CN101142194B - 吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法 - Google Patents

吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法 Download PDF

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CN101142194B
CN101142194B CN2006800084176A CN200680008417A CN101142194B CN 101142194 B CN101142194 B CN 101142194B CN 2006800084176 A CN2006800084176 A CN 2006800084176A CN 200680008417 A CN200680008417 A CN 200680008417A CN 101142194 B CN101142194 B CN 101142194B
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carboxylic acid
imidazol
amide
benzimidazole
group
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CN101142194A (zh
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阿德南·M·M·米亚里
大卫·琼斯
黛维·雷迪·戈穆库拉
黄国响
杰弗·朱
莫汉·饶
罗伯特·C·安德鲁斯
任坦
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Trans Tech Pharma Inc
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2006800084176A 2005-03-14 2006-03-14 吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法 Expired - Fee Related CN101142194B (zh)

Applications Claiming Priority (3)

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US66134905P 2005-03-14 2005-03-14
US60/661,349 2005-03-14
PCT/US2006/009049 WO2006099379A2 (en) 2005-03-14 2006-03-14 Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors

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CN101142194B true CN101142194B (zh) 2012-10-10

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US (4) US7893267B2 (cg-RX-API-DMAC7.html)
EP (2) EP1863771B1 (cg-RX-API-DMAC7.html)
JP (2) JP5066514B2 (cg-RX-API-DMAC7.html)
CN (1) CN101142194B (cg-RX-API-DMAC7.html)
AU (1) AU2006223070B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0608581A2 (cg-RX-API-DMAC7.html)
CA (1) CA2600570C (cg-RX-API-DMAC7.html)
ES (1) ES2400287T3 (cg-RX-API-DMAC7.html)
IL (2) IL185541A (cg-RX-API-DMAC7.html)
MX (1) MX2007011234A (cg-RX-API-DMAC7.html)
NZ (1) NZ561029A (cg-RX-API-DMAC7.html)
WO (1) WO2006099379A2 (cg-RX-API-DMAC7.html)
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