KR20150040359A - 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법 - Google Patents

지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법 Download PDF

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KR20150040359A
KR20150040359A KR1020157006235A KR20157006235A KR20150040359A KR 20150040359 A KR20150040359 A KR 20150040359A KR 1020157006235 A KR1020157006235 A KR 1020157006235A KR 20157006235 A KR20157006235 A KR 20157006235A KR 20150040359 A KR20150040359 A KR 20150040359A
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fatty acid
coa
product
production
malonyl
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한스 리아오
아일린 스핀들러
조셉 알. 워너
마이클 루이
웬디 리블
브리트니 프래더
론 에반스
타냐 이. 더블유. 립스콤
마이클 디. 린치
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오피엑스 바이오테크놀로지스, 인크.
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KR1020157006235A 2012-08-10 2013-08-09 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법 Withdrawn KR20150040359A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682138P 2012-08-10 2012-08-10
US201261682127P 2012-08-10 2012-08-10
US61/682,127 2012-08-10
US61/682,138 2012-08-10
PCT/US2013/054422 WO2014026162A1 (en) 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products

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KR20150040359A true KR20150040359A (ko) 2015-04-14

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KR1020157006235A Withdrawn KR20150040359A (ko) 2012-08-10 2013-08-09 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법

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US (2) US20140051136A1 (enExample)
EP (1) EP2882843A4 (enExample)
JP (1) JP2015524283A (enExample)
KR (1) KR20150040359A (enExample)
CN (2) CN104718282A (enExample)
AU (1) AU2013299414A1 (enExample)
BR (1) BR112015002940A2 (enExample)
CA (1) CA2881666A1 (enExample)
IN (1) IN2015DN01858A (enExample)
MX (1) MX2015001780A (enExample)
SG (1) SG11201501013PA (enExample)
WO (1) WO2014026162A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2843043A1 (en) 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
US20160376600A1 (en) * 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
US10689671B2 (en) 2014-05-12 2020-06-23 Metabolic Explorer Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply
EP2944697A1 (en) 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
EP2946764A1 (en) 2014-05-23 2015-11-25 Evonik Degussa GmbH Biosynthetic production of acyl amino acids
EP2975131A1 (en) 2014-07-17 2016-01-20 Evonik Degussa GmbH Synthesis of alkanes
CN106574238B (zh) 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3081639A1 (en) 2015-04-14 2016-10-19 Evonik Degussa GmbH Acyl amino acid production
EP3091080A1 (en) 2015-05-05 2016-11-09 Evonik Degussa GmbH Process for producing acyl amino acids employing lipases
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017102952A1 (en) 2015-12-17 2017-06-22 Evonik Degussa Gmbh A genetically modified acetogenic cell
WO2018019867A1 (en) 2016-07-27 2018-02-01 Evonik Degussa Gmbh N-acetyl homoserine
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
EP3585798A4 (en) 2017-02-27 2020-10-14 Duke University IN VIVO PROTEIN N ACYLATION

Family Cites Families (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406889A (en) 1942-12-14 1946-09-03 Manning Maxwell & Moore Inc Power unit for traveling cranes
US2469701A (en) 1946-02-13 1949-05-10 American Cyanamid Co Preparation of acrylic acid
US2464768A (en) 1946-02-13 1949-03-15 American Cyanamid Co Preparation of esters of acrylic acid
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US3687885A (en) 1970-04-15 1972-08-29 Du Pont Water base paints having an improved balance of anti-drip and leveling qualities
GB1349586A (en) 1970-12-11 1974-04-03 Polysar Ltd Latex composition and process for producing the same
US3872037A (en) 1970-12-11 1975-03-18 Polysar Ltd Improved carboxylic latex for paper coating utilizing butadiene-styrene-acrylic acid-acrolein tetrapolymers
US3904685A (en) 1973-07-20 1975-09-09 Celanese Corp Polyacrylic acid having high chelation value and its production
US3891591A (en) 1973-08-13 1975-06-24 Du Pont Coating compositions
CH606154A5 (enExample) 1974-07-02 1978-11-15 Goodrich Co B F
US4029577A (en) 1975-11-17 1977-06-14 Betz Laboratories, Inc. Polymers for use in water treatment
