SI3438096T1 - Proizvodni postopek 1-(arilmetil)kinazolin-2,4(1H,3H)-diona - Google Patents

Proizvodni postopek 1-(arilmetil)kinazolin-2,4(1H,3H)-diona

Info

Publication number
SI3438096T1
SI3438096T1 SI201730646T SI201730646T SI3438096T1 SI 3438096 T1 SI3438096 T1 SI 3438096T1 SI 201730646 T SI201730646 T SI 201730646T SI 201730646 T SI201730646 T SI 201730646T SI 3438096 T1 SI3438096 T1 SI 3438096T1
Authority
SI
Slovenia
Prior art keywords
arylmethyl
quinazoline
dione
manufacturing process
manufacturing
Prior art date
Application number
SI201730646T
Other languages
English (en)
Inventor
Suixiong Cai
Ping Huang
Original Assignee
Impact Therapeutics, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Impact Therapeutics, Inc filed Critical Impact Therapeutics, Inc
Publication of SI3438096T1 publication Critical patent/SI3438096T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201730646T 2016-04-01 2017-03-31 Proizvodni postopek 1-(arilmetil)kinazolin-2,4(1H,3H)-diona SI3438096T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610202881 2016-04-01
PCT/CN2017/078913 WO2017167251A1 (zh) 2016-04-01 2017-03-31 1-(芳基甲基)喹唑啉-2,4(1h,3h)-二酮的制备工艺
EP17773281.5A EP3438096B1 (en) 2016-04-01 2017-03-31 Manufacturing process for 1-(arylmethyl) quinazoline-2,4 (1h, 3h)-dione

Publications (1)

Publication Number Publication Date
SI3438096T1 true SI3438096T1 (sl) 2021-04-30

Family

ID=59963547

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201730646T SI3438096T1 (sl) 2016-04-01 2017-03-31 Proizvodni postopek 1-(arilmetil)kinazolin-2,4(1H,3H)-diona

Country Status (13)

Country Link
US (1) US10562889B2 (sl)
EP (1) EP3438096B1 (sl)
CN (1) CN109153652B (sl)
CY (1) CY1123898T1 (sl)
DK (1) DK3438096T3 (sl)
ES (1) ES2859460T3 (sl)
HR (1) HRP20210328T1 (sl)
HU (1) HUE053554T2 (sl)
PL (1) PL3438096T3 (sl)
PT (1) PT3438096T (sl)
RS (1) RS61556B1 (sl)
SI (1) SI3438096T1 (sl)
WO (1) WO2017167251A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230263801A1 (en) * 2020-07-24 2023-08-24 Impact Therapeutics (Shanghai), Inc Combination therapy of parp inhibitors
WO2022099442A1 (zh) * 2020-11-10 2022-05-19 上海瑛派药业有限公司 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1611109A4 (en) * 2003-03-31 2009-06-24 Taisho Pharmaceutical Co Ltd NOVEL QUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USE
CN1980913B (zh) * 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
NZ589252A (en) * 2004-09-02 2012-06-29 Vertex Pharma Quinazolines useful as inhibitors of voltage-gated sodium channels
CN101475537A (zh) * 2009-01-07 2009-07-08 太仓市浦源化工有限公司 一种2,4-二氯喹唑啉的制备方法
US9090568B2 (en) * 2011-03-14 2015-07-28 Impact Therapeutics, Inc. Quinazolinediones and their use
TWI527800B (zh) * 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
WO2013064083A1 (en) * 2011-11-01 2013-05-10 Impact Therapeutics, Inc. 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof
US11179392B2 (en) * 2015-04-03 2021-11-23 Impact Therapeutics, Inc. Solid pharmaceutical formulation of PARP inhibitors and use thereof
WO2017109722A1 (en) * 2015-12-21 2017-06-29 Idemitsu Kosan Co., Ltd. Nitrogen-containing heterocyclic compounds and organic electroluminescence devices containing them

Also Published As

Publication number Publication date
EP3438096A4 (en) 2019-08-21
EP3438096A1 (en) 2019-02-06
ES2859460T3 (es) 2021-10-04
PT3438096T (pt) 2021-03-03
US20190112298A1 (en) 2019-04-18
US10562889B2 (en) 2020-02-18
PL3438096T3 (pl) 2021-05-17
EP3438096B1 (en) 2020-12-02
DK3438096T3 (da) 2021-02-22
CN109153652B (zh) 2021-07-27
RS61556B1 (sr) 2021-04-29
CY1123898T1 (el) 2022-05-27
HRP20210328T1 (hr) 2021-04-02
WO2017167251A1 (zh) 2017-10-05
HUE053554T2 (hu) 2021-07-28
CN109153652A (zh) 2019-01-04

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