CN101790380B - 合成tlr激动剂的缀合物及其应用 - Google Patents
合成tlr激动剂的缀合物及其应用 Download PDFInfo
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- CN101790380B CN101790380B CN2008800115258A CN200880011525A CN101790380B CN 101790380 B CN101790380 B CN 101790380B CN 2008800115258 A CN2008800115258 A CN 2008800115258A CN 200880011525 A CN200880011525 A CN 200880011525A CN 101790380 B CN101790380 B CN 101790380B
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- 0 C=**c(nc1[n]2Cc3ccccc3)nc(N)c1nc2O Chemical compound C=**c(nc1[n]2Cc3ccccc3)nc(N)c1nc2O 0.000 description 3
- HZSJRJNZTVLDKC-QDEBKDIKSA-N C/C=N/Nc(cc1)ncc1C(C)=O Chemical compound C/C=N/Nc(cc1)ncc1C(C)=O HZSJRJNZTVLDKC-QDEBKDIKSA-N 0.000 description 1
- NEWXLIUZIKGISF-VOTSOKGWSA-N C/N=N/C(CCSC)=O Chemical compound C/N=N/C(CCSC)=O NEWXLIUZIKGISF-VOTSOKGWSA-N 0.000 description 1
- UEAPVUOENVLUTR-UHFFFAOYSA-N CC(CC(N1CCC(NCCCCCC(C)=O)=O)=O)C1=O Chemical compound CC(CC(N1CCC(NCCCCCC(C)=O)=O)=O)C1=O UEAPVUOENVLUTR-UHFFFAOYSA-N 0.000 description 1
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/07—Bacillus
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88869907P | 2007-02-07 | 2007-02-07 | |
| US60/888,699 | 2007-02-07 | ||
| PCT/US2008/001631 WO2008115319A2 (en) | 2007-02-07 | 2008-02-07 | Conjugates of synthetic tlr agonists and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101790380A CN101790380A (zh) | 2010-07-28 |
| CN101790380B true CN101790380B (zh) | 2013-07-10 |
Family
ID=39766655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800115258A Active CN101790380B (zh) | 2007-02-07 | 2008-02-07 | 合成tlr激动剂的缀合物及其应用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8357374B2 (enExample) |
| EP (2) | EP2125007B9 (enExample) |
| JP (2) | JP5425642B2 (enExample) |
| KR (1) | KR20090109121A (enExample) |
| CN (1) | CN101790380B (enExample) |
| AU (1) | AU2008227128B2 (enExample) |
| BR (1) | BRPI0807196A2 (enExample) |
| CA (1) | CA2677733A1 (enExample) |
| DK (1) | DK2510946T3 (enExample) |
| EA (1) | EA019151B1 (enExample) |
| ES (2) | ES2552471T3 (enExample) |
| HU (1) | HUE025555T2 (enExample) |
| IL (1) | IL200240A (enExample) |
| PL (2) | PL2125007T3 (enExample) |
| PT (1) | PT2510946E (enExample) |
| SI (1) | SI2510946T1 (enExample) |
| WO (1) | WO2008115319A2 (enExample) |
| ZA (1) | ZA200906094B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311032A (zh) * | 2015-11-09 | 2016-02-10 | 深圳大学 | Tlr7激动剂与酪氨酸激酶抑制剂联用在制备抗肿瘤药物中的应用 |
| US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101304748A (zh) | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
| EP2700638A1 (en) | 2006-05-31 | 2014-02-26 | The Regents Of the University of California | Purine analogs |
| HUE025555T2 (en) | 2007-02-07 | 2016-02-29 | Univ California | Conjugates and applications of synthetic tlr agonists |
| WO2009049365A1 (en) * | 2007-10-15 | 2009-04-23 | Cooperative Research Centre For Asthma | A method of prophylaxis and agents for use therein |
| US20090202626A1 (en) * | 2008-02-07 | 2009-08-13 | Carson Dennis A | Treatment of bladder diseases with a tlr7 activator |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| EP2396328A2 (en) | 2009-02-11 | 2011-12-21 | The Regents of The University of California | Toll-like receptor modulators and treatment of diseases |
| WO2010138193A2 (en) * | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| CA2777824C (en) | 2009-10-22 | 2016-11-29 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
