JP2010540426A - 特定のヒドロキサム酸化合物の合成方法 - Google Patents
特定のヒドロキサム酸化合物の合成方法 Download PDFInfo
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- JP2010540426A JP2010540426A JP2010525442A JP2010525442A JP2010540426A JP 2010540426 A JP2010540426 A JP 2010540426A JP 2010525442 A JP2010525442 A JP 2010525442A JP 2010525442 A JP2010525442 A JP 2010525442A JP 2010540426 A JP2010540426 A JP 2010540426A
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 547
- 238000000034 method Methods 0.000 title claims abstract description 348
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- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract description 10
- -1 Alkenyl carboxylic acid ester Chemical class 0.000 claims abstract description 92
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 32
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97488007P | 2007-09-25 | 2007-09-25 | |
| PCT/GB2008/003226 WO2009040517A2 (en) | 2007-09-25 | 2008-09-23 | Methods of synthesis of certain hydroxamic acid compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540426A true JP2010540426A (ja) | 2010-12-24 |
| JP2010540426A5 JP2010540426A5 (enExample) | 2011-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525442A Pending JP2010540426A (ja) | 2007-09-25 | 2008-09-23 | 特定のヒドロキサム酸化合物の合成方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8642809B2 (enExample) |
| EP (1) | EP2203421B1 (enExample) |
| JP (1) | JP2010540426A (enExample) |
| CN (1) | CN101868446A (enExample) |
| CA (1) | CA2700173C (enExample) |
| MX (1) | MX2010003230A (enExample) |
| WO (1) | WO2009040517A2 (enExample) |
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| JP2019523273A (ja) * | 2016-07-26 | 2019-08-22 | フレゼニウス・カビ・オンコロジー・リミテッド | ベリノスタットの多形形態、およびその調製のためのプロセス |
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| US9095572B2 (en) | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
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| CN102531972A (zh) * | 2010-12-31 | 2012-07-04 | 北京万全阳光医药科技有限公司 | 抗肿瘤药物Belinostat的中间体的制备方法 |
| CN102786448B (zh) * | 2012-08-09 | 2014-03-12 | 深圳万乐药业有限公司 | 一种合成belinostat的方法 |
| EP2887803A4 (en) | 2012-08-24 | 2016-08-03 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
| CN103724239A (zh) * | 2013-12-31 | 2014-04-16 | 无锡万全医药技术有限公司 | 一种3-（3-苯基氨磺酰基-苯基）-丙烯酸酯的制备方法 |
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| CN106565552A (zh) * | 2016-10-31 | 2017-04-19 | 瑞阳制药有限公司 | 贝利司他结晶体及其制备方法 |
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| CN108033902B (zh) * | 2017-12-26 | 2020-07-07 | 深圳万乐药业有限公司 | 一种高纯度贝利司他顺式异构体的制备方法 |
| CN109265377B (zh) * | 2018-10-25 | 2021-01-22 | 瑞阳制药股份有限公司 | 贝利司他的绿色合成方法 |
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| CN111848591B (zh) * | 2019-04-25 | 2022-03-18 | 成都先导药物开发股份有限公司 | Hdac抑制剂及其制备方法和用途 |
| CN115636774B (zh) * | 2022-12-01 | 2023-12-22 | 南开大学 | 一种贝利司他的合成方法 |
| CN119456224B (zh) * | 2024-10-31 | 2025-11-28 | 郑州大学 | 一种矿物的预处理方法协同浮选药剂的分离工艺 |
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| JP2019523273A (ja) * | 2016-07-26 | 2019-08-22 | フレゼニウス・カビ・オンコロジー・リミテッド | ベリノスタットの多形形態、およびその調製のためのプロセス |
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| US11739057B2 (en) | 2016-07-26 | 2023-08-29 | Fresenius Kabi Oncology Ltd. | Polymorphic forms of Belinostat and processes for preparation thereof |
Also Published As
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| HK1145831A1 (en) | 2011-05-06 |
| WO2009040517A2 (en) | 2009-04-02 |
| MX2010003230A (es) | 2010-04-07 |
| EP2203421A2 (en) | 2010-07-07 |
| US20100286279A1 (en) | 2010-11-11 |
| US8642809B2 (en) | 2014-02-04 |
| CA2700173C (en) | 2016-10-11 |
| EP2203421B1 (en) | 2014-05-07 |
| CN101868446A (zh) | 2010-10-20 |
| WO2009040517A3 (en) | 2009-06-25 |
| CA2700173A1 (en) | 2009-04-02 |
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