KR20130103734A - 바이오마커 및 치료 방법 - Google Patents
바이오마커 및 치료 방법 Download PDFInfo
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- KR20130103734A KR20130103734A KR1020137008025A KR20137008025A KR20130103734A KR 20130103734 A KR20130103734 A KR 20130103734A KR 1020137008025 A KR1020137008025 A KR 1020137008025A KR 20137008025 A KR20137008025 A KR 20137008025A KR 20130103734 A KR20130103734 A KR 20130103734A
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- met
- cancer
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- antibody
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- General Business, Economics & Management (AREA)
- Theoretical Computer Science (AREA)
- Wood Science & Technology (AREA)
- Business, Economics & Management (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37891110P | 2010-08-31 | 2010-08-31 | |
| US61/378,911 | 2010-08-31 | ||
| US38992210P | 2010-10-05 | 2010-10-05 | |
| US61/389,922 | 2010-10-05 | ||
| US39099510P | 2010-10-07 | 2010-10-07 | |
| US61/390,995 | 2010-10-07 | ||
| US42070310P | 2010-12-07 | 2010-12-07 | |
| US61/420,703 | 2010-12-07 | ||
| US201161487527P | 2011-05-18 | 2011-05-18 | |
| US61/487,527 | 2011-05-18 | ||
| US201161492338P | 2011-06-01 | 2011-06-01 | |
| US61/492,338 | 2011-06-01 | ||
| US201161503489P | 2011-06-30 | 2011-06-30 | |
| US61/503,489 | 2011-06-30 | ||
| PCT/US2011/050069 WO2012031027A1 (en) | 2010-08-31 | 2011-08-31 | Biomarkers and methods of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130103734A true KR20130103734A (ko) | 2013-09-24 |
Family
ID=44583514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137008025A Ceased KR20130103734A (ko) | 2010-08-31 | 2011-08-31 | 바이오마커 및 치료 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20120089541A1 (https=) |
| EP (2) | EP2612151B1 (https=) |
| JP (2) | JP2013537966A (https=) |
| KR (1) | KR20130103734A (https=) |
| CN (1) | CN103221825A (https=) |
| AU (1) | AU2011295919A1 (https=) |
| BR (1) | BR112013004673A8 (https=) |
| CA (1) | CA2808236A1 (https=) |
| DK (1) | DK2612151T3 (https=) |
| ES (1) | ES2641916T3 (https=) |
| IL (1) | IL248530A0 (https=) |
| MX (1) | MX2013002084A (https=) |
| RU (1) | RU2013114360A (https=) |
| SG (2) | SG10201408229WA (https=) |
| WO (1) | WO2012031027A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150082121A (ko) * | 2014-01-07 | 2015-07-15 | 삼성전자주식회사 | c-Met 저해제의 효능 예측 또는 효능 검증을 위한 바이오마커 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2601892C2 (ru) * | 2008-03-06 | 2016-11-10 | Дженентек, Инк. | Комбинированная терапия антагонистами с-мет и egfr |
| BR112012010153B1 (pt) | 2009-11-05 | 2022-05-03 | Genentech, Inc | Método de produção de um anticorpo |
| RU2013155695A (ru) | 2011-06-30 | 2015-08-10 | Дженентек, Инк. | Препараты антител против с-мет |
| AU2012312515A1 (en) | 2011-09-19 | 2014-03-13 | Genentech, Inc. | Combination treatments comprising c-met antagonists and B-raf antagonists |
| GEP201606523B (en) * | 2011-09-22 | 2016-08-10 | Exelixis Inc | Method for treating osteoporosis |
| JP2015515988A (ja) | 2012-05-02 | 2015-06-04 | エクセリクシス, インク. | 溶骨性骨転移を治療するためのmet−vegf二重調節剤 |
| KR101938698B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Cbl의 항 c-met 항체 적용 대상 환자 선별을 위한 바이오마커로서의 용도 |
