HK1164304A1 - Fused imidazoles and compositions comprising them for the treatment of parasitic diseases, such as e.g. malaria - Google Patents
Fused imidazoles and compositions comprising them for the treatment of parasitic diseases, such as e.g. malariaInfo
- Publication number
- HK1164304A1 HK1164304A1 HK12104874.9A HK12104874A HK1164304A1 HK 1164304 A1 HK1164304 A1 HK 1164304A1 HK 12104874 A HK12104874 A HK 12104874A HK 1164304 A1 HK1164304 A1 HK 1164304A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- malaria
- compositions
- treatment
- parasitic diseases
- fused imidazoles
- Prior art date
Links
- 208000030852 Parasitic disease Diseases 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
- 201000004792 malaria Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22443309P | 2009-07-09 | 2009-07-09 | |
| PCT/US2010/041626 WO2011006143A2 (en) | 2009-07-09 | 2010-07-09 | Compounds and compositions for the treatment of parasitic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1164304A1 true HK1164304A1 (en) | 2012-09-21 |
Family
ID=42727573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12104874.9A HK1164304A1 (en) | 2009-07-09 | 2012-05-17 | Fused imidazoles and compositions comprising them for the treatment of parasitic diseases, such as e.g. malaria |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US8557801B2 (ru) |
| EP (2) | EP2737927B1 (ru) |
| JP (1) | JP5432376B2 (ru) |
| KR (1) | KR101378666B1 (ru) |
| CN (1) | CN102471341B (ru) |
| AR (1) | AR077463A1 (ru) |
| AU (1) | AU2010271247B2 (ru) |
| BR (1) | BR112012000413B1 (ru) |
| CA (1) | CA2767664C (ru) |
| CL (1) | CL2012000042A1 (ru) |
| CO (1) | CO6491060A2 (ru) |
| CR (1) | CR20120008A (ru) |
| CU (1) | CU24155B1 (ru) |
| DK (1) | DK2451814T3 (ru) |
| EA (1) | EA019655B1 (ru) |
| EC (1) | ECSP12011585A (ru) |
| ES (2) | ES2477940T3 (ru) |
| GT (1) | GT201200004A (ru) |
| HK (1) | HK1164304A1 (ru) |
| HN (1) | HN2012000023A (ru) |
| HR (1) | HRP20140641T1 (ru) |
| IL (1) | IL217384A (ru) |
| JO (1) | JO3156B1 (ru) |
| MA (1) | MA33419B1 (ru) |
| MX (1) | MX2012000389A (ru) |
| MY (1) | MY157238A (ru) |
| NZ (1) | NZ597275A (ru) |
| PE (1) | PE20130399A1 (ru) |
| PL (1) | PL2451814T3 (ru) |
| PT (1) | PT2451814E (ru) |
| SG (1) | SG176938A1 (ru) |
| SI (1) | SI2451814T1 (ru) |
| SM (1) | SMT201400096B (ru) |
| TN (1) | TN2011000647A1 (ru) |
| TW (1) | TWI421252B (ru) |
| UA (1) | UA103930C2 (ru) |
| UY (1) | UY32776A (ru) |
| WO (1) | WO2011006143A2 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015118985A (ru) * | 2012-11-14 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| CN105189506A (zh) * | 2012-11-19 | 2015-12-23 | 诺华股份有限公司 | 用于治疗寄生虫疾病的化合物和组合物 |
| ES2655030T3 (es) | 2012-11-19 | 2018-02-16 | Novartis Ag | Compuestos y composiciones para el tratamiento de enfermedades parasitarias |
| CN103126782B (zh) * | 2013-02-26 | 2016-06-29 | 内蒙古农牧业科学院 | 一种寄生病的治疗方法 |
| MX368072B (es) * | 2013-12-19 | 2019-09-18 | Novartis Ag | Derivados de [1,2,4]-triazolo-[1,5-a]-pirimidina como inhibidores del proteasoma de protozoarios para el tratamiento de enfermedades parasitarias tales como leishmaniasis. |
| CA2994027C (en) | 2015-07-31 | 2023-10-10 | Merck Patent Gmbh | Bicyclic heterocyclic derivatives |
| US10660334B2 (en) * | 2016-08-15 | 2020-05-26 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
