CN101099740B - 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物 - Google Patents

取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物 Download PDF

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Publication number
CN101099740B
CN101099740B CN200710104934XA CN200710104934A CN101099740B CN 101099740 B CN101099740 B CN 101099740B CN 200710104934X A CN200710104934X A CN 200710104934XA CN 200710104934 A CN200710104934 A CN 200710104934A CN 101099740 B CN101099740 B CN 101099740B
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China
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hydrogen
pyridazin
derivatives
general formula
ethylamino
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Expired - Fee Related
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CN200710104934XA
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English (en)
Chinese (zh)
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CN101099740A (zh
Inventor
J·巴克齐
G·斯米格
P·科特纳吉
G·勒维
I·加斯利
B·马东尼马克
E·施密特
A·埃杰德
H·科姆派尼
C·勒维莱奇
A·米克洛什内科瓦奇
G·桑纳斯
J·韦尔曼
L·G·哈辛
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Egis Pharmaceuticals PLC
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Egis Pharmaceuticals PLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200710104934XA 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物 Expired - Fee Related CN101099740B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
HUP0103912 2001-09-27

Related Parent Applications (1)

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CNB028189752A Division CN100368404C (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物

Publications (2)

Publication Number Publication Date
CN101099740A CN101099740A (zh) 2008-01-09
CN101099740B true CN101099740B (zh) 2010-09-08

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ID=89979721

Family Applications (3)

Application Number Title Priority Date Filing Date
CN200710104934XA Expired - Fee Related CN101099740B (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物
CNB028204425A Expired - Fee Related CN1325489C (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物
CNB028189752A Expired - Fee Related CN100368404C (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物

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CNB028204425A Expired - Fee Related CN1325489C (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物
CNB028189752A Expired - Fee Related CN100368404C (zh) 2001-09-27 2002-09-26 取代的烷基氨基哒嗪酮衍生物、其制备方法和含有这种衍生物的药用组合物

Country Status (25)

