BRPI0407600A - processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda - Google Patents

processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda

Info

Publication number
BRPI0407600A
BRPI0407600A BRPI0407600-1A BRPI0407600A BRPI0407600A BR PI0407600 A BRPI0407600 A BR PI0407600A BR PI0407600 A BRPI0407600 A BR PI0407600A BR PI0407600 A BRPI0407600 A BR PI0407600A
Authority
BR
Brazil
Prior art keywords
evolved
protein
microorganism
microorganisms
defined medium
Prior art date
Application number
BRPI0407600-1A
Other languages
English (en)
Inventor
Michel Chateau
Benjamin Gonzalez
Isabelle Meynial-Salles
Philippe Noeel Paul Soucaille
Olivier Zink
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32931448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0407600(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0301924A external-priority patent/FR2851256A1/fr
Priority claimed from FR0305769A external-priority patent/FR2854902B1/fr
Priority claimed from FR0305768A external-priority patent/FR2851255B1/fr
Priority claimed from FR0313054A external-priority patent/FR2862067A1/fr
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of BRPI0407600A publication Critical patent/BRPI0407600A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C12P7/20—Glycerol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ecology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"PROCESSOS DE PREPARAçãO DE MICRORGANISMOS EVOLUìDOS E DE UMA PROTEìNA EVOLUìDA E DE BIOTRANSFORMAçãO, GENE EVOLUìDO, PROTEìNA EVOLUìDA, E UTILIZAçãO DE UM MICRORGANISMO EVOLUìDO OU DE UMA PROTEìNA EVOLUìDA". A presente invenção trata de um novo processo de preparação de microrganismo evoluídos permitindo uma modificação das vias metabólicas, caracterizado pelo fato que compreende as etapas seguintes: a) obtenção de um microrganismo modificado por modificação genética das células de um microrganismo inicial de maneira a inibir a produção ou o consumo de um metabólito quando o microrganismo é cultivado sobre um meio definido, afetando desta forma a capacidade de crescimento do microrganismo; b) cultura dos microrganismos modificados obtidos anteriormente sobre o dito meio definido para fazê-lo evoluir; pode ser necessário acrescentar um co-substrato ao meio definido a fim de permitir esta evolução; c) seleção das células de microrganismos modificados capazes de se desenvolver sobre o meio definido, eventualmente com um co-substrato. A invenção trata igualmente das cepas de microrganismos evoluidos assim obtidas, os genes evoluídos codificadores para proteinas evoluídas suscetíveis de ser obtidos pelo processo de acordo com a invenção e a utilização dos ditos microrganismos, genes ou proteinas evoluidos em um processo de biotransformação.
BRPI0407600-1A 2003-02-18 2004-02-17 processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda BRPI0407600A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0301924A FR2851256A1 (fr) 2003-02-18 2003-02-18 Procede de criblage et d'evolution dirigee de souches produisant de la methionine par nouvelle voie metabolique
FR0305769A FR2854902B1 (fr) 2003-05-14 2003-05-14 Microorganisme a activite cysteine synthase modifiee et procede de preparation de la cysteine
FR0305768A FR2851255B1 (fr) 2003-02-18 2003-05-14 Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine
FR0313054A FR2862067A1 (fr) 2003-11-06 2003-11-06 Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
PCT/FR2004/000354 WO2004076659A2 (fr) 2003-02-18 2004-02-17 Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques

Publications (1)

Publication Number Publication Date
BRPI0407600A true BRPI0407600A (pt) 2006-02-14

Family

ID=32931448

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407600-1A BRPI0407600A (pt) 2003-02-18 2004-02-17 processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda

Country Status (6)