DE2757329C2 (de) 1977-12-22 1980-02-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Polymerisaten der Acrylsäure oder Methacrylsäure
US4268641A (en) 1979-04-24 1981-05-19 Union Carbide Corporation Acrylic acid-acrylate copolymer thickening agents
US4431547A (en) 1981-08-24 1984-02-14 Nalco Chemical Company Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca3 (PO4)2
US4985518A (en) 1981-10-26 1991-01-15 American Colloid Company Process for preparing water-absorbing resins
JPS58180233A (ja) 1982-04-19 1983-10-21 Nippon Shokubai Kagaku Kogyo Co Ltd 吸収剤
US4685915A (en) 1984-04-06 1987-08-11 The Procter & Gamble Company Disposable diaper having density and basis weight profiled absorbent core
US4734478A (en) 1984-07-02 1988-03-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Water absorbing agent
US4708997A (en) 1985-07-22 1987-11-24 The Dow Chemical Company Suspending agent for the suspension polymerization of water-soluble monomers
DE3544770A1 (de) 1985-12-18 1987-06-19 Stockhausen Chem Fab Gmbh Verfahren und vorrichtung zum kontinuierlichen herstellen von polymerisaten und copolymerisaten der acrylsaeure und/oder methacrylsaeure
US5009653A (en) 1988-03-31 1991-04-23 The Procter & Gamble Company Thin, flexible sanitary napkin
US4952505A (en) 1988-08-08 1990-08-28 Florida State University Fermentation of trichoderma reesei and apparatus therefor
US5487989A (en) 1988-08-31 1996-01-30 Bioenergy International, L.C. Ethanol production by recombinant hosts
IT1229506B (it) 1989-01-26 1991-09-03 Sigma Prodotti Chimici Srl Polimero dell'acido acrilico esente da solventi residui e procedimento per la sua preparazione.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5145906A (en) 1989-09-28 1992-09-08 Hoechst Celanese Corporation Super-absorbent polymer having improved absorbency properties
JP2938920B2 (ja) 1990-01-31 1999-08-25 住友精化株式会社 吸水性樹脂の製造方法
US5350799A (en) 1990-05-31 1994-09-27 Hoechst Celanese Corporation Process for the conversion of fine superabsorbent polymer particles into larger particles
US5342899A (en) 1991-05-16 1994-08-30 The Dow Chemical Company Process for recycling aqueous fluid absorbents fines to a polymerizer
US5135617A (en) 1991-07-01 1992-08-04 Phillips Petroleum Company Separation of aromatic from olefinic hydrocarbons by extractive distillation
DE4138408A1 (de) 1991-11-22 1993-05-27 Cassella Ag Hydrophile, hochquellfaehige hydrogele
CA2083346A1 (en) 1991-12-13 1993-06-14 Eric G. Lundquist A catalyzed esterification process
US5142023A (en) 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5827255A (en) 1992-07-27 1998-10-27 The Procter & Gamble Company Sanitary napkin comprising an absorbent core having a density gradient
US5405913A (en) 1993-03-22 1995-04-11 The University Of Akron Free radical copper(II)-enolate polymerization initiators
US5510307A (en) 1993-04-08 1996-04-23 Isp Investments Inc. Free radical initiator delivery system
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
EP0723011B1 (en) 1993-08-24 2002-07-03 Ajinomoto Co., Inc. Variant phosphoenolpyruvate carboxylase, gene thereof, and process for producing amino acid
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5558656A (en) 1993-12-20 1996-09-24 The Procter & Gamble Company Sanitary napkin having an internal shaping component
US6274311B1 (en) 1995-05-18 2001-08-14 University Of Guelph Method and nucleotide sequence for transforming microorganisms
US5723639A (en) 1995-10-16 1998-03-03 University Of Chicago Esterification of fermentation-derived acids via pervaporation
DE19629372A1 (de) 1996-07-20 1998-01-22 Degussa Verfahren zur Herstellung von Malonsäure oder einem Salz derselben
JP4327909B2 (ja) 1996-11-13 2009-09-09 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 組み換え生物による1,3―プロパンジオールの生産方法
SK285201B6 (sk) 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
US6117658A (en) 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6087140A (en) 1997-02-19 2000-07-11 Wisconsin Alumni Research Foundation Microbial production of 1,2-propanediol from sugar
US6143538A (en) 1997-02-20 2000-11-07 The United States Of America As Represented By The United States Department Of Energy Fatty acyl-CoA reductase
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
BE1011197A3 (fr) 1997-06-06 1999-06-01 Brussels Biotech En Abrege Bb Procede de purification d'acide lactique.
