EA201200098A1 - Конденсированные имидазолы и содержащие их композиции, предназначенные для лечения паразитарных заболеваний, таких как, например, малярия - Google Patents
Конденсированные имидазолы и содержащие их композиции, предназначенные для лечения паразитарных заболеваний, таких как, например, малярияInfo
- Publication number
- EA201200098A1 EA201200098A1 EA201200098A EA201200098A EA201200098A1 EA 201200098 A1 EA201200098 A1 EA 201200098A1 EA 201200098 A EA201200098 A EA 201200098A EA 201200098 A EA201200098 A EA 201200098A EA 201200098 A1 EA201200098 A1 EA 201200098A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- malarium
- treatment
- compositions intended
- parasitic diseases
- condensed imidazoles
- Prior art date
Links
- 208000030852 Parasitic disease Diseases 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000004792 malaria Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В заявке описаны класс соединений, фармацевтические композиции, содержащие такие соединения, и способы применения таких соединений для лечения или предупреждения малярии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22443309P | 2009-07-09 | 2009-07-09 | |
PCT/US2010/041626 WO2011006143A2 (en) | 2009-07-09 | 2010-07-09 | Compounds and compositions for the treatment of parasitic diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201200098A1 true EA201200098A1 (ru) | 2012-07-30 |
EA019655B1 EA019655B1 (ru) | 2014-05-30 |
Family
ID=42727573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200098A EA019655B1 (ru) | 2009-07-09 | 2010-07-09 | Конденсированные имидазолы и содержащие их композиции, предназначенные для лечения паразитарных заболеваний, таких как, например, малярия |
Country Status (38)
Country | Link |
---|---|
US (3) | US8557801B2 (ru) |
EP (2) | EP2737927B1 (ru) |
JP (1) | JP5432376B2 (ru) |
KR (1) | KR101378666B1 (ru) |
CN (1) | CN102471341B (ru) |
AR (1) | AR077463A1 (ru) |
AU (1) | AU2010271247B2 (ru) |
BR (1) | BR112012000413B1 (ru) |
CA (1) | CA2767664C (ru) |
CL (1) | CL2012000042A1 (ru) |
CO (1) | CO6491060A2 (ru) |
CR (1) | CR20120008A (ru) |
CU (1) | CU24155B1 (ru) |
DK (1) | DK2451814T3 (ru) |
EA (1) | EA019655B1 (ru) |
EC (1) | ECSP12011585A (ru) |
ES (2) | ES2477940T3 (ru) |
GT (1) | GT201200004A (ru) |
HK (1) | HK1164304A1 (ru) |
HN (1) | HN2012000023A (ru) |
HR (1) | HRP20140641T1 (ru) |
IL (1) | IL217384A (ru) |
JO (1) | JO3156B1 (ru) |
MA (1) | MA33419B1 (ru) |
MX (1) | MX2012000389A (ru) |
MY (1) | MY157238A (ru) |
NZ (1) | NZ597275A (ru) |
PE (1) | PE20130399A1 (ru) |
PL (1) | PL2451814T3 (ru) |
PT (1) | PT2451814E (ru) |
SG (1) | SG176938A1 (ru) |
SI (1) | SI2451814T1 (ru) |
SM (1) | SMT201400096B (ru) |
TN (1) | TN2011000647A1 (ru) |
TW (1) | TWI421252B (ru) |
UA (1) | UA103930C2 (ru) |
UY (1) | UY32776A (ru) |
WO (1) | WO2011006143A2 (ru) |
Families Citing this family (17)
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CA2884767A1 (en) | 2012-11-14 | 2014-05-22 | Stephan Bachmann | Imidazopyridine derivatives |
ME03042B (me) * | 2012-11-19 | 2018-10-20 | Novartis Ag | Jedinjenja i kompozicije za tretman parazitskih oboljenja |
US20150291598A1 (en) * | 2012-11-19 | 2015-10-15 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
CN103126782B (zh) * | 2013-02-26 | 2016-06-29 | 内蒙古农牧业科学院 | 一种寄生病的治疗方法 |
