CN102596146B - 带线性可移置的滑动式流控构件的一列式液体药物医疗装置 - Google Patents
带线性可移置的滑动式流控构件的一列式液体药物医疗装置 Download PDFInfo
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Abstract
一列式液体药物医疗装置,它具有长度方向上的装置轴,一外壳,外壳上带有一线性可移置的滑动式流控构件,构件被沿着一横向孔从第一个流控位置到第二个流控位置移置,第一个流控位置用于液体药物重构目的建立起第一对出入口之间的流通,第二个流控位置用于液体药物给药目的建立起第二对出入口之间的流通,以及一手操执行机构以施加线性位移力来推动流控构件沿着孔从其第一个流控位置向第二个流控位置滑动。
Description
技术领域
本发明涉及用于液体药物重构和给药目的的一列式液体药物医疗装置。
背景技术
题为“流控装置”的共同所有美国专利US Patent 6,238,372图解和描述了一种供注射器和至少一个药用容器应用的流控装置。该流控装置包括第一个出入口(port),接受注射器的第二个出入口,包括一衔接器的第三个出入口,衔接器具有连接到药用容器上去时伸至药用容器内部的流道构件(flow conduit member),以及一流(道)控(制)构件,该流控构件可有选择地从第一个流(道)控(制)位置(flow control position)向第二个流控位置任意使用,该第一个流控位置能够允许流体在第一对的两个出入口之间流动,而第二个流控位置能够允许流体在第二对的两个出入口之间流动。流控构件与出入口之一连接,在其流控位置之间操控。
题为“液体药物医疗装置”的共同所有PCT国际申请PCT InternationalApplication No.PCT/IL2005/000376(PCT International Publication No.WO2005/105014公布)图解和描述了一种用于液体药物重构(配)和给药目的的液体药物医疗装置,一种带有弹性体导管和分离针头护罩的装置的小瓶衔接器。液体药物医疗装置有一长轴,打算与生理溶液源和药用容器一起使用。该液体药物医疗装置包括一主体构件,它有第一个出入口与生理溶液源连接,以及一绕着与长轴同方向的转动轴可旋转地安装在主体构件上的流控构件。流控构件具有第一主流动通道和实质上与该旋转轴平行但不共轴的第二主流动通道,且分别在第二个出入口终止,第三个出入口用于液体药物的给药。该液体药物医疗装置还包括手动可旋转的衔接器,它带有流道构件,其近端与第二个出入口流通,其远端在药用容器与衔接器连接上时伸进药用容器中,衔接器与流控构件连接,在第一个流控位置与第二个流控位置之间作同样的旋转,该第一个流控位置连接第一个出入口与第二个出入口,第二个流控装置连接第一个出入口与第三个出入口。
题为“药物混合和注射设备”的共同所有PCT国际申请PCT InternationalApplication No.PCT/US2008/070024(PCT International Publication No.WO2009/038860公布)图解和描述了一种混合和注射设备,该设备包括针和针座,注射器附属部件和混合室衔接组件,该组件包括围绕住针的针室和由该针室封住的第一个液体导管部分,以及混合室衔接部分,该部分包括与第一个液体导管部分连通的第二个液体导管部分,且构造成与混合室连通。注射器附属部件和针座被构造成当注射器附属部件与针座第一相对衔接朝向时允许液体在注射器内部与第一个液体导管部分之间连通,而当注射器附属部件与针头座第二相对衔接朝向时允许液体在注射器内部与针之间连通,轴向地与沿着注射轴的第一相对衔接朝向分离。
发明内容
本发明以用于液体药物重构(配)和给药目的与生理液源和药用容器一起使用的一列式液体药物医疗装置为目标。
一列式液体药物医疗装置包括一长度方向上有装置轴的外壳以及一小瓶衔接器,它可拆卸地连接在外壳上并且可以沿着与装置轴同方向的移除线从外壳上拆下来。外壳有三个出入口,生理液源连接在第一个出入口上,第二个出入口通往药用容器,第三个出入口装有药物投放器,像针,喷雾器等。
