CA2821766A1 - Glucagon analogs exhibiting gip receptor activity - Google Patents
Glucagon analogs exhibiting gip receptor activity Download PDFInfo
- Publication number
- CA2821766A1 CA2821766A1 CA2821766A CA2821766A CA2821766A1 CA 2821766 A1 CA2821766 A1 CA 2821766A1 CA 2821766 A CA2821766 A CA 2821766A CA 2821766 A CA2821766 A CA 2821766A CA 2821766 A1 CA2821766 A1 CA 2821766A1
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- Prior art keywords
- amino acid
- peptide
- seq
- glucagon analog
- optionally
- Prior art date
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- Abandoned
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
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| US61/514,609 | 2011-08-03 | ||
| PCT/US2011/066164 WO2012088116A2 (en) | 2010-12-22 | 2011-12-20 | Glucagon analogs exhibiting gip receptor activity |
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| CA2821766A Abandoned CA2821766A1 (en) | 2010-12-22 | 2011-12-20 | Glucagon analogs exhibiting gip receptor activity |
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| PA8830501A1 (es) | 2008-06-17 | 2010-07-27 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
| EP2528618A4 (en) * | 2010-01-27 | 2015-05-27 | Univ Indiana Res & Tech Corp | GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS |
| AR084558A1 (es) * | 2010-12-22 | 2013-05-22 | Marcadia Biotech | Metodos para tratar trastornos metabolicos y obesidad con peptidos basados en glucagon activos para el receptor de peptido insulinotropico dependiente de glucosa (gip)/peptido-1 similar al glucagon (glp-1) |
| BR112013015389A2 (pt) * | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
| PE20140724A1 (es) | 2011-06-22 | 2014-07-10 | Univ Indiana Res & Tech Corp | Coagonistas del receptor de glucagon/glp-1 |
| WO2013041678A1 (en) | 2011-09-23 | 2013-03-28 | Novo Nordisk A/S | Novel glucagon analogues |
| JP6311708B2 (ja) | 2012-06-21 | 2018-04-18 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | Ｇｉｐ受容体活性を示すグルカゴンアナローグ |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR102365582B1 (ko) * | 2012-11-20 | 2022-02-18 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
| PT2934568T (pt) | 2012-12-21 | 2018-01-04 | Sanofi Sa | Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina |
| HK1220383A1 (zh) * | 2013-03-14 | 2017-05-05 | Medimmune Limited | 用於治疗肥胖症的聚乙二醇化的胰高血糖素和glp-1共激动剂 |
| CN105324125A (zh) * | 2013-03-15 | 2016-02-10 | 印第安纳大学研究及科技有限公司 | 具有长效的前体药物 |
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| SG11201506885UA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of cyclic imide containing peptide products |
| WO2014161835A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof |
| RU2683039C2 (ru) * | 2013-04-18 | 2019-03-26 | Ново Нордиск А/С | Стабильные совместные агонисты рецептора глюкагоноподобного пептида-1/глюкагона пролонгированного действия для медицинского применения |
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| WO2015035419A1 (en) * | 2013-09-09 | 2015-03-12 | Hoffmann-La Roche Inc. | Dosages of gip/glp-1 co-agonist peptides for human administration |
| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
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| WO2015086731A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| AR098614A1 (es) | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Compuesto para el tratamiento de hipoglicemia severa |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| TW201625670A (zh) * | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
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| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| BR112019024410A2 (pt) | 2017-06-20 | 2020-07-14 | Amgen Inc. | método de tratamento ou melhoria de disfunções metabólicas usando proteínas de ligação para receptor do peptídeo inibidor gástrico (gipr) em combinação com agonistas de glp 1 |
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| US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
