CL2014001639A1 - Uso simultaneo, separado o secuencial de un agonista de ppar gamma seleccionado del grupo de glitazonas con un activador de nrf2 aislado seleccionado de un grupo especifico o una composicion que lo comprende, para el tratamiento de un trastorno autoinmune y/o inflamatorio; composicion farmaceutica que comprende a dicho agonista de ppar gamma y al activador de nrf2; y kit que la comprende. - Google Patents
Uso simultaneo, separado o secuencial de un agonista de ppar gamma seleccionado del grupo de glitazonas con un activador de nrf2 aislado seleccionado de un grupo especifico o una composicion que lo comprende, para el tratamiento de un trastorno autoinmune y/o inflamatorio; composicion farmaceutica que comprende a dicho agonista de ppar gamma y al activador de nrf2; y kit que la comprende.Info
- Publication number
- CL2014001639A1 CL2014001639A1 CL2014001639A CL2014001639A CL2014001639A1 CL 2014001639 A1 CL2014001639 A1 CL 2014001639A1 CL 2014001639 A CL2014001639 A CL 2014001639A CL 2014001639 A CL2014001639 A CL 2014001639A CL 2014001639 A1 CL2014001639 A1 CL 2014001639A1
- Authority
- CL
- Chile
- Prior art keywords
- ppar gamma
- gamma agonist
- nrf2 activator
- group
- composition
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194292 | 2011-12-19 | ||
| EP12004652 | 2012-06-21 | ||
| US201261663761P | 2012-06-25 | 2012-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001639A1 true CL2014001639A1 (es) | 2014-11-14 |
Family
ID=48610741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001639A CL2014001639A1 (es) | 2011-12-19 | 2014-06-19 | Uso simultaneo, separado o secuencial de un agonista de ppar gamma seleccionado del grupo de glitazonas con un activador de nrf2 aislado seleccionado de un grupo especifico o una composicion que lo comprende, para el tratamiento de un trastorno autoinmune y/o inflamatorio; composicion farmaceutica que comprende a dicho agonista de ppar gamma y al activador de nrf2; y kit que la comprende. |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US20130158077A1 (enExample) |
| EP (1) | EP2793876B1 (enExample) |
| JP (1) | JP6132850B2 (enExample) |
| KR (2) | KR102188487B1 (enExample) |
| CN (1) | CN103998035B (enExample) |
| AR (1) | AR089301A1 (enExample) |
| AU (4) | AU2012358420B9 (enExample) |
| BR (1) | BR112014014809A8 (enExample) |
| CA (1) | CA2859635C (enExample) |
| CL (1) | CL2014001639A1 (enExample) |
| EA (1) | EA201400729A1 (enExample) |
| ES (1) | ES2959111T3 (enExample) |
| HK (1) | HK1200711A1 (enExample) |
| IL (1) | IL233134A0 (enExample) |
| MX (2) | MX394473B (enExample) |
| PH (1) | PH12014501029A1 (enExample) |
| SG (1) | SG11201403241XA (enExample) |
| WO (1) | WO2013092269A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| MX339243B (es) | 2011-02-03 | 2016-05-18 | Vtv Therapeutics Llc | Derivados fusionados sustituidos de imidazol, composiciones farmaceuticas y metodos de uso de los mismos. |
| US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
| US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| MX2015007479A (es) * | 2012-12-11 | 2015-09-04 | Metabolic Solutions Dev Co Llc | Tiazolidindionas ahorradoras de receptores activados proliferadores de peroxisoma (ppar) y combinaciones para el tratamiento de enfermedades neurodegenerativas. |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US9604922B2 (en) | 2014-02-24 | 2017-03-28 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016071727A1 (en) | 2014-11-04 | 2016-05-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prevention and the treatment of rapidly progressive glomerulonephritis |
| WO2016074684A1 (en) * | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Fumaric acid derivatives for medical use |
| MA40990A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| MA41785A (fr) | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| KR101704410B1 (ko) | 2015-07-22 | 2017-02-22 | 대구가톨릭대학교산학협력단 | 사파논 a를 함유하는 심혈관질환의 예방 및 치료용 조성물 |
| WO2017072699A1 (en) * | 2015-10-28 | 2017-05-04 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of dimethyl fumarate |
| CN108699011B (zh) * | 2016-02-03 | 2022-05-06 | 参宿七制药股份有限公司 | Nrf2活化性化合物及其用途 |
