SI2709990T1 - 1-((3-((1-Piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion derivati kot PARP inhibitorji za zdravljenje raka - Google Patents
1-((3-((1-Piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion derivati kot PARP inhibitorji za zdravljenje rakaInfo
- Publication number
- SI2709990T1 SI2709990T1 SI201231630T SI201231630T SI2709990T1 SI 2709990 T1 SI2709990 T1 SI 2709990T1 SI 201231630 T SI201231630 T SI 201231630T SI 201231630 T SI201231630 T SI 201231630T SI 2709990 T1 SI2709990 T1 SI 2709990T1
- Authority
- SI
- Slovenia
- Prior art keywords
- piperazinyl
- carbonyl
- phenyl
- methyl
- treating cancer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100824756A CN102731416A (zh) | 2011-04-01 | 2011-04-01 | 1-(芳基甲基)-喹唑啉-2，4-二酮作为parp抑制剂及其应用 |
| CN2011077034 | 2011-07-11 | ||
| EP12765230.3A EP2709990B1 (en) | 2011-04-01 | 2012-03-31 | 1-((3-((1-Piperazinyl)carbonyl)phenyl)methyl)-2,4(1H,3H)-quinazolinedione derivatives as PARP inhibitors for treating cancer |
| PCT/CN2012/073362 WO2012130166A1 (en) | 2011-04-01 | 2012-03-31 | 1-(arylmethyl)quinazoline-2,4(1h,3h)-diones as parp inhibitors and the use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2709990T1 true SI2709990T1 (sl) | 2019-09-30 |
Family
ID=46929484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231630T SI2709990T1 (sl) | 2011-04-01 | 2012-03-31 | 1-((3-((1-Piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion derivati kot PARP inhibitorji za zdravljenje raka |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9290460B2 (sl) |
| EP (1) | EP2709990B1 (sl) |
| JP (1) | JP6270713B2 (sl) |
| CN (2) | CN103097361B (sl) |
| AU (1) | AU2012237776B2 (sl) |
| CA (1) | CA2831015C (sl) |
| CY (1) | CY1121847T1 (sl) |
| DK (1) | DK2709990T3 (sl) |
| ES (1) | ES2736299T3 (sl) |
| HR (1) | HRP20191273T1 (sl) |
| HU (1) | HUE046121T2 (sl) |
| PL (1) | PL2709990T3 (sl) |
| PT (1) | PT2709990T (sl) |
| RS (1) | RS59091B1 (sl) |
| SG (1) | SG193599A1 (sl) |
| SI (1) | SI2709990T1 (sl) |
| TR (1) | TR201910675T4 (sl) |
| TW (1) | TWI527800B (sl) |
| WO (1) | WO2012130166A1 (sl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9090568B2 (en) | 2011-03-14 | 2015-07-28 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
| TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用 |
| CN104066723B (zh) | 2011-11-01 | 2016-06-29 | 南京英派药业有限公司 | 1-(芳基甲基)-5,6,7,8-四氢喹唑啉-2,4-二酮和相关化合物及其应用 |
| CA2871453A1 (en) | 2012-04-24 | 2013-10-31 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinedione derivative |
| AR090836A1 (es) | 2012-04-24 | 2014-12-10 | Chugai Pharmaceutical Co Ltd | Derivados de benzamida |
| ME03564B (me) | 2013-03-13 | 2020-07-20 | Forma Therapeutics Inc | DERIVATI 2-HIDROKSI-1-{4-[(4-FENILFENIL)KARBONIL]PIPERAZIN-1-IL}ETAN-1-ONA l SRODNA JEDINJENJA KAO INHIBITORI SINTAZE MASNIH KISELINA (FASN) ZA LEČENJE KANCERA |
| CA2927830A1 (en) | 2013-10-23 | 2015-04-30 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| CN107074791A (zh) | 2014-07-28 | 2017-08-18 | 德累斯顿工业大学 | 用于抑制hsp27的胸腺嘧啶衍生物和喹唑啉二酮衍生物 |
| US11179392B2 (en) * | 2015-04-03 | 2021-11-23 | Impact Therapeutics, Inc. | Solid pharmaceutical formulation of PARP inhibitors and use thereof |
| CN106083741A (zh) * | 2016-02-22 | 2016-11-09 | 南京中医药大学 | 2‑硫代喹唑啉二酮衍生物 |
| CN107098886B (zh) * | 2016-02-26 | 2020-07-14 | 中国医学科学院药物研究所 | 含有哌嗪酮的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| US10562889B2 (en) * | 2016-04-01 | 2020-02-18 | Impact Therapeutics, Inc. | Process for the preparation of 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones |
| CN108727343A (zh) * | 2017-04-21 | 2018-11-02 | 中国医学科学院药物研究所 | 含有3-氨基四氢吡咯的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
| CN111269216A (zh) * | 2018-12-05 | 2020-06-12 | 中国医学科学院药物研究所 | 含有哌嗪酮的喹唑啉二酮盐类化合物、其制备方法、药物组合物和用途 |
| WO2020229595A1 (en) * | 2019-05-14 | 2020-11-19 | Molecular Targeted Radiopharmaceuticals Holding Gmbh (Mtr) | Quinazoline-2,4-dione derivatives as parp inhibitors |
| EP4185295A1 (en) * | 2020-07-24 | 2023-05-31 | Impact Therapeutics (Shanghai), Inc | Combination therapy of parp inhibitors |
| WO2022099442A1 (zh) * | 2020-11-10 | 2022-05-19 | 上海瑛派药业有限公司 | 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备 |
