ES2422603T3 - Compuestos oxiimino y el uso de estos - Google Patents

Compuestos oxiimino y el uso de estos

Info

Publication number
ES2422603T3
ES2422603T3 ES08767992T ES08767992T ES2422603T3 ES 2422603 T3 ES2422603 T3 ES 2422603T3 ES 08767992 T ES08767992 T ES 08767992T ES 08767992 T ES08767992 T ES 08767992T ES 2422603 T3 ES2422603 T3 ES 2422603T3
Authority
ES
Spain
Prior art keywords
optionally substituted
substituted lower
heterocyclyl
cycloalkenyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08767992T
Other languages
English (en)
Inventor
Naoki Tsuno
Hidenori Mikamiyama
Moriyasu Masui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2422603T3 publication Critical patent/ES2422603T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Un compuesto que tiene la Fórmula I: **Fórmula** una sal o solvato farmacéuticamente aceptable de este, donde: Y es CO o SOm; Z es hidrógeno, alquilo inferior opcionalmente sustituido, alquenilo inferior opcionalmente sustituido, alquiniloinferior opcionalmente sustituido, cicloalquilo opcionalmente sustituido, bicicloalquilo opcionalmente sustituido,cicloalquenilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido,NR5R6, OR5, SR5, COR5 o CONR5R6; R1 y R2 son cada uno independientemente hidrógeno, alquilo inferior opcionalmente sustituido, alquenilo inferioropcionalmente sustituido, alquinilo inferior opcionalmente sustituido, cicloalquilo opcionalmente sustituido,cicloalquenilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido,ciano, COR5 o CONR5R6, o R1 y R2, considerados conjuntamente con el átomo al que están unidos, forman un cicloalquilo opcionalmentesustituido, bicicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido o heterocicliloopcionalmente sustituido; R5 y R6 son cada uno independientemente hidrógeno, alquilo inferior opcionalmente sustituido, alquenilo inferioropcionalmente sustituido, alquinilo inferior opcionalmente sustituido, cicloalquilo opcionalmente sustituido,bicicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, arilo opcionalmente sustituido oheterociclilo opcionalmente sustituido; cada X es independientemente >=O, alquilo inferior opcionalmente sustituido, alquenilo inferior opcionalmentesustituido, alquinilo inferior opcionalmente sustituido, halógeno, ciano, nitro, NR5R6, OR5, SR5, COR5, COOR5,CONR5R6, NR5COR5, OCOR5, SOR5, SO2R5, SO3R5, SONR5R6, SO2NR5R6, NR5SOR5 o NR5SO2R5;m es 1 o 2. p es 0, 1 o 2; y q es 0 o 1.
ES08767992T 2007-05-31 2008-05-30 Compuestos oxiimino y el uso de estos Active ES2422603T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92480807P 2007-05-31 2007-05-31
PCT/US2008/006888 WO2008150470A1 (en) 2007-05-31 2008-05-30 Oxyimino compounds and the use thereof

Publications (1)

Publication Number Publication Date
ES2422603T3 true ES2422603T3 (es) 2013-09-12

Family

ID=40094014

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08767992T Active ES2422603T3 (es) 2007-05-31 2008-05-30 Compuestos oxiimino y el uso de estos

Country Status (5)

