CN102939287B - 雌激素受体调节剂及其用途 - Google Patents
雌激素受体调节剂及其用途 Download PDFInfo
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- CN102939287B CN102939287B CN201180028527.XA CN201180028527A CN102939287B CN 102939287 B CN102939287 B CN 102939287B CN 201180028527 A CN201180028527 A CN 201180028527A CN 102939287 B CN102939287 B CN 102939287B
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- substituted
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- phenyl
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- 0 C[C@]1(C*)C=C(*)C=C(*CC(*2ccccc2)=C*)C(C)=C1 Chemical compound C[C@]1(C*)C=C(*)C=C(*CC(*2ccccc2)=C*)C(C)=C1 0.000 description 29
- BFKKDGFRVZPHDK-UHFFFAOYSA-N C(N=C1)=CS1c1cccc2c1nc[nH]2 Chemical compound C(N=C1)=CS1c1cccc2c1nc[nH]2 BFKKDGFRVZPHDK-UHFFFAOYSA-N 0.000 description 1
- HOHKLMDXEHZBCB-UHFFFAOYSA-N C=C(CO)N(CC1)CC1F Chemical compound C=C(CO)N(CC1)CC1F HOHKLMDXEHZBCB-UHFFFAOYSA-N 0.000 description 1
- VZPPPKHBAMPFJB-UHFFFAOYSA-N CC(CO)[n]1cnc(C)c1 Chemical compound CC(CO)[n]1cnc(C)c1 VZPPPKHBAMPFJB-UHFFFAOYSA-N 0.000 description 1
- DZWJRQPMTHONRZ-UHFFFAOYSA-N CC1CCN(CCO)CC1 Chemical compound CC1CCN(CCO)CC1 DZWJRQPMTHONRZ-UHFFFAOYSA-N 0.000 description 1
- FKNXZARUVYOGRK-UHFFFAOYSA-N COC1C=C(CC(c(cc(cc2)OC)c2OC)=O)CCC1C(F)(F)F Chemical compound COC1C=C(CC(c(cc(cc2)OC)c2OC)=O)CCC1C(F)(F)F FKNXZARUVYOGRK-UHFFFAOYSA-N 0.000 description 1
- IIVYNILTINTASR-UHFFFAOYSA-N COc(cc1)cc(C(Cc(cc2OC)cc(F)c2F)=O)c1OC Chemical compound COc(cc1)cc(C(Cc(cc2OC)cc(F)c2F)=O)c1OC IIVYNILTINTASR-UHFFFAOYSA-N 0.000 description 1
- NZZJTIBSHWTYHA-UHFFFAOYSA-N COc1cc(CC(c(c(N)c(cc2)OC)c2OC)=O)ccc1 Chemical compound COc1cc(CC(c(c(N)c(cc2)OC)c2OC)=O)ccc1 NZZJTIBSHWTYHA-UHFFFAOYSA-N 0.000 description 1
- AKNFFYDXPZERQS-UHFFFAOYSA-N COc1cc(CO)cc(F)c1 Chemical compound COc1cc(CO)cc(F)c1 AKNFFYDXPZERQS-UHFFFAOYSA-N 0.000 description 1
- FBYPGWQEOPEKNL-MUIIJQSQSA-N C[C@@H](COc1ccc(C(C(c(cc2)ccc2F)=C(C)c2c3)Oc2ccc3O)cc1)N1C(C2)CC2C1 Chemical compound C[C@@H](COc1ccc(C(C(c(cc2)ccc2F)=C(C)c2c3)Oc2ccc3O)cc1)N1C(C2)CC2C1 FBYPGWQEOPEKNL-MUIIJQSQSA-N 0.000 description 1
- TUJJEFVASDSQFQ-QUZMYUOTSA-N C[C@@H](COc1ccc(C(C(c2cccc(O)c2)=C2C)Oc(cc3)c2c(F)c3O)cc1)N(CC1)CC1=C Chemical compound C[C@@H](COc1ccc(C(C(c2cccc(O)c2)=C2C)Oc(cc3)c2c(F)c3O)cc1)N(CC1)CC1=C TUJJEFVASDSQFQ-QUZMYUOTSA-N 0.000 description 1
- LHZULUDMKUWRMU-AIECAEIUSA-N C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c(cc2)cc(C)c2O)cc1)N1C[C@H](C)CC1 Chemical compound C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c(cc2)cc(C)c2O)cc1)N1C[C@H](C)CC1 LHZULUDMKUWRMU-AIECAEIUSA-N 0.000 description 1
- CJJPACSUPGKACT-GYMJABSESA-N C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c(cc2F)cc(F)c2O)cc1)N1C[C@H](C)CC1 Chemical compound C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c(cc2F)cc(F)c2O)cc1)N1C[C@H](C)CC1 CJJPACSUPGKACT-GYMJABSESA-N 0.000 description 1
- LLVQUBVAOXNDMT-AIECAEIUSA-N C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c2cc(O)c(C)cc2)cc1)N1C[C@H](C)CC1 Chemical compound C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c2cc(O)c(C)cc2)cc1)N1C[C@H](C)CC1 LLVQUBVAOXNDMT-AIECAEIUSA-N 0.000 description 1
- BMISRXBLJGXBBO-ZWNGYIEMSA-N C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c2cccc(O)c2)cc1)N1[C@@H](C)CCC1 Chemical compound C[C@@H](COc1ccc(C2Oc(ccc(O)c3)c3C(C)=C2c2cccc(O)c2)cc1)N1[C@@H](C)CCC1 BMISRXBLJGXBBO-ZWNGYIEMSA-N 0.000 description 1
- YKXZJTXLPYUVNX-FQMNANGRSA-N C[C@@H](COc1ccc(C2Oc(ccc(OC3OCCCC3)c3)c3C(C)=C2c2cccc(OC3OCCCC3)c2)cc1)N1C[C@H](C)CC1 Chemical compound C[C@@H](COc1ccc(C2Oc(ccc(OC3OCCCC3)c3)c3C(C)=C2c2cccc(OC3OCCCC3)c2)cc1)N1C[C@H](C)CC1 YKXZJTXLPYUVNX-FQMNANGRSA-N 0.000 description 1
- VHMICKWLTGFITH-UHFFFAOYSA-N c1c(cccc2)c2c[nH]1 Chemical compound c1c(cccc2)c2c[nH]1 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 description 1
- XSCHRSMBECNVNS-UHFFFAOYSA-N c1ccc2nccnc2c1 Chemical compound c1ccc2nccnc2c1 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 1
- JIHQDMXYYFUGFV-UHFFFAOYSA-N c1ncncn1 Chemical compound c1ncncn1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 description 1
Classifications
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