CO6761302A2 - Análogos de glucagón que presentan actividad de receptor de gip - Google Patents
Análogos de glucagón que presentan actividad de receptor de gipInfo
- Publication number
- CO6761302A2 CO6761302A2 CO13145190A CO13145190A CO6761302A2 CO 6761302 A2 CO6761302 A2 CO 6761302A2 CO 13145190 A CO13145190 A CO 13145190A CO 13145190 A CO13145190 A CO 13145190A CO 6761302 A2 CO6761302 A2 CO 6761302A2
- Authority
- CO
- Colombia
- Prior art keywords
- gip receptor
- receptor activity
- glucagon analogs
- present
- glucagon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Abstract
La presente invención proporciona análogos de glucagón que prestan actividad potente en el receptor de GIP y, como tal, son contemplados para el uso en el tratamiento de diabetes y obesidad. En realizaciones ejemplificadoras, el análogo de glucagón de la presenten invención muestran un EC50 en el receptor de GIP, que se encuentra en el rango nanomolar o picomolar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426285P | 2010-12-22 | 2010-12-22 | |
US201161514609P | 2011-08-03 | 2011-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6761302A2 true CO6761302A2 (es) | 2013-09-30 |
Family
ID=45476658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13145190A CO6761302A2 (es) | 2010-12-22 | 2013-06-18 | Análogos de glucagón que presentan actividad de receptor de gip |
Country Status (21)
Country | Link |
---|---|
US (4) | US8507428B2 (es) |
EP (1) | EP2654773B1 (es) |
JP (1) | JP6086067B2 (es) |
KR (1) | KR20130132931A (es) |
CN (1) | CN103458920B (es) |
AR (1) | AR084459A1 (es) |
AU (1) | AU2011349331A1 (es) |
BR (1) | BR112013015389A2 (es) |
CA (1) | CA2821766A1 (es) |
CL (1) | CL2013001783A1 (es) |
CO (1) | CO6761302A2 (es) |
CR (1) | CR20130295A (es) |
EA (1) | EA201390941A1 (es) |
EC (1) | ECSP13012697A (es) |
ES (1) | ES2713952T3 (es) |
MA (1) | MA34885B1 (es) |
MX (1) | MX2013006304A (es) |
NZ (1) | NZ612297A (es) |
PE (1) | PE20140186A1 (es) |
SG (1) | SG191194A1 (es) |
WO (1) | WO2012088116A2 (es) |
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MX2011013625A (es) | 2009-06-16 | 2012-01-20 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip. |
BR112012018585A2 (pt) * | 2010-01-27 | 2017-01-10 | Univ Indiana Res & Tech Corp | conjungados e composições de glucagon antagonista-gip agonista para o tratamento de distúrbios metabólicos e de obesidade |
AU2011348202A1 (en) * | 2010-12-22 | 2013-07-04 | Marcadia Biotech, Inc. | Methods for treating metabolic disorders and obesity with GIP and GLP-1 receptor-active glucagon-based peptides |
JP6086067B2 (ja) * | 2010-12-22 | 2017-03-01 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | Gipレセプター活性を示すグルカゴンアナローグ |
PT2723367T (pt) | 2011-06-22 | 2017-08-11 | Univ Indiana Res & Tech Corp | Co-agonistas do recetor da glucagina/glp-1 |
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CN104583232B (zh) * | 2012-06-21 | 2018-04-13 | 印第安纳大学研究及科技有限公司 | 展现gip受体活性的胰高血糖素类似物 |
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EP3434696A1 (en) | 2012-11-20 | 2019-01-30 | Mederis Diabetes, LLC | Improved peptide pharmaceuticals for insulin resistance |
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WO2014152460A2 (en) * | 2013-03-15 | 2014-09-25 | Indiana University Research And Technology Corporation | Prodrugs with prolonged action |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
