CN100523187C - 具有改善的药物动力学特性的修饰嵌合多肽 - Google Patents
具有改善的药物动力学特性的修饰嵌合多肽 Download PDFInfo
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| CN108137672A (zh) * | 2015-10-15 | 2018-06-08 | 阿特根公司 | 用于生产具有igg fc结构域的融合蛋白的方法 |
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| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| JP4669984B2 (ja) | 2001-01-19 | 2011-04-13 | ベジェニクス リミテッド | 腫瘍画像化のターゲットとしてのＦ１ｔ４（ＶＥＧＦＲ−３）および抗腫瘍療法 |
| US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
| DE60336341D1 (de) | 2002-05-04 | 2011-04-21 | Acorda Therapeutics Inc | Zusammensetzungen und verfahren zur förderung des neuronalen wachstums |
| US7052691B2 (en) * | 2003-03-28 | 2006-05-30 | Regeneron Pharmaceuticals, Inc. | Methods of treating diabetes by blocking VEGF-mediated activity |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| MX348062B (es) | 2003-05-16 | 2017-05-26 | Acorda Therapeutics Inc | Mutantes que degradan proteoglicanos para tratamiento del snc. |
| EP2354155B1 (en) * | 2003-05-16 | 2017-05-03 | Acorda Therapeutics, Inc. | Fusion Proteins for Treatment of CNS |
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| US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| US7354578B2 (en) | 2003-06-06 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with VEGF inhibitors |
| US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| AR046510A1 (es) | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| JP2007501239A (ja) * | 2003-08-06 | 2007-01-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 放射線治療と組み合わせたｖｅｇｆアンタゴニストの使用 |
| EP1750757B1 (en) | 2004-05-18 | 2013-03-13 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
| CA2569108C (en) | 2004-06-08 | 2012-08-21 | Chengdu Kanghong Biotechnologies Co. Ltd | Angiogenesis-inhibiting chimeric protein and the use |
| WO2005123104A2 (en) * | 2004-06-10 | 2005-12-29 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for the treatment of human cancer |
| JP2008503481A (ja) * | 2004-06-18 | 2008-02-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 悪性胸膜滲出液の処置のためのｖｅｇｆインヒビターの投与および使用の方法 |
| CA2567795C (en) | 2004-07-30 | 2013-06-11 | Regeneron Pharmaceuticals, Inc. | Methods of treating type i diabetes by blocking vegf-mediated activity |
| WO2006031689A2 (en) | 2004-09-13 | 2006-03-23 | Genzyme Corporation | Multimeric constructs |
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| CN108137672A (zh) * | 2015-10-15 | 2018-06-08 | 阿特根公司 | 用于生产具有igg fc结构域的融合蛋白的方法 |
| CN108137672B (zh) * | 2015-10-15 | 2022-09-06 | 阿特根公司 | 用于生产具有igg fc结构域的融合蛋白的方法 |
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