ECSP088930A - Derivados de benzoxazol y benzotiazol como ligandos de - Google Patents

Derivados de benzoxazol y benzotiazol como ligandos de

Info

Publication number
ECSP088930A
ECSP088930A EC2008008930A ECSP088930A ECSP088930A EC SP088930 A ECSP088930 A EC SP088930A EC 2008008930 A EC2008008930 A EC 2008008930A EC SP088930 A ECSP088930 A EC SP088930A EC SP088930 A ECSP088930 A EC SP088930A
Authority
EC
Ecuador
Prior art keywords
ligandos
benzotiazol
benzoxazol
derivatives
receptor
Prior art date
Application number
EC2008008930A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Albert Jean Robichaud
Kevin Liu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088930A publication Critical patent/ECSP088930A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La presente invención suministra un compuesto de fórmula I y el uso de éste para el tratamiento de un trastorno del sistema nervioso central relacionado con o afectado por el receptor 5-HT6.
EC2008008930A 2006-06-01 2008-12-01 Derivados de benzoxazol y benzotiazol como ligandos de ECSP088930A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80999606P 2006-06-01 2006-06-01

Publications (1)

Publication Number Publication Date
ECSP088930A true ECSP088930A (es) 2009-01-30

Family

ID=38668755

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008930A ECSP088930A (es) 2006-06-01 2008-12-01 Derivados de benzoxazol y benzotiazol como ligandos de

Country Status (17)

Country Link
US (1) US7501421B2 (es)
EP (1) EP2024348A2 (es)
JP (1) JP2009538909A (es)
KR (1) KR20090023641A (es)
CN (1) CN101490022A (es)
AR (1) AR061147A1 (es)
AU (1) AU2007255041A1 (es)
BR (1) BRPI0712444A2 (es)
CA (1) CA2659701A1 (es)
CR (1) CR10474A (es)
EC (1) ECSP088930A (es)
IL (1) IL195590A0 (es)
MX (1) MX2008015328A (es)
NO (1) NO20085045L (es)
PE (1) PE20080707A1 (es)
TW (1) TW200804310A (es)
WO (1) WO2007142904A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201401169QA (en) * 2009-04-02 2014-05-29 Merck Serono Sa Dihydroorotate dehydrogenase inhibitors
KR101250606B1 (ko) * 2011-01-24 2013-04-03 이화여자대학교 산학협력단 5-ｈｔ６ 수용체 억제 작용을 갖는 신규한 벤조티아졸 및 벤즈이소티아졸유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물
EP3020718B1 (en) * 2013-07-10 2018-12-26 Meiji Seika Pharma Co., Ltd. Novel pde4 inhibitor
JP6515175B2 (ja) 2014-07-08 2019-05-15 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族ヘテロ環誘導体及びその医薬的適用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
WO2007142904A2 (en) 2007-12-13
IL195590A0 (en) 2009-09-01
WO2007142904A3 (en) 2008-02-07
AU2007255041A1 (en) 2007-12-13
US7501421B2 (en) 2009-03-10
CR10474A (es) 2009-01-07
JP2009538909A (ja) 2009-11-12
MX2008015328A (es) 2008-12-12
KR20090023641A (ko) 2009-03-05
PE20080707A1 (es) 2008-05-22
NO20085045L (no) 2008-12-12
AR061147A1 (es) 2008-08-06
CN101490022A (zh) 2009-07-22
EP2024348A2 (en) 2009-02-18
TW200804310A (en) 2008-01-16
BRPI0712444A2 (pt) 2012-06-05
CA2659701A1 (en) 2007-12-13
US20070281945A1 (en) 2007-12-06

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