US6306636B1 (en) 1997-09-19 2001-10-23 Arch Development Corporation Nucleic acid segments encoding wheat acetyl-CoA carboxylase
AU9402798A (en) 1997-09-19 1999-04-05 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding a ras carboxyl-terminal processing protein
US6229046B1 (en) 1997-10-14 2001-05-08 Cargill, Incorported Lactic acid processing methods arrangements and products
ATE449844T1 (de) 1997-12-05 2009-12-15 Europ Lab Molekularbiolog Neue methode zur klonierung dns unter anwendung des e. coli rece/rect rekombinationssystems
KR100250830B1 (ko) 1997-12-09 2000-04-01 성재갑 자가분해에 의해 폴리하이드록시알킨산으로부터 광학활성을 가진 단량체 하이드록시카르복실산의 제조방법
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
JP4913929B2 (ja) 1998-06-12 2012-04-11 味の素株式会社 核酸系物質の製造法
DE69938105T2 (de) 1998-08-04 2009-01-29 Metabolix, Inc., Cambridge Herstellung von polyhydroxyalkanoaten aus polyolen
DE69930276T2 (de) 1998-08-18 2006-10-05 Metabolix, Inc., Cambridge Transgene polyhydroxyalkanoat produzierende mikroben
US6855516B1 (en) 1998-09-04 2005-02-15 Kyowa Hakko Kogyo, Co., Ltd. Gene conferring lysozyme insensitivity to corynebacterium
KR100547583B1 (ko) 1998-10-30 2006-02-01 캐털리틱 디스틸레이션 테크놀로지스 니트릴로부터 아미드 및/또는 산의 생성
EP0999238B1 (en) 1998-11-05 2008-07-09 Nippon Shokubai Co., Ltd. Water-absorbing agent and production process therefor
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
WO2000039287A2 (en) 1998-12-31 2000-07-06 Millennium Pharmaceuticals, Inc. A. fumigatus acetyl coenzyme-a carboxylase genes and polypeptides and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
WO2000056693A1 (en) 1999-03-22 2000-09-28 Purac Biochem B.V. Method of industrial-scale purification of lactic acid
CA2366222A1 (en) 1999-03-23 2000-09-28 Board Of Trustees Operating Michigan State University Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase
WO2000061740A1 (en) 1999-04-10 2000-10-19 Maxygen, Inc. Modified lipid production
US6355412B1 (en) 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
WO2001016346A1 (en) 1999-08-30 2001-03-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US20020102672A1 (en) 1999-10-04 2002-08-01 Joseph Mizrahi Process for producing a purified lactic acid solution
DE60026563D1 (de) 1999-10-25 2006-05-04 Kosan Biosciences Inc Herstellung von polyketiden
US6531291B1 (en) 1999-11-10 2003-03-11 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof
WO2001038284A1 (en) 1999-11-24 2001-05-31 Cargill Dow Llc Improved lactic acid processing; methods; arrangements; and, products
NL1013682C2 (nl) 1999-11-26 2001-05-30 Purac Biochem Bv Werkwijze en inrichting voor het zuiveren van een waterige oplossing van melkzuur.
