CN100379743C - 用于治疗心律失常的氧杂双皮丁化合物 - Google Patents

用于治疗心律失常的氧杂双皮丁化合物 Download PDF

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Publication number
CN100379743C
CN100379743C CNB00816231XA CN00816231A CN100379743C CN 100379743 C CN100379743 C CN 100379743C CN B00816231X A CNB00816231X A CN B00816231XA CN 00816231 A CN00816231 A CN 00816231A CN 100379743 C CN100379743 C CN 100379743C
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CN
China
Prior art keywords
oxa
diazabicyclo
benzonitrile
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB00816231XA
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English (en)
Chinese (zh)
Other versions
CN1399639A (zh
Inventor
A·比约雷
M·比约尔斯尼
D·克拉丁贝尔
K·-J·霍夫曼
J·佩维
F·庞藤
G·斯特兰伦德
P·斯文松
C·汤姆森
M·维尔斯特曼
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AstraZeneca AB
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AstraZeneca AB
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Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1399639A publication Critical patent/CN1399639A/zh
Application granted granted Critical
Publication of CN100379743C publication Critical patent/CN100379743C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB00816231XA 1999-10-18 2000-10-13 用于治疗心律失常的氧杂双皮丁化合物 Expired - Fee Related CN100379743C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9903759-0 1999-10-18
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
SE99037590 1999-10-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100058488A Division CN101265262A (zh) 1999-10-18 2000-10-13 用于治疗心律失常的氧杂双皮丁化合物

Publications (2)

Publication Number Publication Date
CN1399639A CN1399639A (zh) 2003-02-26
CN100379743C true CN100379743C (zh) 2008-04-09

Family

ID=20417401

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB00816231XA Expired - Fee Related CN100379743C (zh) 1999-10-18 2000-10-13 用于治疗心律失常的氧杂双皮丁化合物
CNA2008100058488A Pending CN101265262A (zh) 1999-10-18 2000-10-13 用于治疗心律失常的氧杂双皮丁化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2008100058488A Pending CN101265262A (zh) 1999-10-18 2000-10-13 用于治疗心律失常的氧杂双皮丁化合物

Country Status (41)

Country Link
US (6) US6559143B1 (https=)
EP (2) EP1235831B1 (https=)
JP (3) JP3973906B2 (https=)
KR (1) KR100796142B1 (https=)
CN (2) CN100379743C (https=)
AP (1) AP1536A (https=)
AR (2) AR026064A1 (https=)
AT (1) ATE292134T1 (https=)
AU (1) AU769513B2 (https=)
BG (1) BG65785B1 (https=)
BR (1) BR0014804A (https=)
CA (1) CA2386910A1 (https=)
CO (1) CO5271655A1 (https=)
CU (1) CU23210A3 (https=)
CZ (1) CZ20021328A3 (https=)
DE (1) DE60019158T2 (https=)
DK (1) DK1235831T3 (https=)
EA (1) EA005319B1 (https=)
EE (1) EE04854B1 (https=)
ES (1) ES2239047T3 (https=)
HK (1) HK1049003B (https=)
HR (1) HRP20020336B1 (https=)
HU (1) HUP0204085A3 (https=)
IL (5) IL149108A0 (https=)
IS (2) IS2224B (https=)
MX (1) MXPA02003848A (https=)
MY (1) MY130661A (https=)
NO (1) NO327977B1 (https=)
NZ (2) NZ518156A (https=)
OA (1) OA12067A (https=)
PL (1) PL354970A1 (https=)
PT (1) PT1235831E (https=)
RS (1) RS50760B (https=)
SE (1) SE9903759D0 (https=)
SI (1) SI1235831T1 (https=)
SK (1) SK286723B6 (https=)
TR (1) TR200201059T2 (https=)
TW (1) TWI283680B (https=)
UA (1) UA75052C2 (https=)
WO (1) WO2001028992A2 (https=)
ZA (1) ZA200202575B (https=)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
BR0214225A (pt) * 2001-11-22 2004-09-21 Astrazeneca Ab Processos para a preparação e para a formação de um composto, e, composto
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) * 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
US20100222335A1 (en) * 2005-06-20 2010-09-02 Astrazeneca Ab Process For The Preparation Of N,N'-Disubstituted Oxabispidines
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation
JP7800143B2 (ja) * 2022-01-07 2026-01-16 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物
JP2023101256A (ja) * 2022-01-07 2023-07-20 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
WO1999031100A1 (en) * 1997-12-17 1999-06-24 Astrazeneca Ab Novel bispidine antiarrhythmic compounds

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US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284070A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
CZ20013608A3 (cs) 1999-04-09 2002-05-15 Astrazeneca Ab Adamantanové deriváty
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
WO1999031100A1 (en) * 1997-12-17 1999-06-24 Astrazeneca Ab Novel bispidine antiarrhythmic compounds