| JP7377717B2 (ja) | 2017-04-24 | 2023-11-10 | ノバルティス アーゲー | ２－アミノ－ｌ－（２－（４－フルオロフェニル）－３－（４－フルオロフェニルアミノ）－８，８－ジメチル－５，６－ジヒドロイミダゾ［１，２－ａ］ピラジン－７（８ｈ）－イル）エタノン及びそれらの組み合わせの治療レジメン |
| EP3652178B1 (en) | 2017-07-14 | 2024-01-24 | F. Hoffmann-La Roche AG | Bicyclic ketone compounds and methods of use thereof |
| JP2020536853A (ja) * | 2017-10-04 | 2020-12-17 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 転写因子ｓａｌｌ４の小分子阻害およびその使用 |
| WO2022049548A1 (en) | 2020-09-04 | 2022-03-10 | Novartis Ag | Kaf156 combinations and methods for the treatment of malaria |
| WO2023168107A2 (en) * | 2022-03-04 | 2023-09-07 | University Of Central Florida Research Foundation, Inc. | Compounds and compositions for anitmalarial therapeutic and prophylactic use |
| CN114569711B (zh) * | 2022-03-24 | 2024-04-19 | 安徽医科大学 | 一种预防弓形虫病的ME49Δcdpk3减毒活疫苗及其制备方法和应用 |
| WO2024006971A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
| WO2024006974A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
| WO2024006970A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK476885D0 (da) | 1985-10-17 | 1985-10-17 | Ferrosan As | Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf |
| US6673927B2 (en) | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
| DK1086086T3 (da) | 1998-06-12 | 2005-01-24 | Sod Conseils Rech Applic | Imidazolylderivater og anvendelse deraf som somatostatinreceptorligander |
| FR2780974B1 (fr) | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique |
| CZ20012358A3 (cs) | 1998-12-31 | 2002-01-16 | Societe De Conseils De Recherches Et D´Application | Prenyltransferázové inhibitory |
| CZ20021550A3 (cs) | 1999-11-09 | 2003-02-12 | Societe De Conseils De Recherches Et D'application | Produkt zahrnující inhibitor transdukce signálů heterotrimerického G proteinu kombinovaný s jiným protirakovinným činidlem pro terapeutické použití v léčbě rakoviny |
| FR2803525B1 (fr) | 2000-01-06 | 2002-05-03 | Sod Conseils Rech Applic | Inhibiteur de la transduction des signaux des proteines g heterotrimeriques associe a un agent anti-hypertenseur dans le traitement de l'hypertension arterielle |
| ATE360620T1 (de) | 2000-08-01 | 2007-05-15 | Sod Conseils Rech Applic | Imidazolderivate |
| ES2241891T3 (es) * | 2001-01-02 | 2005-11-01 | F. Hoffmann-La Roche Ag | Derivados de quinazolona como antagonistas de receptores adrenergicos alfa-1a/b. |
| FR2825278A1 (fr) | 2001-05-30 | 2002-12-06 | Sod Conseils Rech Applic | Produit comprenant du mikanolide, du dihydromikanolide ou un analogue de ceux-ci en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| WO2003082817A2 (en) | 2002-03-25 | 2003-10-09 | Merck & Co., Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| EP1542691B1 (en) | 2002-09-27 | 2009-01-07 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Composition for the treatment of nasopharyngeal carcinoma and use thereof |
| CA2508947A1 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| AU2003301226A1 (en) | 2002-12-20 | 2004-07-22 | Pharmacia Corp | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
| JP2006520819A (ja) * | 2003-03-06 | 2006-09-14 | メルク エンド カムパニー インコーポレーテッド | 抗原虫薬イミダゾピリジン化合物 |
| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| WO2004103276A2 (en) | 2003-05-14 | 2004-12-02 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| FR2856688B1 (fr) | 2003-06-25 | 2008-05-30 | Sod Conseils Rech Applic | PRODUIT COMPRENANT AU MOINS UN INHIBITEUR DE PHOSPHATASE CDc25 EN ASSOCIATION AVEC AU MOINS UN AUTRE AGENT ANTI-CANCEREUX |
| FR2867778B1 (fr) * | 2004-03-16 | 2006-06-09 | Sanofi Synthelabo | Utilisation de derives d'indazolecarboxamides pour la preparation d'un medicament destine au traitement et a la prevention du paludisme |
| CN101232873A (zh) | 2005-08-11 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 含有dpp-iv抑制剂的药物组合物 |
| RU2318818C1 (ru) | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
| AU2007240364A1 (en) | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| US20120142623A1 (en) | 2006-07-07 | 2012-06-07 | Michael Lagunoff | Compositions And Methods For Predicting Inhibitors Of Protein Targets |
| TW200808056A (en) * | 2006-07-26 | 2008-02-01 | Compal Communications Inc | Rear projection display system |
| CN101622001A (zh) * | 2007-01-26 | 2010-01-06 | Irm责任有限公司 | 作为激酶抑制剂用于治疗疟原虫相关疾病的嘌呤化合物和组合物 |
| US20080242862A1 (en) * | 2007-03-27 | 2008-10-02 | Calderwood David J | Novel imidazo based heterocycles |
| US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
| CN101357922B (zh) | 2007-08-02 | 2011-05-18 | 山东轩竹医药科技有限公司 | 新的dpp-iv抑制剂 |
| EP2085398A1 (en) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| EP2090576A1 (en) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
| US8338604B2 (en) | 2008-06-20 | 2012-12-25 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
-
2010
- 2010-07-08 UY UY0001032776A patent/UY32776A/es active IP Right Grant
- 2010-07-08 TW TW099122545A patent/TWI421252B/zh active
- 2010-07-08 JO JOP/2010/0245A patent/JO3156B1/ar active
- 2010-07-08 AR ARP100102479A patent/AR077463A1/es active IP Right Grant
- 2010-07-09 CU CU20120002A patent/CU24155B1/es active IP Right Grant
- 2010-07-09 SI SI201030656T patent/SI2451814T1/sl unknown
- 2010-07-09 KR KR1020127003375A patent/KR101378666B1/ko active IP Right Grant
- 2010-07-09 AU AU2010271247A patent/AU2010271247B2/en active Active
- 2010-07-09 ES ES10733107.6T patent/ES2477940T3/es active Active
- 2010-07-09 WO PCT/US2010/041626 patent/WO2011006143A2/en active Application Filing
- 2010-07-09 US US12/833,909 patent/US8557801B2/en active Active
- 2010-07-09 SG SG2011094612A patent/SG176938A1/en unknown
- 2010-07-09 UA UAA201200238A patent/UA103930C2/ru unknown
- 2010-07-09 NZ NZ597275A patent/NZ597275A/xx unknown
- 2010-07-09 PE PE2012000026A patent/PE20130399A1/es active IP Right Grant
- 2010-07-09 DK DK10733107.6T patent/DK2451814T3/da active
- 2010-07-09 ES ES14156496.3T patent/ES2574529T3/es active Active
- 2010-07-09 MA MA34520A patent/MA33419B1/fr unknown
- 2010-07-09 CA CA2767664A patent/CA2767664C/en active Active
- 2010-07-09 EA EA201200098A patent/EA019655B1/ru not_active IP Right Cessation
- 2010-07-09 PT PT107331076T patent/PT2451814E/pt unknown
- 2010-07-09 EP EP14156496.3A patent/EP2737927B1/en active Active
- 2010-07-09 EP EP10733107.6A patent/EP2451814B1/en active Active
- 2010-07-09 BR BR112012000413-1A patent/BR112012000413B1/pt active IP Right Grant
- 2010-07-09 CN CN201080029052.1A patent/CN102471341B/zh active Active
- 2010-07-09 PL PL10733107T patent/PL2451814T3/pl unknown
- 2010-07-09 MX MX2012000389A patent/MX2012000389A/es active IP Right Grant