US6613553B1 (en) 2000-02-04 2003-09-02 St. Jude Children's Research Hospital Enoyl reductases and methods of use thereof
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US6586229B1 (en) 2000-06-01 2003-07-01 North Carolina State University Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium
US20020164729A1 (en) 2000-07-21 2002-11-07 Skraly Frank A. Production of polyhydroxyalkanoates from polyols
CA2322105A1 (en) 2000-10-23 2002-04-23 Plant Bioscience Limited Antibiotic production (ii)
JP4490628B2 (ja) 2000-11-20 2010-06-30 カーギル インコーポレイテッド 3−ヒドロキシプロピオン酸および他の有機化合物
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
CN1279013C (zh) 2001-05-07 2006-10-11 嘉吉有限公司 羧酸及其衍生物的制备方法
MY146503A (en) 2001-08-13 2012-08-15 Malaysian Palm Oil Board Method and compositions for the production of transgenic plants
US6723799B2 (en) 2001-08-24 2004-04-20 E I. Du Pont De Nemours And Company Acid-dyeable polymer compositions
JP4356454B2 (ja) 2001-10-23 2009-11-04 味の素株式会社 新規グルタミン酸受容体とその利用
CA2466133A1 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
US7230144B2 (en) 2001-12-18 2007-06-12 Metabolix Inc. Methods of making intermediates from polyhydroxyalkanoates
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
US6709919B2 (en) 2002-05-15 2004-03-23 Taiwan Semiconductor Manufacturing Company Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
AU2003225644A1 (en) 2002-03-01 2003-09-16 Monsanto Technology Llc Wax ester synthase dna sequence, protein and uses thereof
JP2005521718A (ja) 2002-03-25 2005-07-21 カーギル,インコーポレイティド β−ヒドロキシカルボン酸の誘導体の製造方法
WO2004038030A2 (en) 2002-05-10 2004-05-06 Metabolix, Inc. Bioabsorbable polymer containing 2-hdroxyacid monomers
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
AU2003205041A1 (en) 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
GB0218019D0 (en) 2002-08-05 2002-09-11 Ciba Spec Chem Water Treat Ltd Production of a fermentation product
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
US7126034B2 (en) 2002-11-01 2006-10-24 Cargill, Incorporated Process for preparation of 1,3-propanediol
AU2003287625A1 (en) 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
WO2004052829A1 (ja) 2002-12-06 2004-06-24 Kaneka Corporation 光学活性3−ヒドロキシプロピオン酸エステル誘導体の製造法
JP2006517796A (ja) 2003-02-18 2006-08-03 メタボリック エクスプローラー 代謝経路の生成または改変を可能とする進化した微生物の生産方法
US7141154B2 (en) 2003-03-06 2006-11-28 Uchicago Argonne Llc Single-stage separation and esterification of cation salt carboxylates using electrodeionization
EP3121269A1 (de) 2003-03-31 2017-01-25 University Of Bristol Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren
DE10314618A1 (de) 2003-04-01 2004-10-14 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
US20040225116A1 (en) 2003-05-08 2004-11-11 Payne Mark S. Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
CN100422131C (zh) 2003-06-26 2008-10-01 嘉吉有限公司 分离和回收3-羟基丙酸和丙烯酸的方法
US7927794B2 (en) 2003-09-29 2011-04-19 The Regents Of The University Of California Methods for identifying a biosynthetic pathway gene product
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
US7326557B2 (en) 2003-11-14 2008-02-05 Rice University Increasing intracellular NADPH availability in E. coli
DK1706457T3 (da) 2003-12-04 2012-05-21 Novozymes As Fremstilling af 3-hydroxypropionsyre ved anvendelse af beta-alanin/pyruvataminotransferase
US7186214B2 (en) 2004-02-12 2007-03-06 Medtronic, Inc. Instruments and methods for accessing an anatomic space