| KR101938699B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Lrig1의 항 c―met 항체 적용 대상 환자 선별을 위한 용도 |
| CA2878183A1 (en) * | 2012-07-27 | 2014-01-30 | Genentech, Inc. | Methods of treating fgfr3 related conditions |
| AU2013307383A1 (en) * | 2012-08-27 | 2015-03-26 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Aminoheteroaryl compounds as MTH1 inhibitors |
| WO2014066860A2 (en) * | 2012-10-25 | 2014-05-01 | Cedars-Sinai Medical Center | Methods of prognosticating and treating cancer |
| KR20140093347A (ko) * | 2013-01-15 | 2014-07-28 | 삼성전자주식회사 | 항 c-Met 항체 처리에 의해 부작용을 유발하는 유전자 및 이를 이용한 약물 스크리닝 방법 |
| MX370858B (es) * | 2013-03-07 | 2020-01-08 | Barmarsa Res Llc | Composiciones que comprenden péptidos de gliadina para usarse en el tratamiento de cáncer. |
| US20160016171A1 (en) * | 2013-03-15 | 2016-01-21 | Nanobiosym, Inc. | Systems and Methods for Mobile Device Analysis of Nucleic Acids and Proteins |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| WO2014150819A2 (en) * | 2013-03-15 | 2014-09-25 | Genentech, Inc. | Biomarkers and methods of treatment |
| KR102389677B1 (ko) * | 2013-03-15 | 2022-04-21 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| WO2015010596A1 (zh) * | 2013-07-22 | 2015-01-29 | 北京盛诺基医药科技有限公司 | 一种乳腺癌预后诊断的方法 |
| WO2015031614A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| WO2015031626A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| US10393748B2 (en) | 2014-01-07 | 2019-08-27 | Samsung Electronics Co., Ltd. | Method for predicting efficacy of c-Met inhibitor |
| EP3116999B1 (en) | 2014-03-14 | 2021-09-15 | F. Hoffmann-La Roche AG | Methods and compositions for secretion of heterologous polypeptides |
| EP3122900A1 (en) * | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| US20160327559A1 (en) * | 2014-04-24 | 2016-11-10 | Fundació Institut Mar D'investigacions Mèdiques (Imim) | Hepatocyte growth factor as marker of prognosis in small cell lung cancer (sclc) |
| JP6779858B2 (ja) * | 2014-07-29 | 2020-11-04 | ウェルマーカー バイオ カンパニー リミテッド | Egfr−標的製剤に対する感受性予測用の新規なバイオマーカー及びその用途 |
| KR20160024639A (ko) | 2014-08-26 | 2016-03-07 | 삼성전자주식회사 | c-Met 표적 치료제의 저항성 또는 효능 예측을 위한 바이오마커 PDGF |
| JP2016155776A (ja) * | 2015-02-24 | 2016-09-01 | 学校法人兵庫医科大学 | 抗腫瘍効果増強剤および抗腫瘍剤 |
| NZ733854A (en) | 2015-02-26 | 2022-07-01 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| PH12017501857B1 (en) | 2015-06-16 | 2024-01-17 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments |
| CN105087775A (zh) * | 2015-07-24 | 2015-11-25 | 北京莱尔生物医药科技有限公司 | 一种基于稀有细胞检测c-MET/CEP7基因状态的方法及相关试剂盒 |
| AU2016325715B2 (en) * | 2015-09-24 | 2019-04-04 | Expression Pathology, Inc. | Quantifying Met protein for cancer treatment |
| US20190336599A1 (en) * | 2016-04-15 | 2019-11-07 | Eli Lilly And Company | Combination of ramucirumab and merestinib for use in treatment of colorectal cancer |
| US20210030737A1 (en) * | 2016-04-19 | 2021-02-04 | Exelixis, Inc. | Triple Negative Breast Cancer Treatment Method |
| CN107561625A (zh) * | 2016-06-30 | 2018-01-09 | 扬升照明股份有限公司 | 光源模组以及导光板 |
| KR20190062515A (ko) | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
| ES2866348T3 (es) | 2016-11-16 | 2021-10-19 | Lilly Co Eli | Terapia de combinación para el cáncer con mutación o mutaciones de omisión del exón 14 o fenotipo de omisión del exón 14 |
