PT2630146T - Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino - Google Patents
Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalinoInfo
- Publication number
- PT2630146T PT2630146T PT117770057T PT11777005T PT2630146T PT 2630146 T PT2630146 T PT 2630146T PT 117770057 T PT117770057 T PT 117770057T PT 11777005 T PT11777005 T PT 11777005T PT 2630146 T PT2630146 T PT 2630146T
- Authority
- PT
- Portugal
- Prior art keywords
- phtalazin
- crystaline
- pyrido
- triazol
- fluorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40547610P | 2010-10-21 | 2010-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2630146T true PT2630146T (pt) | 2020-07-20 |
Family
ID=44903424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117770057T PT2630146T (pt) | 2010-10-21 | 2011-10-20 | Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8735392B2 (pt) |
| EP (2) | EP2630146B1 (pt) |
| JP (5) | JP2013540158A (pt) |
| KR (4) | KR20140009181A (pt) |
| CN (1) | CN103282365B (pt) |
| AR (1) | AR083502A1 (pt) |
| AU (2) | AU2011317040B2 (pt) |
| BR (1) | BR112013009117A2 (pt) |
| CA (1) | CA2814581C (pt) |
| CY (1) | CY1123356T1 (pt) |
| DK (1) | DK2630146T3 (pt) |
| ES (1) | ES2816600T3 (pt) |
| HU (1) | HUE051535T2 (pt) |
| IL (2) | IL225789B (pt) |
| MX (1) | MX362563B (pt) |
| NZ (1) | NZ609490A (pt) |
| PL (1) | PL2630146T3 (pt) |
| PT (1) | PT2630146T (pt) |
| RU (1) | RU2598606C3 (pt) |
| SG (2) | SG10201710578TA (pt) |
| SI (1) | SI2630146T1 (pt) |
| TW (2) | TWI643858B (pt) |
| WO (1) | WO2012054698A1 (pt) |
| ZA (1) | ZA201302810B (pt) |
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| WO2010017055A2 (en) | 2008-08-06 | 2010-02-11 | Lead Therapeutics, Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| EP2406389B1 (en) | 2009-03-13 | 2019-05-08 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| CR20170071A (es) | 2009-06-29 | 2017-03-28 | Agios Pharmaceuticals Inc | Compuestos terapeuticos y composiciones |
| EP3064595B1 (en) | 2009-10-21 | 2019-02-27 | Agios Pharmaceuticals, Inc. | Methods for cell-proliferation-related disorders |
| US8541403B2 (en) | 2010-02-03 | 2013-09-24 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency |
| KR101826652B1 (ko) * | 2010-02-08 | 2018-02-07 | 메디베이션 테크놀로지즈, 인크. | 디히드로피리도프탈라지논 유도체의 합성 방법 |
| SG10201710578TA (en) | 2010-10-21 | 2018-02-27 | Medivation Technologies Inc | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
| HRP20240225T1 (hr) | 2011-05-03 | 2024-04-26 | Agios Pharmaceuticals, Inc. | Aktivatori piruvat kinaze za uporabu u terapiji |
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| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CA2855948C (en) * | 2011-08-11 | 2020-07-28 | Bayer Cropscience Ag | 1,2,4-triazolyl-substituted keto-enols |
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| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
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| BR112016021012B1 (pt) * | 2014-03-14 | 2024-01-23 | Les Laboratoires Servier | Uso de uma composição farmacêutica de (s)-n-((s)-1-(2-clorofenil)-2-((3,3-difluorciclobutil)amino)-2-oxoetil)-1-(4-cianopiridin-2-il)-n-(5-fluorpiridin-3-il) -5-oxopirrolidina-2- carboxamida e seus sais para tratamento de tumores sólidos avançados |
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| EA201790290A1 (ru) * | 2014-07-31 | 2017-07-31 | Медивэйшн Текнолоджиз, Инк. | Формерные соли (2s,3s)-метил 7-фтор-2-(4-фторфенил)-3-(1-метил-1h-1,2,4-триазол-5-ил)-4-оксо-1,2,3,4-тетрагидрохинолин-5-карбоксилата и способы их получения |
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2011
- 2011-10-20 SG SG10201710578TA patent/SG10201710578TA/en unknown
- 2011-10-20 PT PT117770057T patent/PT2630146T/pt unknown
- 2011-10-20 MX MX2013004195A patent/MX362563B/es active IP Right Grant
- 2011-10-20 JP JP2013535079A patent/JP2013540158A/ja active Pending
- 2011-10-20 ES ES11777005T patent/ES2816600T3/es active Active
- 2011-10-20 KR KR1020137012297A patent/KR20140009181A/ko active Application Filing
- 2011-10-20 AR ARP110103892A patent/AR083502A1/es not_active Application Discontinuation
- 2011-10-20 EP EP11777005.7A patent/EP2630146B1/en active Active
- 2011-10-20 KR KR1020197030773A patent/KR20190120458A/ko not_active Application Discontinuation
- 2011-10-20 TW TW105123467A patent/TWI643858B/zh active
- 2011-10-20 DK DK11777005.7T patent/DK2630146T3/da active
- 2011-10-20 CA CA2814581A patent/CA2814581C/en active Active
- 2011-10-20 US US13/277,607 patent/US8735392B2/en active Active
- 2011-10-20 HU HUE11777005A patent/HUE051535T2/hu unknown
- 2011-10-20 EP EP20175014.8A patent/EP3757106A1/en not_active Withdrawn
- 2011-10-20 TW TW100138150A patent/TWI557123B/zh active
- 2011-10-20 SI SI201131903T patent/SI2630146T1/sl unknown
- 2011-10-20 CN CN201180062085.0A patent/CN103282365B/zh active Active
- 2011-10-20 SG SG2013029731A patent/SG189939A1/en unknown
- 2011-10-20 PL PL11777005T patent/PL2630146T3/pl unknown
- 2011-10-20 KR KR1020187016905A patent/KR20180069132A/ko active Application Filing
- 2011-10-20 WO PCT/US2011/057039 patent/WO2012054698A1/en active Application Filing
- 2011-10-20 KR KR1020217006784A patent/KR20210028747A/ko not_active Application Discontinuation
- 2011-10-20 RU RU2013123036A patent/RU2598606C3/ru active Protection Beyond IP Right Term
- 2011-10-20 AU AU2011317040A patent/AU2011317040B2/en active Active
- 2011-10-20 BR BR112013009117A patent/BR112013009117A2/pt not_active Application Discontinuation
- 2011-10-20 NZ NZ609490A patent/NZ609490A/en unknown
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2013
- 2013-04-17 IL IL225789A patent/IL225789B/en active IP Right Grant
- 2013-04-18 ZA ZA2013/02810A patent/ZA201302810B/en unknown
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2014
- 2014-04-14 US US14/252,668 patent/US20140228369A1/en not_active Abandoned
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2016
- 2016-11-18 JP JP2016224670A patent/JP2017061526A/ja active Pending
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2017
- 2017-03-07 AU AU2017201564A patent/AU2017201564B2/en active Active
- 2017-07-17 US US15/651,735 patent/US10189837B2/en active Active
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2018
- 2018-10-11 JP JP2018192521A patent/JP2019034951A/ja not_active Withdrawn
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2019
- 2019-12-17 IL IL271497A patent/IL271497A/en unknown
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2020
- 2020-07-09 JP JP2020118281A patent/JP2020169209A/ja not_active Withdrawn
- 2020-09-22 CY CY20201100893T patent/CY1123356T1/el unknown
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2022
- 2022-08-02 JP JP2022123448A patent/JP2022140637A/ja active Pending
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