SMT201600049B - Formulazioni di apixaban - Google Patents

Formulazioni di apixaban

Info

Publication number
SMT201600049B
SMT201600049B SM201600049T SM201600049T SMT201600049B SM T201600049 B SMT201600049 B SM T201600049B SM 201600049 T SM201600049 T SM 201600049T SM 201600049 T SM201600049 T SM 201600049T SM T201600049 B SMT201600049 B SM T201600049B
Authority
SM
San Marino
Prior art keywords
apixaban formulations
apixaban
formulations
Prior art date
Application number
SM201600049T
Other languages
English (en)
Inventor
Jatin Patel
Charles Frost
Jingpin Jia
Chandra Vema-Varapu
Original Assignee
Bristol Myers Squibb Co
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43901603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201600049(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co, Pfizer filed Critical Bristol Myers Squibb Co
Publication of SMT201600049B publication Critical patent/SMT201600049B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SM201600049T 2010-02-25 2016-02-17 Formulazioni di apixaban SMT201600049B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30805610P 2010-02-25 2010-02-25
PCT/US2011/025994 WO2011106478A2 (en) 2010-02-25 2011-02-24 Apixaban formulations

Publications (1)

Publication Number Publication Date
SMT201600049B true SMT201600049B (it) 2016-04-29

Family

ID=43901603

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600049T SMT201600049B (it) 2010-02-25 2016-02-17 Formulazioni di apixaban

Country Status (31)