Country Link
US (2) US20060270013A1 (pt)
EP (2) EP2348107A3 (pt)
JP (1) JP2006517796A (pt)
BR (1) BRPI0407600A (pt)
MX (1) MXPA05008857A (pt)
WO (1) WO2004076659A2 (pt)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05008857A (es) * 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
JP4479283B2 (ja) 2004-03-04 2010-06-09 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
WO2006082254A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Microorganisms comprising enzymes expressed with low gamma-elimination activity
CA2615315C (en) * 2005-07-18 2015-10-06 Basf Aktiengesellschaft Use of dimethyl disulfide for methionine production in microorganisms
CN101351558B (zh) 2006-01-04 2013-08-14 代谢探索者公司 使用硫酸盐通透酶表达增强的微生物制备甲硫氨酸及其前体高丝氨酸或琥珀酰高丝氨酸的方法
KR100905381B1 (ko) 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
US20100092954A1 (en) * 2006-08-02 2010-04-15 Bernhard Palsson Method for Determining the Genetic Basis for Physiological Changes in Organisms
CN101903513B (zh) * 2007-01-12 2013-08-21 科罗拉多大学董事会法人 增强微生物对产生的有机化学物质的耐受性的组合物和方法
US9051588B2 (en) * 2007-03-23 2015-06-09 Metabolic Explorer Microorganisms and methods for production of 1,2-propanediol and acetol
DK2109681T3 (en) * 2007-03-23 2014-12-08 Metabolic Explorer Sa NEW MICROORGANISMS FOR THE PREPARATION OF 1,2-PROPANDIOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN
PL2808381T3 (pl) 2007-04-11 2016-09-30 Kompozycje i sposoby wytwarzania metioniny
WO2009043372A1 (en) * 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US20090181901A1 (en) * 2007-11-14 2009-07-16 Thomas Eidenberger Compositions and methods to increase bioavailability of carotenoids
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US7815801B2 (en) * 2007-12-17 2010-10-19 APT Water, Inc. Removal of selenium in contaminated wastewater streams
US9005952B2 (en) * 2008-04-04 2015-04-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US7851180B2 (en) 2008-04-04 2010-12-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US20110244575A1 (en) * 2008-07-23 2011-10-06 Lipscomb Tanya E W Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)
WO2010022763A1 (en) * 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
KR101827230B1 (ko) 2008-12-31 2018-02-07 메타볼릭 익스플로러 디올의 제조 방법
EP2267126A1 (en) 2009-06-26 2010-12-29 Metabolic Explorer Process for the stable gene interruption in clostridia
BR112012006801A2 (pt) 2009-09-27 2018-04-10 Opx Biotechnologies Inc método para produção de ácido 3-hidroxipropiônico e outros produtos
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
WO2011063363A2 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
WO2011073738A1 (en) 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
MX2012007718A (es) 2009-12-30 2012-07-25 Metabolic Explorer Sa Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa.
KR101915819B1 (ko) 2009-12-30 2018-11-06 에보니크 데구사 게엠베하 메티오닌 생산을 위한 균주 및 방법
EP2588598B1 (en) 2010-07-02 2016-03-09 Metabolic Explorer Method for the preparation of hydroxy acids
TWI500768B (zh) 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
WO2012087039A2 (ko) 2010-12-21 2012-06-28 씨제이제일제당 (주) 호모세린 아세틸 트랜스퍼라제 활성을 가지는 변이형 폴리펩티드 및 이를 발현하는 미생물
WO2012091479A2 (en) * 2010-12-29 2012-07-05 Cj Cheiljedang Corporation Methods for production of l-methionine and related products
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
EP2540834A1 (en) 2011-06-29 2013-01-02 Metabolic Explorer Method for the preparation of 1,3-propanediol
EP2578559A1 (en) 2011-10-07 2013-04-10 Metabolic Explorer Process for producing isobutene from isobutylamine
WO2013053824A1 (en) 2011-10-11 2013-04-18 Metabolic Explorer New biosynthesis pathway for prenol in a recombinant microorganism
US20140342419A1 (en) 2011-11-21 2014-11-20 Metabolic Explorer Microorganism strains for the production of 2,3-butanediol
US9434963B2 (en) 2012-03-02 2016-09-06 Metabolic Explorer Process for butanol production
EP2647718A3 (en) 2012-04-06 2014-12-24 Metabolic Explorer Process for producing 5-aminopentanoate empolying a recombinant microorganism
WO2013190343A1 (en) 2012-06-18 2013-12-27 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
SG11201501013PA (en) 2012-08-10 2015-04-29 Opx Biotechnologies Inc Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2014049382A2 (en) 2012-09-26 2014-04-03 Metabolic Explorer Ethylenediamine fermentative production by a recombinant microorganism
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CA2922597A1 (en) 2013-08-30 2015-03-05 Metabolic Explorer Microorganism for methionine production with improved methionine synthase activity and methionine efflux
MX2017002662A (es) 2014-09-01 2017-05-30 Metabolic Explorer Sa Metodo y microorganismo para produccion de metionina por fermentacion con eflujo de metionina mejorado.
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
KR20160111285A (ko) 2015-03-16 2016-09-26 씨제이제일제당 (주) 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물