EP1731604A4 (en) 2004-03-26 2007-04-04 Nippon Catalytic Chem Ind PROCESS FOR THE PREPARATION OF 1,3-PROPANEL AND / OR 3-HYDROXYPROPIONIC ACID
EP1732874A1 (en) 2004-04-02 2006-12-20 Ciba Speciality Chemicals Water Treatments Limited Preparation of acrylic acid derivatives from alpha or beta-hydroxy carboxylic acids
BRPI0510512A (pt) 2004-04-28 2007-10-30 Icos Corp derivados de arilfenilamino, arilfenilamida e sulfeto de arilfeniléter
US20050272135A1 (en) 2004-06-02 2005-12-08 The University Of Chicago Processs for production and purification of fermentation derived organic acids
US7652167B2 (en) 2004-07-19 2010-01-26 Board Of Trustees Of Michigan State University Process for production of organic acid esters
ES2551852T3 (es) 2004-07-23 2015-11-24 Acceleron Pharma Inc. Polipéptidos del receptor ActRII
WO2006022664A2 (en) 2004-07-30 2006-03-02 Cargill Incorporated Alanine 2, 3 aminomutases
US7148051B2 (en) 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
EP1789569A2 (en) 2004-09-17 2007-05-30 Rice University High succinate producing bacteria
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
KR101340580B1 (ko) 2004-10-12 2013-12-11 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성
US8530633B2 (en) 2004-10-14 2013-09-10 Carnegie Institution Of Washington Development of sensitive FRET sensors and methods of using the same
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
US7273746B2 (en) 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
DE102004062294A1 (de) 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
TWI529181B (zh) 2005-02-28 2016-04-11 贏創德固賽有限責任公司 以可更新原料為基之吸水聚合物結構及其生產的方法
US20080193937A1 (en) 2005-03-30 2008-08-14 Jitao Zou Identification of a Sterol Acyltransferase Gene
JP5149785B2 (ja) 2005-04-12 2013-02-20 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー エタノールを得るためのバイオマスの処理
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
US7772444B2 (en) 2005-05-19 2010-08-10 E. I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
AU2006269864A1 (en) 2005-07-18 2007-01-25 Evonik Degussa Gmbh Methionine producing recombinant microorganisms
US20090132178A1 (en) 2005-08-03 2009-05-21 Dharamsi Akil I Crystalline enoyl-(acyl-carrier-protein) Reductase from Heliobacter Pylori
EP1752532A1 (en) * 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
US7846688B2 (en) 2005-08-15 2010-12-07 The Regents Of The University Of Colorado Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
WO2007047680A2 (en) 2005-10-14 2007-04-26 Cargill, Incorporated Increasing the activity of radical s-adenosyl methionine (sam) enzymes
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
JP5064761B2 (ja) 2005-12-21 2012-10-31 富士フイルム株式会社 ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体
US8535916B2 (en) 2006-02-13 2013-09-17 Ls9, Inc. Modified microorganisms and uses therefor
WO2007130745A1 (en) 2006-03-15 2007-11-15 Regents Of The University Of Colorado Enhanced alcohol tolerant microorganism and methods of use thereof
US20070219390A1 (en) 2006-03-15 2007-09-20 Battelle Memorial Institute Method and apparatus for conversion of beta-hydroxy carbonyl compounds
US7687661B2 (en) 2006-03-15 2010-03-30 Battelle Memorial Institute Method for conversion of β-hydroxy carbonyl compounds
MX340759B (es) 2006-03-15 2015-03-11 Dsm Ip Assets B V * Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados.
