CN102171214B - 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 - Google Patents

聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 Download PDF

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CN102171214B
CN102171214B CN200980139634.2A CN200980139634A CN102171214B CN 102171214 B CN102171214 B CN 102171214B CN 200980139634 A CN200980139634 A CN 200980139634A CN 102171214 B CN102171214 B CN 102171214B
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phenyl
methyl
dihydro
pyrido
compound
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CN102171214A (zh
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兵·王
丹尼尔·楚
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Medivation Technologies LLC
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Biomarin Pharmaceutical Inc
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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CN200980139634.2A 2008-08-06 2009-07-27 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 Active CN102171214B (zh)

Priority Applications (1)

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CN201410640197.5A CN104478875B (zh) 2008-08-06 2009-07-27 聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8668708P 2008-08-06 2008-08-06
US61/086,687 2008-08-06
US15103609P 2009-02-09 2009-02-09
US61/151,036 2009-02-09
US17308809P 2009-04-27 2009-04-27
US61/173,088 2009-04-27
PCT/US2009/051879 WO2010017055A2 (en) 2008-08-06 2009-07-27 Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)

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CN201410003342.9A Division CN103896942A (zh) 2008-08-06 2009-07-27 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
CN201410640197.5A Division CN104478875B (zh) 2008-08-06 2009-07-27 聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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CN102171214A CN102171214A (zh) 2011-08-31
CN102171214B true CN102171214B (zh) 2015-06-24

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CN200980139634.2A Active CN102171214B (zh) 2008-08-06 2009-07-27 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
CN201410003342.9A Pending CN103896942A (zh) 2008-08-06 2009-07-27 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
CN201410640197.5A Active CN104478875B (zh) 2008-08-06 2009-07-27 聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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CN201410640197.5A Active CN104478875B (zh) 2008-08-06 2009-07-27 聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104478875A (zh) * 2008-08-06 2015-04-01 生物马林药物股份有限公司 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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US20110190266A1 (en) * 2010-02-04 2011-08-04 Daniel Chu 5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
ES2606174T3 (es) * 2010-02-08 2017-03-23 Medivation Technologies, Inc. Procesos de síntesis de derivados de dihidropiridoftalazinona
WO2011130661A1 (en) * 2010-04-16 2011-10-20 Biomarin Pharmaceutical Inc. Methods of using dihydropyridophthalazinone inhibitors of poly (adp-ribose)polymerase (parp)
KR20130066633A (ko) 2010-05-12 2013-06-20 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 키나제의 억제제로서 유용한 화합물
PT2630146T (pt) * 2010-10-21 2020-07-20 Medivation Tech Llc Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino
WO2012166151A1 (en) * 2011-06-03 2012-12-06 Biomarin Pharmaceutical Inc. Use of dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) in the treatment of myelodysplastic syndrome (mds) and acute myeloid leukaemia (aml)
WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma
KR102056586B1 (ko) 2011-09-30 2019-12-18 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 억제제를 이용한 췌장암 및 비소세포 폐암의 치료
BR112014007721B1 (pt) 2011-09-30 2022-11-01 Vertex Pharmaceuticals Incorporated Processos para preparar compostos úteis como inibidores de atr quinase
ME02855B (me) * 2011-12-31 2018-04-20 Beigene Ltd KONDENZOVANI TETRA ILl PENTA-CIKLIČNI DIHIDRODIAZEPINOKARBAZOLONI KAO PARP INHIBITORI
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