CL2013001783A1 - Analogos de glucagon que presentan actividad potente en receptor de gip; dimero o multidimero; conjugado; composicion farmaceutica que los comprende; y sus usos en tratar diabetes u obesidad. - Google Patents
Analogos de glucagon que presentan actividad potente en receptor de gip; dimero o multidimero; conjugado; composicion farmaceutica que los comprende; y sus usos en tratar diabetes u obesidad.Info
- Publication number
- CL2013001783A1 CL2013001783A1 CL2013001783A CL2013001783A CL2013001783A1 CL 2013001783 A1 CL2013001783 A1 CL 2013001783A1 CL 2013001783 A CL2013001783 A CL 2013001783A CL 2013001783 A CL2013001783 A CL 2013001783A CL 2013001783 A1 CL2013001783 A1 CL 2013001783A1
- Authority
- CL
- Chile
- Prior art keywords
- multidimero
- dimero
- obesity
- conjugate
- pharmaceutical composition
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426285P | 2010-12-22 | 2010-12-22 | |
| US201161514609P | 2011-08-03 | 2011-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013001783A1 true CL2013001783A1 (es) | 2014-01-24 |
Family
ID=45476658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013001783A CL2013001783A1 (es) | 2010-12-22 | 2013-06-18 | Analogos de glucagon que presentan actividad potente en receptor de gip; dimero o multidimero; conjugado; composicion farmaceutica que los comprende; y sus usos en tratar diabetes u obesidad. |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8507428B2 (enExample) |
| EP (1) | EP2654773B1 (enExample) |
| JP (1) | JP6086067B2 (enExample) |
| KR (1) | KR20130132931A (enExample) |
| CN (1) | CN103458920B (enExample) |
| AR (1) | AR084459A1 (enExample) |
| AU (1) | AU2011349331A1 (enExample) |
| BR (1) | BR112013015389A2 (enExample) |
| CA (1) | CA2821766A1 (enExample) |
| CL (1) | CL2013001783A1 (enExample) |
| CO (1) | CO6761302A2 (enExample) |
| CR (1) | CR20130295A (enExample) |
| EA (1) | EA201390941A1 (enExample) |
| EC (1) | ECSP13012697A (enExample) |
| ES (1) | ES2713952T3 (enExample) |
| MA (1) | MA34885B1 (enExample) |
| MX (1) | MX2013006304A (enExample) |
| NZ (1) | NZ612297A (enExample) |
| PE (1) | PE20140186A1 (enExample) |
| PH (1) | PH12013501215A1 (enExample) |
| SG (1) | SG191194A1 (enExample) |
| WO (1) | WO2012088116A2 (enExample) |
Families Citing this family (81)
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|---|---|---|---|---|
| PA8830501A1 (es) | 2008-06-17 | 2010-07-27 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
| EP2528618A4 (en) * | 2010-01-27 | 2015-05-27 | Univ Indiana Res & Tech Corp | GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS |
| AR084558A1 (es) * | 2010-12-22 | 2013-05-22 | Marcadia Biotech | Metodos para tratar trastornos metabolicos y obesidad con peptidos basados en glucagon activos para el receptor de peptido insulinotropico dependiente de glucosa (gip)/peptido-1 similar al glucagon (glp-1) |
| BR112013015389A2 (pt) * | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
| PE20140724A1 (es) | 2011-06-22 | 2014-07-10 | Univ Indiana Res & Tech Corp | Coagonistas del receptor de glucagon/glp-1 |
| WO2013041678A1 (en) | 2011-09-23 | 2013-03-28 | Novo Nordisk A/S | Novel glucagon analogues |
| JP6311708B2 (ja) | 2012-06-21 | 2018-04-18 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | Ｇｉｐ受容体活性を示すグルカゴンアナローグ |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR102365582B1 (ko) * | 2012-11-20 | 2022-02-18 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
| PT2934568T (pt) | 2012-12-21 | 2018-01-04 | Sanofi Sa | Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina |
| HK1220383A1 (zh) * | 2013-03-14 | 2017-05-05 | Medimmune Limited | 用於治疗肥胖症的聚乙二醇化的胰高血糖素和glp-1共激动剂 |
| CN105324125A (zh) * | 2013-03-15 | 2016-02-10 | 印第安纳大学研究及科技有限公司 | 具有长效的前体药物 |
| HK1219477A1 (zh) | 2013-03-21 | 2017-04-07 | Sanofi-Aventis Deutschland Gmbh | 合成含有乙内酰脲的肽产物 |
| SG11201506885UA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of cyclic imide containing peptide products |