- 2010-07-09 MY MYPI2011006324A patent/MY157238A/en unknown
- 2010-07-09 JP JP2012519791A patent/JP5432376B2/ja active Active
-
2011
- 2011-12-16 TN TNP2011000647A patent/TN2011000647A1/en unknown
-
2012
- 2012-01-05 HN HN2012000023A patent/HN2012000023A/es unknown
- 2012-01-05 IL IL217384A patent/IL217384A/en active IP Right Grant
- 2012-01-06 CL CL2012000042A patent/CL2012000042A1/es unknown
- 2012-01-06 GT GT201200004A patent/GT201200004A/es unknown
- 2012-01-09 CR CR20120008A patent/CR20120008A/es unknown
- 2012-01-09 EC EC2012011585A patent/ECSP12011585A/es unknown
- 2012-01-19 CO CO12007883A patent/CO6491060A2/es active IP Right Grant
- 2012-05-17 HK HK12104874.9A patent/HK1164304A1/xx unknown
-
2013
- 2013-06-07 US US13/912,898 patent/US9469645B2/en active Active
-
2014
- 2014-07-07 HR HRP20140641AT patent/HRP20140641T1/hr unknown
- 2014-07-22 SM SM201400096T patent/SMT201400096B/xx unknown
-
2015
- 2015-12-22 US US14/978,059 patent/US9963454B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1164304A1 (en) | Fused imidazoles and compositions comprising them for the treatment of parasitic diseases, such as e.g. malaria | |
| SMT201600254B (it) | Procedimento per la preparazione di idromagnesite | |
| IL214396A (en) | Anti-viral anti-viral nucleosides, pharmaceutical preparations containing them and methods for their preparation, as well as their preparation of antiviral intermediates | |
| PL2768937T3 (pl) | Preparaty, ich zastosowanie jako środków do mycia naczyń lub do wytwarzania środków do mycia naczyń i ich wytwarzanie | |
| WO2011072099A3 (en) | Compositions and methods comprising protease variants | |
| IT1404931B1 (it) | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . | |
| PL2768936T3 (pl) | Preparaty, ich zastosowanie jako środków do zmywania naczyń lub do wytwarzania środków do zmywania naczyń i ich wytwarzanie | |
| MX2011014019A (es) | Derivados de diazahomoadamantano y sus metodos de uso. | |
| IT1391866B1 (it) | Composizione iniettabile di polinucleotidi per il trattamento di patologie osteoarticolari. | |
| WO2012103810A1 (en) | Certain chemical entities, compositions, and methods | |
| IL209360A (en) | Medications containing pm00104 for the treatment of multiple myeloma | |
| IT1404454B1 (it) | Procedimento per la realizzazione di sbozzati per scatole su misura. | |
| IN2012DN03404A (ru) | ||
| WO2011069032A3 (en) | Formulations, salts and polymorphs of transnorsertraline and uses thereof | |
| EP3081097B8 (en) | Composition for the treatment of infertility | |
| PL2502635T3 (pl) | Połączone preparaty do leczenia męskiej niepłodności | |
| MY165088A (en) | Pharmaceutical compositions comprising alisporivir | |
| IT1405996B1 (it) | Procedimento per la preparazione di 2,5-diaminotoluolo | |
| WO2012082942A3 (en) | Neuropeptide analogs, compositions, and methods for treating pain | |
| ITTO20110857A1 (it) | Procedimento per la produzione di cicloesanonossina. | |
| AP2012006119A0 (en) | Pharmaceutical composition of isoniazid. | |
| WO2012139074A3 (en) | Migrastatins and uses thereof | |
| IT1403988B1 (it) | Processo per la preparazione di agenti di contrasto. | |
| IT1396373B1 (it) | Procedimento per la preparazione di fesoterodina. | |
| EP2872145B8 (en) | Fused benzazepines for treatment of tourette's syndrome |