SI1704230T1 - Razviti mikroorganizem za pridobivanje 1,2-propandiola - Google Patents
Razviti mikroorganizem za pridobivanje 1,2-propandiolaInfo
- Publication number
- SI1704230T1 SI1704230T1 SI200530761T SI200530761T SI1704230T1 SI 1704230 T1 SI1704230 T1 SI 1704230T1 SI 200530761 T SI200530761 T SI 200530761T SI 200530761 T SI200530761 T SI 200530761T SI 1704230 T1 SI1704230 T1 SI 1704230T1
- Authority
- SI
- Slovenia
- Prior art keywords
- strain
- propanediol
- gene
- methylglyoxal
- carbon
- Prior art date
Links
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 4
- 235000013772 propylene glycol Nutrition 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 101150080369 tpiA gene Proteins 0.000 abstract 2
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- 101100280051 Brucella abortus biovar 1 (strain 9-941) eryH gene Proteins 0.000 abstract 1
- 101100235161 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) lerI gene Proteins 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
| EP05717405A EP1704230B1 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
| PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1704230T1 true SI1704230T1 (sl) | 2009-12-31 |
Family
ID=34684930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200530761T SI1704230T1 (sl) | 2004-01-12 | 2005-01-12 | Razviti mikroorganizem za pridobivanje 1,2-propandiola |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8252579B2 (sl) |
| EP (2) | EP2192180A1 (sl) |
| JP (1) | JP4613177B2 (sl) |
| KR (1) | KR101229525B1 (sl) |
| CN (1) | CN1910278B (sl) |
| AT (1) | ATE440135T1 (sl) |
| BR (1) | BRPI0506790B1 (sl) |
| CA (1) | CA2547695C (sl) |
| DE (1) | DE602005016073D1 (sl) |
| DK (1) | DK1704230T3 (sl) |
| ES (1) | ES2329914T3 (sl) |
| FR (1) | FR2864967B1 (sl) |
| PL (1) | PL1704230T3 (sl) |
| PT (1) | PT1704230E (sl) |
| RU (1) | RU2407793C2 (sl) |
| SI (1) | SI1704230T1 (sl) |
| WO (1) | WO2005073364A2 (sl) |
| ZA (1) | ZA200605440B (sl) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010524428A (ja) * | 2006-05-01 | 2010-07-22 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | 非組み換え宿主におけるエタノール産生 |
| EP2084288A1 (en) * | 2006-10-31 | 2009-08-05 | Metabolic Explorer | Process for the biological production of 1,3-propanediol from glycerol with high yield |
| WO2008072921A1 (en) * | 2006-12-15 | 2008-06-19 | Biofuelchem Co., Ltd. | Enhanced butanol producing microorganisms and method for preparing butanol using the same |
| BRPI0720566A2 (pt) * | 2006-12-21 | 2014-02-04 | Gevo Inc | Produção de butanol através de levedura metabolicamente projetada |
| WO2008091627A2 (en) * | 2007-01-22 | 2008-07-31 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
| MY156388A (en) * | 2007-02-08 | 2016-02-15 | Biofuelchem Co Ltd | Method for preparing butanol through butyryl-coa as an intermediate using yeast |
| MY147186A (en) | 2007-02-09 | 2012-11-14 | Univ California | Biofuel production by recombinant microorganisms |
| EP3214179B1 (en) | 2007-03-16 | 2021-03-03 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| CN104694449B (zh) * | 2007-03-20 | 2018-05-22 | 佛罗里达大学研究基金公司 | 用于有效生产琥珀酸和苹果酸的材料和方法 |
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| KR20100015815A (ko) | 2007-03-23 | 2010-02-12 | 메타볼릭 익스플로러 | 1,2-프로판디올 및 아세톨의 제조를 위한 미생물 및 방법 |
| WO2008116849A1 (en) * | 2007-03-23 | 2008-10-02 | Metabolic Explorer | New micro-organisms for the production of acetol obtained by a combination of evolution and rational design. |
| CN101679940A (zh) * | 2007-03-23 | 2010-03-24 | 代谢探索者公司 | 用于产生1,2-丙二醇的代谢工程改造的微生物 |
| US20090111154A1 (en) * | 2007-04-04 | 2009-04-30 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| EP2543657A3 (en) * | 2007-08-10 | 2013-08-14 | Genomatica, Inc. | Methods for the synthesis of acrylic acid and derivatives from fumaric acid |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| AU2008310573A1 (en) * | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| EP3037541A1 (en) | 2007-12-17 | 2016-06-29 | Photanol B.V. | Light-driven co2 reduction to organic compounds to serve as fuels or as industrial half products by an autotroph containing a fermentative gene cassette |
| EP2245137B1 (en) | 2008-01-22 | 2017-08-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| EP2225127B1 (en) * | 2008-02-21 | 2013-04-03 | Takata AG | Airbag module for a motor vehicle |
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| JP2011519561A (ja) * | 2008-05-01 | 2011-07-14 | ジェノマティカ， インコーポレイテッド | メタクリル酸の産生のための微生物 |
| BRPI0913901A2 (pt) * | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