| WO2022199697A1 (en) * | 2021-03-26 | 2022-09-29 | Impact Therapeutics (Shanghai) , Inc | Oral capsule of parp inhibitor and preparation method thereof |
| WO2023138667A1 (zh) * | 2022-01-21 | 2023-07-27 | 上海瑛派药业有限公司 | Senaparib和替莫唑胺的复方制剂及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| DE2652144A1 (de) * | 1976-11-16 | 1978-05-18 | Merck Patent Gmbh | Neue chinazolindione |
| US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| CA1161036A (en) | 1980-05-15 | 1984-01-24 | Masayuki Ishikawa | Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
| PH23853A (en) | 1986-08-21 | 1989-11-23 | Pfizer | Pyridopyrimidinediones |
| WO1997011941A1 (en) | 1995-09-28 | 1997-04-03 | Suntory Limited | Quinazoline derivatives and use thereof |
| US6201121B1 (en) | 1995-12-28 | 2001-03-13 | Fuji Chemical Industry Co., Ltd. | Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives |
| WO1998027975A1 (en) | 1996-12-20 | 1998-07-02 | Geron Corporation | Poly(adp-ribose) polymerase inhibitors to treat diseases associated with cellular senescence |
| AUPO440496A0 (en) | 1996-12-30 | 1997-01-23 | Fujisawa Pharmaceutical Co., Ltd. | Quinazoline derivatives |
| CA2283514A1 (en) | 1997-03-17 | 1998-09-24 | Fujisawa Pharmaceutical Co., Ltd. | Process for producing quinazoline derivatives |
| JP2001302515A (ja) * | 2000-04-18 | 2001-10-31 | Sumitomo Pharmaceut Co Ltd | ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤 |
| JP2002284699A (ja) * | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | 視細胞変性疾患治療剤 |
| JP2005501021A (ja) * | 2001-06-19 | 2005-01-13 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗細菌剤 |
| DE10201240A1 (de) | 2002-01-15 | 2003-07-24 | Bayer Ag | Substituierte Alkyluracile und ihre Verwendung |
| JP5100376B2 (ja) | 2004-06-30 | 2012-12-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体 |
| JP2007137818A (ja) | 2005-11-17 | 2007-06-07 | Taisho Pharmaceut Co Ltd | ８−ヒドロキシ−２，４（１ｈ，３ｈ）−キナゾリンジオン誘導体 |
| EP2164325B1 (en) | 2007-05-31 | 2013-04-24 | Shionogi&Co., Ltd. | Oxyimino compounds and the use thereof |
| GB0716532D0 (en) | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| ES2367760T3 (es) | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
| US20140018376A1 (en) * | 2009-10-20 | 2014-01-16 | Hans Allgeier | Use of 1H-Quinazoline-2,4-Diones |
| US9090568B2 (en) * | 2011-03-14 | 2015-07-28 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
| TWI527800B (zh) | 2011-04-01 | 2016-04-01 | 南京英派藥業有限公司 | 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用 |
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2012
- 2012-03-29 TW TW101111039A patent/TWI527800B/zh active
- 2012-03-31 DK DK12765230.3T patent/DK2709990T3/da active
- 2012-03-31 TR TR2019/10675T patent/TR201910675T4/tr unknown
- 2012-03-31 CA CA2831015A patent/CA2831015C/en active Active
- 2012-03-31 CN CN201280001822.0A patent/CN103097361B/zh active Active
- 2012-03-31 US US14/006,722 patent/US9290460B2/en active Active
- 2012-03-31 WO PCT/CN2012/073362 patent/WO2012130166A1/en active Application Filing
- 2012-03-31 HU HUE12765230A patent/HUE046121T2/hu unknown
- 2012-03-31 SG SG2013071543A patent/SG193599A1/en unknown
- 2012-03-31 JP JP2014501428A patent/JP6270713B2/ja active Active
- 2012-03-31 EP EP12765230.3A patent/EP2709990B1/en active Active
- 2012-03-31 ES ES12765230T patent/ES2736299T3/es active Active
- 2012-03-31 CN CN201410398758.5A patent/CN104230827B/zh active Active
- 2012-03-31 PT PT12765230T patent/PT2709990T/pt unknown
- 2012-03-31 AU AU2012237776A patent/AU2012237776B2/en active Active
- 2012-03-31 RS RS20190877A patent/RS59091B1/sr unknown
- 2012-03-31 PL PL12765230T patent/PL2709990T3/pl unknown
- 2012-03-31 SI SI201231630T patent/SI2709990T1/sl unknown
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2016
- 2016-02-12 US US15/042,366 patent/US9926304B2/en active Active
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2018
- 2018-03-26 US US15/935,694 patent/US10316027B2/en active Active
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2019
- 2019-05-17 US US16/415,803 patent/US11358955B2/en active Active
- 2019-07-16 HR HRP20191273TT patent/HRP20191273T1/hr unknown
- 2019-07-18 CY CY20191100769T patent/CY1121847T1/el unknown
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