MA31700B1 - Derives d'azacyclylisoquinolinone et -isoindolinone servant d'antagonistes du recepteur d'histamine-3 - Google Patents
Derives d'azacyclylisoquinolinone et -isoindolinone servant d'antagonistes du recepteur d'histamine-3Info
- Publication number
- MA31700B1 MA31700B1 MA32689A MA32689A MA31700B1 MA 31700 B1 MA31700 B1 MA 31700B1 MA 32689 A MA32689 A MA 32689A MA 32689 A MA32689 A MA 32689A MA 31700 B1 MA31700 B1 MA 31700B1
- Authority
- MA
- Morocco
- Prior art keywords
- histamine
- azacyclylisoquinolinone
- receptor antagonists
- isoindolinone derivatives
- isoindolinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne un composé représenté par la formule (i) et son utilisation pour le traitement d'un trouble du système nerveux central en relation avec ou affecté par le récepteur de l'histamine-3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99355407P | 2007-09-12 | 2007-09-12 | |
PCT/US2008/075942 WO2009036117A1 (fr) | 2007-09-12 | 2008-09-11 | Dérivés d'azacyclylisoquinolinone et d'isoindolinone convenant comme antagonistes de l'histamine-3 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31700B1 true MA31700B1 (fr) | 2010-09-01 |
Family
ID=40261508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32689A MA31700B1 (fr) | 2007-09-12 | 2010-03-12 | Derives d'azacyclylisoquinolinone et -isoindolinone servant d'antagonistes du recepteur d'histamine-3 |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090069370A1 (fr) |
EP (1) | EP2200998A1 (fr) |
JP (1) | JP2010539178A (fr) |
KR (1) | KR20100054852A (fr) |
CN (1) | CN101842366A (fr) |
AP (1) | AP2010005199A0 (fr) |
AU (1) | AU2008298983A1 (fr) |
BR (1) | BRPI0816806A2 (fr) |
CA (1) | CA2699383A1 (fr) |
CL (1) | CL2008002708A1 (fr) |
CO (1) | CO6300951A2 (fr) |
CR (1) | CR11309A (fr) |
DO (1) | DOP2010000078A (fr) |
EA (1) | EA201000319A1 (fr) |
EC (1) | ECSP10010032A (fr) |
MA (1) | MA31700B1 (fr) |
MX (1) | MX2010002899A (fr) |
NI (1) | NI201000035A (fr) |
PA (1) | PA8795601A1 (fr) |
PE (1) | PE20090679A1 (fr) |
TN (1) | TN2010000107A1 (fr) |
TW (1) | TW200918062A (fr) |
WO (1) | WO2009036117A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
JP2011213700A (ja) * | 2010-04-02 | 2011-10-27 | Nishizaki Soyaku Kenkyusho:Kk | 認知症改善用組成物 |
TW201202251A (en) | 2010-05-11 | 2012-01-16 | Sanofi Aventis | Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたn−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
AR081498A1 (es) | 2010-05-11 | 2012-09-19 | Sanofi Aventis | Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos |
AR081382A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
EP2535062A1 (fr) | 2011-06-13 | 2012-12-19 | Dentsply IH AB | Article revêtu de collagène |
EP2717933B1 (fr) | 2011-06-13 | 2019-05-01 | Dentsply IH AB | Article revêtu de collagène |
JP6382108B2 (ja) * | 2011-11-30 | 2018-08-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規二環式ジヒドロイソキノリン−1−オン誘導体 |
JO3442B1 (ar) * | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
EP3063139B1 (fr) | 2013-10-29 | 2018-11-21 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
CN112209876B (zh) * | 2020-10-15 | 2022-08-26 | 华侨大学 | 一种3-三氟甲基异喹啉酮衍生物的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
AU4319797A (en) * | 1996-09-25 | 1998-04-17 | Yamanouchi Pharmaceutical Co., Ltd. | 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof |
WO1998048800A1 (fr) * | 1997-05-01 | 1998-11-05 | Eli Lilly And Company | Agents antithrombotiques |
US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
ATE381566T1 (de) * | 2004-05-14 | 2008-01-15 | Millennium Pharm Inc | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
MX2007008843A (es) * | 2005-01-21 | 2007-08-22 | Schering Corp | Derivados de imidazol y bencimidazol utiles como antagonistas de histamina h3. |
JP2008537953A (ja) * | 2005-04-15 | 2008-10-02 | エラン ファーマシューティカルズ,インコーポレイテッド | ブラジキニンb1受容体拮抗作用に有用な新規化合物 |
US8143284B2 (en) * | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
-
2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Application Discontinuation
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/fr active Application Filing
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 EP EP08830104A patent/EP2200998A1/fr not_active Withdrawn
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 CA CA2699383A patent/CA2699383A1/fr not_active Abandoned
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
-
2010
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PA8795601A1 (es) | 2009-05-15 |
TW200918062A (en) | 2009-05-01 |
TN2010000107A1 (fr) | 2011-09-26 |
DOP2010000078A (es) | 2010-04-15 |
AU2008298983A1 (en) | 2009-03-19 |
WO2009036117A1 (fr) | 2009-03-19 |
CA2699383A1 (fr) | 2009-03-19 |
JP2010539178A (ja) | 2010-12-16 |
CO6300951A2 (es) | 2011-07-21 |
CL2008002708A1 (es) | 2008-10-10 |
AP2010005199A0 (en) | 2010-04-30 |
CR11309A (es) | 2010-04-07 |
EP2200998A1 (fr) | 2010-06-30 |
BRPI0816806A2 (pt) | 2015-03-10 |
EA201000319A1 (ru) | 2010-10-29 |
PE20090679A1 (es) | 2009-05-28 |
ECSP10010032A (es) | 2010-08-31 |
KR20100054852A (ko) | 2010-05-25 |
US20090069370A1 (en) | 2009-03-12 |
CN101842366A (zh) | 2010-09-22 |
MX2010002899A (es) | 2010-04-09 |
NI201000035A (es) | 2010-07-15 |
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