WO2016193161A1 (en) 2015-05-29 2016-12-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Multivalent immunogenic composition for inducing an immune response against yersinia species
WO2017211883A1 (en) * 2016-06-07 2017-12-14 Danmarks Tekniske Universitet Bacterial cells with improved tolerance to polyols
EP3267345A1 (en) * 2016-07-06 2018-01-10 European Molecular Biology Laboratory Methods for adaptive laboratory evolution
US20190276859A1 (en) 2016-07-08 2019-09-12 Evonik Degussa Gmbh Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)
WO2018037098A1 (en) 2016-08-24 2018-03-01 Danmarks Tekniske Universitet Method of improving methyltransferase activity
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
US11162122B2 (en) 2017-07-11 2021-11-02 Adisseo France S.A.S. Methionine-producing yeast
US11319564B2 (en) 2017-07-11 2022-05-03 Adisseo France S.A.S. Enhanced metabolite-producing yeast
WO2019011946A1 (en) 2017-07-11 2019-01-17 Adisseo France S.A.S. YEAST PRODUCING THREONINE
US11608488B2 (en) 2017-07-11 2023-03-21 Adisseo France S.A.S. Enhanced metabolite-producing yeast
EP3428282A1 (en) 2017-07-11 2019-01-16 Alderys Ectoine-producing yeast
KR101866884B1 (ko) 2018-01-29 2018-06-14 씨제이제일제당(주) 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물
CN110684811B (zh) * 2019-11-13 2021-06-29 浙江工业大学 一种提高甲硫氨酸产量的方法
CN113388630B (zh) * 2020-03-11 2022-07-26 华东理工大学 合成l-半胱氨酸的重组大肠杆菌的构建方法及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3071518A (en) * 1960-02-09 1963-01-01 Cons Lab Inc Method of increasing metabolic product yield of organisms
JPS51151391A (en) 1975-06-19 1976-12-25 Ajinomoto Co Inc Process for preparing l-sulfur- containing amino acids
JPS56144092A (en) * 1980-04-14 1981-11-10 Ajinomoto Co Inc Preparation of l-methionine by fermentation
JPS61242589A (ja) 1985-04-22 1986-10-28 Mitsui Toatsu Chem Inc Ｌ−含硫アミノ酸の製造方法
CA1299128C (en) 1986-11-19 1992-04-21 Tooru Miyahara Method of producing l-cystine
JPH02222692A (ja) 1989-02-23 1990-09-05 Kyowa Hakko Kogyo Co Ltd Ｌ―含硫アミノ酸の製造法
EP0519113A1 (en) * 1991-06-21 1992-12-23 Ajinomoto Co., Inc. Bacterial strains having high productivity of an amino acid and method of constructing these strains
FR2678601B1 (fr) 1991-07-01 1993-10-22 Commissariat Energie Atomique Procede de preparation de sulfures et d'acides amines marques au soufre 35.
CA2130347A1 (en) * 1992-02-20 1993-09-02 Jefferson C. Lievense Biosynthesis of methionine using a reduced source of sulfur
FR2693207B1 (fr) 1992-07-03 1994-09-30 Orsan Souche de levure permettant la co-expression d'une activité mono-oxygénase de cytochrome P450 hétérologue et d'une NADPH-cytochrome P450-réductase endogène ou hétérologue et son utilisation à des fins de bioconversion.
JP3514507B2 (ja) 1994-05-13 2004-03-31 サントリー株式会社 硫化水素生成が低減された酵母とこの酵母を用いたビール製造法
DE19539952A1 (de) 1995-10-26 1997-04-30 Consortium Elektrochem Ind Verfahren zur Herstellung von O-Acetylserin, L-Cystein und L-Cystein-verwandten Produkten
DE19726083A1 (de) 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
WO2000012745A1 (de) 1998-08-26 2000-03-09 Lonza Ag Verfahren zur herstellung von (2r)-piperidinderivaten
US6368793B1 (en) 1998-10-14 2002-04-09 Microgenomics, Inc. Metabolic selection methods
JP2000157267A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
KR100309327B1 (ko) 1999-05-06 2001-09-29 담철근 아라비노스 이성화효소를 포함한 재조합 대장균주와 이를 이용한타가토스의 생산방법
DE19924364A1 (de) 1999-05-27 2000-11-30 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP2003169674A (ja) 1999-07-02 2003-06-17 Ajinomoto Co Inc Ｌ−リジンの製造法
DE19949579C1 (de) 1999-10-14 2000-11-16 Consortium Elektrochem Ind Verfahren zur fermentativen Herstellung von L-Cystein oder L-Cystein-Derivaten
JP4380029B2 (ja) * 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
DE10109690A1 (de) * 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
DE10136986A1 (de) 2000-09-03 2002-03-21 Degussa Für Gene cysD, cysN, cysK, cysE und cysH kodierende Nukleotidsequenzen
CA2424178A1 (en) * 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
AU2002239733A1 (en) 2000-10-26 2002-06-18 Paradigm Genetics, Inc. Methods for the identification of inhibitors of cysteine syhthase in plants
EP1345714A1 (en) * 2000-12-22 2003-09-24 Basf Aktiengesellschaft Genes of corynebacterium
DE10104722A1 (de) 2001-02-02 2002-08-14 Ipk Inst Fuer Pflanzengenetik Verfahren zur fermentativen Herstellung von Cystein, Cystin und Glutathion
US6579705B2 (en) 2001-04-04 2003-06-17 Consortium Fur Elektrochemische Industrie Gmbh Process for preparing non-proteinogenic L-amino acids
FR2823219B1 (fr) 2001-04-10 2003-07-04 Pasteur Institut Mutants de la desoxycytidine kinase possedant une activite enzymatique elargie
WO2003004656A1 (en) 2001-07-06 2003-01-16 Institut Pasteur Method for obtaining cells with new properties
DE10222858A1 (de) * 2002-05-23 2003-12-04 Basf Ag Verfahren zur fermentativen Herstellung schwefelhaltiger Feinchemikalien
MXPA05008857A (es) * 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.

