CN103221825A - 生物标志物和治疗方法 - Google Patents

生物标志物和治疗方法 Download PDF

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Publication number
CN103221825A
CN103221825A CN2011800517811A CN201180051781A CN103221825A CN 103221825 A CN103221825 A CN 103221825A CN 2011800517811 A CN2011800517811 A CN 2011800517811A CN 201180051781 A CN201180051781 A CN 201180051781A CN 103221825 A CN103221825 A CN 103221825A
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met
cancer
patient
antibody
biomarker
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Chinese (zh)
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P.帕特尔
A.C.彼得森
R.L.约克
J.査
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Genentech Inc
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Genentech Inc
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CN2011800517811A 2010-08-31 2011-08-31 生物标志物和治疗方法 Pending CN103221825A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US37891110P 2010-08-31 2010-08-31
US61/378,911 2010-08-31
US38992210P 2010-10-05 2010-10-05
US61/389,922 2010-10-05
US39099510P 2010-10-07 2010-10-07
US61/390,995 2010-10-07
US42070310P 2010-12-07 2010-12-07
US61/420,703 2010-12-07
US201161487527P 2011-05-18 2011-05-18
US61/487,527 2011-05-18
US201161492338P 2011-06-01 2011-06-01
US61/492,338 2011-06-01
US201161503489P 2011-06-30 2011-06-30
US61/503,489 2011-06-30
PCT/US2011/050069 WO2012031027A1 (en) 2010-08-31 2011-08-31 Biomarkers and methods of treatment

Publications (1)

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CN103221825A true CN103221825A (zh) 2013-07-24

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US (2) US20120089541A1 (https=)
EP (2) EP2612151B1 (https=)
JP (2) JP2013537966A (https=)
KR (1) KR20130103734A (https=)
CN (1) CN103221825A (https=)
AU (1) AU2011295919A1 (https=)
BR (1) BR112013004673A8 (https=)
CA (1) CA2808236A1 (https=)
DK (1) DK2612151T3 (https=)
ES (1) ES2641916T3 (https=)
IL (1) IL248530A0 (https=)
MX (1) MX2013002084A (https=)
RU (1) RU2013114360A (https=)
SG (2) SG10201408229WA (https=)
WO (1) WO2012031027A1 (https=)

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CN105087775A (zh) * 2015-07-24 2015-11-25 北京莱尔生物医药科技有限公司 一种基于稀有细胞检测c-MET/CEP7基因状态的方法及相关试剂盒
CN107002119A (zh) * 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
CN109069632A (zh) * 2016-04-15 2018-12-21 伊莱利利公司 用于治疗结直肠癌的雷莫芦单抗和merestinib的组合
WO2020244654A1 (en) * 2019-06-06 2020-12-10 Apollomics Inc. (Hangzhou) Method for treating cancer patients using c-met inhibitor
CN114512183A (zh) * 2022-01-27 2022-05-17 北京吉因加医学检验实验室有限公司 一种预测met基因扩增或多倍体的方法及装置
CN115678993A (zh) * 2022-01-27 2023-02-03 上海爱谱蒂康生物科技有限公司 一种生物标志物组合、含其的试剂及其应用
WO2025103450A1 (en) * 2023-11-15 2025-05-22 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Antibody-drug conjugates targeting egfr/c-met and preparation methods and uses thereof

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KR20100135780A (ko) * 2008-03-06 2010-12-27 제넨테크, 인크. Ｃ-ｍｅｔ 및 ｅｇｆｒ 길항제로의 조합 요법
EP2496601B1 (en) 2009-11-05 2017-06-07 F. Hoffmann-La Roche AG Methods and composition for secretion of heterologous polypeptides
AR086823A1 (es) * 2011-06-30 2014-01-22 Genentech Inc Formulaciones de anticuerpo anti-c-met, metodos
SG11201400724SA (en) 2011-09-19 2014-04-28 Genentech Inc Combination treatments comprising c-met antagonists and b-raf antagonists
EP2758057B1 (en) * 2011-09-22 2017-05-31 Exelixis, Inc. Method for treating osteoporosis
WO2013166296A1 (en) 2012-05-02 2013-11-07 Exelixis, Inc. A dual met - vegf modulator for treating osteolytic bone metastases
KR101938699B1 (ko) * 2012-07-23 2019-01-16 삼성전자주식회사 Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도
KR101938698B1 (ko) 2012-07-23 2019-01-16 삼성전자주식회사 Ｃｂｌ의 항 ｃ－ｍｅｔ 항체 적용 대상 환자 선별을 위한 바이오마커로서의 용도
US20140030259A1 (en) * 2012-07-27 2014-01-30 Genentech, Inc. Methods of treating fgfr3 related conditions
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JP6352952B2 (ja) 2013-03-07 2018-07-04 バーマーサ・リサーチ・エルエルシーＢａｒｍａｒｓａ Ｒｅｓｅａｒｃｈ Ｌｌｃ グリアジンペプチドを用いた癌の治療のためのキットおよび方法
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
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BR112015023120A2 (pt) * 2013-03-15 2017-11-21 Genentech Inc método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado
WO2015010596A1 (zh) * 2013-07-22 2015-01-29 北京盛诺基医药科技有限公司 一种乳腺癌预后诊断的方法
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KR102272788B1 (ko) * 2014-01-07 2021-07-05 삼성전자주식회사 c-Met 저해제의 효능 예측 또는 효능 검증을 위한 바이오마커
EP2891884B1 (en) 2014-01-07 2017-10-25 Samsung Electronics Co., Ltd IL-8 for predicting or monitoring efficacy of c-MET inhibitor
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CN107517590B (zh) * 2014-07-29 2021-11-12 威马克生物有限公司 与表皮生长因子受体-靶制剂有关的感受性预测用新型生物标志物及其用途
KR20160024639A (ko) 2014-08-26 2016-03-07 삼성전자주식회사 c-Met 표적 치료제의 저항성 또는 효능 예측을 위한 바이오마커 PDGF
JP2016155776A (ja) * 2015-02-24 2016-09-01 学校法人兵庫医科大学 抗腫瘍効果増強剤および抗腫瘍剤
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CN107561625A (zh) * 2016-06-30 2018-01-09 扬升照明股份有限公司 光源模组以及导光板
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JP6709340B2 (ja) 2016-11-16 2020-06-10 イーライ リリー アンド カンパニー エクソン１４スキッピング変異（複数可）またはエクソン１４スキッピング表現型を有するがんの併用療法
RU2765997C2 (ru) 2017-03-30 2022-02-07 Мерк Патент Гмбх Комбинация анти-pd-l1 антитела и ингибитора днк-пк для лечения злокачественного новообразования
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