CN101679408B - 作为fgfr抑制剂的双环杂环化合物 - Google Patents

作为fgfr抑制剂的双环杂环化合物 Download PDF

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Publication number
CN101679408B
CN101679408B CN200780047672.6A CN200780047672A CN101679408B CN 101679408 B CN101679408 B CN 101679408B CN 200780047672 A CN200780047672 A CN 200780047672A CN 101679408 B CN101679408 B CN 101679408B
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group
compound
formula
phenyl
alkyl
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Expired - Fee Related
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CN200780047672.6A
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CN101679408A (zh
Inventor
瓦雷奥·伯蒂尼
基伯特·俄白·苯菘
欧文·卡拉格汉
马日拉·格拉斯阿·卡尔
莫尔·斯图阿特·空各日乌
阿德热安·利安姆·吉尔
莎乐特·马里·各热夫斯-琼斯
安竺·马丁
克斯托弗·威廉·姆热
娆吉狄浦·卡尔·尼基价
麦克·阿里斯塔·欧布赖恩
安竺·俳克
果登·萨克斯提
里查德·大为·忒勒
爱玛·魏克-斯塔夫
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GB0625826A external-priority patent/GB0625826D0/en
Priority claimed from GB0720000A external-priority patent/GB0720000D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
CN200780047672.6A 2006-12-22 2007-12-21 作为fgfr抑制剂的双环杂环化合物 Expired - Fee Related CN101679408B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US87154306P 2006-12-22 2006-12-22
GB0625826A GB0625826D0 (en) 2006-12-22 2006-12-22 New compounds
GB0625826.3 2006-12-22
US60/871,543 2006-12-22
US97958707P 2007-10-12 2007-10-12
GB0720000A GB0720000D0 (en) 2007-10-12 2007-10-12 New compounds
GB0720000.9 2007-10-12
US60/979,587 2007-10-12
US98103907P 2007-10-18 2007-10-18
US60/981,039 2007-10-18
PCT/GB2007/004934 WO2008078091A1 (en) 2006-12-22 2007-12-21 Bicyclic heterocyclic compounds as fgfr inhibitors

Publications (2)

Publication Number Publication Date
CN101679408A CN101679408A (zh) 2010-03-24
CN101679408B true CN101679408B (zh) 2016-04-27

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CN200780047672.6A Expired - Fee Related CN101679408B (zh) 2006-12-22 2007-12-21 作为fgfr抑制剂的双环杂环化合物

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Country Link
US (1) US8895745B2 (OSRAM)
EP (1) EP2114941B1 (OSRAM)
JP (1) JP5442448B2 (OSRAM)
CN (1) CN101679408B (OSRAM)
AR (1) AR064491A1 (OSRAM)
AU (1) AU2007337886C1 (OSRAM)
CA (1) CA2672172C (OSRAM)
HR (1) HRP20150642T1 (OSRAM)
MX (1) MX2009006706A (OSRAM)
NO (1) NO343370B1 (OSRAM)
WO (1) WO2008078091A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

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TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
HRP20151398T1 (hr) 2006-12-22 2016-02-12 Astex Therapeutics Limited Tricikliäśni derivati amina kao inhibitori protein tirozin kinaze
CN101679408B (zh) 2006-12-22 2016-04-27 Astex治疗学有限公司 作为fgfr抑制剂的双环杂环化合物
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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CN101848893B (zh) 2007-09-14 2012-06-06 奥梅-杨森制药有限公司 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮
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WO2010017046A1 (en) 2008-08-05 2010-02-11 Merck & Co., Inc. Pyrazolo[1,5-a]pyridines as mark inhibitors
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WO2010060589A1 (en) * 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
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GB0906470D0 (en) * 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
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EP2430022B1 (en) 2009-05-12 2013-11-20 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
JP5707390B2 (ja) 2009-05-12 2015-04-30 ジャンセン ファーマシューティカルズ， インコーポレイテッド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
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HRP20190016T1 (hr) * 2009-08-17 2019-03-08 Intellikine, Llc Heterociklički spojevi i njihova upotreba
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
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CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
GB201020179D0 (en) * 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
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