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HUP0204085A3 (en) 2006-01-30
AR039226A2 (es) 2005-02-09
US6559143B1 (en) 2003-05-06
NO20021811L (no) 2002-06-06
JP2003512352A (ja) 2003-04-02
HRP20020336A2 (en) 2004-02-29
EE200200203A (et) 2003-06-16
ATE292134T1 (de) 2005-04-15
IL149108A0 (en) 2002-11-10
DE60019158T2 (de) 2006-02-02
US7164017B2 (en) 2007-01-16
CO5271655A1 (es) 2003-04-30
IS6346A (is) 2002-04-17
EP1559717A3 (en) 2009-04-29
YU29402A (sh) 2004-12-31
NO20021811D0 (no) 2002-04-17
CN101265262A (zh) 2008-09-17
IS8586A (is) 2006-12-27
US7351821B2 (en) 2008-04-01
JP3973906B2 (ja) 2007-09-12
EP1235831B1 (en) 2005-03-30
SE9903759D0 (sv) 1999-10-18
US7772229B2 (en) 2010-08-10
SI1235831T1 (https=) 2005-08-31
US20030153564A1 (en) 2003-08-14
MY130661A (en) 2007-07-31
HRP20020336B1 (en) 2006-02-28
BR0014804A (pt) 2002-06-11
WO2001028992A3 (en) 2001-09-13
EP1235831A2 (en) 2002-09-04
AP1536A (en) 2006-01-09
BG65785B1 (bg) 2009-11-30
EA005319B1 (ru) 2005-02-24
AU1069101A (en) 2001-04-30
IL149108A (en) 2009-12-24
US20090326221A1 (en) 2009-12-31
BG106588A (en) 2003-01-31
AR026064A1 (es) 2002-12-26
PT1235831E (pt) 2005-06-30
HK1049003B (en) 2005-09-09
SK5062002A3 (en) 2002-11-06
US20060166979A1 (en) 2006-07-27
SK286723B6 (sk) 2009-04-06
CZ20021328A3 (cs) 2002-09-11
US20060166980A1 (en) 2006-07-27
MXPA02003848A (es) 2002-10-23
US20070117799A1 (en) 2007-05-24
KR20020038956A (ko) 2002-05-24
IS2224B (is) 2007-04-15
CN1399639A (zh) 2003-02-26
TWI283680B (en) 2007-07-11
JP2007204486A (ja) 2007-08-16
NZ531260A (en) 2005-08-26
HUP0204085A2 (hu) 2003-04-28
IL183852A0 (en) 2009-02-11
ES2239047T3 (es) 2005-09-16
KR100796142B1 (ko) 2008-01-21
HK1049003A1 (en) 2003-04-25
DE60019158D1 (de) 2005-05-04
TR200201059T2 (tr) 2002-09-23
CA2386910A1 (en) 2001-04-26
EA200200390A1 (ru) 2002-10-31
DK1235831T3 (da) 2005-06-27
ZA200202575B (en) 2003-09-23
UA75052C2 (en) 2006-03-15
NZ518156A (en) 2004-05-28
IL183854A0 (en) 2009-02-11
AP2002002471A0 (en) 2002-06-30
EP1559717A2 (en) 2005-08-03
JP2006342182A (ja) 2006-12-21
IL183853A0 (en) 2009-02-11
NO327977B1 (no) 2009-11-02
OA12067A (en) 2006-05-04
RS50760B (sr) 2010-08-31
CU23210A3 (es) 2007-06-20
EE04854B1 (et) 2007-06-15
AU769513B2 (en) 2004-01-29
PL354970A1 (en) 2004-03-22
WO2001028992A2 (en) 2001-04-26

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CI01 Publication of corrected invention patent application

Correction item: Inventor

Correct: A * Bjornie|M * Bjornerney|D. * Claping Bell|K * J * Hoffman|J * Pewei F * Pantone|G * Stirlinge * P * Swainson C. Thomson|M. Wilsteinman

False: A * Bjornie|M * Bjornerney|D * Claping Bell|K * J * Hoffman|G * Strand Lunds|P * Swainson

Number: 9

Volume: 19

CI02 Correction of invention patent application

Correction item: Inventor

Correct: A * Bjornie|M * Bjornerney|D. * Claping Bell|K * J * Hoffman|J * Pewei F * Pantone|G * Stirlinge * P * Swainson C. Thomson|M. Wilsteinman

False: A * Bjornie|M * Bjornerney|D * Claping Bell|K * J * Hoffman|G * Strand Lunds|P * Swainson

Number: 9

Page: The title page

Volume: 19

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: A. BJULE ^ BJOERSNE MAGNUS ^ BJOERSNE MAGNUS ^ K-J HOFFMAN ^ G. STRANDLUND^ P. SVANSSON TO: A. BJULE ^ BJOERSNE MAGNUS ^ BJOERSNE MAGNUS ^ K-J HOFFMAN ^ J PAVEY F. PONTEN;G. STRANDLUND ^ G. STRANDLUND ^ P. SVANSSON ^ C THOMSON ^ M WEIERSHITEMAN ^

ERR Gazette correction

Free format text: CORRECT: INVENTOR; FROM: A. BJULE ^ BJOERSNE MAGNUS ^ BJOERSNE MAGNUS ^ K-J HOFFMAN ^ G. STRANDLUND^ P. SVANSSON TO: A. BJULE ^ BJOERSNE MAGNUS ^ BJOERSNE MAGNUS ^ K-J HOFFMAN ^ J PAVEY F. PONTEN;G. STRANDLUND ^ G. STRANDLUND ^ P. SVANSSON ^ C THOMSON ^ M WEIERSHITEMAN ^

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080409

Termination date: 20101013