一列式液体药物医疗装置包括一手操执行机构给密封安装在外壳上的一孔中的流(道)控(制)构件施加线性位移力,使该流控构件沿着与装置轴横向的孔从最初的第一个流控位置向后继的第二个流(道)控(制)位置滑动,第一个流控位置的目的是液体药物重构,第二个流控位置的目的是液体药物的给药。第一个流控位置为了液体药物的重构目的能够使流体在第一个与第二个出入口之间传递。第二个流控位置为了液体药物的给药目的能够使流体在第一个与装有药物投放器,像针,喷雾器等的第三个出入口之间传递。优选第一个出入口与第三个出入口共轴以方便装置更加直觉地使用。
该执行机构具有最初的液体药物重构(配)位置,它对应于流控构件的第一个流控位置,执行机构后继的液体药物给药位置则对应于流控构件的第二个流控位置。一种类型的执行机构采用手动的径向的作用力,它有一分力传递给流控构件一线性位移力。另一种类型的执行机构采用手动的线性作用力传递给流控构件一线性位移力。优选执行机构与小瓶衔接器总成在一起,这样在药物重构之后和给药之前在从外壳上拆下小瓶衔接器时,执行机构就与小瓶衔接器一起拿走。执行机构还可以与外壳总成在一起。
附图简要说明
为了理解本发明并且看到它如何付之实践,只是通过不限定的实例并参考附图来说明优选的实施例,附图中相同的部件标号相同:
图1为注射器,小瓶和一列式液体药物医疗装置的示意图,该装置具有转动的执行机构和线性可移置的滑动式流控构件;
图2为图1装置的底视图;
图3A为图1装置的部分分解图;
图3B为图1装置另外一带整体式小瓶衔接器的实施例的部分分解图;
图4A为图1装置流控构件的顶视图;
图4B为图1装置流控构件的底视图;
图5A和5B分别为图1装置长度方向上在图1中的A-A和B-B剖面图,显示了其执行机构处于最初的液体药物重构位置,其流控构件处于为液体药物重构目的的第一个流控位置;
图5C与图5A相似,显示了执行机构的两个相对的内表面之间相对于其转动轴的间隔距离S1和S2;
图5D为图1装置在图5C中的C-C横向剖面图,显示了执行机构的两个相对的内表面之间相对于其转动轴的间隔距离S1和S2;
图6A为图1装置长度方向上在图1中的A-A剖面图,显示了其执行机构处于后继的液体药物给药位置,其流控构件处于为液体药物给药目的的第二个流控位置;
图6B为图1装置在图6A中的C-C横向剖面图,显示了其执行机构处于后继的液体药物给药位置,其流控构件处于为液体药物给药目的的第二个流控位置;
图6C为图1装置长度方向上在图1中的B-B剖面图,显示了其执行机构处于液体药物给药位置,其流控构件处于为液体药物给药目的的第二个流控位置;
图7A至图7G显示了为了液体药物重构和给药目的利用图1的装置;
图8为注射器,小瓶和一列式液体药物医疗装置的示意图,该装置的执行机构带有类似钢板弹簧主片的动作机构和线性可移置的滑动式流控构件;
图9为图8装置的底视图;
图10图8装置的部分分解图;
图11为图8装置流控构件的顶视图;
图12为图8装置长度方向上在图8中的D-D剖面图,显示了其执行机构处于最初的液体药物重构位置,其流控构件处于为液体药物重构目的的第一个流控位置;
图13为图8装置长度方向上在图8中的D-D剖面图,显示了其在执行机构执行动作后处于为液体药物给药目的的第二个流控位置;
图14A至14H显示了为了液体药物重构和给药目的利用图8的装置;
图15为图8装置另外一实施例的示意图,它包括一线性可移置的滑动式流控构件为了液体药物给药目的处于第一个流控位置;
图16为图15装置长度方向上在图15中的E-E剖面图;以及
图17为带小瓶衔接器的图8装置另外一实施例的示意图,它具有椭圆形的杆和具有杆尖端空腔的杆尖端。
本发明优选实施例的详细说明
包括手操转动的执行机构和线性可移置的滑动式流控构件的一列式液体药物医疗装置
