CR11309A - Derivados de azaciclilisoquinolinona e isoindolinona como antagonista de la histamnia-3 - Google Patents

Derivados de azaciclilisoquinolinona e isoindolinona como antagonista de la histamnia-3

Info

Publication number
CR11309A
CR11309A CR11309A CR11309A CR11309A CR 11309 A CR11309 A CR 11309A CR 11309 A CR11309 A CR 11309A CR 11309 A CR11309 A CR 11309A CR 11309 A CR11309 A CR 11309A
Authority
CR
Costa Rica
Prior art keywords
isoindolinona
histamnia
azaciclilisoquinolinona
antagonist
derivatives
Prior art date
Application number
CR11309A
Other languages
English (en)
Inventor
Dahui Zhou
Jonathan Laird Gross
Albert Jean Robichaud
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CR11309A publication Critical patent/CR11309A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona un compuesto de formula I y su uso para el tratamiento de un trastorno del sistema nervioso central relacionado con, o que se ve afectado por, el receptor de la histamina-3
CR11309A 2007-09-12 2010-03-11 Derivados de azaciclilisoquinolinona e isoindolinona como antagonista de la histamnia-3 CR11309A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99355407P 2007-09-12 2007-09-12

Publications (1)

Publication Number Publication Date
CR11309A true CR11309A (es) 2010-04-07

Family

ID=40261508

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11309A CR11309A (es) 2007-09-12 2010-03-11 Derivados de azaciclilisoquinolinona e isoindolinona como antagonista de la histamnia-3

Country Status (23)

Country Link
US (1) US20090069370A1 (es)
EP (1) EP2200998A1 (es)
JP (1) JP2010539178A (es)
KR (1) KR20100054852A (es)
CN (1) CN101842366A (es)
AP (1) AP2010005199A0 (es)
AU (1) AU2008298983A1 (es)
BR (1) BRPI0816806A2 (es)
CA (1) CA2699383A1 (es)
CL (1) CL2008002708A1 (es)
CO (1) CO6300951A2 (es)
CR (1) CR11309A (es)
DO (1) DOP2010000078A (es)
EA (1) EA201000319A1 (es)
EC (1) ECSP10010032A (es)
MA (1) MA31700B1 (es)
MX (1) MX2010002899A (es)
NI (1) NI201000035A (es)
PA (1) PA8795601A1 (es)
PE (1) PE20090679A1 (es)
TN (1) TN2010000107A1 (es)
TW (1) TW200918062A (es)
WO (1) WO2009036117A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
JP2011213700A (ja) * 2010-04-02 2011-10-27 Nishizaki Soyaku Kenkyusho:Kk 認知症改善用組成物
EP2569297A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
JP5968307B2 (ja) 2010-05-11 2016-08-10 サノフイ 置換フェニルシクロアルキルピロリジン（ピペリジン）スピロラクタム類及びアミド類、それらの製造及び治療的使用
WO2011143145A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
EP2569304A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
JP5784110B2 (ja) 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
EP2569294B1 (en) 2010-05-11 2015-03-11 Sanofi Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
EP2535062A1 (en) 2011-06-13 2012-12-19 Dentsply IH AB Collagen coated article
WO2012173555A1 (en) 2011-06-13 2012-12-20 Dentsply Ih Ab Collagen coated article
CA2850700C (en) * 2011-11-30 2019-11-12 F. Hoffmann-La Roche Ag New bicyclic dihydroisoquinoline-1-one derivatives
JO3442B1 (ar) * 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
LT3063139T (lt) 2013-10-29 2019-02-25 Takeda Pharmaceutical Company Limited Heterociklinis junginys
CN112209876B (zh) * 2020-10-15 2022-08-26 华侨大学 一种3-三氟甲基异喹啉酮衍生物的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933829A (en) * 1974-08-22 1976-01-20 John Wyeth & Brother Limited 4-Aminoquinoline derivatives
US4166853A (en) * 1978-05-05 1979-09-04 The Upjohn Company Antihypertensive 7-trifluoromethyl-4-aminoquinolones
US4159331A (en) * 1978-05-05 1979-06-26 The Upjohn Company Antihypertensive 4-aminoquinolines
SE7907121L (sv) * 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
AU4319797A (en) * 1996-09-25 1998-04-17 Yamanouchi Pharmaceutical Co., Ltd. 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof
US6541499B1 (en) * 1997-05-01 2003-04-01 Eli Lilly And Company Antithrombotic agents
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
ES2540987T3 (es) * 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
US20060014733A1 (en) * 2004-07-19 2006-01-19 Pfizer Inc Histamine-3 agonists and antagonists
SE0401970D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
CN101107231A (zh) * 2005-01-21 2008-01-16 先灵公司 用作组胺h3拮抗剂的咪唑和苯并咪唑衍生物
US20070032475A1 (en) * 2005-04-15 2007-02-08 Ye Xiaocong M Novel compounds useful for bradykinin B1 receptor antagonism
US8143284B2 (en) * 2006-10-05 2012-03-27 Abbott Laboratories Poly(ADP-ribose)polymerase inhibitors
US7799806B2 (en) * 2007-04-04 2010-09-21 Hoffmann-La Roche Inc. Substituted n-benzyl piperidines as somatostatin receptor modulators