CN101573451B (zh) 2006-03-15 2014-04-30 Dsmip资产公司 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法
KR20070096348A (ko) 2006-03-23 2007-10-02 주식회사 엘지화학 1,4―butanediol〔1,4―BDO〕생성능을가지는 변이체 및 이를 이용한 1,4―BDO의 제조방법
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
JP5933909B2 (ja) 2006-05-19 2016-06-15 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪酸およびその誘導体の生産
CN101490241A (zh) * 2006-05-19 2009-07-22 Ls9公司 脂肪酸及其衍生物的制备
CA2651747C (en) 2006-05-26 2017-10-24 Amyris Biotechnologies, Inc. Production of isoprenoids
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US20080103060A1 (en) 2006-08-08 2008-05-01 Regents Of The University Of Colorado Compositions and methods for chemical reporter vectors
DE102006039203B4 (de) 2006-08-22 2014-06-18 Evonik Degussa Gmbh Verfahren zur Herstellung von durch Kristallisation gereinigter Acrylsäure aus Hydroxypropionsäure sowie Vorrichtung dazu
WO2008028002A1 (en) 2006-08-29 2008-03-06 Rice University Increasing nadph-dependent products
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico
US20100028962A1 (en) 2006-09-18 2010-02-04 Qiang Hu Algal Medium Chain Length Fatty Acids and Hydrocarbons
WO2008042958A2 (en) 2006-10-04 2008-04-10 Cargill, Incorporated Carboxylic acids prepared using a salt-splitting process
MX2009004221A (es) 2006-10-20 2009-09-10 Univ Arizona State Cianobacterias modificadas.
AU2007332241A1 (en) 2006-12-15 2008-06-19 Biofuelchem Co., Ltd. Enhanced butanol producing microorganisms and method for preparing butanol using the same
AU2008206403A1 (en) 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
AU2008212826A1 (en) 2007-02-09 2008-08-14 Zeachem Inc. Energy efficient methods to produce products
WO2008113041A2 (en) 2007-03-14 2008-09-18 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
BRPI0809039A2 (pt) 2007-03-23 2014-09-16 Metabolic Explorer Sa Microorganismos metabolicamente projetados úteis para a produção de 1,2-propanodiol
WO2008133131A1 (ja) 2007-04-16 2008-11-06 Ajinomoto Co., Inc. 有機酸の製造方法
BRPI0813359A2 (pt) * 2007-05-22 2014-10-14 Ls9 Inc Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos
JP5449142B2 (ja) 2007-06-01 2014-03-19 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング メタクリル酸又はメタクリルエステルの製造方法
JP5342809B2 (ja) 2007-06-06 2013-11-13 花王株式会社 透明固形石鹸
US8198055B2 (en) 2007-06-08 2012-06-12 Coskata, Inc. Process for converting syngas to liquid products with microorganisms on two-layer membrane
WO2009006430A1 (en) 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing fatty acid derived compounds
JP2010263790A (ja) 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
KR20090026230A (ko) 2007-09-09 2009-03-12 김건 임베디드 시스템의 범용 고속 실시간 모니터링 장치
WO2009036095A1 (en) 2007-09-10 2009-03-19 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
JP2009067775A (ja) 2007-09-17 2009-04-02 Rohm & Haas Co ヒドロキシカルボン酸、またはその塩を、不飽和カルボン酸および/またはそのエステルに変換する方法
AU2008304180B2 (en) 2007-09-27 2014-02-27 Genomatica, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
CA2704227A1 (en) 2007-11-10 2009-05-14 Joule Biotechnologies, Inc. Hyperphotosynthetic organisms
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8518678B2 (en) 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
WO2009089457A1 (en) 2008-01-11 2009-07-16 Novozymes A/S Methods for producing 3-hydroxypropionic acid and compounds thereof
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CN102015995B (zh) 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
JP5755884B2 (ja) 2008-03-05 2015-07-29 ジェノマティカ, インコーポレイテッド 第一級アルコールを産生する生物
US8598378B2 (en) 2008-03-14 2013-12-03 University Of Hawaii Methods and compositions for extraction and transesterification of biomass components
WO2009121066A1 (en) 2008-03-28 2009-10-01 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
TWI456949B (zh) 2008-04-30 2014-10-11 Thomson Licensing 閘口裝置及其使用方法
MX2010012192A (es) 2008-05-16 2011-04-26 Ls9 Inc Metodos y composiciones para producir hidrocarburos.
