CN101868446A - 某些异羟肟酸化合物的合成方法 - Google Patents

某些异羟肟酸化合物的合成方法 Download PDF

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Publication number
CN101868446A
CN101868446A CN200880116916A CN200880116916A CN101868446A CN 101868446 A CN101868446 A CN 101868446A CN 200880116916 A CN200880116916 A CN 200880116916A CN 200880116916 A CN200880116916 A CN 200880116916A CN 101868446 A CN101868446 A CN 101868446A
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compound
formula
independently
described formula
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H·A·雷施
P·里明
P·S·拉耶
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Topotarget UK Ltd
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Topotarget UK Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880116916A 2007-09-25 2008-09-23 某些异羟肟酸化合物的合成方法 Pending CN101868446A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97488007P 2007-09-25 2007-09-25
US60/974,880 2007-09-25
PCT/GB2008/003226 WO2009040517A2 (en) 2007-09-25 2008-09-23 Methods of synthesis of certain hydroxamic acid compounds

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CN101868446A true CN101868446A (zh) 2010-10-20

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CN200880116916A Pending CN101868446A (zh) 2007-09-25 2008-09-23 某些异羟肟酸化合物的合成方法

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US (1) US8642809B2 (enExample)
EP (1) EP2203421B1 (enExample)
JP (1) JP2010540426A (enExample)
CN (1) CN101868446A (enExample)
CA (1) CA2700173C (enExample)
MX (1) MX2010003230A (enExample)
WO (1) WO2009040517A2 (enExample)

Cited By (14)

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CN102531972A (zh) * 2010-12-31 2012-07-04 北京万全阳光医药科技有限公司 抗肿瘤药物Belinostat的中间体的制备方法
CN102786448A (zh) * 2012-08-09 2012-11-21 深圳万乐药业有限公司 一种合成belinostat的方法
CN103724239A (zh) * 2013-12-31 2014-04-16 无锡万全医药技术有限公司 一种3-（3-苯基氨磺酰基-苯基）-丙烯酸酯的制备方法
CN103787924A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 抗肿瘤药物Belinostat的一种新纯化方法
CN104478769A (zh) * 2014-12-22 2015-04-01 深圳万乐药业有限公司 一种适合工业化生产的贝利司他合成方法
CN105367455A (zh) * 2015-12-18 2016-03-02 深圳万乐药业有限公司 一种贝利司他异构体的制备方法
CN106565552A (zh) * 2016-10-31 2017-04-19 瑞阳制药有限公司 贝利司他结晶体及其制备方法
CN108033902A (zh) * 2017-12-26 2018-05-15 深圳万乐药业有限公司 一种高纯度贝利司他顺式异构体的制备方法
CN109265377A (zh) * 2018-10-25 2019-01-25 瑞阳制药有限公司 贝利司他的绿色合成方法
CN109336788A (zh) * 2018-10-31 2019-02-15 安徽省庆云医药股份有限公司 一种贝利司他的制备方法
CN109496210A (zh) * 2016-07-26 2019-03-19 费森尤斯卡比肿瘤学有限公司 贝利司他的多晶型及其制备方法
WO2020216298A1 (zh) * 2019-04-25 2020-10-29 成都先导药物开发股份有限公司 Hdac抑制剂及其制备方法和用途
CN115636774A (zh) * 2022-12-01 2023-01-24 南开大学 一种贝利司他的合成方法
CN119456224A (zh) * 2024-10-31 2025-02-18 郑州大学 一种矿物的预处理方法协同浮选药剂的分离工艺

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US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
US8604074B2 (en) 2009-01-09 2013-12-10 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
EP2451790A4 (en) * 2009-07-07 2012-12-26 Anthem Biosciences Private Ltd INHIBITORS OF HISTONE DEACETYLASE
CA2804161A1 (en) 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CA2882826A1 (en) 2012-08-24 2014-02-27 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9902713B2 (en) 2013-11-11 2018-02-27 Board Of Regents Of The University Of Texas System Neuroprotective compounds and use thereof
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
CA3253937A1 (en) 2016-03-15 2025-03-04 Oryzon Genomics, S.A. Combinations of Lysine-Specific Demethylase 1 Inhibitors for the Treatment of Hematological Maligna
EA201892075A1 (ru) 2016-03-15 2019-04-30 Оризон Дженомикс, С.А. Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
WO2017199264A1 (en) * 2016-05-17 2017-11-23 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of belinostat
WO2018029699A1 (en) * 2016-08-11 2018-02-15 Msn Research & Development Center Solid state forms of (2e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide and process for preparation thereof
CN111601805A (zh) * 2017-11-27 2020-08-28 科学和工业研究协会 作为选择性hdac抑制剂的吲哚(氨磺酰基)n-羟基苯甲酰胺衍生物

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Cited By (20)

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Publication number Priority date Publication date Assignee Title
CN102531972A (zh) * 2010-12-31 2012-07-04 北京万全阳光医药科技有限公司 抗肿瘤药物Belinostat的中间体的制备方法
CN102786448A (zh) * 2012-08-09 2012-11-21 深圳万乐药业有限公司 一种合成belinostat的方法
CN102786448B (zh) * 2012-08-09 2014-03-12 深圳万乐药业有限公司 一种合成belinostat的方法
CN103724239A (zh) * 2013-12-31 2014-04-16 无锡万全医药技术有限公司 一种3-（3-苯基氨磺酰基-苯基）-丙烯酸酯的制备方法
CN103787924A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 抗肿瘤药物Belinostat的一种新纯化方法
CN104478769A (zh) * 2014-12-22 2015-04-01 深圳万乐药业有限公司 一种适合工业化生产的贝利司他合成方法
CN104478769B (zh) * 2014-12-22 2016-01-06 深圳万乐药业有限公司 一种适合工业化生产的贝利司他合成方法
CN105367455A (zh) * 2015-12-18 2016-03-02 深圳万乐药业有限公司 一种贝利司他异构体的制备方法
CN109496210A (zh) * 2016-07-26 2019-03-19 费森尤斯卡比肿瘤学有限公司 贝利司他的多晶型及其制备方法
CN106565552A (zh) * 2016-10-31 2017-04-19 瑞阳制药有限公司 贝利司他结晶体及其制备方法
CN108033902A (zh) * 2017-12-26 2018-05-15 深圳万乐药业有限公司 一种高纯度贝利司他顺式异构体的制备方法
CN109265377A (zh) * 2018-10-25 2019-01-25 瑞阳制药有限公司 贝利司他的绿色合成方法
CN109265377B (zh) * 2018-10-25 2021-01-22 瑞阳制药股份有限公司 贝利司他的绿色合成方法
CN109336788A (zh) * 2018-10-31 2019-02-15 安徽省庆云医药股份有限公司 一种贝利司他的制备方法
WO2020216298A1 (zh) * 2019-04-25 2020-10-29 成都先导药物开发股份有限公司 Hdac抑制剂及其制备方法和用途
CN111848591A (zh) * 2019-04-25 2020-10-30 成都先导药物开发股份有限公司 Hdac抑制剂及其制备方法和用途
CN111848591B (zh) * 2019-04-25 2022-03-18 成都先导药物开发股份有限公司 Hdac抑制剂及其制备方法和用途
CN115636774A (zh) * 2022-12-01 2023-01-24 南开大学 一种贝利司他的合成方法
CN115636774B (zh) * 2022-12-01 2023-12-22 南开大学 一种贝利司他的合成方法
CN119456224A (zh) * 2024-10-31 2025-02-18 郑州大学 一种矿物的预处理方法协同浮选药剂的分离工艺

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