IL172663A0 - A process for the preparation of ??-(phenoxy)phenylacetic acid derivatives - Google Patents

A process for the preparation of ??-(phenoxy)phenylacetic acid derivatives

Info

Publication number
IL172663A0
IL172663A0 IL172663A IL17266305A IL172663A0 IL 172663 A0 IL172663 A0 IL 172663A0 IL 172663 A IL172663 A IL 172663A IL 17266305 A IL17266305 A IL 17266305A IL 172663 A0 IL172663 A0 IL 172663A0
Authority
IL
Israel
Prior art keywords
phenoxy
preparation
acid derivatives
phenylacetic acid
phenylacetic
Prior art date
Application number
IL172663A
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/656,567 external-priority patent/US7199259B2/en
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of IL172663A0 publication Critical patent/IL172663A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
IL172663A 2003-06-20 2005-12-18 A process for the preparation of ??-(phenoxy)phenylacetic acid derivatives IL172663A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60018903A 2003-06-20 2003-06-20
US10/656,567 US7199259B2 (en) 2003-06-20 2003-09-04 Resolution of α-(phenoxy)phenylacetic acid derivatives
PCT/US2004/019616 WO2004112774A1 (en) 2003-06-20 2004-06-18 RESOLUTION OF α-(PHENOXY)PHENYLACETIC ACID DERIVATIVES

Publications (1)

Publication Number Publication Date
IL172663A0 true IL172663A0 (en) 2006-04-10

Family

ID=33544772

Family Applications (1)

Application Number Title Priority Date Filing Date
IL172663A IL172663A0 (en) 2003-06-20 2005-12-18 A process for the preparation of ??-(phenoxy)phenylacetic acid derivatives

Country Status (7)

Country Link
EP (1) EP1635809A4 (en)
KR (1) KR101073742B1 (en)
CA (1) CA2529774C (en)
IL (1) IL172663A0 (en)
MX (1) MXPA05013981A (en)
RS (1) RS20050937A (en)
WO (1) WO2004112774A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US7199259B2 (en) 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
JP2008533206A (en) 2005-03-21 2008-08-21 メタボレックス インコーポレーティッド Methods for avoiding edema in the treatment of metabolism, inflammation, and cardiovascular disorders
KR100678287B1 (en) * 2005-06-23 2007-02-02 한미약품 주식회사 Method of preparing clopidogrel and intermediates used therein
US7714131B2 (en) 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6712585A (en) * 1966-10-03 1968-04-04
US3517050A (en) * 1966-10-03 1970-06-23 Merck & Co Inc Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid
US6624194B1 (en) * 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia

Also Published As

Publication number Publication date
EP1635809A4 (en) 2006-09-27
CA2529774C (en) 2014-05-27
CA2529774A1 (en) 2004-12-29
EP1635809A1 (en) 2006-03-22
KR101073742B1 (en) 2011-10-13
MXPA05013981A (en) 2006-03-02
KR20060030048A (en) 2006-04-07
WO2004112774A1 (en) 2004-12-29
RS20050937A (en) 2008-04-04

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