BR112013004673A2 - biomarcadores e métodos de tratamento. - Google Patents
biomarcadores e métodos de tratamento.Info
- Publication number
- BR112013004673A2 BR112013004673A2 BR112013004673A BR112013004673A BR112013004673A2 BR 112013004673 A2 BR112013004673 A2 BR 112013004673A2 BR 112013004673 A BR112013004673 A BR 112013004673A BR 112013004673 A BR112013004673 A BR 112013004673A BR 112013004673 A2 BR112013004673 A2 BR 112013004673A2
- Authority
- BR
- Brazil
- Prior art keywords
- biomarkers
- methods
- treatment methods
- relates
- cancer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000090 biomarker Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000000107 tumor biomarker Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Theoretical Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Business, Economics & Management (AREA)
Abstract
biomarcadores e métodos de tratamento. a presente invenção refere-se a biomarcadores de cancer. em particular, a invenção refere-se a c-met como um biomarcador para a seleção de pacientes e prognóstico de pacientes com câncer, bem como métodos de tratamento terapêutico, artigos de fabricação e métodos para fabricar os mesmos, kits de diagnóstico, métodos de detecção e métodos de publicidade relacionados aos mesmos.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37891110P | 2010-08-31 | 2010-08-31 | |
US38992210P | 2010-10-05 | 2010-10-05 | |
US39099510P | 2010-10-07 | 2010-10-07 | |
US42070310P | 2010-12-07 | 2010-12-07 | |
US201161487527P | 2011-05-18 | 2011-05-18 | |
US201161492338P | 2011-06-01 | 2011-06-01 | |
US201161503489P | 2011-06-30 | 2011-06-30 | |
PCT/US2011/050069 WO2012031027A1 (en) | 2010-08-31 | 2011-08-31 | Biomarkers and methods of treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013004673A2 true BR112013004673A2 (pt) | 2016-08-02 |
BR112013004673A8 BR112013004673A8 (pt) | 2018-01-02 |
Family
ID=44583514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013004673A BR112013004673A8 (pt) | 2010-08-31 | 2011-08-31 | biomarcadores e métodos de tratamento. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20120089541A1 (pt) |
EP (2) | EP2612151B1 (pt) |
JP (2) | JP2013537966A (pt) |
KR (1) | KR20130103734A (pt) |
CN (1) | CN103221825A (pt) |
AU (1) | AU2011295919A1 (pt) |
BR (1) | BR112013004673A8 (pt) |
CA (1) | CA2808236A1 (pt) |
DK (1) | DK2612151T3 (pt) |
ES (1) | ES2641916T3 (pt) |
IL (1) | IL248530A0 (pt) |
MX (1) | MX2013002084A (pt) |
RU (1) | RU2013114360A (pt) |
SG (2) | SG10201408229WA (pt) |
WO (1) | WO2012031027A1 (pt) |
Families Citing this family (47)
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CL2009000542A1 (es) * | 2008-03-06 | 2010-11-05 | Genentech Inc | Uso de un antagonista de c-met y egfr de formula general i para preparar un medicamento para tratar el cancer. |
US8361744B2 (en) | 2009-11-05 | 2013-01-29 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
TW201306866A (zh) | 2011-06-30 | 2013-02-16 | Genentech Inc | 抗-c-met抗體調配物 |
US20130078252A1 (en) | 2011-09-19 | 2013-03-28 | Genentech, Inc. | Combination treatments comprising c-met antagonists and b-raf antagonists |
EP2758057B1 (en) * | 2011-09-22 | 2017-05-31 | Exelixis, Inc. | Method for treating osteoporosis |
WO2013166296A1 (en) | 2012-05-02 | 2013-11-07 | Exelixis, Inc. | A dual met - vegf modulator for treating osteolytic bone metastases |
KR101938698B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Cbl의 항 c-met 항체 적용 대상 환자 선별을 위한 바이오마커로서의 용도 |
KR101938699B1 (ko) * | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Lrig1의 항 c―met 항체 적용 대상 환자 선별을 위한 용도 |
WO2014018841A1 (en) * | 2012-07-27 | 2014-01-30 | Genentech, Inc. | Methods of treating fgfr3 related conditions |
EP2892530A1 (en) * | 2012-08-27 | 2015-07-15 | CeMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH | Aminoheteroaryl compounds as mth1 inhibitors |
WO2014066860A2 (en) * | 2012-10-25 | 2014-05-01 | Cedars-Sinai Medical Center | Methods of prognosticating and treating cancer |
KR20140093347A (ko) * | 2013-01-15 | 2014-07-28 | 삼성전자주식회사 | 항 c-Met 항체 처리에 의해 부작용을 유발하는 유전자 및 이를 이용한 약물 스크리닝 방법 |
CA2903471C (en) | 2013-03-07 | 2022-11-01 | Barmarsa Research Llc | Kits and methods for the treatment of cancer using gliadin peptides |
WO2014150819A2 (en) * | 2013-03-15 | 2014-09-25 | Genentech, Inc. | Biomarkers and methods of treatment |
SG10201701380TA (en) * | 2013-03-15 | 2017-04-27 | Genentech Inc | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
EP2969218A2 (en) * | 2013-03-15 | 2016-01-20 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