Country Link
US (5) US9326945B2 (it)
EP (7) EP2538925B1 (it)
JP (4) JP5846647B2 (it)
KR (4) KR20210124532A (it)
CN (3) CN109602716A (it)
AU (1) AU2011220775B2 (it)
BR (1) BR112012021337A8 (it)
CA (1) CA2791171C (it)
CO (1) CO6640207A2 (it)
CY (5) CY1117434T1 (it)
DK (5) DK3246021T3 (it)
ES (5) ES2757603T3 (it)
HK (5) HK1180248A1 (it)
HR (5) HRP20160179T1 (it)
HU (4) HUE027168T2 (it)
IL (3) IL309564A (it)
IN (1) IN2012DN06587A (it)
LT (4) LT3246021T (it)
MX (3) MX353145B (it)
NZ (1) NZ601738A (it)
PE (3) PE20130378A1 (it)
PL (5) PL2538925T3 (it)
PT (5) PT3257500T (it)
RS (5) RS59576B1 (it)
RU (1) RU2685724C2 (it)
SG (2) SG182750A1 (it)
SI (5) SI3257500T1 (it)
SM (1) SMT201600049B (it)
TR (1) TR201903195T4 (it)
WO (1) WO2011106478A2 (it)
ZA (1) ZA201205807B (it)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3257500T (pt) * 2010-02-25 2019-11-26 Pfizer Formulações de apixaban
WO2013164839A2 (en) * 2012-03-06 2013-11-07 Cadila Healthcare Limited Amorphous form of apixaban, process of preparation and compositions thereof
CA2873949A1 (en) * 2012-05-24 2013-11-28 Ratiopharm Gmbh Dosage forms comprising apixaban and matrix former
RU2660358C2 (ru) * 2012-09-26 2018-07-05 Бристол-Майерс Сквибб Холдингс Айеленд Жидкие лекарственные композиции апиксабана
CN102908324A (zh) * 2012-10-31 2013-02-06 南京正科制药有限公司 一种阿哌沙班片
EP2752414A1 (en) 2013-01-04 2014-07-09 Sandoz AG Crystalline form of apixaban
CZ2013305A3 (cs) 2013-04-23 2014-11-05 Zentiva, K.S. Nové krystalické formy APIXABANU a způsob jejich přípravy
WO2014203275A2 (en) * 2013-06-18 2014-12-24 Cadila Healthcare Limited An improved process for the preparation of apixaban and intermediates thereof
EP2907507A1 (en) 2014-02-17 2015-08-19 Sandoz Ag Pharmaceutical composition comprising apixaban
CN103830199A (zh) * 2014-03-24 2014-06-04 重庆东得医药科技有限公司 含阿哌沙班的药用制剂及其制备方法
CN104316637B (zh) * 2014-10-30 2016-08-17 江苏宝众宝达药业有限公司 高效液相色谱法测定阿哌沙班清洗残留量
US9603846B2 (en) 2014-11-25 2017-03-28 Cadila Healthcare Limited Process for the preparation of apixaban
KR20180002642A (ko) * 2015-05-08 2018-01-08 욱크하르트 리미티드 항박테리아제를 포함하는 안정한 약학 조성물
WO2017088841A1 (en) 2015-11-26 2017-06-01 Zentiva, K.S. Preparation of a drug form containing amorphous apixaban
CN106913528A (zh) * 2015-12-25 2017-07-04 中美华世通生物医药科技（武汉）有限公司 阿哌沙班微丸及其制备方法
US10537524B2 (en) * 2016-01-12 2020-01-21 North & South Brother Pharmacy Investment Company Limited Apixaban solid composition and preparation method thereof
EP3195860A1 (de) * 2016-01-22 2017-07-26 STADA Arzneimittel AG Verfahren zur herstellung eines apixaban-granulates
WO2017163170A1 (en) * 2016-03-21 2017-09-28 Sun Pharmaceutical Industries Limited Pharmaceutical composition comprising apixaban
WO2017182908A1 (en) * 2016-04-18 2017-10-26 Emcure Pharmaceuticals Limited Pharmaceutical compositions of apixaban
EP3243505A1 (en) 2016-05-13 2017-11-15 Zaklady Farmaceutyczne Polpharma SA A pharmaceutical composition comprising amorphous apixaban
CN106822006B (zh) * 2016-06-08 2020-08-28 北京普德康利医药科技发展有限公司 一种阿哌沙班片及其制备方法
WO2017221209A1 (en) 2016-06-23 2017-12-28 Lupin Limited Pharmaceutical formulations of apixaban
SG10201912389WA (en) * 2016-09-24 2020-02-27 Kbp Biosciences Co Ltd Pharmaceutical composition comprising mineralocorticoid receptor antagonist and use thereof
CN106420651B (zh) * 2016-09-28 2019-03-08 乐普药业股份有限公司 一种阿哌沙班片的制备方法
WO2018150286A1 (en) 2017-02-17 2018-08-23 Unichem Laboratories Ltd Pharmaceutical composition of apixaban
KR102470151B1 (ko) 2017-11-27 2022-11-25 미쯔비시 케미컬 주식회사 고무 함유 그래프트 중합체, 고무 함유 그래프트 중합체 함유 수지 조성물 및 그의 성형체
KR20190075566A (ko) 2017-12-21 2019-07-01 전자부품연구원 다중 센서를 활용한 용변 습관 모니터링 시스템 및 방법
TR201722523A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Api̇ksaban i̇çeren kati oral farmasöti̇k kompozi̇syonlar
