A (ru) | 2017-05-24 |
| US9751927B2 (en) | 2017-09-05 |
| US9474790B2 (en) | 2016-10-25 |
| PL2986313T3 (pl) | 2019-12-31 |
| AU2014255608A1 (en) | 2015-10-08 |
| WO2014170496A1 (en) | 2014-10-23 |
| US20180044394A1 (en) | 2018-02-15 |
| KR20160021758A (ko) | 2016-02-26 |
| MY174727A (en) | 2020-05-11 |
| CN105307672A (zh) | 2016-02-03 |
| SI2986313T1 (sl) | 2019-09-30 |
| RU2015146600A3 (enExample) | 2018-03-29 |
| CN105307672B (zh) | 2021-01-05 |
| RU2683039C2 (ru) | 2019-03-26 |
| JP6594856B2 (ja) | 2019-10-23 |
| AU2014255608B2 (en) | 2018-01-25 |
| BR112015025464A2 (pt) | 2017-10-10 |
| RS59124B1 (sr) | 2019-09-30 |
| US20150374794A1 (en) | 2015-12-31 |
| ZA201507010B (en) | 2017-08-30 |
| EP2986313A1 (en) | 2016-02-24 |
| MX362275B (es) | 2019-01-10 |
| JP2016526012A (ja) | 2016-09-01 |
| MX2015014408A (es) | 2017-07-28 |
| EP2986313B1 (en) | 2019-06-12 |
| US20160355562A1 (en) | 2016-12-08 |
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