CN106029666B (zh) * | 2013-12-19 | 2018-05-18 | 诺华股份有限公司 | 作为原生动物蛋白酶体抑制剂用于治疗寄生虫疾病例如利什曼病的[1,2,4]三唑并[1,5-a]嘧啶衍生物 |
US10526325B2 (en) | 2015-07-31 | 2020-01-07 | Merck Patent Gmbh | Bicyclic heterocyclic derivatives |
BR112019003158B1 (pt) * | 2016-08-15 | 2022-10-25 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico condensado, seu uso, formulação agroquímica, e método para controlar pragas animais |
WO2018198021A1 (en) * | 2017-04-24 | 2018-11-01 | Novartis Ag | Therapeutic regimen of 2-amino-l-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8h)-yl)ethanone and combinations thereof |
LT3652178T (lt) | 2017-07-14 | 2024-04-10 | F. Hoffmann-La Roche Ag | Bicikliniai ketoniniai junginiai ir jų naudojimo būdai |
JP2020536853A (ja) * | 2017-10-04 | 2020-12-17 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 転写因子sall4の小分子阻害およびその使用 |
WO2022049548A1 (en) | 2020-09-04 | 2022-03-10 | Novartis Ag | Kaf156 combinations and methods for the treatment of malaria |
WO2023168107A2 (en) * | 2022-03-04 | 2023-09-07 | University Of Central Florida Research Foundation, Inc. | Compounds and compositions for anitmalarial therapeutic and prophylactic use |
CN114569711B (zh) * | 2022-03-24 | 2024-04-19 | 安徽医科大学 | 一种预防弓形虫病的ME49Δcdpk3减毒活疫苗及其制备方法和应用 |
WO2024006970A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
WO2024006974A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
WO2024006971A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
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FR2780974B1 (fr) | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique |
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CZ20021550A3 (cs) | 1999-11-09 | 2003-02-12 | Societe De Conseils De Recherches Et D'application | Produkt zahrnující inhibitor transdukce signálů heterotrimerického G proteinu kombinovaný s jiným protirakovinným činidlem pro terapeutické použití v léčbě rakoviny |
FR2803525B1 (fr) | 2000-01-06 | 2002-05-03 | Sod Conseils Rech Applic | Inhibiteur de la transduction des signaux des proteines g heterotrimeriques associe a un agent anti-hypertenseur dans le traitement de l'hypertension arterielle |
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2010
- 2010-07-08 AR ARP100102479A patent/AR077463A1/es active IP Right Grant
- 2010-07-08 JO JOP/2010/0245A patent/JO3156B1/ar active
- 2010-07-08 TW TW099122545A patent/TWI421252B/zh active
- 2010-07-08 UY UY0001032776A patent/UY32776A/es active IP Right Grant
- 2010-07-09 JP JP2012519791A patent/JP5432376B2/ja active Active
- 2010-07-09 WO PCT/US2010/041626 patent/WO2011006143A2/en active Application Filing
- 2010-07-09 PE PE2012000026A patent/PE20130399A1/es active IP Right Grant
- 2010-07-09 AU AU2010271247A patent/AU2010271247B2/en active Active
- 2010-07-09 KR KR1020127003375A patent/KR101378666B1/ko active IP Right Grant
- 2010-07-09 NZ NZ597275A patent/NZ597275A/xx unknown
- 2010-07-09 US US12/833,909 patent/US8557801B2/en active Active
- 2010-07-09 MX MX2012000389A patent/MX2012000389A/es active IP Right Grant
- 2010-07-09 CA CA2767664A patent/CA2767664C/en active Active
- 2010-07-09 MA MA34520A patent/MA33419B1/fr unknown
- 2010-07-09 CN CN201080029052.1A patent/CN102471341B/zh active Active
- 2010-07-09 SI SI201030656T patent/SI2451814T1/sl unknown
- 2010-07-09 EA EA201200098A patent/EA019655B1/ru not_active IP Right Cessation
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