SMT201400096B - Immidazoli fusi e composizioni che li comprendono per il trattamento di malattie parassitarie, come ad esempio la malaria - Google Patents

Immidazoli fusi e composizioni che li comprendono per il trattamento di malattie parassitarie, come ad esempio la malaria

Info

Publication number
SMT201400096B
SMT201400096B SM201400096T SM201400096T SMT201400096B SM T201400096 B SMT201400096 B SM T201400096B SM 201400096 T SM201400096 T SM 201400096T SM 201400096 T SM201400096 T SM 201400096T SM T201400096 B SMT201400096 B SM T201400096B
Authority
SM
San Marino
Prior art keywords
immidazoles
malaria
melted
compositions
treatment
Prior art date
Application number
SM201400096T
Other languages
English (en)
Italian (it)
Inventor
Arnab K Chatterjee
Advait Nagle
Tao Wu
David Tully
Kelli L Kuhen
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42727573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201400096(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of SMT201400096B publication Critical patent/SMT201400096B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SM201400096T 2009-07-09 2014-07-22 Immidazoli fusi e composizioni che li comprendono per il trattamento di malattie parassitarie, come ad esempio la malaria SMT201400096B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22443309P 2009-07-09 2009-07-09
PCT/US2010/041626 WO2011006143A2 (en) 2009-07-09 2010-07-09 Compounds and compositions for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
SMT201400096B true SMT201400096B (it) 2014-09-08

Family

ID=42727573

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201400096T SMT201400096B (it) 2009-07-09 2014-07-22 Immidazoli fusi e composizioni che li comprendono per il trattamento di malattie parassitarie, come ad esempio la malaria

Country Status (38)

Country Link
US (3) US8557801B2 (xx)
EP (2) EP2451814B1 (xx)
JP (1) JP5432376B2 (xx)
KR (1) KR101378666B1 (xx)
CN (1) CN102471341B (xx)
AR (1) AR077463A1 (xx)
AU (1) AU2010271247B2 (xx)
BR (1) BR112012000413B1 (xx)
CA (1) CA2767664C (xx)
CL (1) CL2012000042A1 (xx)
CO (1) CO6491060A2 (xx)
CR (1) CR20120008A (xx)
CU (1) CU24155B1 (xx)
DK (1) DK2451814T3 (xx)
EA (1) EA019655B1 (xx)
EC (1) ECSP12011585A (xx)
ES (2) ES2477940T3 (xx)
GT (1) GT201200004A (xx)
HK (1) HK1164304A1 (xx)
HN (1) HN2012000023A (xx)
HR (1) HRP20140641T1 (xx)
IL (1) IL217384A (xx)
JO (1) JO3156B1 (xx)
MA (1) MA33419B1 (xx)
MX (1) MX2012000389A (xx)
MY (1) MY157238A (xx)
NZ (1) NZ597275A (xx)
PE (1) PE20130399A1 (xx)
PL (1) PL2451814T3 (xx)
PT (1) PT2451814E (xx)
SG (1) SG176938A1 (xx)
SI (1) SI2451814T1 (xx)
SM (1) SMT201400096B (xx)
TN (1) TN2011000647A1 (xx)
TW (1) TWI421252B (xx)
UA (1) UA103930C2 (xx)
UY (1) UY32776A (xx)
WO (1) WO2011006143A2 (xx)

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CN105164124B (zh) * 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
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Also Published As

Publication number Publication date
TW201105675A (en) 2011-02-16
UY32776A (es) 2011-02-28
WO2011006143A3 (en) 2011-06-09
EP2737927A1 (en) 2014-06-04
SG176938A1 (en) 2012-01-30
CL2012000042A1 (es) 2012-12-21
EA201200098A1 (ru) 2012-07-30
CU20120002A7 (es) 2012-06-21
TWI421252B (zh) 2014-01-01
BR112012000413A2 (pt) 2020-08-11
PT2451814E (pt) 2014-07-16
US9469645B2 (en) 2016-10-18
EA019655B1 (ru) 2014-05-30
CU24155B1 (es) 2016-03-31
BR112012000413B1 (pt) 2022-02-15
IL217384A0 (en) 2012-02-29
JP5432376B2 (ja) 2014-03-05
CA2767664C (en) 2013-12-10
US9963454B2 (en) 2018-05-08
AR077463A1 (es) 2011-08-31
HRP20140641T1 (hr) 2014-09-26
CR20120008A (es) 2012-03-12
US20130281403A1 (en) 2013-10-24
UA103930C2 (ru) 2013-12-10
EP2451814A2 (en) 2012-05-16
EP2737927B1 (en) 2016-03-30
GT201200004A (es) 2014-03-27
US8557801B2 (en) 2013-10-15
ES2477940T3 (es) 2014-07-18
JP2012532890A (ja) 2012-12-20
MY157238A (en) 2016-05-13
CN102471341B (zh) 2014-07-02
SI2451814T1 (sl) 2014-08-29
DK2451814T3 (da) 2014-07-14
PE20130399A1 (es) 2013-04-06
HK1164304A1 (en) 2012-09-21
MA33419B1 (fr) 2012-07-03
US20110059934A1 (en) 2011-03-10
AU2010271247B2 (en) 2013-07-18
ECSP12011585A (es) 2012-02-29
US20160108051A1 (en) 2016-04-21
CA2767664A1 (en) 2011-01-13
PL2451814T3 (pl) 2014-09-30
TN2011000647A1 (en) 2013-05-24
CN102471341A (zh) 2012-05-23
EP2451814B1 (en) 2014-04-09
KR101378666B1 (ko) 2014-03-26
AU2010271247A1 (en) 2012-01-19
IL217384A (en) 2015-07-30
MX2012000389A (es) 2012-03-07
JO3156B1 (ar) 2017-09-20
HN2012000023A (es) 2014-08-18
KR20120047939A (ko) 2012-05-14
CO6491060A2 (es) 2012-07-31
ES2574529T3 (es) 2016-06-20
WO2011006143A2 (en) 2011-01-13
NZ597275A (en) 2013-05-31

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