图1显示了构成生理液源的注射器10,构成药用容器的小瓶20以及与注射器10和小瓶20一起使用的一列式液体药物医疗装置100。注射器10包括带活塞12的空筒11以及鲁尔锁外(阳)连接器(male Luer lock connector)13。注射器10可以用其他形式的连接器来构成。小瓶20包括开口的加盖瓶子21,它用小瓶塞22封住,小瓶塞22用金属带23或者其它合适的压盖材料封盖。小瓶20含有粉末的或者液体的药物24。注射器10中典型地含有用于再配小瓶内容物24的稀释剂。
图2至图6显示一列式液体药物医疗装置100,它在长度方向上有装置轴101,并且包括外壳102和可拆卸地连接在外壳102上和沿着与装置轴101同方向的移除线而从该外壳上可拆卸下来的小瓶衔接器103。外壳102包括通常为圆筒(柱)形的与装置轴101共轴的主体104,它在一端有注射器出入口108,在它相对的一端有出入口集合管109。主体104包括一通孔106,它的孔轴107横向对着装置轴101,一近孔端106A和一远孔端106B。主体104包括一带螺纹的中间段112,其周围环绕着紧固螺纹112A。一环状的手持式套筒111共轴地对准装置轴101,套筒111通过两个相对的附属壁118与中间段112相连,能够让使用者在使用过程中舒适地握住外壳102。套筒111包括套筒开口111A以便进入注射器出入口108。
注射器出入口108构成了与孔106流通的第一个出入口。注射器出入口108预定给注射器的连接器13,且与装置轴101同方向,最好是与其共轴。注射器出入口108典型地为鲁尔锁内(阴)连接器供接受注射器的鲁尔锁外(阳)连接器用。出入口集合管109通常为圆筒(柱)形,与装置轴101共轴对准。出入口集合管109包括第二个出入口113和第三个出入口114,二者均与孔106流通。第二个出入口113和第三个出入口114与装置轴101同方向,第三个出入口114最好与装置轴101共轴。第三个出入口114最好装有针116用来液体药物给药。第二个出入口113最好相对于第三个出入口114凹进去以形成环形的空腔117与外壳102上的小瓶衔接器103可拆卸地连接在一起。
装置100包括线性可移置的滑动式流(体)控(制)构件(FCM)120,它密封地安置在孔106中建立起注射器出入口108与第二个出入口113之间为了药物重构目的在第一个流(体)控(制)位置上的流通,以及建立起注射器出入口108与第三个出入口114之间为了药物给药目的在第二个流控位置上的流通。流控构件120通常为圆筒(柱)形,具有外围的圆筒(柱)形表面121,表面121带有半圆形的圆周流道122和长度方向上的断流切口123,盲孔124,流控构件(FCM)近端126和流控构件(FCM)远端127。
邻近的圆形突出物128延伸超过FCM近端126,它作为墩式台座表面用来施加与之相反的径向作用力RAF以传递一线性位移力LDF沿着孔106推动流控构件120。在第一个流控位置上,流控构件120密封地插在孔106中,邻近的圆形突出物128基本上从近孔端106A伸出(见图5A-5D)。在第二个流控位置上,邻近的圆形突出物128基本上完全插在近孔端106A中(见图6A-6C)。
指向长度方向上的断流切口123的断面尺寸被选定成当流控构件120在其第一个流控位置和其第二个流控位置上时,它都与第一个出入口108流通。被配置成朝向FCM近端126的流道122圆周地从与断流切口123流通的近通道端122A延伸至远通道端122B。在第一个流控位置上,远通道端122B与第二个出入口113流通(见图5A),在第二个流控位置上,远通道端122B与第三个出入口114流通(见图6A)。
小瓶衔接器103包括具有顶部表面131和朝下垂悬的拐折部分132的外撑裙130用以与小瓶20锁扣式密接。小瓶衔接器103包括往上延伸并在圆形杆的末端部分134终止的杆133,该末端部分具有杆空腔135,它的形状适应外壳102。杆空腔135包括上部主体空腔段135A以可转动地安装在通常为圆筒(柱)形的主体104上,以及圆筒(柱)形的下部集合管空腔段135B以可转动地安装在出入口集合管109上。