Also Published As

Publication number Publication date
BRPI0816806A2 (pt) 2015-03-10
AU2008298983A1 (en) 2009-03-19
AP2010005199A0 (en) 2010-04-30
CN101842366A (zh) 2010-09-22
KR20100054852A (ko) 2010-05-25
MA31700B1 (fr) 2010-09-01
PA8795601A1 (es) 2009-05-15
US20090069370A1 (en) 2009-03-12
CA2699383A1 (en) 2009-03-19
EP2200998A1 (en) 2010-06-30
TW200918062A (en) 2009-05-01
PE20090679A1 (es) 2009-05-28
JP2010539178A (ja) 2010-12-16
WO2009036117A1 (en) 2009-03-19
ECSP10010032A (es) 2010-08-31
EA201000319A1 (ru) 2010-10-29
DOP2010000078A (es) 2010-04-15
MX2010002899A (es) 2010-04-09
CO6300951A2 (es) 2011-07-21
NI201000035A (es) 2010-07-15
TN2010000107A1 (fr) 2011-09-26
CL2008002708A1 (es) 2008-10-10

Similar Documents

Publication Publication Date Title
CR11309A (es) Derivados de azaciclilisoquinolinona e isoindolinona como antagonista de la histamnia-3
DOP2010000079A (es) Derivados de isoquinolinilo e isoindolinilo como antagonistas de la histamina-3
NI201500077A (es) Novedosos derivados de bencimidazol como antagonistas de ep4
CR7643A (es) Derivados de 1-heterociclialquil -3-sulfonilazaindol o azaindazol como ligandos de 5-hidroxitriptamina-6
CL2007001670A1 (es) Uso de compuestos derivados de amina para el tratamiento de un trastorno mediado por citoquinas.
NI201100166A (es) Derivados de benzofuranilo utilizados como inhibidores de glucoquinasa
CR10309A (es) "compuestos y composiciones como inhibidores de la actividad del receptor canabinoide 1"
HN2009001597A (es) 4-aril-1, 4-dihidro-1,6-naftiridinamidas sustituidas y su uso
UY32384A (es) Nuevas bencenosulfonamidas como bloqueadores de canales de calcio
UY30572A1 (es) N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2
TW200800958A (en) N-substituted-azacyclylamines as histamine-3 antagonists
PA8790101A1 (es) Derivados de aminoalquilazol como antagonistas de histamina-3
UY32432A (es) Compuestos de pirimidina fusionada como inhibidores de akt
UY33655A (es) Co-cristales y sales de inhibidores de ccr30
HN2010002558A (es) DERIVADOS DE UREA MACROCICLICOS Y DE SULFAMIDA COMO INHIBIDORES DE TAFIa
CO6341625A2 (es) Derivados de indol como agentes anticáncer
PA8781601A1 (es) " derivados de azaciclilbenzamida como antagonistas de histamina-3
CR9733A (es) Derivados de azinil-3-sulfonilindazol como ligandos de 5-hidroxitriptamina-6
CR9734A (es) Derivados de 3-sulfonilindazol sustituido como ligandos de 5-hidroxitriptamina-6
BR112016012552A8 (pt) derivado de cromona como um antagonista do receptor d3 de dopamina, seu uso e sua composição farmacêutica
UY31646A1 (es) Uso de fenilimidazolidinas sustituidas para producir medicamentos para el tratamiento del síndrome metabólico
ECSP088930A (es) Derivados de benzoxazol y benzotiazol como ligandos de
ECSP067096A (es) Metabolitos de indolilalquilamina como ligandos 5-hidroxitriptamina-6
ECSP088789A (es) Derivados de sulfonil-3-heterociclilindazol como ligandos de 5-hidroxitriptamina-6
CU20110020A7 (es) Compuestos de fenantrenona, composiciones y métodos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)