EA200901078A1 - Конъюгаты синтетических агонистов tlr и их применение - Google Patents

Конъюгаты синтетических агонистов tlr и их применение

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Publication number
EA200901078A1
EA200901078A1 EA200901078A EA200901078A EA200901078A1 EA 200901078 A1 EA200901078 A1 EA 200901078A1 EA 200901078 A EA200901078 A EA 200901078A EA 200901078 A EA200901078 A EA 200901078A EA 200901078 A1 EA200901078 A1 EA 200901078A1
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EA
Eurasian Patent Office
Prior art keywords
conjugates
synthetic agonists
tlr
agonists tlr
synthetic
Prior art date
Application number
EA200901078A
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English (en)
Other versions
EA019151B1 (ru
Inventor
Деннис А. Карсон
Ховард Б. Коттам
Вольфганг Врасидло
Кристина С.Н. Ву
Грегори А. Дэниелс
Original Assignee
Дзе Регентс Оф Дзе Юниверсити Оф Калифорния
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Publication of EA200901078A1 publication Critical patent/EA200901078A1/ru
Publication of EA019151B1 publication Critical patent/EA019151B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • A61P11/06Antiasthmatics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Данное изобретение предусматривает TLR агонисты и их конъюгаты, пригодные для вакцин и для предотвращения, ингибирования или лечения различных нарушений, включая инфекцию, вызванную патогенами, и астму.
EA200901078A 2007-02-07 2008-02-07 Конъюгаты синтетических агонистов tlr и их применение EA019151B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88869907P 2007-02-07 2007-02-07
PCT/US2008/001631 WO2008115319A2 (en) 2007-02-07 2008-02-07 Conjugates of synthetic tlr agonists and uses therefor

Publications (2)

Publication Number Publication Date
EA200901078A1 true EA200901078A1 (ru) 2010-06-30
EA019151B1 EA019151B1 (ru) 2014-01-30

Family

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Family Applications (1)

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EA200901078A EA019151B1 (ru) 2007-02-07 2008-02-07 Конъюгаты синтетических агонистов tlr и их применение

Country Status (19)

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US (3) US8357374B2 (ru)
EP (2) EP2125007B9 (ru)
JP (2) JP5425642B2 (ru)
KR (1) KR20090109121A (ru)
CN (1) CN101790380B (ru)
AU (1) AU2008227128B2 (ru)
BR (1) BRPI0807196A2 (ru)
CA (1) CA2677733A1 (ru)
DK (1) DK2510946T3 (ru)
EA (1) EA019151B1 (ru)
ES (2) ES2456964T3 (ru)
HK (2) HK1138767A1 (ru)
HU (1) HUE025555T2 (ru)
IL (1) IL200240A (ru)
PL (2) PL2510946T3 (ru)
PT (1) PT2510946E (ru)
SI (1) SI2510946T1 (ru)
WO (1) WO2008115319A2 (ru)
ZA (1) ZA200906094B (ru)

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