杆133包括在下部集合管空腔段135B远端的环形集合管支撑136以与环形空腔117圆周面结合。与装置轴101共轴的流道137在环形集合管支撑136中具有近端137A,在小瓶衔接器103结合到外壳102上时,提供与第二个出入口113之间密封的流通。流道137在远端137B通过流体互联管(通)道137C流体连接共轴的穿孔插管141。穿孔插管141用来在其正向插入小瓶衔接器103时给小瓶塞22穿孔,再稍稍延伸到它之外,这样在将小瓶20倒转过来时,小瓶中几乎所有的内容物24可以被抽出来经过穿孔插管141进入注射器10。杆133还包括盲针孔138,它在小瓶衔接器103连接到外壳102上时用来接收针116。
如图3A所示,在第一个实施例中,杆133沿着底部有一圆周凸缘139以连接一接头142,将杆133固定在顶部表面131上。在另一实施例中,如图3B所示,类似于装置100的一装置100A包括一组装好的小瓶衔接器103A,它可拆卸地与外壳102连接。
小瓶衔接器103利用一对对置的紧固构件143螺纹连接在外壳102上,紧固构件143从杆末端部分134同方向地且在装置轴101面对面的两侧向上延伸。每一个紧固构件有一垂直的凸齿144来咬合紧固螺纹112A。当小瓶衔接器103围绕着与装置轴101共轴的转动轴146相对于外壳102转动时,小瓶衔接器103从外壳102上拧松,可以从该外壳上沿着与装置轴101同方向的移除线拆下来。
小瓶衔接器103与一手操转动的执行机构150总成在一起施加一径向的作用力RAF来产生一线性位移力LDF,它使流控构件120沿着孔106从它的第一个流控位置滑到它的第二个流控位置。当小瓶衔接器103转动着从外壳102上拆下来时,执行机构150利用杆末端部分134的一半圆形内部凸轮表面151靠在邻近的圆形突出物128上来完成。执行机构150具有初始的液体药物重构位置,它对应于当小瓶衔接器103螺纹连接在外壳102上时流控构件120的第一个流控位置,执行机构后续的液体药物给药位置则对应于当小瓶衔接器103从外壳102上拆下时流控构件120的第二个流控位置。内部凸轮表面151限定了相对于转动轴146的间隔距离(S)。在执行机构150的液体药物重构位置上,内部凸轮表面151有最大的间隔距离S1,在执行机构150的液体药物给药位置上,内部凸轮表面151有最小的间隔距离S2。间隔距离S2小于间隔距离S1,这样的话,当小瓶衔接器103从外壳102螺纹上拧下来时,内部凸轮表面151对着突出物128施加了一径向的作用力RAF,它有一分力传递给流控构件120一线性位移力(LDF)使其沿着孔106从它的第一个流控位置滑动到它的第二个流控位置。杆末端部分134的外表面134A相对转动轴146具有相同的半径,这样一来,其壁厚从就在执行机构的液体药物重构位置上、内部凸轮表面151靠在流控构件120上时的最薄处往就在执行机构的液体药物给药位置上、内部凸轮表面151靠在流控构件120上时的最厚处增加。
装置100的操作最好参考图5A-5D和图6A-6C来解释。
图5A–5D显示执行机构150在其初始的液体药物重构位置上,流控构件120在其第一个流控位置上。小瓶衔接器103螺纹连接在外壳102上,流控构件120从近孔端106A突出来,邻近的圆形突出物128靠在内部凸轮表面151上。
图6A–6C显示执行机构150处于其后继的液体药物给药位置上,流控构件120在小瓶衔接器103从外壳120上松脱一半后处于其第二个流控位置上。径向作用力RAF通过离转动轴146的间隔距离S越来越短的内部凸轮表面151被连续地施加到流控构件120上,以传递一线性位移力LDF使流控构件120滑动地移置到其第二个流控位置上。当流控构件120处于第二个流控位置上,在执行机构的液体药物给药的位置上凸齿144完全脱开紧固螺纹112A,那时,小瓶衔接器103从外壳102上拆卸下来。
图7A至图7G如下显示利用一列式液体药物医疗装置100实现液体药物重构和给药:
图7A显示装置100在其初始的第一个流控位置上用于液体药物重构,如箭头M所示,使用者将装置100安装在一小瓶20上。
