BRPI0506790A - processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa - Google Patents
processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepaInfo
- Publication number
- BRPI0506790A BRPI0506790A BRPI0506790-1A BRPI0506790A BRPI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A
- Authority
- BR
- Brazil
- Prior art keywords
- propanediol
- microorganisms
- evolved
- strain
- preparing
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 7
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 6
- 235000013772 propylene glycol Nutrition 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 229960004063 propylene glycol Drugs 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 abstract 1
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004690 coupled electron pair approximation Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 101150080369 tpiA gene Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROCESSOS DE PREPARAçãO DE UMA CEPA DE MICROORGANISMOS EVOLUìDOS E DE 1,2-PROPANODIOL, E, CEPA" A invenção refere-se a um novo processo de preparação de um cepa de microorganismos evoluídos para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples, o dito processo compreendendo a cultura sob pressão de seleção em um meio de cultura adequado que compreende uma fonte de carbono simples, de uma cepa bacteriana inicial compreendendo uma deleção do gene tpiA e uma deleção de ao menos um gene implicado na conversão do metil glioxal (propanal) em lactato, a fim de fazer evoluir na dita cepa inicial um mais genes implicados na via de biosíntese do DHAP em metilglioxal e depois em 1,2-propanodiol para os genes evoluídos que têm uma atividade <sym>1,2-propanodiol síntase<sym> melhorada, e depois seleciona-se e isola-se a ou as cepas de microorganismos evoluídos que têm uma atividade <sym>1,2 propanodiol síntase<sym> melhorada. A invenção refere-se igualmente aos microorganismos iniciais e os microorganismos eveoluidos assim obtidos e um processo de preparação de 1,2-propanodiol e eventualmente de acetona por cultura dos microorganismos evoluídos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
FR0400214 | 2004-01-12 | ||
PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0506790A true BRPI0506790A (pt) | 2007-05-22 |
BRPI0506790B1 BRPI0506790B1 (pt) | 2020-12-22 |
Family
ID=34684930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506790-1A BRPI0506790B1 (pt) | 2004-01-12 | 2005-01-12 | processo de preparação de uma cepa de escherichia coli evoluída para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples e processo de preparação de 1,2-propanodiol |
Country Status (18)
Country | Link |
---|---|
US (1) | US8252579B2 (pt) |
EP (2) | EP2192180A1 (pt) |
JP (1) | JP4613177B2 (pt) |
KR (1) | KR101229525B1 (pt) |
CN (1) | CN1910278B (pt) |
AT (1) | ATE440135T1 (pt) |
BR (1) | BRPI0506790B1 (pt) |
CA (1) | CA2547695C (pt) |
DE (1) | DE602005016073D1 (pt) |
DK (1) | DK1704230T3 (pt) |
ES (1) | ES2329914T3 (pt) |
FR (1) | FR2864967B1 (pt) |
PL (1) | PL1704230T3 (pt) |
PT (1) | PT1704230E (pt) |
RU (1) | RU2407793C2 (pt) |
SI (1) | SI1704230T1 (pt) |
WO (1) | WO2005073364A2 (pt) |
ZA (1) | ZA200605440B (pt) |
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ES2866823T3 (es) | 2015-07-27 | 2021-10-19 | Institut Nat Des Sciences Appliquees | Nuevo polipéptido que presenta una actividad de ferredoxina-NADP+ reductasa, polinucleótido que codifica el mismo y utilizaciones del mismo |
PL3331998T3 (pl) | 2015-08-07 | 2020-12-28 | Evonik Operations Gmbh | Wytwarzanie przez fermentację l-metioniny zależne od tiokarboksylanu białka |
US10731137B2 (en) | 2015-09-10 | 2020-08-04 | Metabolic Explorer | Lactaldehyde reductases for the production of 1,2-propanediol |
DK3365427T3 (da) | 2015-10-23 | 2020-10-26 | Metabolic Explorer Sa | Mikroorganisme, der er modificeret til assimilation af levulinsyre |
PL3380627T3 (pl) | 2015-11-27 | 2020-01-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-metioniny |
WO2017211883A1 (en) * | 2016-06-07 | 2017-12-14 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to polyols |
US20190276859A1 (en) * | 2016-07-08 | 2019-09-12 | Evonik Degussa Gmbh | Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts) |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP3342873A1 (en) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof |
EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
US10710950B2 (en) | 2017-11-09 | 2020-07-14 | Braskem S.A. | Process for the recovery of ketones and glycols from fermentation |
CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
CN115125263B (zh) * | 2022-05-31 | 2024-01-23 | 中国科学院天津工业生物技术研究所 | 解除pts依赖碳源对相关启动子阻遏的方法及其应用 |
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US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
CA2733616C (en) * | 1999-08-18 | 2016-09-27 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high titer |
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DK1704230T3 (da) | 2009-11-02 |
ATE440135T1 (de) | 2009-09-15 |
RU2006129295A (ru) | 2008-02-20 |
ZA200605440B (en) | 2007-04-25 |
CN1910278B (zh) | 2010-05-26 |
PL1704230T3 (pl) | 2010-01-29 |
JP4613177B2 (ja) | 2011-01-12 |
EP1704230A2 (fr) | 2006-09-27 |
JP2007517517A (ja) | 2007-07-05 |
CA2547695A1 (fr) | 2005-08-11 |
KR20060123490A (ko) | 2006-12-01 |
PT1704230E (pt) | 2009-10-14 |
EP2192180A1 (fr) | 2010-06-02 |
US20070072279A1 (en) | 2007-03-29 |
FR2864967B1 (fr) | 2006-05-19 |
KR101229525B1 (ko) | 2013-02-04 |
DE602005016073D1 (de) | 2009-10-01 |
WO2005073364A2 (fr) | 2005-08-11 |
WO2005073364A3 (fr) | 2005-09-29 |
BRPI0506790B1 (pt) | 2020-12-22 |
CN1910278A (zh) | 2007-02-07 |
FR2864967A1 (fr) | 2005-07-15 |
SI1704230T1 (sl) | 2009-12-31 |
ES2329914T3 (es) | 2009-12-02 |
CA2547695C (fr) | 2015-03-10 |
EP1704230B1 (fr) | 2009-08-19 |
RU2407793C2 (ru) | 2010-12-27 |
US8252579B2 (en) | 2012-08-28 |
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