CN104395315B - 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 - Google Patents
作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 Download PDFInfo
- Publication number
- CN104395315B CN104395315B CN201380034594.1A CN201380034594A CN104395315B CN 104395315 B CN104395315 B CN 104395315B CN 201380034594 A CN201380034594 A CN 201380034594A CN 104395315 B CN104395315 B CN 104395315B
- Authority
- CN
- China
- Prior art keywords
- base
- pyrrolo
- pyrimidine
- morpholine
- benzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC1(C)O*OC1(C)C Chemical compound CC1(C)O*OC1(C)C 0.000 description 1
- RRWDJJOVLHJYLA-UHFFFAOYSA-N CCCOCCN1C=C(B(OC(C)(C)C(C)(C)O)I)C2=C(N3CCOCC3)N=CN=CC12 Chemical compound CCCOCCN1C=C(B(OC(C)(C)C(C)(C)O)I)C2=C(N3CCOCC3)N=CN=CC12 RRWDJJOVLHJYLA-UHFFFAOYSA-N 0.000 description 1
- CFMUBXRVBJVJIO-UHFFFAOYSA-N CN(C)c1c(c(-c2cccc(CO)c2)c[n]2COCC[Si](C)(C)C)c2ncn1 Chemical compound CN(C)c1c(c(-c2cccc(CO)c2)c[n]2COCC[Si](C)(C)C)c2ncn1 CFMUBXRVBJVJIO-UHFFFAOYSA-N 0.000 description 1
- IDPYRTCOKCLNHC-UHFFFAOYSA-N CN(C)c1c(c(I)c[n]2COCC[Si](C)(C)C)c2ncn1 Chemical compound CN(C)c1c(c(I)c[n]2COCC[Si](C)(C)C)c2ncn1 IDPYRTCOKCLNHC-UHFFFAOYSA-N 0.000 description 1
- UIRWOYIXFYHFAE-UHFFFAOYSA-O CNc1ncnc(N(C)C)c1Cc1cc(COC[n]2c3[nH+]cnc(N(C)C)c3c(-c3cccc(COC=O)c3)c2)cc(CO)c1 Chemical compound CNc1ncnc(N(C)C)c1Cc1cc(COC[n]2c3[nH+]cnc(N(C)C)c3c(-c3cccc(COC=O)c3)c2)cc(CO)c1 UIRWOYIXFYHFAE-UHFFFAOYSA-O 0.000 description 1
- HGTDLKXUWVKLQX-UHFFFAOYSA-N OB(c1cccc(CO)c1)O Chemical compound OB(c1cccc(CO)c1)O HGTDLKXUWVKLQX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261666299P | 2012-06-29 | 2012-06-29 | |
US61/666,299 | 2012-06-29 | ||
US201361820828P | 2013-05-08 | 2013-05-08 | |
US61/820,828 | 2013-05-08 | ||
PCT/IB2013/055039 WO2014001973A1 (en) | 2012-06-29 | 2013-06-19 | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610111744.XA Division CN105732639A (zh) | 2012-06-29 | 2013-06-19 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104395315A CN104395315A (zh) | 2015-03-04 |
CN104395315B true CN104395315B (zh) | 2016-08-17 |
Family
ID=49029142
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610111744.XA Pending CN105732639A (zh) | 2012-06-29 | 2013-06-19 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
CN201380034594.1A Expired - Fee Related CN104395315B (zh) | 2012-06-29 | 2013-06-19 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610111744.XA Pending CN105732639A (zh) | 2012-06-29 | 2013-06-19 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
Country Status (32)
Country | Link |
---|---|
US (2) | US9156845B2 (ja) |
EP (2) | EP3255049A1 (ja) |
JP (3) | JP6189948B2 (ja) |
KR (1) | KR20150027267A (ja) |
CN (2) | CN105732639A (ja) |
AP (1) | AP3902A (ja) |
AR (1) | AR091628A1 (ja) |
AU (1) | AU2013282869B2 (ja) |
BR (1) | BR112014032913A2 (ja) |
CA (1) | CA2878054C (ja) |
CL (1) | CL2014003566A1 (ja) |
CO (1) | CO7160063A2 (ja) |
CR (1) | CR20140566A (ja) |
DO (1) | DOP2014000303A (ja) |
EA (1) | EA025186B1 (ja) |
ES (1) | ES2637245T3 (ja) |
GE (1) | GEP201706620B (ja) |