图7B显示使用者,如箭头N所示,将注射器10接近装置100,如箭头O所示,将注射器10螺纹拧在装置100上。
图7C显示使用者,如箭头P所示,将注射器里的内容物注射到小瓶20中去。使用者搅动该总成以重构液体药物。
图7D显示使用者将该总成翻转过来,如箭头Q所示,将经重构的液体药物内容物抽吸进注射器10中。
图7E显示使用者将小瓶衔接器103转动到后继的液体药物给药位置上以滑动地将流控构件120移置到其后继的第二个流控位置上,如箭头R所示。可选地,有关这一步和以下的步骤,使用者将该总成翻转过来,这样,注射器10在小瓶20的上方。
图7F显示使用者将小瓶衔接器103从外壳102上拧开螺纹,如箭头S所示,以露出针116,因而使液体药物的给药成为可能(见图7G)。使用者丢掉了小瓶衔接器103和用过的小瓶20。
一列式液体药物医疗装置包括带类似钢板弹簧主片的动作机构的手动操作执行机
构以及线性可移的滑动式流控构件
图8显示注射器10,小瓶20以及与注射器10和小瓶20一起使用的一列式液体药物医疗装置200。
图9至图13显示一列式液体药物医疗装置200有长度方向上的装置轴201,且包括一外壳202,一小瓶衔接器203可拆卸地连接在外壳202上,且可以沿着与装置轴201同方向的移除线从外壳202上拆下来。外壳202包括通常为圆筒(柱)形的中心主体204,它具有一孔轴为207的通孔206与装置轴201成横向,通孔206有近端206A和远端206B。
外壳202包括注射器出入口208,它构成了与孔206流通的第一个出入口,外壳202还包括位于中心主体204对面的出入口集合管209。注射器出入口208与装置轴201同方向,优选与装置轴共轴。出入口集合管209包括一对对置且平行的与孔轴207同方向的主表面211和一对对置的次端面(minor end surface)212以将小瓶衔接器203固定在外壳202上。出入口集合管209包括第二个出入口213和第三个出入口214,二者都与孔206流通。第二个出入口213和第三个出入口214与装置轴201同方向,第三个出入口214最好与装置轴201共轴。第二个出入口213的中心偏离装置轴201的长度为L。第三个出入口214最好装上针216。相对于第三个出入口214,第二个出入口213优选凹进去形成一空腔217以将小瓶衔接器203密封地结合在外壳202上。
外壳202包括流控构件218用来实现沿着孔206的线性滑动动作,从初始的用以建立第一个出入口208与第二个出入口213之间流通的第一个流控位置往后继的用以建立第一个出入口208与第三个出入口214之间流通的第二个流控位置滑动。孔206除了在其远端206B外具有均匀的截面积,远端206B是在出入口集合管209的侧面与平台219形成的,它作为一制动器终止流控构件218在其第二个流控位置上的线性滑动动作。该平台可以在注射器208的侧面形成。
流控构件218具有近端218A和远端218B以及一外围的圆筒(柱)形表面221。流控构件218的形状和大小尺寸是要密封地插入通孔206,它比通孔206长,这样,其近端218A在其第一个流控位置上突出在通孔206的近端206A的外面(见图12),其远端218B在其第二个流控位置上突出在通孔206的远端206B的外面(见图13)。
流控构件218包括与装置轴201同方向的,朝着近端218A布置的流道222。流道222具有近端223和远端224。外围的表面221是与指向长度方向上的断流切口226和断流切口226对面的第二个指向长度方向上的断流切口227形成的。断流切口227面对出入口集合管209,位置朝着远端218B,它限定了一墩式台座表面228靠在制动器219上以在流控构件218的第二个流控位置上终止流控构件218。
小瓶衔接器203包括带顶部表面231和朝下垂悬的拐折部分232的外撑裙230用以锁扣式密接在小瓶20上。小瓶衔接器203包括往上延伸的杆233,它的末端是一二分的尖端234,有一对对置且平行有间隔的内表面236用以摩擦配合在出入口集合管209的主表面211上。杆233包括流道237,它的近端237A用以密封地插入在空腔217中、用来将小瓶衔接器203结合到外壳202上时与第二个出入口213密封流通。流道237终止在远端237B,与尖的插管241形成流体的连接。杆233还包括一盲针孔238,用来将小瓶衔接器203结合到外壳202上时接收针216。