EP2620501A3 (en) 2008-05-23 2013-10-02 E. I. du Pont de Nemours and Company DGAT genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
BRPI0909964A2 (pt) 2008-06-04 2017-06-13 Butamax Advanced Biofuels Llc "hospedeiro de produção entérico para a produção de isobutanol e método para a produção de isobutanol"
AU2009258344B2 (en) 2008-06-09 2013-11-07 Lanzatech Nz, Inc. Production of butanediol by anaerobic microbial fermentation
DE102008002309A1 (de) 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008002715A1 (de) 2008-06-27 2009-12-31 Evonik Röhm Gmbh 2-Hydroxyisobuttersäure produzierende rekombinante Zelle
EP2313491A4 (en) 2008-07-08 2011-12-07 Opx Biotechnologies Inc METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL
US20110244575A1 (en) 2008-07-23 2011-10-06 Lipscomb Tanya E W Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)
US20100021978A1 (en) 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
US20110281314A1 (en) 2008-08-04 2011-11-17 Lynch Michael D Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
US20160362710A9 (en) 2008-08-18 2016-12-15 REG Life Sciences, LLC Systems and methods for production of mixed fatty esters
EP2326709A4 (en) 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
US8546645B2 (en) 2008-10-03 2013-10-01 Agrisoma Biosciences Inc. Production of modified fatty acids in plants through rDNA targeted integration of heterologous genes
MX2011003597A (es) 2008-10-07 2011-06-20 Ls9 Inc Metodos y composiciones para producir aldehidos grasos.
MY153590A (en) 2008-12-12 2015-02-26 Celexion Llc Biological synthesis of difunctional alkanes from alpha ketoacids
CN110129296A (zh) 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
US8835137B2 (en) 2008-12-23 2014-09-16 Matrix Genetics, Llc Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products
US20120094386A1 (en) 2009-03-11 2012-04-19 Sapphire Energy, Inc. Engineering salt tolerance in photosynthetic microorganisms
KR20120025450A (ko) 2009-04-02 2012-03-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 석시네이트 생성을 위한 경로의 엔지니어링
CN102459569B (zh) 2009-04-10 2018-02-23 Reg生命科学有限责任公司 脂肪酸衍生物的产生
CN102459622B (zh) * 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
US20110144377A1 (en) 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
WO2011008565A1 (en) 2009-06-29 2011-01-20 Synthetic Genomics, Inc. Acyl-acp thioesterase genes and uses therefor
CN102482692A (zh) 2009-07-01 2012-05-30 诺维信北美公司 用于分离和回收3-羟基丙酸的工艺
WO2011038134A1 (en) 2009-09-25 2011-03-31 Ls9, Inc. Production of fatty acid derivatives
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
AU2010306785B2 (en) 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US20120240289A1 (en) 2009-10-20 2012-09-20 Ivo Feussner Methods and means to alter lipid biosynthesis by targeting multiple enzymes to suborganelle domains
WO2011063363A2 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
CA2781443A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Methods, systems, and compositions for microbial bio-production of biomolecules using syngas components, or sugars, as feedstocks
JP2013511283A (ja) 2009-11-23 2013-04-04 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 電解質の添加を伴う抽出発酵を用いたブタノールの生成方法
IN2012DN04907A (enExample) 2009-12-02 2015-09-25 Univ Michigan State
WO2011081658A2 (en) 2009-12-15 2011-07-07 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentants
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
CA2788045A1 (en) 2010-01-27 2011-08-04 Opx Biotechnologies, Inc. Microorganism production of high-valve chemical products, and related compositions, methods and systems
CN101745245B (zh) 2010-02-05 2012-05-23 北京化工大学 一种多级逆流式旋转床反应精馏装置及其应用
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
ES2899431T3 (es) * 2010-08-06 2022-03-11 Melt&Marble Ab Métodos y productos para la producción de ésteres de cera
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
AU2011314084B2 (en) 2010-09-28 2016-06-02 The Regents Of The University Of California Producing alpha-olefins using polyketide synthases
WO2012054400A1 (en) 2010-10-18 2012-04-26 Zeachem, Inc. Recovery of organic acid using a complex extraction solvent
MX2013005654A (es) 2010-11-22 2013-07-17 Novozymes Inc Composiciones y metodos para la produccion de acido 3-hidroxipropionico.