GT (1) | GT201400301A (ja) |
HK (1) | HK1204619A1 (ja) |
IL (1) | IL236294A (ja) |
MD (1) | MD20140130A2 (ja) |
MX (1) | MX2014015769A (ja) |
NI (1) | NI201400151A (ja) |
NZ (1) | NZ702571A (ja) |
PE (1) | PE20150153A1 (ja) |
PH (1) | PH12014502886B1 (ja) |
SG (1) | SG11201408044QA (ja) |
TN (1) | TN2014000537A1 (ja) |
TW (1) | TWI482774B (ja) |
UY (1) | UY34883A (ja) |
WO (1) | WO2014001973A1 (ja) |
ZA (1) | ZA201409136B (ja) |
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PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
KR20150027267A (ko) * | 2012-06-29 | 2015-03-11 | 화이자 인코포레이티드 | LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘 |
US8963597B1 (en) * | 2013-10-02 | 2015-02-24 | Nanya Technology Corporation | Cross-domain enablement method and electronic apparatus |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
CN105980388B (zh) * | 2014-01-29 | 2018-01-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
CR20160348A (es) | 2014-01-29 | 2017-04-28 | Glaxosmithline Intellectual Property Dev Ltd | Compuestos |
WO2015176010A1 (en) * | 2014-05-15 | 2015-11-19 | The United States Of America, As Represented By The Secretary, Departmentof Health & Human Services | Treatment or prevention of an intestinal disease or disorder |
CN104086553B (zh) * | 2014-06-13 | 2016-04-27 | 南京药石科技股份有限公司 | 一种制备7-溴咪唑并[2,1-f][1,2,4]三嗪-4-胺的方法 |
WO2016007540A2 (en) | 2014-07-10 | 2016-01-14 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
JP6421241B2 (ja) | 2014-11-14 | 2018-11-07 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | タンパク質キナーゼ阻害剤としての6−アミノ−7−ビシクロ−7−デアザ−プリン誘導体 |
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FR3041640B1 (fr) * | 2015-09-30 | 2019-05-17 | Les Laboratoires Servier | NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
EP3527570A4 (en) | 2016-10-14 | 2020-04-15 | Jiangsu Hengrui Medicine Co., Ltd. | FIVE-LINKED HETERARYARYLE CYCLE BRIDGE DERIVATIVE, METHOD FOR PREPARING SAME, AND MEDICAL USE THEREOF |
JP7101176B2 (ja) * | 2017-02-03 | 2022-07-14 | レオ ファーマ アクティーゼルスカブ | 新規JAKキナーゼ阻害剤としての5-(7H-ピロロ[2,3-d]ピリミジン-4-イル)-5-アザスピロ[2.5]オクタン-8-カルボン酸誘導体 |
CN106831790B (zh) * | 2017-02-17 | 2019-07-26 | 四川大学华西医院 | 7H-吡咯并[2,3-d]嘧啶衍生物 |
SG11201908234WA (en) | 2017-02-24 | 2019-10-30 | Daegu Gyeongbuk Medical Innovation Found | Pharmaceutical composition comprising compound capable of penetrating blood-brain barrier as effective ingredient for preventing or treating brain cancer |
KR20190131981A (ko) * | 2018-05-18 | 2019-11-27 | 재단법인 대구경북첨단의료산업진흥재단 | 외상성 뇌손상 또는 뇌졸중의 예방 또는 치료용 약학적 조성물 |
KR101990739B1 (ko) * | 2018-07-24 | 2019-06-19 | 재단법인 대구경북첨단의료산업진흥재단 | 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물 |
KR101992059B1 (ko) * | 2018-08-23 | 2019-06-21 | 재단법인 대구경북첨단의료산업진흥재단 | 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물 |
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- 2013-06-19 KR KR20157002334A patent/KR20150027267A/ko not_active Application Discontinuation
- 2013-06-19 EP EP17175308.0A patent/EP3255049A1/en not_active Withdrawn
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