DE60026563D1 - Herstellung von polyketiden - Google Patents

Herstellung von polyketiden

Info

Publication number
DE60026563D1
DE60026563D1 DE60026563T DE60026563T DE60026563D1 DE 60026563 D1 DE60026563 D1 DE 60026563D1 DE 60026563 T DE60026563 T DE 60026563T DE 60026563 T DE60026563 T DE 60026563T DE 60026563 D1 DE60026563 D1 DE 60026563D1
Authority
DE
Germany
Prior art keywords
product
precursor
produce
host cells
polycetides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026563T
Other languages
English (en)
Inventor
Leonard Katz
Peter Revill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Application granted granted Critical
Publication of DE60026563D1 publication Critical patent/DE60026563D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Saccharide Compounds (AREA)
DE60026563T 1999-10-25 2000-10-25 Herstellung von polyketiden Expired - Lifetime DE60026563D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16141499P 1999-10-25 1999-10-25
PCT/US2000/029447 WO2001031049A2 (en) 1999-10-25 2000-10-25 Production of polyketides

Publications (1)

Publication Number Publication Date
DE60026563D1 true DE60026563D1 (de) 2006-05-04

Family

ID=22581090

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026563T Expired - Lifetime DE60026563D1 (de) 1999-10-25 2000-10-25 Herstellung von polyketiden

Country Status (6)

Country Link
US (2) US6627427B1 (de)
EP (1) EP1224317B1 (de)
AT (1) ATE319848T1 (de)
AU (1) AU1231701A (de)
DE (1) DE60026563D1 (de)
WO (1) WO2001031049A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6790605B1 (en) 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
JP2005529579A (ja) * 2000-05-02 2005-10-06 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドの生合成のための過剰産生宿主
WO2004007688A2 (en) * 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
US7067290B2 (en) 2002-11-12 2006-06-27 Kosan Biosciences Incorporated Method for production of polyketides
US20060069360A1 (en) * 2004-09-29 2006-03-30 Kimberly-Clark Worldwide, Inc. Absorbent article with insult indicators
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
WO2010011874A2 (en) * 2008-07-23 2010-01-28 Opx Biotechnologies, Inc Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CN102695799A (zh) 2009-09-27 2012-09-26 Opx生物工艺学公司 用于制备3-羟基丙酸和其它产物的方法
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
EP2658855A2 (de) * 2010-12-31 2013-11-06 Acies Bio d.o.o. Neue polyketidverbindungen und verfahren zu ihrer herstellung
CN104718282A (zh) 2012-08-10 2015-06-17 Opx生物工艺学公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
US10047383B2 (en) 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
CA2905602A1 (en) 2013-03-15 2014-09-18 Sarah M. Hoyt Flash evaporation for product purification and recovery
EP3022310B1 (de) 2013-07-19 2019-10-16 Cargill, Incorporated Mikroorganismen und verfahren zur herstellung von fettsäuren und aus fettsäuren gewonnenen produkten
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (de) 2014-09-02 2019-10-09 Cargill, Incorporated Herstellung von fettsäureestern
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
CN110914425B (zh) 2017-06-06 2024-06-25 齐默尔根公司 用于改良刺糖多孢菌的高通量(htp)基因组工程改造平台
CN111454975B (zh) * 2020-04-17 2023-06-20 长沙微智生物科技有限公司 一种与多杀菌素相关的ech基因的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
JP3633629B2 (ja) 1995-07-06 2005-03-30 ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドの無細胞合成
DE69636195T2 (de) 1995-10-13 2007-03-29 President And Fellows Of Harvard College, Cambridge Phosphopantethenyltransferasen und deren verwendungen
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
AU732909B2 (en) 1997-04-30 2001-05-03 Board Of Trustees Of The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6262340B1 (en) * 1997-07-10 2001-07-17 Kosan Biosciences, Inc. Production of polyketides in plants
US6503737B1 (en) * 1998-10-02 2003-01-07 Kosan Biosciences, Inc. Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster
EP1135470A2 (de) * 1998-11-20 2001-09-26 Kosan Biosciences, Inc. Rekombinante methoden und produkte zur herstellung von epothilone und epothilone derivaten
NZ517557A (en) 1999-10-13 2004-05-28 Univ Leland Stanford Junior E. coli host cells that synthesize methylmalonyl CoA
EP1224300B9 (de) 1999-10-27 2007-09-26 Kosan Biosciences, Inc. Heterologe herstellung von polyketiden

Also Published As

Publication number Publication date
US20030235892A1 (en) 2003-12-25
WO2001031049A2 (en) 2001-05-03
WO2001031049A3 (en) 2002-01-24
AU1231701A (en) 2001-05-08
ATE319848T1 (de) 2006-03-15
EP1224317A2 (de) 2002-07-24
US6627427B1 (en) 2003-09-30
EP1224317B1 (de) 2006-03-08

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Legal Events

Date Code Title Description
8332 No legal effect for de