| AR079345A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina |
| EP2528618A4 (en) | 2010-01-27 | 2015-05-27 | Univ Indiana Res & Tech Corp | GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS |
| AR080592A1 (es) | 2010-03-26 | 2012-04-18 | Lilly Co Eli | Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso |
| EP2569000B1 (en) | 2010-05-13 | 2017-09-27 | Indiana University Research and Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
| CN103179976A (zh) | 2010-05-13 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 呈现g蛋白偶联受体活性的胰高血糖素超家族肽 |
| RU2580317C2 (ru) | 2010-06-24 | 2016-04-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов |
| WO2011163473A1 (en) | 2010-06-25 | 2011-12-29 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers |
| BR112013015389A2 (pt) * | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
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2011
- 2011-12-20 BR BR112013015389A patent/BR112013015389A2/pt unknown
- 2011-12-20 MA MA36136A patent/MA34885B1/fr unknown
- 2011-12-20 MX MX2013006304A patent/MX2013006304A/es not_active Application Discontinuation
- 2011-12-20 PE PE2013001437A patent/PE20140186A1/es not_active Application Discontinuation
- 2011-12-20 EP EP11808086.0A patent/EP2654773B1/en not_active Not-in-force
- 2011-12-20 JP JP2013546329A patent/JP6086067B2/ja not_active Expired - Fee Related
- 2011-12-20 NZ NZ612297A patent/NZ612297A/en not_active IP Right Cessation
- 2011-12-20 KR KR1020137018994A patent/KR20130132931A/ko not_active Withdrawn
- 2011-12-20 EA EA201390941A patent/EA201390941A1/ru unknown
- 2011-12-20 WO PCT/US2011/066164 patent/WO2012088116A2/en not_active Ceased
- 2011-12-20 US US13/331,816 patent/US8507428B2/en not_active Expired - Fee Related
- 2011-12-20 CA CA2821766A patent/CA2821766A1/en not_active Abandoned
- 2011-12-20 ES ES11808086T patent/ES2713952T3/es active Active
- 2011-12-20 SG SG2013046412A patent/SG191194A1/en unknown
- 2011-12-20 CN CN201180068157.2A patent/CN103458920B/zh not_active Expired - Fee Related
- 2011-12-20 PH PH1/2013/501215A patent/PH12013501215A1/en unknown
- 2011-12-20 AU AU2011349331A patent/AU2011349331A1/en not_active Abandoned
- 2011-12-21 AR ARP110104846A patent/AR084459A1/es not_active Application Discontinuation
-
2012
- 2012-12-27 US US13/728,110 patent/US9249206B2/en not_active Expired - Fee Related
-
2013
- 2013-06-18 CO CO13145190A patent/CO6761302A2/es unknown
- 2013-06-18 CL CL2013001783A patent/CL2013001783A1/es unknown
- 2013-06-18 CR CR20130295A patent/CR20130295A/es not_active Application Discontinuation
- 2013-06-18 EC ECSP13012697 patent/ECSP13012697A/es unknown
-
2015
- 2015-03-23 US US14/665,508 patent/US20150259393A1/en not_active Abandoned
- 2015-12-28 US US14/981,187 patent/US9587005B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP13012697A (es) | 2013-10-31 |
| JP2014507402A (ja) | 2014-03-27 |
| ES2713952T3 (es) | 2019-05-24 |
| SG191194A1 (en) | 2013-07-31 |
| BR112013015389A2 (pt) | 2016-11-22 |
| AU2011349331A1 (en) | 2013-07-11 |
| WO2012088116A3 (en) | 2012-11-15 |
| AR084459A1 (es) | 2013-05-15 |
| CO6761302A2 (es) | 2013-09-30 |
| CL2013001783A1 (es) | 2014-01-24 |
| US9587005B2 (en) | 2017-03-07 |
| CN103458920A (zh) | 2013-12-18 |
| NZ612297A (en) | 2015-10-30 |
| US20150259393A1 (en) | 2015-09-17 |
| PE20140186A1 (es) | 2014-02-13 |
| MA34885B1 (fr) | 2014-02-01 |
| US20120238493A1 (en) | 2012-09-20 |
| US20160115215A1 (en) | 2016-04-28 |
| EA201390941A1 (ru) | 2013-12-30 |
| KR20130132931A (ko) | 2013-12-05 |
| MX2013006304A (es) | 2013-07-02 |
| US8507428B2 (en) | 2013-08-13 |
| US9249206B2 (en) | 2016-02-02 |
| PH12013501215A1 (en) | 2013-11-18 |
| EP2654773A2 (en) | 2013-10-30 |
| CR20130295A (es) | 2013-10-09 |
| US20130116173A1 (en) | 2013-05-09 |
| CN103458920B (zh) | 2016-07-06 |
| WO2012088116A2 (en) | 2012-06-28 |
| JP6086067B2 (ja) | 2017-03-01 |
| EP2654773B1 (en) | 2018-10-03 |
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