TN2010000107A1 - Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 - Google Patents

Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3

Info

Publication number
TN2010000107A1
TN2010000107A1 TNP2010000107A TN2010000107A TN2010000107A1 TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1 TN P2010000107 A TNP2010000107 A TN P2010000107A TN 2010000107 A TN2010000107 A TN 2010000107A TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1
Authority
TN
Tunisia
Prior art keywords
azacyclylisoquinolinone
receptor antagonists
histamine receptor
isoindolinone derivatives
isoindolinone
Prior art date
Application number
TNP2010000107A
Other languages
English (en)
Inventor
Dahui Zhou
Jonathan Laird Gross
Albert Jean Robichaud
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of TN2010000107A1 publication Critical patent/TN2010000107A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un composé représenté par la formule (I) et son utilisation pour le traitement d'un trouble du système nerveux central en rapport avec ou influencé par le récepteur de l'histamine-3.
TNP2010000107A 2007-09-12 2010-03-11 Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 TN2010000107A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99355407P 2007-09-12 2007-09-12
PCT/US2008/075942 WO2009036117A1 (fr) 2007-09-12 2008-09-11 Dérivés d'azacyclylisoquinolinone et d'isoindolinone convenant comme antagonistes de l'histamine-3

Publications (1)

Publication Number Publication Date
TN2010000107A1 true TN2010000107A1 (fr) 2011-09-26

Family

ID=40261508

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000107A TN2010000107A1 (fr) 2007-09-12 2010-03-11 Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3

Country Status (23)

Country Link
US (1) US20090069370A1 (fr)
EP (1) EP2200998A1 (fr)
JP (1) JP2010539178A (fr)
KR (1) KR20100054852A (fr)
CN (1) CN101842366A (fr)
AP (1) AP2010005199A0 (fr)
AU (1) AU2008298983A1 (fr)
BR (1) BRPI0816806A2 (fr)
CA (1) CA2699383A1 (fr)
CL (1) CL2008002708A1 (fr)
CO (1) CO6300951A2 (fr)
CR (1) CR11309A (fr)
DO (1) DOP2010000078A (fr)
EA (1) EA201000319A1 (fr)
EC (1) ECSP10010032A (fr)
MA (1) MA31700B1 (fr)
MX (1) MX2010002899A (fr)
NI (1) NI201000035A (fr)
PA (1) PA8795601A1 (fr)
PE (1) PE20090679A1 (fr)
TN (1) TN2010000107A1 (fr)
TW (1) TW200918062A (fr)
WO (1) WO2009036117A1 (fr)

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Publication number Priority date Publication date Assignee Title
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
JP2011213700A (ja) * 2010-04-02 2011-10-27 Nishizaki Soyaku Kenkyusho:Kk 認知症改善用組成物
EP2569297A1 (fr) 2010-05-11 2013-03-20 Sanofi Dérivés de n-hétérocycloalkyl-bipyrrolidinylphénylamide substitués, préparation et utilisation thérapeutique de ceux-ci
JP5968307B2 (ja) 2010-05-11 2016-08-10 サノフイ 置換フェニルシクロアルキルピロリジン（ピペリジン）スピロラクタム類及びアミド類、それらの製造及び治療的使用
WO2011143145A1 (fr) * 2010-05-11 2011-11-17 Sanofi Dérivés n-alkyl et n-acyl tétrahydro-isoquinoline substitués, procédé de préparation et application thérapeutiques associés
EP2569304A1 (fr) 2010-05-11 2013-03-20 Sanofi Bipyrrolidines n-hétéroaryl spirolactame substituées, procédé de préparation et usage thérapeutique associés
JP5784110B2 (ja) 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
EP2569294B1 (fr) 2010-05-11 2015-03-11 Sanofi Bipyrrolidine carboxamides n-heteroaromatiques, leur preparation et usage therapeutique
EP2535062A1 (fr) 2011-06-13 2012-12-19 Dentsply IH AB Article revêtu de collagène
WO2012173555A1 (fr) 2011-06-13 2012-12-20 Dentsply Ih Ab Article revêtu de collagène
CA2850700C (fr) * 2011-11-30 2019-11-12 F. Hoffmann-La Roche Ag Nouveaux derives bicycliques de la dihydroisoquinoline-1-one
JO3442B1 (ar) * 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
LT3063139T (lt) 2013-10-29 2019-02-25 Takeda Pharmaceutical Company Limited Heterociklinis junginys
CN112209876B (zh) * 2020-10-15 2022-08-26 华侨大学 一种3-三氟甲基异喹啉酮衍生物的制备方法

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US4166853A (en) * 1978-05-05 1979-09-04 The Upjohn Company Antihypertensive 7-trifluoromethyl-4-aminoquinolones
US4159331A (en) * 1978-05-05 1979-06-26 The Upjohn Company Antihypertensive 4-aminoquinolines
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US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
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ES2540987T3 (es) * 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
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Also Published As

Publication number Publication date
BRPI0816806A2 (pt) 2015-03-10
AU2008298983A1 (en) 2009-03-19
AP2010005199A0 (en) 2010-04-30
CN101842366A (zh) 2010-09-22
KR20100054852A (ko) 2010-05-25
MA31700B1 (fr) 2010-09-01
PA8795601A1 (es) 2009-05-15
US20090069370A1 (en) 2009-03-12
CA2699383A1 (fr) 2009-03-19
EP2200998A1 (fr) 2010-06-30
TW200918062A (en) 2009-05-01
PE20090679A1 (es) 2009-05-28
JP2010539178A (ja) 2010-12-16
WO2009036117A1 (fr) 2009-03-19
ECSP10010032A (es) 2010-08-31
CR11309A (es) 2010-04-07
EA201000319A1 (ru) 2010-10-29
DOP2010000078A (es) 2010-04-15
MX2010002899A (es) 2010-04-09
CO6300951A2 (es) 2011-07-21
NI201000035A (es) 2010-07-15
CL2008002708A1 (es) 2008-10-10

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