KR20140019302A (ko) 2010-11-22 2014-02-14 유니버시티 오브 플로리다 리서치 파운데이션, 인크. D(-)-젖산을 생산하기 위한 내열성 바실러스 코아귤란스의 조작
US20140121118A1 (en) 2010-11-23 2014-05-01 Opx Biotechnologies, Inc. Methods, systems and compositions regarding multiplex construction protein amino-acid substitutions and identification of sequence-activity relationships, to provide gene replacement such as with tagged mutant genes, such as via efficient homologous recombination
CN103492560B (zh) * 2011-02-07 2016-09-28 威廉马什莱斯大学 逆向β氧化途径
BR112013024288A2 (pt) * 2011-03-22 2016-08-16 Opx Biotechnologies Inc método para a produção de ácido graxo ou derivado de ácido graxo, organismo geneticamente modificado e produto
KR20120108538A (ko) 2011-03-24 2012-10-05 삼성전자주식회사 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법
WO2012135760A1 (en) 2011-03-30 2012-10-04 Ls9, Inc. Compositions comprising and methods for producing beta-hydroxy fatty acid esters
US20120264902A1 (en) 2011-04-18 2012-10-18 The Regents Of The University Of Colorado, A Body Corporate Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP)
WO2012177726A1 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganism for producing primary alcohols and related compounds and methods related thereto
KR101860442B1 (ko) 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작
CA2840525A1 (en) 2011-06-28 2013-01-03 Brookhaven Science Associates, Llc Modified plants with increased oil content
DK2740797T3 (da) * 2011-08-04 2017-02-20 Suntory Holdings Ltd Protein med aktivitet til at fremme fedtsyreforlængelse, derfor kodende gen samt anvendelse deraf
AU2012289886A1 (en) 2011-08-04 2014-02-20 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-CoA synthase
CN103975070A (zh) 2011-09-27 2014-08-06 艾克森美孚研究与工程公司 酰基-酰基载体蛋白(acyl-acp)蜡酯合酶
US8790901B2 (en) 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
WO2013126855A1 (en) 2012-02-23 2013-08-29 The Regents Of The University Of California Atp driven direct photosynthetic production of fuels and chemicals
ES2786633T3 (es) 2012-04-02 2020-10-13 Genomatica Inc Enzimas CAR y producción mejorada de alcoholes grasos
BR122019026142B1 (pt) 2012-04-02 2021-12-14 Genomatica, Inc Célula hospedeira recombinante
US20130345470A1 (en) 2012-06-20 2013-12-26 Opx Biotechnologies, Inc. Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide
EP2864282A4 (en) 2012-06-20 2016-01-20 Opx Biotechnologies Inc CLEANING OF 3-HYDROXYPROPIONIC ACID FROM RAW CELLBOUILLON AND DEHYDRATION TO ACRYLIC ACID
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
KR20230020007A (ko) 2012-09-14 2023-02-09 게노마티카 인코포레이티드 개선된 에스테르 신타아제 특성을 갖는 효소 변이체
CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
US9809804B2 (en) 2013-01-23 2017-11-07 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using KASIII for production of bi-functional fatty acids
US20150044746A1 (en) 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2014145343A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
EP3008178A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark Microbial production of 3-hydroxypropionic acid
WO2015010103A2 (en) * 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters

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AU2013299414A1 (en) 2015-03-26
US20160340700A1 (en) 2016-11-24
CN104718282A (zh) 2015-06-17
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