WO2014161835A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof |
MY174727A (en) | 2013-04-18 | 2020-05-11 | Novo Nordisk As | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
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-
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- 2011-12-20 JP JP2013546329A patent/JP6086067B2/ja not_active Expired - Fee Related
- 2011-12-20 MA MA36136A patent/MA34885B1/fr unknown
- 2011-12-20 SG SG2013046412A patent/SG191194A1/en unknown
- 2011-12-20 WO PCT/US2011/066164 patent/WO2012088116A2/en active Application Filing
- 2011-12-20 MX MX2013006304A patent/MX2013006304A/es not_active Application Discontinuation
- 2011-12-20 AU AU2011349331A patent/AU2011349331A1/en not_active Abandoned
- 2011-12-20 BR BR112013015389A patent/BR112013015389A2/pt unknown
- 2011-12-20 CN CN201180068157.2A patent/CN103458920B/zh not_active Expired - Fee Related
- 2011-12-20 CA CA2821766A patent/CA2821766A1/en not_active Abandoned
- 2011-12-20 EA EA201390941A patent/EA201390941A1/ru unknown
- 2011-12-20 US US13/331,816 patent/US8507428B2/en not_active Expired - Fee Related
- 2011-12-20 KR KR1020137018994A patent/KR20130132931A/ko not_active Application Discontinuation
- 2011-12-20 NZ NZ612297A patent/NZ612297A/en not_active IP Right Cessation
- 2011-12-20 PE PE2013001437A patent/PE20140186A1/es not_active Application Discontinuation
- 2011-12-20 ES ES11808086T patent/ES2713952T3/es active Active
- 2011-12-20 EP EP11808086.0A patent/EP2654773B1/en not_active Not-in-force
- 2011-12-21 AR ARP110104846A patent/AR084459A1/es not_active Application Discontinuation
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- 2012-12-27 US US13/728,110 patent/US9249206B2/en not_active Expired - Fee Related
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- 2013-06-18 CL CL2013001783A patent/CL2013001783A1/es unknown
- 2013-06-18 CR CR20130295A patent/CR20130295A/es not_active Application Discontinuation
- 2013-06-18 CO CO13145190A patent/CO6761302A2/es unknown
- 2013-06-18 EC ECSP13012697 patent/ECSP13012697A/es unknown
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- 2015-03-23 US US14/665,508 patent/US20150259393A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
WO2012088116A2 (en) | 2012-06-28 |
PE20140186A1 (es) | 2014-02-13 |
US20120238493A1 (en) | 2012-09-20 |
SG191194A1 (en) | 2013-07-31 |
EA201390941A1 (ru) | 2013-12-30 |
MA34885B1 (fr) | 2014-02-01 |
MX2013006304A (es) | 2013-07-02 |
NZ612297A (en) | 2015-10-30 |
CN103458920A (zh) | 2013-12-18 |
EP2654773B1 (en) | 2018-10-03 |
CR20130295A (es) | 2013-10-09 |
US20130116173A1 (en) | 2013-05-09 |
US20160115215A1 (en) | 2016-04-28 |
CL2013001783A1 (es) | 2014-01-24 |
US8507428B2 (en) | 2013-08-13 |
KR20130132931A (ko) | 2013-12-05 |
ECSP13012697A (es) | 2013-10-31 |
US9249206B2 (en) | 2016-02-02 |
CN103458920B (zh) | 2016-07-06 |
US9587005B2 (en) | 2017-03-07 |
US20150259393A1 (en) | 2015-09-17 |
AU2011349331A1 (en) | 2013-07-11 |
WO2012088116A3 (en) | 2012-11-15 |
AR084459A1 (es) | 2013-05-15 |
JP2014507402A (ja) | 2014-03-27 |
EP2654773A2 (en) | 2013-10-30 |
JP6086067B2 (ja) | 2017-03-01 |
ES2713952T3 (es) | 2019-05-24 |
CA2821766A1 (en) | 2012-06-28 |
BR112013015389A2 (pt) | 2016-11-22 |
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