| WO2014161835A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof |
| RU2683039C2 (ru) * | 2013-04-18 | 2019-03-26 | Ново Нордиск А/С | Стабильные совместные агонисты рецептора глюкагоноподобного пептида-1/глюкагона пролонгированного действия для медицинского применения |
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| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
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| CN106999602B (zh) * | 2014-11-27 | 2022-02-01 | 诺和诺德股份有限公司 | Glp-1衍生物及其用途 |
| JP6691125B2 (ja) | 2014-12-17 | 2020-04-28 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１誘導体及びその使用 |
| AR103322A1 (es) * | 2014-12-30 | 2017-05-03 | Hanmi Pharm Ind Co Ltd | Derivados de glucagón con estabilidad mejorada |
| JOP20200119A1 (ar) | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
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| US10294303B2 (en) | 2015-12-23 | 2019-05-21 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists |
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- 2011-12-20 MA MA36136A patent/MA34885B1/fr unknown
- 2011-12-20 MX MX2013006304A patent/MX2013006304A/es not_active Application Discontinuation
- 2011-12-20 PE PE2013001437A patent/PE20140186A1/es not_active Application Discontinuation
- 2011-12-20 EP EP11808086.0A patent/EP2654773B1/en not_active Not-in-force
- 2011-12-20 JP JP2013546329A patent/JP6086067B2/ja not_active Expired - Fee Related
- 2011-12-20 NZ NZ612297A patent/NZ612297A/en not_active IP Right Cessation
- 2011-12-20 KR KR1020137018994A patent/KR20130132931A/ko not_active Withdrawn
- 2011-12-20 EA EA201390941A patent/EA201390941A1/ru unknown
- 2011-12-20 WO PCT/US2011/066164 patent/WO2012088116A2/en not_active Ceased
- 2011-12-20 US US13/331,816 patent/US8507428B2/en not_active Expired - Fee Related
- 2011-12-20 CA CA2821766A patent/CA2821766A1/en not_active Abandoned
- 2011-12-20 ES ES11808086T patent/ES2713952T3/es active Active
- 2011-12-20 SG SG2013046412A patent/SG191194A1/en unknown
- 2011-12-20 CN CN201180068157.2A patent/CN103458920B/zh not_active Expired - Fee Related
- 2011-12-20 PH PH1/2013/501215A patent/PH12013501215A1/en unknown
- 2011-12-20 AU AU2011349331A patent/AU2011349331A1/en not_active Abandoned
- 2011-12-21 AR ARP110104846A patent/AR084459A1/es not_active Application Discontinuation
-
2012
- 2012-12-27 US US13/728,110 patent/US9249206B2/en not_active Expired - Fee Related
-
2013
- 2013-06-18 CO CO13145190A patent/CO6761302A2/es unknown
- 2013-06-18 CL CL2013001783A patent/CL2013001783A1/es unknown
- 2013-06-18 CR CR20130295A patent/CR20130295A/es not_active Application Discontinuation
- 2013-06-18 EC ECSP13012697 patent/ECSP13012697A/es unknown
-
2015
- 2015-03-23 US US14/665,508 patent/US20150259393A1/en not_active Abandoned
- 2015-12-28 US US14/981,187 patent/US9587005B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP13012697A (es) | 2013-10-31 |
| JP2014507402A (ja) | 2014-03-27 |
| CA2821766A1 (en) | 2012-06-28 |
| ES2713952T3 (es) | 2019-05-24 |
| SG191194A1 (en) | 2013-07-31 |
| BR112013015389A2 (pt) | 2016-11-22 |
| AU2011349331A1 (en) | 2013-07-11 |
| WO2012088116A3 (en) | 2012-11-15 |
| AR084459A1 (es) | 2013-05-15 |
| CO6761302A2 (es) | 2013-09-30 |
| US9587005B2 (en) | 2017-03-07 |
| CN103458920A (zh) | 2013-12-18 |
| NZ612297A (en) | 2015-10-30 |
| US20150259393A1 (en) | 2015-09-17 |
| PE20140186A1 (es) | 2014-02-13 |
| MA34885B1 (fr) | 2014-02-01 |
| US20120238493A1 (en) | 2012-09-20 |
| US20160115215A1 (en) | 2016-04-28 |
| EA201390941A1 (ru) | 2013-12-30 |
| KR20130132931A (ko) | 2013-12-05 |
| MX2013006304A (es) | 2013-07-02 |
| US8507428B2 (en) | 2013-08-13 |
| US9249206B2 (en) | 2016-02-02 |
| PH12013501215A1 (en) | 2013-11-18 |
| EP2654773A2 (en) | 2013-10-30 |
| CR20130295A (es) | 2013-10-09 |
| US20130116173A1 (en) | 2013-05-09 |
| CN103458920B (zh) | 2016-07-06 |
| WO2012088116A2 (en) | 2012-06-28 |
| JP6086067B2 (ja) | 2017-03-01 |
| EP2654773B1 (en) | 2018-10-03 |
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