TR201910675T4 - Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. - Google Patents
Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. Download PDFInfo
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- TR201910675T4 TR201910675T4 TR2019/10675T TR201910675T TR201910675T4 TR 201910675 T4 TR201910675 T4 TR 201910675T4 TR 2019/10675 T TR2019/10675 T TR 2019/10675T TR 201910675 T TR201910675 T TR 201910675T TR 201910675 T4 TR201910675 T4 TR 201910675T4
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- Prior art keywords
- piperazinyl
- carbonyl
- phenyl
- methyl
- treating cancer
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- 239000012661 PARP inhibitor Substances 0.000 title abstract 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 title abstract 2
- IYTKPANZKKVRJO-UHFFFAOYSA-N N1(CCNCC1)C(=O)C=1C=C(C=CC=1)CN1C(NC(C2=CC=CC=C12)=O)=O Chemical class N1(CCNCC1)C(=O)C=1C=C(C=CC=1)CN1C(NC(C2=CC=CC=C12)=O)=O IYTKPANZKKVRJO-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 abstract 1
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000008516 quinazoline-2,4(1H,3H)-diones Chemical class 0.000 abstract 1
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Abstract
Ar, R1-R6'nın burada açıklandığı, Formül (I) ile temsil edilen 1-(arilmetil)kinazolin-2,4(1H,3H)-dionlar açıklanır. Formüle (I) sahip bileşikler, PARP inhibitörleridir. Dolayısıyla buluş bileşikleri, PARP aktivitesinin inhibisyonuna yanıt veren klinik durumları tedavi etmek üzere kullanılabilir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100824756A CN102731416A (zh) | 2011-04-01 | 2011-04-01 | 1-(芳基甲基)-喹唑啉-2,4-二酮作为parp抑制剂及其应用 |
CN2011077034 | 2011-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910675T4 true TR201910675T4 (tr) | 2019-08-21 |
Family
ID=46929484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10675T TR201910675T4 (tr) | 2011-04-01 | 2012-03-31 | Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. |
Country Status (19)
Country | Link |
---|---|
US (4) | US9290460B2 (tr) |
EP (1) | EP2709990B1 (tr) |
JP (1) | JP6270713B2 (tr) |
CN (2) | CN104230827B (tr) |
AU (1) | AU2012237776B2 (tr) |
CA (1) | CA2831015C (tr) |
CY (1) | CY1121847T1 (tr) |
DK (1) | DK2709990T3 (tr) |
ES (1) | ES2736299T3 (tr) |
HR (1) | HRP20191273T1 (tr) |
HU (1) | HUE046121T2 (tr) |
PL (1) | PL2709990T3 (tr) |
PT (1) | PT2709990T (tr) |
RS (1) | RS59091B1 (tr) |
SG (1) | SG193599A1 (tr) |
SI (1) | SI2709990T1 (tr) |
TR (1) | TR201910675T4 (tr) |
TW (1) | TWI527800B (tr) |
WO (1) | WO2012130166A1 (tr) |
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CA2829123C (en) | 2011-03-14 | 2016-04-12 | Eternity Bioscience Inc. | Quinazolinediones and their use |
TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚(二磷酸腺苷酸-核醣)聚合酶(parp)之抑制劑之1-(芳基甲基)喹唑啉-2,4(1h,3h)-二酮及其應用 |
WO2013064083A1 (en) | 2011-11-01 | 2013-05-10 | Impact Therapeutics, Inc. | 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof |
JP6177768B2 (ja) | 2012-04-24 | 2017-08-09 | 中外製薬株式会社 | ベンズアミド誘導体 |
BR112014026305A2 (pt) | 2012-04-24 | 2017-06-27 | Chugai Pharmaceutical Co Ltd | derivado de quinazolidinadiona |
PT2968316T (pt) | 2013-03-13 | 2019-10-29 | Forma Therapeutics Inc | Derivados de 2-hidroxi-1-{4-[(4-fenilfenil)carbonil]piperazin-1-il}etano-1-ona e compostos relacionados como inibidores da sintase de ácidos gordos (fasn) para o tratamento do cancro |
CA2927830A1 (en) | 2013-10-23 | 2015-04-30 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
US10940150B2 (en) | 2014-07-28 | 2021-03-09 | Technische Universitaet Dresden | Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27 |
DK3278803T3 (da) * | 2015-04-03 | 2022-08-29 | Impact Therapeutics Shanghai Inc | Fast farmaceutisk doseringsform af PARP-inhibitor, og anvendelse af fast farmaceutisk doseringsform af PARP-inhibitor |
CN106083741A (zh) * | 2016-02-22 | 2016-11-09 | 南京中医药大学 | 2‑硫代喹唑啉二酮衍生物 |
CN107098886B (zh) * | 2016-02-26 | 2020-07-14 | 中国医学科学院药物研究所 | 含有哌嗪酮的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途 |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
HUE053554T2 (hu) * | 2016-04-01 | 2021-07-28 | Impact Therapeutics Inc | Eljárás 1-(arilmetil)-kinazolin-2,4-(1H, 3H)-dion elõállítására |
CN108727343A (zh) * | 2017-04-21 | 2018-11-02 | 中国医学科学院药物研究所 | 含有3-氨基四氢吡咯的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途 |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
CN111269216A (zh) * | 2018-12-05 | 2020-06-12 | 中国医学科学院药物研究所 | 含有哌嗪酮的喹唑啉二酮盐类化合物、其制备方法、药物组合物和用途 |
CN114206864B (zh) * | 2019-05-14 | 2024-05-24 | 苏州四体康宸医药科技有限公司 | 喹唑啉-2.4-二酮衍生物作为parp抑制剂 |
CN116322680A (zh) * | 2020-07-24 | 2023-06-23 | 上海瑛派药业有限公司 | Parp抑制剂的联合用药方案 |
WO2022099442A1 (zh) * | 2020-11-10 | 2022-05-19 | 上海瑛派药业有限公司 | 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备 |
CN117062608A (zh) * | 2021-03-26 | 2023-11-14 | 上海瑛派药业有限公司 | Parp抑制剂的口服胶囊及其制备方法 |
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- 2012-03-31 DK DK12765230.3T patent/DK2709990T3/da active
- 2012-03-31 HU HUE12765230A patent/HUE046121T2/hu unknown
- 2012-03-31 WO PCT/CN2012/073362 patent/WO2012130166A1/en active Application Filing
- 2012-03-31 AU AU2012237776A patent/AU2012237776B2/en active Active
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