小瓶衔接器203与手动操作的执行机构250总成在一起施加一沿轴的作用力LAF来产生一线性位移力LDF,它使流控构件218沿着孔206从它的第一个流控位置滑到它的第二个流控位置。执行机构250是手动形式朝上的类似钢板弹簧主片的动作机构251,朝着杆233的基座相连,具有与流控构件近端218A对置的自由端252。动作机构251有一销子253用以滑动插入流控构件近端218A中形成的凹槽254中。动作机构251最好有从初始的与流控构件218并列的位置上弹性恢复原状地拐折。执行机构250最好被设计成在用来将流控构件218推到其第二个流控位置后释放时,销子253自由从凹槽254中滑动恢复到其原来的垂直位置。
图14A至图14H显示一列式液体药物医疗装置200用于液体药物重构和给药如下:
图14A显示装置200在其初始的第一个流控位置上用于液体药物重构,如箭头M所示,使用者将装置200安装在一小瓶20上。
图14B显示使用者,如箭头N所示,将注射器10接近装置200,如箭头O所示,将注射器10用螺纹拧在装置200上。
图14C显示使用者,如箭头P所示,将注射器里的内容物注射到小瓶20中去。使用者搅动该总成以重构液体药物。
图14D显示使用者将该总成翻转过来,如箭头Q所示,将经重构的液体药物内容物抽吸进注射器10中。
图14E显示使用者,如箭头R所示,压住手操动作机构239将流控构件218推到其后继的第二个流控位置上,在这个位置上,注射器出入口208与第三个出入口214流通。
图14F显示使用者,如箭头S所示,放开手操动作机构251,它恢复到其压下去之前的位置。可选地,有关这一步和以下的步骤,使用者将该总成翻转过来,这样,注射器10在小瓶20的上方。
图14G显示使用者,如箭头T所示,将小瓶衔接器203与用过的小瓶20一起从位置202上拔下来,露出针216,因而使液体药物的给药成为可能(见图14H)。
图15和图16显示结构上与装置200类似的一种一列式液体药物医疗装置200A,因此,同样的部件编号相同。装置200A与装置200的区别限于前者200A包括一衔接的机构256,其中,自由端252通过环形法兰257形成以衔接近端218A。
图17显示结构与操作上与装置200类似的一种一列式液体药物医疗装置200B,因此,同样的部件编号相同。装置200B与装置200的区别限于前者200B包括一椭圆形的杆258和带杆空腔261的杆尖端259,以及一圆筒(柱)形的孔206,它包括沿着孔延伸的契形突出物262与流控构件218中的凹槽263相配。契形突出物262和凹槽263防止流控构件218在孔206内转动。
尽管已经就有限数量的实施例对本发明进行了描述,应该理解到,在所附权利要求的范围内可以进行许多改变,、修饰,、和其他应用。
Claims (9)
1.一种与生理溶液源和药用容器一起使用于液体药物重构和给药的一列式液体药物医疗装置 ,它具有长度方向上的装置轴 ,其特征在于,包括:
(a)一外壳 ,它有第一个出入口与生理溶液源流通 ,第二个出入口与药用容器流通 ,第三个出入口用于液体药物给药 ,以及一与装置轴横向布置的并与所述的第一个出入口 ,所述的第二个出入口和所述的第三个出入口流通的孔;
(b)一线性可移置的滑动式流控构件 ,它可以沿着所述孔从第一个流控位置移置到第二个流控位置 ,该第一个流控位置是为液体药物重构目的建立起所述第一个出入口与所述第二个出入口之间的流通 ,该第二个流控位置上是为液体药物给药目的建立起所述第一个出入口与所述第三个出入口之间的流通;
(c)一手操执行机构 ,它有与所述第一个流控位置相对应的初始液体药物重构位置以及与所述第二个流控位置相对应的后继的液体药物给药位置 ,在从所述初始液体药物重构位置到所述液体药物给药位置手操所述执行机构时 ,所述执行机构施加一线性位移力来推动所述流控构件沿着所述的孔从所述第一个流控位置滑到所述第二个流控位置 ;以及
