CO6300951A2 - Derivados de azaciclilisoquinolinona e- isoindolinona como antagonistas de la histamina-3 - Google Patents
Derivados de azaciclilisoquinolinona e- isoindolinona como antagonistas de la histamina-3Info
- Publication number
- CO6300951A2 CO6300951A2 CO10030401A CO10030401A CO6300951A2 CO 6300951 A2 CO6300951 A2 CO 6300951A2 CO 10030401 A CO10030401 A CO 10030401A CO 10030401 A CO10030401 A CO 10030401A CO 6300951 A2 CO6300951 A2 CO 6300951A2
- Authority
- CO
- Colombia
- Prior art keywords
- histamine
- isoindolinona
- azaciclilisoquinolinona
- antagonists
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona un compuesto de fórmula I y su uso para el tratamiento de un trastorno del sistema nervioso central relacionado con, o que se ve afectado por, el receptor de la histamina-3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99355407P | 2007-09-12 | 2007-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6300951A2 true CO6300951A2 (es) | 2011-07-21 |
Family
ID=40261508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10030401A CO6300951A2 (es) | 2007-09-12 | 2010-03-15 | Derivados de azaciclilisoquinolinona e- isoindolinona como antagonistas de la histamina-3 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090069370A1 (es) |
EP (1) | EP2200998A1 (es) |
JP (1) | JP2010539178A (es) |
KR (1) | KR20100054852A (es) |
CN (1) | CN101842366A (es) |
AP (1) | AP2010005199A0 (es) |
AU (1) | AU2008298983A1 (es) |
BR (1) | BRPI0816806A2 (es) |
CA (1) | CA2699383A1 (es) |
CL (1) | CL2008002708A1 (es) |
CO (1) | CO6300951A2 (es) |
CR (1) | CR11309A (es) |
DO (1) | DOP2010000078A (es) |
EA (1) | EA201000319A1 (es) |
EC (1) | ECSP10010032A (es) |
MA (1) | MA31700B1 (es) |
MX (1) | MX2010002899A (es) |
NI (1) | NI201000035A (es) |
PA (1) | PA8795601A1 (es) |
PE (1) | PE20090679A1 (es) |
TN (1) | TN2010000107A1 (es) |
TW (1) | TW200918062A (es) |
WO (1) | WO2009036117A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
JP2011213700A (ja) * | 2010-04-02 | 2011-10-27 | Nishizaki Soyaku Kenkyusho:Kk | 認知症改善用組成物 |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたn−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
AR081498A1 (es) | 2010-05-11 | 2012-09-19 | Sanofi Aventis | Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos |
WO2011143162A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
TW201206910A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
EP2535062A1 (en) | 2011-06-13 | 2012-12-19 | Dentsply IH AB | Collagen coated article |
EP2717933B1 (en) | 2011-06-13 | 2019-05-01 | Dentsply IH AB | Collagen coated article |
BR112014013136B1 (pt) * | 2011-11-30 | 2020-05-26 | F. Hoffmann-La Roche Ag | Novos derivados de dihidroisoquinolina-1-ona biciclicos |
JO3442B1 (ar) * | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
RS58321B1 (sr) | 2013-10-29 | 2019-03-29 | Takeda Pharmaceuticals Co | Heterociklično jedinjenje |
CN112209876B (zh) * | 2020-10-15 | 2022-08-26 | 华侨大学 | 一种3-三氟甲基异喹啉酮衍生物的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
AU4319797A (en) * | 1996-09-25 | 1998-04-17 | Yamanouchi Pharmaceutical Co., Ltd. | 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof |
ES2210747T3 (es) * | 1997-05-01 | 2004-07-01 | Eli Lilly And Company | Agentes antitromboticos. |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
MY139355A (en) * | 2004-05-14 | 2009-09-30 | Millennium Pharm Inc | Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase |
US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
WO2006078775A1 (en) * | 2005-01-21 | 2006-07-27 | Schering Corporation | Imidazole and benzimidazole derivatives useful as histamine h3 antagonists |
US20070032475A1 (en) * | 2005-04-15 | 2007-02-08 | Ye Xiaocong M | Novel compounds useful for bradykinin B1 receptor antagonism |
US8143284B2 (en) * | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
-
2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Application Discontinuation
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 CA CA2699383A patent/CA2699383A1/en not_active Abandoned
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 EP EP08830104A patent/EP2200998A1/en not_active Withdrawn
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/en active Application Filing
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
-
2010
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TN2010000107A1 (fr) | 2011-09-26 |
KR20100054852A (ko) | 2010-05-25 |
BRPI0816806A2 (pt) | 2015-03-10 |
MA31700B1 (fr) | 2010-09-01 |
EP2200998A1 (en) | 2010-06-30 |
CN101842366A (zh) | 2010-09-22 |
TW200918062A (en) | 2009-05-01 |
NI201000035A (es) | 2010-07-15 |
AP2010005199A0 (en) | 2010-04-30 |
EA201000319A1 (ru) | 2010-10-29 |
AU2008298983A1 (en) | 2009-03-19 |
WO2009036117A1 (en) | 2009-03-19 |
CA2699383A1 (en) | 2009-03-19 |
ECSP10010032A (es) | 2010-08-31 |
MX2010002899A (es) | 2010-04-09 |
CR11309A (es) | 2010-04-07 |
JP2010539178A (ja) | 2010-12-16 |
CL2008002708A1 (es) | 2008-10-10 |
PA8795601A1 (es) | 2009-05-15 |
DOP2010000078A (es) | 2010-04-15 |
US20090069370A1 (en) | 2009-03-12 |
PE20090679A1 (es) | 2009-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |