FR2851255B1 - Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine - Google Patents

Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine

Info

Publication number
FR2851255B1
FR2851255B1 FR0305768A FR0305768A FR2851255B1 FR 2851255 B1 FR2851255 B1 FR 2851255B1 FR 0305768 A FR0305768 A FR 0305768A FR 0305768 A FR0305768 A FR 0305768A FR 2851255 B1 FR2851255 B1 FR 2851255B1
Authority
FR
France
Prior art keywords
methionine
microorganism
preparation
synthase activity
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0305768A
Other languages
English (en)
Other versions
FR2851255A1 (fr
Inventor
Michel Chateau
Benjamin Gonzales
Philippe Noel Paul Soucaille
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolic Explorer SA
Original Assignee
Metabolic Explorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0301924A external-priority patent/FR2851256A1/fr
Application filed by Metabolic Explorer SA filed Critical Metabolic Explorer SA
Priority to FR0305768A priority Critical patent/FR2851255B1/fr
Priority to EP10183261A priority patent/EP2348107A3/fr
Priority to US10/546,139 priority patent/US20060270013A1/en
Priority to PCT/FR2004/000354 priority patent/WO2004076659A2/fr
Priority to JP2006502150A priority patent/JP2006517796A/ja
Priority to MXPA05008857A priority patent/MXPA05008857A/es
Priority to BRPI0407600-1A priority patent/BRPI0407600A/pt
Priority to EP04711626.4A priority patent/EP1597364B1/fr
Priority to US10/781,499 priority patent/US7745195B2/en
Publication of FR2851255A1 publication Critical patent/FR2851255A1/fr
Publication of FR2851255B1 publication Critical patent/FR2851255B1/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR0305768A 2003-02-18 2003-05-14 Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine Expired - Fee Related FR2851255B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR0305768A FR2851255B1 (fr) 2003-02-18 2003-05-14 Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine
BRPI0407600-1A BRPI0407600A (pt) 2003-02-18 2004-02-17 processos de preparação de microorganismos evoluìdos e de uma proteìna evoluìda e de biotransformação, gene evoluìdo, proteìna evoluìda, e utilização de um microorganismo evoluìdo ou de uma proteìna evoluìda
US10/546,139 US20060270013A1 (en) 2003-02-18 2004-02-17 Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways
PCT/FR2004/000354 WO2004076659A2 (fr) 2003-02-18 2004-02-17 Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
JP2006502150A JP2006517796A (ja) 2003-02-18 2004-02-17 代謝経路の生成または改変を可能とする進化した微生物の生産方法
MXPA05008857A MXPA05008857A (es) 2003-02-18 2004-02-17 Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
EP10183261A EP2348107A3 (fr) 2003-02-18 2004-02-17 Procédé de préparation de microorganismes évolués permettant la création ou la modification de voies métaboliques
EP04711626.4A EP1597364B1 (fr) 2003-02-18 2004-02-17 Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
US10/781,499 US7745195B2 (en) 2003-02-18 2004-02-18 Method for the preparation of an evolved microorganism for the creation or the modification of metabolic pathways

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0301924A FR2851256A1 (fr) 2003-02-18 2003-02-18 Procede de criblage et d'evolution dirigee de souches produisant de la methionine par nouvelle voie metabolique
FR0305768A FR2851255B1 (fr) 2003-02-18 2003-05-14 Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine

Publications (2)

Publication Number Publication Date
FR2851255A1 FR2851255A1 (fr) 2004-08-20
FR2851255B1 true FR2851255B1 (fr) 2007-05-25

Family

ID=32773884

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0305768A Expired - Fee Related FR2851255B1 (fr) 2003-02-18 2003-05-14 Microorganisme a activite methionine synthase modifiee et procede de preparation de la methionine

Country Status (1)

Country Link
FR (1) FR2851255B1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5981995B2 (ja) 2011-09-02 2016-08-31 アルケマ フランス Ｌ−メチオニンの製造方法
KR101836719B1 (ko) * 2015-10-13 2018-04-20 씨제이제일제당 (주) O-아세틸호모세린 설피드릴라제 변이체 및 이를 이용한 l-메치오닌 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51151391A (en) * 1975-06-19 1976-12-25 Ajinomoto Co Inc Process for preparing l-sulfur- containing amino acids
CA2130347A1 (fr) * 1992-02-20 1993-09-02 Jefferson C. Lievense Biosynthese de methionine a l'aide d'une source de soufre reduite
JP2000157267A (ja) * 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
DE10109690A1 (de) * 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
CN100334213C (zh) * 2000-12-22 2007-08-29 巴斯福股份公司 棒状杆菌基因

Also Published As

Publication number Publication date
FR2851255A1 (fr) 2004-08-20

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Legal Events

Date Code Title Description
AS Court action brought to claim ownership of the patent
ST Notification of lapse

Effective date: 20160129