Country Link
US (1) US8563732B2 (es)
EP (1) EP2164325B1 (es)
JP (1) JP5323063B2 (es)
ES (1) ES2422603T3 (es)
WO (1) WO2008150470A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563732B2 (en) 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
JP5380435B2 (ja) * 2007-05-31 2014-01-08 ユーロ−セルティーク ソシエテ アノニム アミド化合物およびその使用
ES2408159T3 (es) 2008-06-11 2013-06-18 Shionogi & Co., Ltd. Compuestos de oxicarbamoilo y su utilización
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
ES2436566T3 (es) 2009-04-02 2014-01-03 Shionogi & Co., Ltd. Compuestos de acrilamida y utilización de los mismos
WO2012125521A1 (en) 2011-03-14 2012-09-20 Eternity Bioscience Inc. Quinazolinediones and their use
TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577441A (en) 1967-03-07 1971-05-04 Warner Lambert Pharmaceutical Nitro substituted benzofurans
HU167365B (es) 1973-11-29 1975-09-27
MX6634E (es) 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4585785A (en) 1979-01-09 1986-04-29 A. H. Robins Company, Inc. Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
GB8518869D0 (en) * 1985-07-25 1985-08-29 Beecham Group Plc Compounds
EP0210815A3 (en) * 1985-07-25 1988-04-20 Beecham Group Plc 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use
GB8908529D0 (en) 1989-04-14 1989-06-01 Merck Sharp & Dohme Therapeutic agents
ATE301457T1 (de) 1995-06-12 2005-08-15 Searle & Co Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
US5880138A (en) 1996-10-01 1999-03-09 Eli Lilly And Company NMDA receptor selective antagonists
AR011913A1 (es) 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
ATE231837T1 (de) 1997-11-12 2003-02-15 Darwin Discovery Ltd Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung
AU751412B2 (en) 1997-11-26 2002-08-15 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6310059B1 (en) * 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
TR200102533T2 (tr) 1998-12-18 2006-06-21 Axys Pharmaceuticals, Inc. Proteaz inhibitörleri
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
WO2002057241A1 (en) * 2000-12-22 2002-07-25 Bayer Pharmaceuticals Corporation 8-(AMINOALKOXYMINO)-8H-DIBENZO[a,e]TRIAZOLO[4,5-c]CYCLOHEPTENES AS GROWTH HORMONE SECRETAGOGUES
EP1390347B1 (en) 2001-03-20 2008-05-07 Laboratoires Serono SA Pyrrolidine ester derivatives with oxytocin modulating activity
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
AU2003261756A1 (en) 2002-08-28 2004-03-29 Toray Industries, Inc. Acrylamide derivatives
US20040204404A1 (en) 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
TW200505834A (en) 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
EP1633343A1 (en) * 2003-05-30 2006-03-15 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
EP1664010A1 (en) * 2003-08-29 2006-06-07 Vernalis (R&D) Limited Sulfonamides antagonising n-type calcium channels
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
EP1732566A4 (en) 2004-04-05 2010-01-13 Takeda Pharmaceutical 6-azaindole COMPOUND
EP1741702A1 (en) 2004-04-28 2007-01-10 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and medicinal use thereof
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
KR20080015102A (ko) * 2005-05-10 2008-02-18 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서의 바이사이클릭 유도체
TWI359149B (en) * 2005-07-11 2012-03-01 Mitsubishi Tanabe Pharma Corp An oxime derivative and preparations thereof
JP2009507800A (ja) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． 縮合およびスピロ環化合物ならびにその使用
EP1987009A1 (en) 2006-01-30 2008-11-05 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
US8247442B2 (en) 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
CN1850823A (zh) 2006-05-19 2006-10-25 中国科学院上海药物研究所 一类含有肟基的喹诺酮类化合物及其制备方法和用途
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
JP5539717B2 (ja) 2006-07-14 2014-07-02 塩野義製薬株式会社 オキシム化合物およびその使用
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
JP5380435B2 (ja) 2007-05-31 2014-01-08 ユーロ−セルティーク ソシエテ アノニム アミド化合物およびその使用
US8563732B2 (en) 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
ES2408159T3 (es) 2008-06-11 2013-06-18 Shionogi & Co., Ltd. Compuestos de oxicarbamoilo y su utilización
EP2331522B1 (en) 2008-08-01 2013-09-18 Purdue Pharma LP Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof

Also Published As

Publication number Publication date
JP5323063B2 (ja) 2013-10-23
US20100240703A1 (en) 2010-09-23
US8563732B2 (en) 2013-10-22
WO2008150470A1 (en) 2008-12-11
EP2164325A4 (en) 2011-09-14
EP2164325A1 (en) 2010-03-24
JP2010529020A (ja) 2010-08-26
EP2164325B1 (en) 2013-04-24

Similar Documents

Publication Publication Date Title
ES2422603T3 (es) Compuestos oxiimino y el uso de estos
ECSP055974A (es) Síntesis de cloruros de 4 amino-2-butenoil y su uso en la preparación de 3-ciano quinolinas
AR106942A2 (es) Compuestos de isoindolina y composiciones farmacéuticas de los mismos
AR072166A1 (es) Derivado de piperidina y su uso como inhibidor de renina superior
AR078520A1 (es) Compuesto heterociclico y su uso para el control de una plaga de artro-podos
ECSP088479A (es) Derivados de oxadiazol
AR100807A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
ECSP10010060A (es) Derivados de pirazol sustituídos
CO6321230A2 (es) Compuesto espiro, una sal aceptable para uso farmaceutico y un solvato del mismo y composicion farmaceutica que lo contenga
AR105340A2 (es) Derivados de quinazolinona 5-sustituida y composiciones que los comprenden
AR077849A2 (es) Compuestos y composiciones como inhibidores de proteina quinasa
CY1113687T1 (el) Παραγωγα αμινο νικοτινικου και ισο-νικοτινικου οξεος σαν παραγοντες καταστολης της dhodh
AR098666A1 (es) Compuestos de biarilacetamida y sus métodos de uso
ES2678086T3 (es) Compuestos de diona cíclicos (alquil-fenil)-sustituidos activos como herbicidas y derivados de los mismos
EA201070182A1 (ru) Алкилсульфонилзамещённые тиазолидные соединения
ES2546851T3 (es) Inhibidores de fosfatidilinositol 3-cinasa
AR085327A1 (es) Inhibidores del virus de la hepatitis c
AR067691A1 (es) Derivados heterociclicos de sulfonimidoil, composiciones plaguicidas que los contienen y usos de los mismos para el control de plagas.
UY29388A1 (es) Derivados del (1,5-difenil-h-pirazol-3-il)oxadiazol, su preparación y su aplicacion en terapéutica.
AR099498A1 (es) Compuestos de triazina y su uso farmacéutico
AR097866A1 (es) Derivados de 4-azaindol
CO6321269A2 (es) Derivados de benzoxazinona que actuan como agonistas de receptores adrenergicos beta 2 para el tratamiento de transtornos respiratorios
DOP2010000226A (es) Compuestos triciclicos que tienen actividad antagonista de factor de liberacion de corticotropina y composiciones farmaceuticas que contienen los mismos
AR045805A1 (es) Quinolonas y naftridonas 7- amino alquidenil - heterociclicas
ES2531159T3 (es) Compuestos y métodos para el tratamiento del cáncer