CN108236604A (zh) * 2018-02-07 2018-07-03 中国药科大学 阿哌沙班柔性脂质体
WO2019204193A1 (en) 2018-04-16 2019-10-24 Bristol-Myers Squibb Company Apixaban formulations
KR20190130411A (ko) * 2018-05-14 2019-11-22 신일제약주식회사 아픽사반 약제학적 제제 및 그의 제조방법
EP3838265A4 (en) 2018-08-14 2022-05-11 Jiangsu Hengrui Medicine Co., Ltd. INJECTABLE PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARATION
EP3666773A1 (en) 2018-12-11 2020-06-17 KRKA, D.D., Novo Mesto Process for preparing apixaban
EP3669866A1 (en) 2018-12-19 2020-06-24 KRKA, d.d., Novo mesto Pharmaceutical composition comprising apixaban
CN111377915B (zh) * 2018-12-30 2023-10-24 鲁南制药集团股份有限公司 一种吡唑并-吡啶酮化合物晶型d
CN109464415B (zh) * 2019-01-09 2021-08-17 常州恒邦药业有限公司 阿哌沙班药物组合物及其制备方法
CN111214442B (zh) * 2020-02-13 2021-12-10 山东百诺医药股份有限公司 一种阿哌沙班共微粉化物
CN111494326A (zh) * 2020-04-11 2020-08-07 南京正大天晴制药有限公司 一种阿哌沙班片及其制备方法
EP4251155A1 (en) * 2020-11-27 2023-10-04 Santa Farma Ilac Sanayii A.S. Improved wet granulation processes for apixaban comprising formulations
WO2022150030A2 (en) 2021-01-08 2022-07-14 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A film coated tablet of apixaban
TR202100250A2 (tr) 2021-01-08 2022-07-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Api̇ksaban i̇çeren fi̇lm kapli tablet
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150366A (en) 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
ES2232202T3 (es) 1998-12-23 2005-05-16 Bristol-Myers Squibb Pharma Company Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.
AU2002341693B2 (en) 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
TWI331526B (en) * 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US20070025991A1 (en) * 2003-03-19 2007-02-01 Charalabos Pothoulakis Use of antagonists of ghrelin or ghrelin receptor to treat intestinal inflammation
US20050059719A1 (en) * 2003-09-16 2005-03-17 Badawy Sherif Ibrahim Farag Solid dosage formulation containing a Factor Xa inhibitor and method
DE10355461A1 (de) * 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
US7434502B2 (en) 2004-07-21 2008-10-14 Husqvarna Outdoor Products Inc. Bar knob with cam-operated locking mechanism
US20060016084A1 (en) * 2004-07-24 2006-01-26 Ching-Lin Liao Laser-Based datum instrument
US7396932B2 (en) 2004-09-28 2008-07-08 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20060160841A1 (en) * 2005-01-19 2006-07-20 Chenkou Wei Crystallization via high-shear transformation
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US20070191306A1 (en) 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
EP1951197A4 (en) 2005-11-10 2011-12-21 Alphapharm Pty Ltd METHOD OF CHECKING THE PARTICLE SIZE
US20070259913A1 (en) 2006-05-04 2007-11-08 David Deitchman Prophylaxis of thromboembolic events in cancer patients
KR20090052346A (ko) * 2006-09-12 2009-05-25 글락소 그룹 리미티드 인자 ｘａ 억제제를 포함하는 복수의 소형 정제를 포함하는제약 조성물
FI20080351A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
CN101686959B (zh) * 2007-05-02 2014-05-07 波托拉医药品公司 作为血小板adp受体抑制剂的化合物的组合疗法
US8865692B2 (en) * 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
CA2723409C (en) * 2008-05-09 2016-11-08 Atacama Labs Oy Method and apparatus for dry granulation
JP2011527668A (ja) 2008-07-11 2011-11-04 ビーエーエスエフ ソシエタス・ヨーロピア 形態改質剤としての両親媒性タンパク質
US20100018486A1 (en) * 2008-07-22 2010-01-28 Hung-Tao Liu Cathode energy fuel-saving device
CN104042617A (zh) * 2009-04-29 2014-09-17 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
EP2442791B1 (en) 2009-06-16 2019-11-27 Pfizer Inc. Dosage forms of apixaban
PT3257500T (pt) 2010-02-25 2019-11-26 Pfizer Formulações de apixaban
AU2011225810B2 (en) * 2010-03-10 2014-11-06 Lupin Limited Rifaximin ready-to-use suspension