| EP2563401A1 (en) * | 2010-04-30 | 2013-03-06 | Telormedix SA | Methods for inducing an immune response |
| CA2797315C (en) * | 2010-04-30 | 2018-09-11 | Telormedix Sa | Phospholipid drug analogs |
| US20130202629A1 (en) * | 2010-04-30 | 2013-08-08 | The Regents Of The University Of California | Uses of phospholipid conjugates of synthetic tlr7 agonists |
| US9050319B2 (en) | 2010-04-30 | 2015-06-09 | Telormedix, Sa | Phospholipid drug analogs |
| US20110293700A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| US20120083473A1 (en) | 2010-09-21 | 2012-04-05 | Johanna Holldack | Treatment of conditions by toll-like receptor modulators |
| US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
| EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
| MY170941A (en) | 2011-04-08 | 2019-09-19 | Janssen Sciences Ireland Uc | Pyrimidine derivatives for the treatment of viral infections |
| CN103582496B (zh) | 2011-06-03 | 2016-05-11 | 3M创新有限公司 | 具有聚乙二醇链段的异双官能连接基以及由其制成的免疫应答调节剂缀合物 |
| WO2012167081A1 (en) * | 2011-06-03 | 2012-12-06 | 3M Innovative Properties Company | Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom |
| CN109172819A (zh) | 2011-07-29 | 2019-01-11 | 西莱克塔生物科技公司 | 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体 |
| IN2014MN00862A (enExample) | 2011-11-09 | 2015-04-17 | Janssen R & D Ireland | |
| ES2731524T3 (es) | 2012-04-05 | 2019-11-15 | Massachusetts Inst Technology | Composiciones inmunoestimuladoras y métodos de uso de las mismas |
| AU2013288600B2 (en) | 2012-07-13 | 2017-06-29 | Janssen Sciences Ireland Uc | Macrocyclic purines for the treatment of viral infections |
| CN103566377A (zh) * | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2014052828A1 (en) | 2012-09-27 | 2014-04-03 | The Regents Of The University Of California | Compositions and methods for modulating tlr4 |
| CN111420045B (zh) * | 2012-10-10 | 2023-03-31 | 深圳大学 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
| MX365114B (es) | 2012-10-10 | 2019-05-23 | Janssen Sciences Ireland Uc | Derivados pirrolo[3,2-d]pirimidinicos para el tratamiento de infecciones viricas y otras enfermedades. |
| MY171115A (en) | 2012-11-16 | 2019-09-26 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
| UA118751C2 (uk) | 2013-02-21 | 2019-03-11 | ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі | Похідні 2-амінопіримідину для лікування вірусних інфекцій |
| WO2014131023A1 (en) * | 2013-02-25 | 2014-08-28 | The Scripps Research Institute | Neoseptins: small molecule adjuvants |
| CN105263513A (zh) * | 2013-03-14 | 2016-01-20 | 王荣福 | 调控调节性t细胞功能的方法和组合物 |
| WO2014144365A1 (en) * | 2013-03-15 | 2014-09-18 | University Of Maryland, College Park | Nano-liposomal formulations and methods of use |
| ES2625456T3 (es) * | 2013-03-29 | 2017-07-19 | Janssen Sciences Ireland Uc | Desazapurinonas macrocíclicas para el tratamiento de infecciones víricas |
| JP6377139B2 (ja) | 2013-05-24 | 2018-08-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体 |
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| WO2015023858A2 (en) * | 2013-08-16 | 2015-02-19 | The Regents Of The University Of California | Uses of phospholipid conjugates of synthetic tlr7 agonists |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311032A (zh) * | 2015-11-09 | 2016-02-10 | 深圳大学 | Tlr7激动剂与酪氨酸激酶抑制剂联用在制备抗肿瘤药物中的应用 |
| CN105311032B (zh) * | 2015-11-09 | 2018-09-25 | 深圳大学 | Tlr7激动剂与酪氨酸激酶抑制剂联用在制备抗肿瘤药物中的应用 |
| US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
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