CN104718282A - 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 - Google Patents

用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 Download PDF

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Publication number
CN104718282A
CN104718282A CN201380053005.4A CN201380053005A CN104718282A CN 104718282 A CN104718282 A CN 104718282A CN 201380053005 A CN201380053005 A CN 201380053005A CN 104718282 A CN104718282 A CN 104718282A
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China
Prior art keywords
coa
fatty acid
bxf
product
production
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Pending
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CN201380053005.4A
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English (en)
Chinese (zh)
Inventor
汉斯·廖
艾琳·斯宾德勒
约瑟夫·R·华纳
迈克尔·路易
温迪·里布尔
布里特妮·普莱瑟
罗恩·埃文斯
坦尼娅·E·W·利普斯科布
迈克尔·D·林奇
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Cargill Inc
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OPX Biotechnologies Inc
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Priority to CN201811066880.7A priority Critical patent/CN109182238A/zh
Publication of CN104718282A publication Critical patent/CN104718282A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01157—3-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
    • C—CHEMISTRY; METALLURGY
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    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01009—Enoyl-[acyl-carrier-protein] reductase (NADH) (1.3.1.9)
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    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01194—Acetoacetyl-CoA synthase (2.3.1.194)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Microbiology (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380053005.4A 2012-08-10 2013-08-09 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 Pending CN104718282A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811066880.7A CN109182238A (zh) 2012-08-10 2013-08-09 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682138P 2012-08-10 2012-08-10
US201261682127P 2012-08-10 2012-08-10
US61/682,127 2012-08-10
US61/682,138 2012-08-10
PCT/US2013/054422 WO2014026162A1 (en) 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products

Related Child Applications (1)

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CN201811066880.7A Division CN109182238A (zh) 2012-08-10 2013-08-09 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法

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CN104718282A true CN104718282A (zh) 2015-06-17

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CN201380053005.4A Pending CN104718282A (zh) 2012-08-10 2013-08-09 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
CN201811066880.7A Pending CN109182238A (zh) 2012-08-10 2013-08-09 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法

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US (2) US20140051136A1 (enExample)
EP (1) EP2882843A4 (enExample)
JP (1) JP2015524283A (enExample)
KR (1) KR20150040359A (enExample)
CN (2) CN104718282A (enExample)
AU (1) AU2013299414A1 (enExample)
BR (1) BR112015002940A2 (enExample)
CA (1) CA2881666A1 (enExample)
IN (1) IN2015DN01858A (enExample)
MX (1) MX2015001780A (enExample)
SG (1) SG11201501013PA (enExample)
WO (1) WO2014026162A1 (enExample)

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WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
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US20160376600A1 (en) * 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
US10689671B2 (en) 2014-05-12 2020-06-23 Metabolic Explorer Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply
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CN106574238B (zh) 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
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US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
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