KR100796142B1 - 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 - Google Patents

심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 Download PDF

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Publication number
KR100796142B1
KR100796142B1 KR1020027004902A KR20027004902A KR100796142B1 KR 100796142 B1 KR100796142 B1 KR 100796142B1 KR 1020027004902 A KR1020027004902 A KR 1020027004902A KR 20027004902 A KR20027004902 A KR 20027004902A KR 100796142 B1 KR100796142 B1 KR 100796142B1
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KR
South Korea
Prior art keywords
oxa
diazabicyclo
benzonitrile
propyl
ethyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020027004902A
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English (en)
Korean (ko)
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KR20020038956A (ko
Inventor
아니카 외레
마그누스 외르스네
데이비드 클라딩보엘
쿠르트-위르겐 호프만
존 파베이
프리티오프 폰텐
게르트 스트란드룬드
페데르 스벤손
콜린 톰슨
미카엘 윌스테르만
Original Assignee
아스트라제네카 아베
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Publication of KR20020038956A publication Critical patent/KR20020038956A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020027004902A 1999-10-18 2000-10-13 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 Expired - Fee Related KR100796142B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759-0 1999-10-18
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
KR20020038956A KR20020038956A (ko) 2002-05-24
KR100796142B1 true KR100796142B1 (ko) 2008-01-21

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027004902A Expired - Fee Related KR100796142B1 (ko) 1999-10-18 2000-10-13 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물

Country Status (41)

Country Link
US (6) US6559143B1 (https=)
EP (2) EP1235831B1 (https=)
JP (3) JP3973906B2 (https=)
KR (1) KR100796142B1 (https=)
CN (2) CN100379743C (https=)
AP (1) AP1536A (https=)
AR (2) AR026064A1 (https=)
AT (1) ATE292134T1 (https=)
AU (1) AU769513B2 (https=)
BG (1) BG65785B1 (https=)
BR (1) BR0014804A (https=)
CA (1) CA2386910A1 (https=)
CO (1) CO5271655A1 (https=)
CU (1) CU23210A3 (https=)
CZ (1) CZ20021328A3 (https=)
DE (1) DE60019158T2 (https=)
DK (1) DK1235831T3 (https=)
EA (1) EA005319B1 (https=)
EE (1) EE04854B1 (https=)
ES (1) ES2239047T3 (https=)
HK (1) HK1049003B (https=)
HR (1) HRP20020336B1 (https=)
HU (1) HUP0204085A3 (https=)
IL (5) IL149108A0 (https=)
IS (2) IS2224B (https=)
MX (1) MXPA02003848A (https=)
MY (1) MY130661A (https=)
NO (1) NO327977B1 (https=)
NZ (2) NZ518156A (https=)
OA (1) OA12067A (https=)
PL (1) PL354970A1 (https=)
PT (1) PT1235831E (https=)
RS (1) RS50760B (https=)
SE (1) SE9903759D0 (https=)
SI (1) SI1235831T1 (https=)
SK (1) SK286723B6 (https=)
TR (1) TR200201059T2 (https=)
TW (1) TWI283680B (https=)
UA (1) UA75052C2 (https=)
WO (1) WO2001028992A2 (https=)
ZA (1) ZA200202575B (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
BR0214225A (pt) * 2001-11-22 2004-09-21 Astrazeneca Ab Processos para a preparação e para a formação de um composto, e, composto
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) * 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
US20100222335A1 (en) * 2005-06-20 2010-09-02 Astrazeneca Ab Process For The Preparation Of N,N'-Disubstituted Oxabispidines
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation
JP7800143B2 (ja) * 2022-01-07 2026-01-16 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物
JP2023101256A (ja) * 2022-01-07 2023-07-20 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125825A2 (en) * 1983-05-09 1984-11-21 Oy Partek Ab Method and slide-casting device for the casting of concrete objects
JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
CZ20013608A3 (cs) 1999-04-09 2002-05-15 Astrazeneca Ab Adamantanové deriváty
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125825A2 (en) * 1983-05-09 1984-11-21 Oy Partek Ab Method and slide-casting device for the casting of concrete objects
JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法