WO2015010596A1 (zh) * | 2013-07-22 | 2015-01-29 | 北京盛诺基医药科技有限公司 | 一种乳腺癌预后诊断的方法 |
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WO2015031626A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
KR102272788B1 (ko) * | 2014-01-07 | 2021-07-05 | 삼성전자주식회사 | c-Met 저해제의 효능 예측 또는 효능 검증을 위한 바이오마커 |
US10393748B2 (en) | 2014-01-07 | 2019-08-27 | Samsung Electronics Co., Ltd. | Method for predicting efficacy of c-Met inhibitor |
EP3116999B1 (en) | 2014-03-14 | 2021-09-15 | F. Hoffmann-La Roche AG | Methods and compositions for secretion of heterologous polypeptides |
WO2015148531A1 (en) | 2014-03-24 | 2015-10-01 | Genentech, Inc. | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
US20160327559A1 (en) * | 2014-04-24 | 2016-11-10 | Fundació Institut Mar D'investigacions Mèdiques (Imim) | Hepatocyte growth factor as marker of prognosis in small cell lung cancer (sclc) |
EP3176268B1 (en) * | 2014-07-29 | 2019-07-17 | Wellmarker Bio Co., Ltd. | Novel biomarker for predicting sensitivity to egfr-targeting agent, and use thereof |
KR20160024639A (ko) | 2014-08-26 | 2016-03-07 | 삼성전자주식회사 | c-Met 표적 치료제의 저항성 또는 효능 예측을 위한 바이오마커 PDGF |
JP2016155776A (ja) * | 2015-02-24 | 2016-09-01 | 学校法人兵庫医科大学 | 抗腫瘍効果増強剤および抗腫瘍剤 |
CN112263677A (zh) | 2015-02-26 | 2021-01-26 | 默克专利股份公司 | 用于治疗癌症的pd-1/pd-l1抑制剂 |
IL256245B (en) | 2015-06-16 | 2022-09-01 | Merck Patent Gmbh | Treatments that combine a pd-l1 antagonist |
CN105087775A (zh) * | 2015-07-24 | 2015-11-25 | 北京莱尔生物医药科技有限公司 | 一种基于稀有细胞检测c-MET/CEP7基因状态的方法及相关试剂盒 |
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EP3442573A1 (en) * | 2016-04-15 | 2019-02-20 | Eli Lilly and Company | Combination of ramucirumab and merestinib for use in treatment of colorectal cancer |
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BR112021004935A2 (pt) | 2018-09-26 | 2021-06-01 | Merck Patent Gmbh | combinação de antagonista de pd-1, inibidor de atr e agente de platinação para tratamento de câncer |
EP3980783A4 (en) * | 2019-06-06 | 2023-09-13 | Apollomics Inc. (Hangzhou) | METHOD FOR TREATING CANCER PATIENTS USING A C-MET INHIBITOR |
US20230044248A1 (en) | 2019-11-01 | 2023-02-09 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFBeta AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
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-
2011
- 2011-08-31 DK DK11754597.0T patent/DK2612151T3/en active
- 2011-08-31 JP JP2013526209A patent/JP2013537966A/ja active Pending
- 2011-08-31 EP EP11754597.0A patent/EP2612151B1/en active Active
- 2011-08-31 EP EP17183227.2A patent/EP3264089A1/en not_active Withdrawn
- 2011-08-31 ES ES11754597.0T patent/ES2641916T3/es active Active
- 2011-08-31 AU AU2011295919A patent/AU2011295919A1/en not_active Abandoned
- 2011-08-31 RU RU2013114360/15A patent/RU2013114360A/ru not_active Application Discontinuation
- 2011-08-31 SG SG10201408229WA patent/SG10201408229WA/en unknown
- 2011-08-31 US US13/223,173 patent/US20120089541A1/en not_active Abandoned
- 2011-08-31 SG SG2013011911A patent/SG187886A1/en unknown
- 2011-08-31 KR KR1020137008025A patent/KR20130103734A/ko not_active Application Discontinuation
- 2011-08-31 CA CA2808236A patent/CA2808236A1/en not_active Abandoned
- 2011-08-31 WO PCT/US2011/050069 patent/WO2012031027A1/en active Application Filing
- 2011-08-31 MX MX2013002084A patent/MX2013002084A/es not_active Application Discontinuation
- 2011-08-31 BR BR112013004673A patent/BR112013004673A8/pt not_active IP Right Cessation
- 2011-08-31 CN CN2011800517811A patent/CN103221825A/zh active Pending
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2013
- 2013-10-04 US US14/046,867 patent/US20140037625A1/en not_active Abandoned
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- 2015-12-25 JP JP2015253669A patent/JP2016105096A/ja active Pending
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US20140037625A1 (en) | 2014-02-06 |
SG10201408229WA (en) | 2015-02-27 |
MX2013002084A (es) | 2013-05-09 |
EP2612151B1 (en) | 2017-08-09 |
CA2808236A1 (en) | 2012-03-08 |
US20120089541A1 (en) | 2012-04-12 |
WO2012031027A1 (en) | 2012-03-08 |
CN103221825A (zh) | 2013-07-24 |
JP2016105096A (ja) | 2016-06-09 |
JP2013537966A (ja) | 2013-10-07 |
IL248530A0 (en) | 2016-12-29 |
RU2013114360A (ru) | 2014-10-10 |
KR20130103734A (ko) | 2013-09-24 |
EP3264089A1 (en) | 2018-01-03 |
BR112013004673A8 (pt) | 2018-01-02 |
EP2612151A1 (en) | 2013-07-10 |
ES2641916T3 (es) | 2017-11-14 |
DK2612151T3 (en) | 2017-10-02 |
AU2011295919A1 (en) | 2013-03-07 |
SG187886A1 (en) | 2013-04-30 |
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