Also Published As

Publication number Publication date
EP1597364B1 (fr) 2013-07-24
EP2348107A3 (fr) 2012-07-11
WO2004076659A2 (fr) 2004-09-10
US7745195B2 (en) 2010-06-29
WO2004076659A3 (fr) 2004-12-16
EP1597364A2 (fr) 2005-11-23
MXPA05008857A (es) 2006-03-09
US20050054060A1 (en) 2005-03-10
US20060270013A1 (en) 2006-11-30
EP2348107A2 (fr) 2011-07-27
JP2006517796A (ja) 2006-08-03

Similar Documents

Publication Publication Date Title
BRPI0407600A (pt) processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda
Blier et al. Holding our breath in our modern world: will mitochondria keep the pace with climate changes?
Li et al. Metabolic engineering of Corynebacterium glutamicum for methionine production by removing feedback inhibition and increasing NADPH level
TWI330199B (en) Microorganism strain and its preparation method and uses
Bai et al. Enhanced L-(+)-lactic acid production by an adapted strain of Rhizopus oryzae using corncob hydrolysate
EP2511285A3 (en) Gene knockout mesophilic and thermophilic organisms, and methods of use thereof
BRPI0506790A (pt) processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa
Ganzert et al. Methanosarcina spelaei sp. nov., a methanogenic archaeon isolated from a floating biofilm of a subsurface sulphurous lake
BRPI0921734A2 (pt) micro-organismos criados geneticamente capazes de produzir compostos-alvo sob condições anaeróbicas
BR0012712A (pt) Métodos de produção de l-aminoácidos aumentando-se o nadph celular
DK1766028T3 (da) Ethanolproduktiviteter for Saccharomyces Cerevisiaes-stammer i fermentering af fortyndede syre-hydrolysater afhænger af deres furan-reducerende formåen
BRPI0400577A (pt) Processo para produzir um l-aminoácido
KR101525663B1 (ko) 신규 ｏ-포스포세린 배출 단백질 및 이를 이용한 ｏ-포스포세린의 생산방법
Rao et al. Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol production
WO2010056805A3 (en) Gene knockout mesophilic and thermophilic organisms, and methods of use thereof
BRPI0208535B8 (pt) método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a
Zhou et al. Methanospirillum psychrodurum sp. nov., isolated from wetland soil
Suzuki et al. Characterization and origin of bacterial arginine kinases
L'Haridon et al. Desulfurobacterium atlanticum sp. nov., Desulfurobacterium pacificum sp. nov. and Thermovibrio guaymasensis sp. nov., three thermophilic members of the Desulfurobacteriaceae fam. nov., a deep branching lineage within the Bacteria
Klatte et al. Role of L-alanine for redox self-sufficient amination of alcohols
BRPI0500729A (pt) processo para a produção de l-aminoácidos usando as bactérias corineformes
Liu et al. Exploring eukaryotic formate metabolisms to enhance microbial growth and lipid accumulation
ES2670035T3 (es) Nuevas variantes de la proteína RhtB y método de producción de O-fosfoserina utilizando las mismas
BR122019023670B1 (pt) Método para a preparação de cisteína ou de um derivado desta usando uma nova ofosfoserina sulfidrilase
Chandel et al. Purification and characterization of tyrosine phenol lyase from Citrobacter freundii

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.