(d)一用以锁扣式密接在药用容器上的小瓶衔接器 ,它包括一流道构件 ,该流道构件具有与所述第二个出入口流通的近端和与穿孔插管流通的远端 ,当该药用容器与所述小瓶衔接器连接时 ,该插管伸进该药用容器中去 ,并且所述小瓶衔接器可以沿着与装置轴同方向的移除线可拆卸地连接到所述外壳上。
2.根据权利要求第1项所述的装置 ,其特征在于 ,所述执行机构绕着与装置轴同方向的转动轴转动,并且具有靠在所述流控构件上的内部凸轮表面 ,在所述液体药物重构位置上所述内部凸轮表面相对于所述转动轴有第一个间隔距离S1 ,以及在所述液体药物给药位置上所述内部凸轮表面相对于所述转动轴有第二个间隔距离S2 ,所述第二个间隔距离S2小于所述第一个间隔距离S1 ,由此 ,所述执行机构从所述液体药物重构位置往所述液体药物给药位置的手动操作施加了一径向的作用力以传递所述线性位移力。
3.根据权利要求第2项所述的装置 ,其特征在于 ,所述小瓶衔接器可以转动地从所述外壳上拆卸下 ,所述转动拆卸同时使所述执行机构从所述液体药物重构位置到所述液体药物给药位置。
4.根据权利要求第2项所述的装置 ,其特征在于 ,所述转动轴与装置轴共轴。
5.根据权利要求第1项所述的装置 ,其特征在于 ,所述执行机构包括手动压下去的动作机构 ,由此 ,所述执行机构的手动动作施加了一线性作用力以传递所述线性位移力。
6.根据权利要求第5项所述的装置 ,其特征在于 ,所述手动压下去的动作机构具有类似钢板弹簧主片的结构 ,它包括一有弹性易弯地安装在所述小瓶衔接器上的第一端以及一第二自由端以将所述流控构件从所述第一个流控位置推到所述第二个流控位置。
7.根据权利要求第1至第6项的任意一项所述的装置 ,其特征在于 ,所述流控构件包括一外围的圆柱形表面 ,所述圆柱形表面具有长度方向上的断流切口 ,它在所述第一个流控位置和所述第二个流控位置上与所述第一个出入口流通 ,以及一流道以建立在所述第一个流控位置上的在所述断流切口与所述第二个出入口之间的流通,并且建立在所述第二个流控位置上的在所述断流切口与所述第三个出入口之间的流通。
8.根据权利要求第7项所述的装置 ,其特征在用于 ,所述流道是一内腔 ,它延伸穿过所述的流控构件。
9.根据权利要求第7项所述的装置 ,其特征在于 ,所述流道是一在所述外围的圆柱形表面上的半圆形流道。
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BR112012011423A2 (pt) | 2016-05-03 |
IN2012DN03347A (zh) | 2015-10-23 |
IL202070A0 (en) | 2010-06-16 |
US9132063B2 (en) | 2015-09-15 |
CN102596146A (zh) | 2012-07-18 |
IL219609A (en) | 2015-08-31 |
US20120323172A1 (en) | 2012-12-20 |
DK2490648T3 (da) | 2014-07-07 |
BR112012011423B1 (pt) | 2020-10-13 |
EP2490648A1 (en) | 2012-08-29 |
EP2490648B1 (en) | 2014-05-07 |
JP2013510634A (ja) | 2013-03-28 |
WO2011058548A1 (en) | 2011-05-19 |
US20150020920A1 (en) | 2015-01-22 |
JP5356609B2 (ja) | 2013-12-04 |
US8979792B2 (en) | 2015-03-17 |
IL219609A0 (en) | 2012-07-31 |
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