| CN106389457A (zh) * | 2016-11-30 | 2017-02-15 | 胡立志 | PPAR‑γ激动剂在制备治疗脱发药物中的应用及治疗脱发的药物 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| CN108685903B (zh) * | 2018-07-05 | 2019-10-18 | 陕西师范大学 | 鼠尾草酚在制备防治实验性自身免疫性脑脊髓炎药物的应用 |
| WO2020094767A1 (en) | 2018-11-08 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of nrf2 activators for the treatment of staphylococcus aureus infections |
| KR20210096162A (ko) * | 2018-11-27 | 2021-08-04 | 쿄와 기린 가부시키가이샤 | 의약 조성물 |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| CN111606828B (zh) * | 2019-02-22 | 2023-07-28 | 浙江海正药业股份有限公司 | (E)-α,β-不饱和酰胺化合物的晶型及其制备方法和用途 |
| CN109846867A (zh) * | 2019-03-29 | 2019-06-07 | 北京中医药大学 | 花姜酮用于制备抗心肌缺血的药物的用途 |
| WO2021024054A1 (en) * | 2019-08-05 | 2021-02-11 | International Business Machines Corporation | Combination therapy to achieve enhanced antimicrobial activity |
| CN110279866B (zh) * | 2019-08-12 | 2021-06-29 | 浙江养生堂天然药物研究所有限公司 | 包含柠檬苦素类化合物和噻唑烷二酮类药物的组合产品 |
| CN110613712B (zh) * | 2019-10-22 | 2021-06-29 | 上海交通大学医学院附属第九人民医院 | 中药组合物及其在治疗血管炎症和内皮损伤中的应用 |
| WO2021142062A1 (en) | 2020-01-10 | 2021-07-15 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| CN113244221B (zh) * | 2020-02-12 | 2022-10-25 | 华东师范大学 | 双甲基鼠尾草酚在制备治疗恶病质疾病的药物中的应用 |
| US20250002436A1 (en) * | 2020-02-24 | 2025-01-02 | Robert F. Hofmann | Naphthoquinone-based chalcone derivatives and uses thereof |
| US20230134760A1 (en) * | 2020-03-04 | 2023-05-04 | Hongbing Wang | Car and nrf2 dual activator agents for cyclophosphamide-based and doxorubicin-based treatments of cancer |
| EP4117785A4 (en) * | 2020-03-13 | 2024-04-17 | Marc J. Simard | METHODS OF TREATMENT OF MULTIPLE SCLEROSIS |
| CN111574437A (zh) * | 2020-06-22 | 2020-08-25 | 上海长车生物科技有限公司 | (e)-3-芳杂环基丙-2-烯酸衍生物及其制备和用途 |
| CN111529514A (zh) * | 2020-06-23 | 2020-08-14 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 一种特丁基对苯二酚的应用及治疗椎间盘退变的药物 |
| WO2022056439A1 (en) * | 2020-09-14 | 2022-03-17 | Triterpenoid Therapeutics, Inc. | Analogs of cddo-2p-im and cddo-3p-im |
| US20250134845A1 (en) * | 2022-02-15 | 2025-05-01 | Emory University | Fumaric Acid Esters, Inhalation Administration Methods, Pharmaceutical Uses and Compositions |
| KR20230123323A (ko) | 2022-02-16 | 2023-08-23 | 대구대학교 산학협력단 | 알릴 이소티오시아네이트(Allyl isothiocyanate)를 유효성분으로 포함하는 골 대사성 질환의 예방, 개선 또는 치료용 조성물 |
| CN114414809B (zh) * | 2022-03-28 | 2022-06-21 | 中元伯瑞生物科技(珠海横琴)有限公司 | 用于诊断尘肺病的生物标志物的应用 |
| WO2024047248A1 (en) | 2022-09-02 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Use of nrf2 activators for the treatment of cerebral small vessel disease |
| CN117137897B (zh) * | 2023-10-31 | 2024-02-13 | 中国中医科学院中药研究所 | 索法酮在制备用于预防/治疗银屑病的药物中的应用 |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US807113A (en) | 1905-03-27 | 1905-12-12 | Frederick O Dyer | Puzzle. |
| AR240698A1 (es) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| EP0306228B1 (en) | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US4959389A (en) | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| DE19721099C2 (de) | 1997-05-20 | 1999-12-02 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten |
| US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
| ES2317688T3 (es) | 1998-01-29 | 2009-04-16 | Amgen Inc. | Moduladores ppar-gamma. |
| DE19814358C2 (de) | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
| DE19839566C2 (de) | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| DE19848260C2 (de) | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| TWI249401B (en) | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| DK1192137T3 (da) | 1999-06-30 | 2013-11-11 | Amgen Inc | Forbindelser til modulering af PPAR-gamma aktivitet |
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| DE10000577A1 (de) | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| US6403121B1 (en) | 2000-05-01 | 2002-06-11 | Aeropharm Technology Incorporated | Core formulation |
| WO2001082916A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Combination therapeutic compositions and methods of use |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| GB0021978D0 (en) * | 2000-09-07 | 2000-10-25 | Smithkline Beecham Plc | Novel pharmaceutical |