Country Link
US (2) US6930110B2 (cg-RX-API-DMAC7.html)
EP (2) EP1430047B1 (cg-RX-API-DMAC7.html)
JP (2) JP2005508914A (cg-RX-API-DMAC7.html)
KR (2) KR100890667B1 (cg-RX-API-DMAC7.html)
CN (3) CN101099740B (cg-RX-API-DMAC7.html)
AT (2) ATE288910T1 (cg-RX-API-DMAC7.html)
AU (2) AU2002328166B2 (cg-RX-API-DMAC7.html)
BR (2) BR0212839A (cg-RX-API-DMAC7.html)
CA (2) CA2461510C (cg-RX-API-DMAC7.html)
CZ (2) CZ2004528A3 (cg-RX-API-DMAC7.html)
DE (2) DE60202970T2 (cg-RX-API-DMAC7.html)
DK (2) DK1430047T3 (cg-RX-API-DMAC7.html)
EA (2) EA006942B1 (cg-RX-API-DMAC7.html)
ES (2) ES2237690T3 (cg-RX-API-DMAC7.html)
HU (1) HU227237B1 (cg-RX-API-DMAC7.html)
MA (2) MA27068A1 (cg-RX-API-DMAC7.html)
MX (2) MXPA04002838A (cg-RX-API-DMAC7.html)
NO (2) NO326370B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ532103A (cg-RX-API-DMAC7.html)
PL (2) PL369256A1 (cg-RX-API-DMAC7.html)
PT (2) PT1430034E (cg-RX-API-DMAC7.html)
SI (2) SI1430047T1 (cg-RX-API-DMAC7.html)
SK (2) SK1902004A3 (cg-RX-API-DMAC7.html)
WO (2) WO2003027078A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA200402544B (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
AU2008227100B2 (en) * 2007-03-15 2014-01-09 Albany Molecular Research, Inc. Pyridazinone derivatives useful as glucan synthase inhibitors
TWI877697B (zh) * 2018-04-30 2025-03-21 美商律幫治療股份有限公司 作為parp7抑制劑的嗒酮
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
CN117425648A (zh) * 2021-03-12 2024-01-19 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931176A (en) * 1970-11-12 1976-01-06 Sandoz Inc. Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
CN1043129A (zh) * 1988-12-06 1990-06-20 Cl.药物股份公司 新的哌嗪基烷基-3(2h)-哒嗪酮，其制备方法及其作为降血压剂的应用
US5395934A (en) * 1991-12-20 1995-03-07 Egis Gyogyszergyar 3(2H)-pyridazinone derivatives and process for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU224067B1 (hu) * 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
US6800758B1 (en) * 1998-06-05 2004-10-05 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2H)-pyridazinone-4- substituted amino 5-chloro derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931176A (en) * 1970-11-12 1976-01-06 Sandoz Inc. Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
CN1043129A (zh) * 1988-12-06 1990-06-20 Cl.药物股份公司 新的哌嗪基烷基-3(2h)-哒嗪酮，其制备方法及其作为降血压剂的应用
US5395934A (en) * 1991-12-20 1995-03-07 Egis Gyogyszergyar 3(2H)-pyridazinone derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
AU2002330656A2 (en) 2003-04-07
NO326370B1 (no) 2008-11-17
CA2461510C (en) 2009-07-07
SI1430034T1 (en) 2005-08-31
ZA200402544B (en) 2005-04-26
EA006392B1 (ru) 2005-12-29
EP1430047A1 (en) 2004-06-23
HUP0103912A2 (hu) 2003-07-28
CZ2004532A3 (cs) 2004-08-18
HK1115728A1 (en) 2008-12-05
KR20040039445A (ko) 2004-05-10
CA2461467A1 (en) 2003-04-03
NO20041551L (no) 2004-06-10
PL369107A1 (en) 2005-04-18
WO2003027078A1 (en) 2003-04-03
AU2002328166B2 (en) 2008-04-17
AU2002330656B9 (en) 2009-09-03
DE60202969D1 (de) 2005-03-17
US6930110B2 (en) 2005-08-16
EP1430034B1 (en) 2005-02-09
DE60202969T2 (de) 2006-01-19
JP2005503437A (ja) 2005-02-03
ES2237696T3 (es) 2005-08-01
US20050043314A1 (en) 2005-02-24
KR100911069B1 (ko) 2009-08-06
CN101099740A (zh) 2008-01-09
AU2002330656B2 (en) 2009-04-09
MXPA04002836A (es) 2004-07-05
HU227237B1 (en) 2010-12-28
DK1430047T3 (da) 2005-06-06
SK1892004A3 (en) 2004-10-05
MXPA04002838A (es) 2004-07-05
CN100368404C (zh) 2008-02-13
PT1430047E (pt) 2005-06-30
EA200400470A1 (ru) 2004-08-26
HUP0103912A3 (en) 2004-03-01
JP4472337B2 (ja) 2010-06-02
SI1430047T1 (en) 2005-08-31
ZA200402545B (en) 2005-04-26
NZ532104A (en) 2005-10-28
MA27137A1 (fr) 2005-01-03
US20040242873A1 (en) 2004-12-02
HU0103912D0 (en) 2001-12-28
EA200400469A1 (ru) 2004-08-26
DE60202970T2 (de) 2006-02-16
KR100890667B1 (ko) 2009-03-26
CA2461510A1 (en) 2003-04-03
CN1571783A (zh) 2005-01-26
HK1069816A1 (en) 2005-06-03
BR0212932A (pt) 2004-10-13
ES2237690T3 (es) 2005-08-01
DE60202970D1 (de) 2005-03-17
ATE288910T1 (de) 2005-02-15
ATE288899T1 (de) 2005-02-15
PL369256A1 (en) 2005-04-18
BR0212839A (pt) 2004-10-13
CZ2004528A3 (cs) 2004-08-18
HK1069817A1 (en) 2005-06-03
NO20041704L (no) 2004-04-26
CN1325489C (zh) 2007-07-11
NZ532103A (en) 2005-08-26
EP1430047B1 (en) 2005-02-09
DK1430034T3 (da) 2005-05-30
JP2005508914A (ja) 2005-04-07
NO325080B1 (no) 2008-01-28
MA27068A1 (fr) 2004-12-20
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
KR20040039446A (ko) 2004-05-10
SK1902004A3 (en) 2004-10-05
PT1430034E (pt) 2005-06-30
EA006942B1 (ru) 2006-06-30
WO2003027097A1 (en) 2003-04-03
EP1430034A1 (en) 2004-06-23

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