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HUP0204085A3 (en) 2006-01-30
AR039226A2 (es) 2005-02-09
US6559143B1 (en) 2003-05-06
NO20021811L (no) 2002-06-06
JP2003512352A (ja) 2003-04-02
HRP20020336A2 (en) 2004-02-29
EE200200203A (et) 2003-06-16
ATE292134T1 (de) 2005-04-15
IL149108A0 (en) 2002-11-10
DE60019158T2 (de) 2006-02-02
US7164017B2 (en) 2007-01-16
CN100379743C (zh) 2008-04-09
CO5271655A1 (es) 2003-04-30
IS6346A (is) 2002-04-17
EP1559717A3 (en) 2009-04-29
YU29402A (sh) 2004-12-31
NO20021811D0 (no) 2002-04-17
CN101265262A (zh) 2008-09-17
IS8586A (is) 2006-12-27
US7351821B2 (en) 2008-04-01
JP3973906B2 (ja) 2007-09-12
EP1235831B1 (en) 2005-03-30
SE9903759D0 (sv) 1999-10-18
US7772229B2 (en) 2010-08-10
SI1235831T1 (https=) 2005-08-31
US20030153564A1 (en) 2003-08-14
MY130661A (en) 2007-07-31
HRP20020336B1 (en) 2006-02-28
BR0014804A (pt) 2002-06-11
WO2001028992A3 (en) 2001-09-13
EP1235831A2 (en) 2002-09-04
AP1536A (en) 2006-01-09
BG65785B1 (bg) 2009-11-30
EA005319B1 (ru) 2005-02-24
AU1069101A (en) 2001-04-30
IL149108A (en) 2009-12-24
US20090326221A1 (en) 2009-12-31
BG106588A (en) 2003-01-31
AR026064A1 (es) 2002-12-26
PT1235831E (pt) 2005-06-30
HK1049003B (en) 2005-09-09
SK5062002A3 (en) 2002-11-06
US20060166979A1 (en) 2006-07-27
SK286723B6 (sk) 2009-04-06
CZ20021328A3 (cs) 2002-09-11
US20060166980A1 (en) 2006-07-27
MXPA02003848A (es) 2002-10-23
US20070117799A1 (en) 2007-05-24
KR20020038956A (ko) 2002-05-24
IS2224B (is) 2007-04-15
CN1399639A (zh) 2003-02-26
TWI283680B (en) 2007-07-11
JP2007204486A (ja) 2007-08-16
NZ531260A (en) 2005-08-26
HUP0204085A2 (hu) 2003-04-28
IL183852A0 (en) 2009-02-11
ES2239047T3 (es) 2005-09-16
HK1049003A1 (en) 2003-04-25
DE60019158D1 (de) 2005-05-04
TR200201059T2 (tr) 2002-09-23
CA2386910A1 (en) 2001-04-26
EA200200390A1 (ru) 2002-10-31
DK1235831T3 (da) 2005-06-27
ZA200202575B (en) 2003-09-23
UA75052C2 (en) 2006-03-15
NZ518156A (en) 2004-05-28
IL183854A0 (en) 2009-02-11
AP2002002471A0 (en) 2002-06-30
EP1559717A2 (en) 2005-08-03
JP2006342182A (ja) 2006-12-21
IL183853A0 (en) 2009-02-11
NO327977B1 (no) 2009-11-02
OA12067A (en) 2006-05-04
RS50760B (sr) 2010-08-31
CU23210A3 (es) 2007-06-20
EE04854B1 (et) 2007-06-15
AU769513B2 (en) 2004-01-29
PL354970A1 (en) 2004-03-22
WO2001028992A2 (en) 2001-04-26

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