| US20040013643A1 (en) | 2000-09-19 | 2004-01-22 | Novlmmune S.A. | Methods for treatment of multiple sclerosis with statins |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| AU2002219236B2 (en) | 2001-01-12 | 2006-02-09 | Biogen International Gmbh | Fumaric acid amides |
| DE10101307A1 (de) | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| GB2373725A (en) | 2001-03-30 | 2002-10-02 | Novartis Ag | Use of a PPAR gamma agonist in the production of a medicament for the prevention or treatment of diseases associated with IL-10 production |
| CA2440017A1 (en) * | 2001-05-03 | 2002-11-14 | Cornell Research Foundation, Inc. | Treatment of hpv caused diseases |
| FR2825023B1 (fr) | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| DE10217314A1 (de) | 2002-04-18 | 2003-11-13 | Fumapharm Ag Muri | Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere |
| BRPI0407074A (pt) | 2003-01-29 | 2006-01-24 | Takeda Pharmaceutical | Método para produção de uma preparação revestida, preparação revestida, e, método para melhorar a dissolução do cloridreto de pioglitazona de uma preparação revestida com cloridreto de pioglitazona |
| WO2004098510A2 (en) * | 2003-04-30 | 2004-11-18 | Beth Israel Deaconess Medical Center | Cystic fibrosis therapy |
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| DE10342423A1 (de) | 2003-09-13 | 2005-04-14 | Heidland, August, Prof. Dr.med. Dr.h.c. | Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| EP1691806A2 (en) | 2003-12-03 | 2006-08-23 | Smithkline Beecham Corporation | Novel therapeutic method and compositions |
| AU2005221140A1 (en) | 2004-03-08 | 2005-09-22 | Amgen Inc. | Therapeutic modulation of PPAR (gamma) activity |
| AU2005259864A1 (en) | 2004-06-30 | 2006-01-12 | Combinatorx, Incorporated | Methods and reagents for the treatment of metabolic disorders |
| ITMI20041825A1 (it) | 2004-09-24 | 2004-12-24 | Medestea Res & Production Srl | Agonisti dei ricettori attivanti la proliferazione dei perossisomi, utili nella prevenzione o nel trattamento della gastrite |
| DE14172396T1 (de) | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| US20060089387A1 (en) * | 2004-10-26 | 2006-04-27 | Le Huang | Stabilized pharmaceutical composition comprising antidiabetic agent |
| US20080004344A1 (en) | 2004-11-10 | 2008-01-03 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
| GB0504206D0 (en) | 2005-03-01 | 2005-04-06 | Glaxo Group Ltd | Combination therapy |
| DE102005022845A1 (de) | 2005-05-18 | 2006-11-23 | Fumapharm Ag | Thiobernsteinsäurederivate und deren Verwendung |
| DE602006011910D1 (de) | 2005-07-07 | 2010-03-11 | Aditech Pharma Ag | Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung |
| EP1951206A1 (en) | 2005-10-07 | 2008-08-06 | Aditech Pharma AB | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| WO2007042035A2 (en) | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
| HRP20160679T1 (hr) | 2005-12-22 | 2016-07-15 | Takeda Pharmaceutical Company Limited | Kruti pripravak koji sadrži senzibilizator inzulina |
| AU2007248473B2 (en) | 2006-05-05 | 2011-01-27 | The Regents Of The University Of Michigan | Bivalent Smac mimetics and the uses thereof |
| US20080089861A1 (en) | 2006-07-10 | 2008-04-17 | Went Gregory T | Combination therapy for treatment of demyelinating conditions |
| CA2663347A1 (en) | 2006-09-19 | 2008-03-27 | Braincells, Inc. | Ppar mediated modulation of neurogenesis |
| WO2008096271A2 (en) | 2007-02-08 | 2008-08-14 | Ralf Gold | Neuroprotection in demyelinating diseases |
| PT2137537E (pt) | 2007-02-08 | 2013-08-22 | Biogen Idec Inc | Composições e respectivas utilizações para o tratamento da esclerose múltipla |
| WO2008136838A1 (en) | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| US20100184783A1 (en) | 2007-07-11 | 2010-07-22 | Johan Raud | Combination for use in the treatment of inflammatory atherosclerosis comprising a mast cell inhibitor and a ppar gamma agonist |
| US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
| LT2252283T (lt) * | 2008-01-11 | 2019-03-25 | Reata Pharmaceuticals, Inc. | Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą |
| WO2009097997A1 (de) | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE102008030023A1 (de) | 2008-06-16 | 2009-12-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit |
| GB0913672D0 (en) | 2009-08-05 | 2009-09-16 | Argenta Discovery Ltd | Glitazones |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| US20110190242A1 (en) * | 2008-09-23 | 2011-08-04 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| US20100087481A1 (en) | 2008-10-03 | 2010-04-08 | Lee Kathleen M | Oral pharmaceutical formulations for antidiabetic compounds |
| ES2646816T3 (es) | 2009-02-13 | 2017-12-18 | Reata Pharmaceuticals, Inc. | Composiciones de dosificaciones orales de liberación retardada que contienen CDDO-Me amorfo |
| NZ617130A (en) | 2009-04-29 | 2015-06-26 | Biogen Ma Inc | Treatment of neurodegeneration and neuroinflammation |
| WO2011039175A1 (en) * | 2009-09-29 | 2011-04-07 | Bodo Melnik | Treatment of acne vulgaris, rosacea and androgenetic alopecia and cancer protection in smokers, obesity and diabetes mellitus |
| WO2011057110A1 (en) | 2009-11-06 | 2011-05-12 | Ruprecht-Karls-Universitat-Heidelberg | Gpr109a agonists for the treatment of cerebral ischemia |
| NZ600421A (en) | 2009-12-15 | 2014-06-27 | Metabolic Solutions Dev Co Llc | Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases |
| WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
| ME02317B (me) | 2010-02-12 | 2016-06-20 | Biogen Ma Inc | Neuroprotekcija kod demijelinizacijskih bolesti |
| US8486922B2 (en) * | 2010-04-28 | 2013-07-16 | Chien-Hung Chen | Composition |
| MX390695B (es) | 2010-09-21 | 2025-03-21 | Intekrin Therapeutics Inc | Composiciones farmaceuticas solidas antidiabeticas |
| US20140080795A1 (en) | 2010-11-19 | 2014-03-20 | University Of Rochester | NRF2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 Reduction |
| CN102552140B (zh) * | 2011-01-12 | 2013-05-29 | 北京人福军威医药技术开发有限公司 | 罗格列酮的液体组合物 |
| CA2865316A1 (en) | 2011-04-28 | 2012-11-01 | Gino Cortopassi | Agents useful for treating friedreich's ataxia and other neurodegenerative diseases |
| US20140308244A1 (en) | 2011-08-08 | 2014-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Combination Therapy for Treatment of Inflammatory Demyelinating Disease |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US8865747B2 (en) | 2012-03-23 | 2014-10-21 | Fundació Institute D'Investigació Biomėdica de Bellvitge (IDIBELL) | Pioglitazone for use in the treatment of adrenoleukodystrophy |
| US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| ME02926B (me) | 2012-04-27 | 2018-04-20 | Reata Pharmaceuticals Inc | 2,2-difluoropropionamidni derivati bardoksolon metila, polimorfni oblici i postupci za njihovu upotrebu |
| EP2692343A1 (en) | 2012-08-03 | 2014-02-05 | Forward Pharma A/S | Combination therapy for treatment of multiple sclerosis |
| EA201792096A3 (ru) | 2013-01-30 | 2018-05-31 | Интекрин Терапьютикс, Инк. | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
| EA201592020A1 (ru) | 2013-04-22 | 2016-05-31 | Кадила Хелзкэр Лимитед | Новая композиция для неалкогольной жировой болезни печени (нажбп) |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| DK3388064T3 (da) | 2014-04-02 | 2021-04-19 | Minoryx Therapeutics S L | 2,4-thiazolidindionderivater i behandling af forstyrrelse i centralnervesystemet |
| WO2016074684A1 (en) | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Fumaric acid derivatives for medical use |
| AU2017326261A1 (en) | 2016-09-13 | 2019-04-04 | Intekrin Therapeutics, Inc. | Treatment of multiple sclerosis with CHS-131 |
| US11382889B2 (en) | 2018-04-19 | 2022-07-12 | Institut D'investigació Biomèdica De Bellvitge (Idibell) | NRF2 activators for the prevention and/or treatment of axonal degeneration |
| US20210228558A1 (en) | 2018-06-06 | 2021-07-29 | Minoryx Therapeutics S.L. | Use of 5-[[4-[2-[5-acetylpyridin-2-yl]ethoxy]benzyl]-1,3-thiazolidine-2,4-dione and its salts |
| KR20210031435A (ko) | 2018-06-06 | 2021-03-19 | 미노릭스 테라퓨틱스 에스.엘. | 치료학적 유효량의 5-[[4-[2-[5-(1-히드록시에틸)피리딘-2-일]에톡시]페닐]메틸]-1,3-티아졸리딘-2,4-디온을 투여하는 방법 |
| SI3801515T1 (sl) | 2018-06-06 | 2025-07-31 | Minoryx Therapeutics S.L. | 5-[[4-[2-[5-(1-hidroksietil)piridin-2-il]etoksi]fenil]metil]-1,3-tiazolidin-2,4-dion in soli za uporabo pri zdravljenju mitohondrijske bolezni |
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