Also Published As

Publication number Publication date
TR201903195T4 (tr) 2019-03-21
SI3246021T1 (sl) 2020-03-31
IL309564A (en) 2024-02-01
LT3257500T (lt) 2019-12-10
JP2017039768A (ja) 2017-02-23
NZ601738A (en) 2014-02-28
RU2012140690A (ru) 2014-03-27
JP6192078B2 (ja) 2017-09-06
HRP20190430T8 (hr) 2019-06-14
LT3246021T (lt) 2020-02-10
RU2685724C2 (ru) 2019-04-23
US20170202824A1 (en) 2017-07-20
KR20130009753A (ko) 2013-01-23
LT3017811T (lt) 2019-02-25
HUE047140T2 (hu) 2020-04-28
MX353145B (es) 2017-12-20
EP3257500B1 (en) 2019-10-16
JP2016065086A (ja) 2016-04-28
CA2791171A1 (en) 2011-09-01
KR101796300B1 (ko) 2017-11-10
US20130045245A1 (en) 2013-02-21
CN102770126A (zh) 2012-11-07
PE20130378A1 (es) 2013-03-30
RS59810B1 (sr) 2020-02-28
IN2012DN06587A (it) 2015-10-23
DK3246021T3 (da) 2020-02-03
BR112012021337A2 (pt) 2016-10-25
PL2538925T3 (pl) 2016-06-30
HUE047139T2 (hu) 2020-04-28
PT3251660T (pt) 2019-12-02
ES2714363T3 (es) 2019-05-28
PT3246021T (pt) 2020-02-21
WO2011106478A3 (en) 2012-04-12
KR20230149861A (ko) 2023-10-27
EP2538925B1 (en) 2015-12-16
US20160243101A1 (en) 2016-08-25
RS58699B1 (sr) 2019-06-28
ES2767848T3 (es) 2020-06-18
HUE027168T2 (en) 2016-10-28
PL3017811T3 (pl) 2019-06-28
KR20210124532A (ko) 2021-10-14
JP6033945B2 (ja) 2016-11-30
ES2562279T3 (es) 2016-03-03
BR112012021337A8 (pt) 2016-11-29
HRP20200046T1 (hr) 2020-03-20
JP5846647B2 (ja) 2016-01-20
DK2538925T3 (en) 2016-03-14
US20170202825A1 (en) 2017-07-20
SG182750A1 (en) 2012-08-30
EP3246021A1 (en) 2017-11-22
PT3017811T (pt) 2019-03-21
CN109602713A (zh) 2019-04-12
HK1180248A1 (zh) 2013-10-18
EP3017811B1 (en) 2018-12-05
HRP20190430T1 (hr) 2019-05-17
SI3257500T1 (sl) 2019-12-31
PE20210468A1 (es) 2021-03-08
RS59576B1 (sr) 2019-12-31
EP3017811A1 (en) 2016-05-11
RS54559B1 (en) 2016-06-30
EP3643301A1 (en) 2020-04-29
IL251991A0 (en) 2017-06-29
CY1117434T1 (el) 2017-04-26
PL3246021T3 (pl) 2020-04-30
JP6577980B2 (ja) 2019-09-18
PT2538925E (pt) 2016-03-18
CN109602716A (zh) 2019-04-12
HRP20192064T1 (hr) 2020-02-21
DK3257500T3 (da) 2019-11-25
PL3251660T3 (pl) 2020-02-28
LT3251660T (lt) 2019-12-10
CO6640207A2 (es) 2013-03-22
WO2011106478A2 (en) 2011-09-01
IL221064A0 (en) 2012-09-24
MX364938B (es) 2019-05-15
JP2017226679A (ja) 2017-12-28
ES2757603T3 (es) 2020-04-29
AU2011220775A1 (en) 2012-09-13
HRP20160179T1 (hr) 2016-04-08
HK1243945B (zh) 2020-06-19
RS59593B1 (sr) 2020-01-31
PE20160042A1 (es) 2016-01-28
PL3257500T3 (pl) 2020-03-31
HK1243946A1 (zh) 2018-07-27
JP2013521226A (ja) 2013-06-10
SG10201501349VA (en) 2015-04-29
ES2758031T8 (es) 2020-08-05
CY1122384T1 (el) 2021-01-27
EP3257500A1 (en) 2017-12-20
CY1121597T1 (el) 2020-05-29
HUE043932T2 (hu) 2019-09-30
EP3662899A1 (en) 2020-06-10
SI3251660T1 (sl) 2019-12-31
SI2538925T1 (sl) 2016-04-29
MX2012009244A (es) 2012-08-23
AU2011220775B2 (en) 2015-09-24
HRP20192069T1 (hr) 2020-02-07
PT3257500T (pt) 2019-11-26
CY1122529T1 (el) 2021-01-27
US9326945B2 (en) 2016-05-03
US20200375968A1 (en) 2020-12-03
CA2791171C (en) 2017-08-29
DK3017811T3 (en) 2019-04-01
CY1122382T1 (el) 2021-01-27
SI3017811T1 (sl) 2019-04-30
KR20170126016A (ko) 2017-11-15
HK1243947B (zh) 2020-06-19
ES2758031T3 (es) 2020-05-04
HK1224216A1 (zh) 2017-08-18
ZA201205807B (en) 2016-01-27
EP3251660A1 (en) 2017-12-06
EP3246021B1 (en) 2019-11-13
EP3251660B1 (en) 2019-10-16
EP2538925A2 (en) 2013-01-02
DK3251660T3 (da) 2019-11-25

Similar Documents

Publication Publication Date Title
SMT201600049B (it) Formulazioni di apixaban
SMT201600350B (it) Composizioni farmaceutiche
DK2640893T4 (da) Sammensætninger
DK3170508T3 (da) Vaccineformuleringer
FIU20114054U0 (fi) Dieettiformulaatiot
GT201200303A (es) Formulaciones farmacéuticas
CO6801722A2 (es) Composiciones farmacéuticas
DK2672817T3 (da) Forbedrede insekticide formuleringer
BR112013000109A2 (pt) composições
FI9608U1 (fi) Formulaatiot
DK2598472T3 (da) Formuleringer
BR112013013304A2 (pt) composições farmacêuticas
BR112013012833A2 (pt) composições farmacêuticas