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| WO2010012604A1 (en) * | 2008-07-28 | 2010-02-04 | Clariant International Ltd | Production method |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| EP3514242A3 (en) | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Microrganisms for the production of 1,4-butanediol |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| MX2011003558A (es) | 2008-10-03 | 2011-05-02 | Metabolic Explorer Sa | Metodo para purificar un alcohol de un caldo de fermentacion usando un evaporador de pelicula descendente, un evaporador de pelicula enjuagada, un evaporador de pelicula delgada o un evaporador de trayectoria corta. |
| MX2011004842A (es) | 2008-11-07 | 2011-05-30 | Metabolic Explorer Sa | Uso de sacarosa como sustrato para la produccion fermentativa de 1,2-propanodiol. |
| US20100184173A1 (en) * | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| WO2010064744A1 (en) * | 2008-12-03 | 2010-06-10 | Korea Research Institute Of Bioscience And Biotechnology | Mutant blocked in glycerol oxidaion pathway for producing 1,3-propanediol |
| CN102307986A (zh) * | 2008-12-16 | 2012-01-04 | 基因组股份公司 | 用于将合成气和其他碳源转化成有用产品的微生物和方法 |
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| KR101711308B1 (ko) | 2009-04-02 | 2017-02-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 석시네이트 생성을 위한 경로의 엔지니어링 |
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| EP4273255A3 (en) | 2009-05-07 | 2024-01-03 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of hexamethylenediamine |
| EP2429587A4 (en) * | 2009-05-15 | 2014-10-08 | Genomatica Inc | ORGANISMS FOR THE PREPARATION OF CYCLOHEXANONE |
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| EP2440669A4 (en) * | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
| EP2267126A1 (en) | 2009-06-26 | 2010-12-29 | Metabolic Explorer | Process for the stable gene interruption in clostridia |
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| KR20180014240A (ko) | 2009-10-23 | 2018-02-07 | 게노마티카 인코포레이티드 | 아닐린의 제조를 위한 미생물 |
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| WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
| CN103589756B (zh) * | 2013-11-15 | 2015-12-02 | 中国科学院微生物研究所 | 利用l-乳酸生物合成s-1,2-丙二醇的方法 |
| MX2016014821A (es) * | 2014-05-12 | 2017-03-10 | Metabolic Explorer Sa | Microorganismo y metodo nuevos para la produccion de 1,2-propanodiol basada en acetol reductasa dependiente de nadph y suministro mejorado de nadph. |
| JP6026494B2 (ja) * | 2014-12-05 | 2016-11-16 | メタボリック エクスプローラー | １，２−プロパンジオールの発酵製造のための基質としてのスクロースの使用 |
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| CN107690482B (zh) | 2015-04-07 | 2022-11-29 | 代谢探索者公司 | 用于2,4-二羟基丁酸的优化生产的经修饰的微生物 |
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| KR20190026851A (ko) * | 2016-07-08 | 2019-03-13 | 에보니크 데구사 게엠베하 | 당 포스포트랜스퍼라제 시스템 (pts)을 코딩하는 유전자를 포함하는 미생물에 의한 메티오닌 또는 그의 히드록시 유사체 형태의 발효적 생산을 위한 방법 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3342873A1 (en) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof |
| EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
| BR112020009129A2 (pt) * | 2017-11-09 | 2020-10-20 | Braskem S.A. | processo para a recuperação de cetonas e glicóis a partir de fermentação |
| CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
| CN115125263B (zh) * | 2022-05-31 | 2024-01-23 | 中国科学院天津工业生物技术研究所 | 解除pts依赖碳源对相关启动子阻遏的方法及其应用 |
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| US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| ATE335823T1 (de) * | 1999-08-18 | 2006-09-15 | Du Pont | Verfahren zur biologischen herstellung von 1,3- propandiol |
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|---|---|
| BRPI0506790B1 (pt) | 2020-12-22 |
| CN1910278B (zh) | 2010-05-26 |
| RU2006129295A (ru) | 2008-02-20 |
| CA2547695A1 (fr) | 2005-08-11 |
| US20070072279A1 (en) | 2007-03-29 |
| EP1704230A2 (fr) | 2006-09-27 |
| CA2547695C (fr) | 2015-03-10 |
| US8252579B2 (en) | 2012-08-28 |
| KR20060123490A (ko) | 2006-12-01 |
| PT1704230E (pt) | 2009-10-14 |
| WO2005073364A3 (fr) | 2005-09-29 |
| PL1704230T3 (pl) | 2010-01-29 |
| WO2005073364A2 (fr) | 2005-08-11 |
| ATE440135T1 (de) | 2009-09-15 |
| EP2192180A1 (fr) | 2010-06-02 |
| JP2007517517A (ja) | 2007-07-05 |
| CN1910278A (zh) | 2007-02-07 |
| FR2864967B1 (fr) | 2006-05-19 |
| DK1704230T3 (da) | 2009-11-02 |
| EP1704230B1 (fr) | 2009-08-19 |
| BRPI0506790A (pt) | 2007-05-22 |
| RU2407793C2 (ru) | 2010-12-27 |
| DE602005016073D1 (de) | 2009-10-01 |
| KR101229525B1 (ko) | 2013-02-04 |
| JP4613177B2 (ja) | 2011-01-12 |
| FR2864967A1 (fr) | 2005-07-15 |
| ES2329914T3 (es) | 2009-12-02 |
| ZA200605440B (en) | 2007-04-25 |
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