TN2010000107A1 - Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 - Google Patents
Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3Info
- Publication number
- TN2010000107A1 TN2010000107A1 TNP2010000107A TN2010000107A TN2010000107A1 TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1 TN P2010000107 A TNP2010000107 A TN P2010000107A TN 2010000107 A TN2010000107 A TN 2010000107A TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1
- Authority
- TN
- Tunisia
- Prior art keywords
- azacyclylisoquinolinone
- receptor antagonists
- histamine receptor
- isoindolinone derivatives
- isoindolinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne un composé représenté par la formule (I) et son utilisation pour le traitement d'un trouble du système nerveux central en rapport avec ou influencé par le récepteur de l'histamine-3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99355407P | 2007-09-12 | 2007-09-12 | |
PCT/US2008/075942 WO2009036117A1 (fr) | 2007-09-12 | 2008-09-11 | Dérivés d'azacyclylisoquinolinone et d'isoindolinone convenant comme antagonistes de l'histamine-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000107A1 true TN2010000107A1 (fr) | 2011-09-26 |
Family
ID=40261508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2010000107A TN2010000107A1 (fr) | 2007-09-12 | 2010-03-11 | Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090069370A1 (fr) |
EP (1) | EP2200998A1 (fr) |
JP (1) | JP2010539178A (fr) |
KR (1) | KR20100054852A (fr) |
CN (1) | CN101842366A (fr) |
AP (1) | AP2010005199A0 (fr) |
AU (1) | AU2008298983A1 (fr) |
BR (1) | BRPI0816806A2 (fr) |
CA (1) | CA2699383A1 (fr) |
CL (1) | CL2008002708A1 (fr) |
CO (1) | CO6300951A2 (fr) |
CR (1) | CR11309A (fr) |
DO (1) | DOP2010000078A (fr) |
EA (1) | EA201000319A1 (fr) |
EC (1) | ECSP10010032A (fr) |
MA (1) | MA31700B1 (fr) |
MX (1) | MX2010002899A (fr) |
NI (1) | NI201000035A (fr) |
PA (1) | PA8795601A1 (fr) |
PE (1) | PE20090679A1 (fr) |
TN (1) | TN2010000107A1 (fr) |
TW (1) | TW200918062A (fr) |
WO (1) | WO2009036117A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
JP2011213700A (ja) * | 2010-04-02 | 2011-10-27 | Nishizaki Soyaku Kenkyusho:Kk | 認知症改善用組成物 |
AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
EP2569303A1 (fr) | 2010-05-11 | 2013-03-20 | Sanofi | Dérivés n-alkyl et n-acyl tétrahydro-isoquinoline substitués, procédé de préparation et application thérapeutiques associés |
EP2569297A1 (fr) | 2010-05-11 | 2013-03-20 | Sanofi | Dérivés de n-hétérocycloalkyl-bipyrrolidinylphénylamide substitués, préparation et utilisation thérapeutique de ceux-ci |
AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
EP2717933B1 (fr) | 2011-06-13 | 2019-05-01 | Dentsply IH AB | Article revêtu de collagène |
EP2535062A1 (fr) | 2011-06-13 | 2012-12-19 | Dentsply IH AB | Article revêtu de collagène |
AR088989A1 (es) * | 2011-11-30 | 2014-07-23 | Hoffmann La Roche | Derivados biciclicos de dihidroisoquinolin-1-ona |
JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
PT3063139T (pt) | 2013-10-29 | 2019-02-22 | Takeda Pharmaceuticals Co | Composto heterocíclico |
CN112209876B (zh) * | 2020-10-15 | 2022-08-26 | 华侨大学 | 一种3-三氟甲基异喹啉酮衍生物的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
AU4319797A (en) * | 1996-09-25 | 1998-04-17 | Yamanouchi Pharmaceutical Co., Ltd. | 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof |
WO1998048800A1 (fr) * | 1997-05-01 | 1998-11-05 | Eli Lilly And Company | Agents antithrombotiques |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
KR101748290B1 (ko) * | 2004-05-14 | 2017-06-16 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 방법 |
US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
US7482468B2 (en) * | 2005-01-21 | 2009-01-27 | Schering Corporation | Imidazole and benzimidazole derivatives useful as histamine H3 antagonists |
EP1877401A2 (fr) * | 2005-04-15 | 2008-01-16 | Elan Pharmaceuticals Inc. | Nouveaux composes s'utilisant dans l'antagonisme du recepteur de bradykinine b1 |
US8143284B2 (en) * | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
-
2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/fr active Application Filing
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 CA CA2699383A patent/CA2699383A1/fr not_active Abandoned
- 2008-09-11 EP EP08830104A patent/EP2200998A1/fr not_active Withdrawn
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Application Discontinuation
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
-
2010
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA31700B1 (fr) | 2010-09-01 |
CN101842366A (zh) | 2010-09-22 |
CR11309A (es) | 2010-04-07 |
AP2010005199A0 (en) | 2010-04-30 |
ECSP10010032A (es) | 2010-08-31 |
JP2010539178A (ja) | 2010-12-16 |
CO6300951A2 (es) | 2011-07-21 |
WO2009036117A1 (fr) | 2009-03-19 |
PA8795601A1 (es) | 2009-05-15 |
AU2008298983A1 (en) | 2009-03-19 |
CA2699383A1 (fr) | 2009-03-19 |
MX2010002899A (es) | 2010-04-09 |
EP2200998A1 (fr) | 2010-06-30 |
DOP2010000078A (es) | 2010-04-15 |
CL2008002708A1 (es) | 2008-10-10 |
PE20090679A1 (es) | 2009-05-28 |
BRPI0816806A2 (pt) | 2015-03-10 |
TW200918062A (en) | 2009-05-01 |
KR20100054852A (ko) | 2010-05-25 |
EA201000319A1 (ru) | 2010-10-29 |
US20090069370A1 (en) | 2009-03-12 |
NI201000035A (es) | 2010-07-15 |
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