| SG10202110707UA (en) | 2017-03-30 | 2021-11-29 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
| CN112512576A (zh) | 2018-05-04 | 2021-03-16 | 默克专利有限公司 | PD-1/PD-L1、TGFβ和DNA-PK联合抑制用于治疗癌症 |
| WO2020064971A1 (en) | 2018-09-26 | 2020-04-02 | Merck Patent Gmbh | Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer |
| EP3980783A4 (en) * | 2019-06-06 | 2023-09-13 | Apollomics Inc. (Hangzhou) | Method for treating cancer patients using c-met inhibitor |
| EP4051279A1 (en) | 2019-11-01 | 2022-09-07 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFß AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
| WO2021224293A1 (en) * | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| DE102020005002A1 (de) * | 2020-08-17 | 2022-02-17 | Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh | Mittel zur Therapie von Tumorerkrankungen |
| TW202309094A (zh) * | 2021-05-18 | 2023-03-01 | 美商健生生物科技公司 | 用於識別癌症患者以進行組合治療之方法 |
| CN115678993B (zh) * | 2022-01-27 | 2025-09-02 | 上海爱谱蒂康生物科技有限公司 | 一种生物标志物组合、含其的试剂及其应用 |
| CN114512183B (zh) * | 2022-01-27 | 2022-09-20 | 北京吉因加医学检验实验室有限公司 | 一种预测met基因扩增或多倍体的方法及装置 |
| TW202527997A (zh) * | 2023-11-15 | 2025-07-16 | 大陸商四川科倫博泰生物醫藥股份有限公司 | 靶向egfr/c—met之抗體—藥物結合物以及其製備方法及用途 |
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-
2011
- 2011-08-31 KR KR1020137008025A patent/KR20130103734A/ko not_active Ceased
- 2011-08-31 SG SG10201408229WA patent/SG10201408229WA/en unknown
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- 2011-08-31 CN CN2011800517811A patent/CN103221825A/zh active Pending
- 2011-08-31 DK DK11754597.0T patent/DK2612151T3/en active
- 2011-08-31 BR BR112013004673A patent/BR112013004673A8/pt not_active IP Right Cessation
- 2011-08-31 CA CA2808236A patent/CA2808236A1/en not_active Abandoned
- 2011-08-31 RU RU2013114360/15A patent/RU2013114360A/ru not_active Application Discontinuation
- 2011-08-31 ES ES11754597.0T patent/ES2641916T3/es active Active
- 2011-08-31 US US13/223,173 patent/US20120089541A1/en not_active Abandoned
- 2011-08-31 AU AU2011295919A patent/AU2011295919A1/en not_active Abandoned
- 2011-08-31 EP EP11754597.0A patent/EP2612151B1/en active Active
- 2011-08-31 WO PCT/US2011/050069 patent/WO2012031027A1/en not_active Ceased
- 2011-08-31 EP EP17183227.2A patent/EP3264089A1/en not_active Withdrawn
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2015
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150082121A (ko) * | 2014-01-07 | 2015-07-15 | 삼성전자주식회사 | c-Met 저해제의 효능 예측 또는 효능 검증을 위한 바이오마커 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013537966A (ja) | 2013-10-07 |
| WO2012031027A1 (en) | 2012-03-08 |
| SG187886A1 (en) | 2013-04-30 |
| CA2808236A1 (en) | 2012-03-08 |
| MX2013002084A (es) | 2013-05-09 |
| US20140037625A1 (en) | 2014-02-06 |
| BR112013004673A2 (pt) | 2016-08-02 |
| RU2013114360A (ru) | 2014-10-10 |
| SG10201408229WA (en) | 2015-02-27 |
| DK2612151T3 (en) | 2017-10-02 |
| CN103221825A (zh) | 2013-07-24 |
| AU2011295919A1 (en) | 2013-03-07 |
| ES2641916T3 (es) | 2017-11-14 |
| JP2016105096A (ja) | 2016-06-09 |
| BR112013004673A8 (pt) | 2018-01-02 |
| EP2612151A1 (en) | 2013-07-10 |
| EP2612151B1 (en) | 2017-08-09 |
| EP3264089A1 (en) | 2018-01-03 |
| US20120089541A1 (en) | 2012-04-12 |
| IL248530A0 (en) | 2016-12-29 |
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