HUE053554T2 - Eljárás 1-(arilmetil)-kinazolin-2,4-(1H, 3H)-dion elõállítására - Google Patents
Eljárás 1-(arilmetil)-kinazolin-2,4-(1H, 3H)-dion elõállításáraInfo
- Publication number
- HUE053554T2 HUE053554T2 HUE17773281A HUE17773281A HUE053554T2 HU E053554 T2 HUE053554 T2 HU E053554T2 HU E17773281 A HUE17773281 A HU E17773281A HU E17773281 A HUE17773281 A HU E17773281A HU E053554 T2 HUE053554 T2 HU E053554T2
- Authority
- HU
- Hungary
- Prior art keywords
- arylmethyl
- quinazoline
- dione
- manufacturing process
- manufacturing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610202881 | 2016-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE053554T2 true HUE053554T2 (hu) | 2021-07-28 |
Family
ID=59963547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17773281A HUE053554T2 (hu) | 2016-04-01 | 2017-03-31 | Eljárás 1-(arilmetil)-kinazolin-2,4-(1H, 3H)-dion elõállítására |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10562889B2 (hu) |
| EP (1) | EP3438096B1 (hu) |
| CN (1) | CN109153652B (hu) |
| CY (1) | CY1123898T1 (hu) |
| DK (1) | DK3438096T3 (hu) |
| ES (1) | ES2859460T3 (hu) |
| HR (1) | HRP20210328T1 (hu) |
| HU (1) | HUE053554T2 (hu) |
| PL (1) | PL3438096T3 (hu) |
| PT (1) | PT3438096T (hu) |
| RS (1) | RS61556B1 (hu) |
| SI (1) | SI3438096T1 (hu) |
| WO (1) | WO2017167251A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116322680A (zh) * | 2020-07-24 | 2023-06-23 | 上海瑛派药业有限公司 | Parp抑制剂的联合用药方案 |
| WO2022099442A1 (zh) * | 2020-11-10 | 2022-05-19 | 上海瑛派药业有限公司 | 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006522109A (ja) * | 2003-03-31 | 2006-09-28 | 大正製薬株式会社 | 新規なキナゾリン誘導体及びそれらの使用に関連する治療方法 |
| MXPA06014541A (es) * | 2004-06-30 | 2007-03-23 | Janssen Pharmaceutica Nv | Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa. |
| AU2005282761B2 (en) * | 2004-09-02 | 2012-02-02 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| CN101475537A (zh) * | 2009-01-07 | 2009-07-08 | 太仓市浦源化工有限公司 | 一种2,4-二氯喹唑啉的制备方法 |
| CN103443085B (zh) * | 2011-03-14 | 2016-03-23 | 南京英派药业有限公司 | 喹唑啉二酮及其应用 |
| TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用 |
| US9102631B2 (en) * | 2011-11-01 | 2015-08-11 | Impact Therapeutics, Inc. | 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof |
| DK3278803T3 (da) * | 2015-04-03 | 2022-08-29 | Impact Therapeutics Shanghai Inc | Fast farmaceutisk doseringsform af PARP-inhibitor, og anvendelse af fast farmaceutisk doseringsform af PARP-inhibitor |
| US20190006601A1 (en) * | 2015-12-21 | 2019-01-03 | Idemitsu Kosan Co., Ltd. | Nitrogen-containing heterocyclic compounds and organic electroluminescence devices containing them |
-
2017
- 2017-03-31 DK DK17773281.5T patent/DK3438096T3/da active
- 2017-03-31 ES ES17773281T patent/ES2859460T3/es active Active
- 2017-03-31 SI SI201730646T patent/SI3438096T1/sl unknown
- 2017-03-31 PL PL17773281T patent/PL3438096T3/pl unknown
- 2017-03-31 RS RS20210217A patent/RS61556B1/sr unknown
- 2017-03-31 CN CN201780021765.5A patent/CN109153652B/zh active Active
- 2017-03-31 PT PT177732815T patent/PT3438096T/pt unknown
- 2017-03-31 WO PCT/CN2017/078913 patent/WO2017167251A1/zh active Application Filing
- 2017-03-31 EP EP17773281.5A patent/EP3438096B1/en active Active
- 2017-03-31 US US16/089,486 patent/US10562889B2/en active Active
- 2017-03-31 HU HUE17773281A patent/HUE053554T2/hu unknown
-
2021
- 2021-02-19 CY CY20211100143T patent/CY1123898T1/el unknown
- 2021-02-25 HR HRP20210328TT patent/HRP20210328T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS61556B1 (sr) | 2021-04-29 |
| WO2017167251A1 (zh) | 2017-10-05 |
| CN109153652B (zh) | 2021-07-27 |
| PL3438096T3 (pl) | 2021-05-17 |
| EP3438096A1 (en) | 2019-02-06 |
| CY1123898T1 (el) | 2022-05-27 |
| US20190112298A1 (en) | 2019-04-18 |
| US10562889B2 (en) | 2020-02-18 |
| ES2859460T3 (es) | 2021-10-04 |
| EP3438096A4 (en) | 2019-08-21 |
| CN109153652A (zh) | 2019-01-04 |
| DK3438096T3 (da) | 2021-02-22 |
| HRP20210328T1 (hr) | 2021-04-02 |
| EP3438096B1 (en) | 2020-12-02 |
| SI3438096T1 (sl) | 2021-04-30 |
| PT3438096T (pt) | 2021-03-03 |
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