MX2009012734A - Derivados de azaciclilbenzamida como antagonistas de histamina-3. - Google Patents

Derivados de azaciclilbenzamida como antagonistas de histamina-3.

Info

Publication number
MX2009012734A
MX2009012734A MX2009012734A MX2009012734A MX2009012734A MX 2009012734 A MX2009012734 A MX 2009012734A MX 2009012734 A MX2009012734 A MX 2009012734A MX 2009012734 A MX2009012734 A MX 2009012734A MX 2009012734 A MX2009012734 A MX 2009012734A
Authority
MX
Mexico
Prior art keywords
histamine
azacyclylbenzamide
antagonists
derivatives
aromatic ring
Prior art date
Application number
MX2009012734A
Other languages
English (en)
Inventor
Jonathan Laird Gross
Albert Jean Robichaud
Dahui Zhou
Jean Y Sze
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2009012734A publication Critical patent/MX2009012734A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de fórmula I y el uso de este para el tratamiento de un trastorno del sistema nervioso central relacionado con o afectado por el receptor de histamina-3, en donde R3 y R4 se toman juntos con el átomo al cual ellos se adhieren para formar un sistema de anillo aromático de 5 miembros monocíclico opcionalmente sustituido que contiene opcionalmente uno o dos heteroátomos adicionales seleccionados de N, O o S o un sistema de anillo aromático de 9- a 15-miembros bicíclico o tricíclico fusionado opcionalmente sustituido que contiene opcionalmente uno a tres heteroátomos adicionales seleccionados de N, O o S; y en donde R1, R2, R5, R6 y x son como se definen aquí. (ver fórmula (I)).
MX2009012734A 2007-05-24 2008-05-23 Derivados de azaciclilbenzamida como antagonistas de histamina-3. MX2009012734A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93151907P 2007-05-24 2007-05-24
PCT/US2008/064634 WO2008147945A1 (en) 2007-05-24 2008-05-23 Azacyclylbenzamide derivatives as histamine-3 antagonists

Publications (1)

Publication Number Publication Date
MX2009012734A true MX2009012734A (es) 2010-03-30

Family

ID=39713748

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012734A MX2009012734A (es) 2007-05-24 2008-05-23 Derivados de azaciclilbenzamida como antagonistas de histamina-3.

Country Status (14)

Country Link
US (1) US20080293771A1 (es)
EP (1) EP2155719A1 (es)
KR (1) KR20100020487A (es)
CN (1) CN101778838A (es)
AR (1) AR066721A1 (es)
AU (1) AU2008256803A1 (es)
CA (1) CA2688110A1 (es)
CL (1) CL2008001503A1 (es)
IL (1) IL202339A0 (es)
MX (1) MX2009012734A (es)
PA (1) PA8781601A1 (es)
PE (1) PE20090720A1 (es)
TW (1) TW200901983A (es)
WO (1) WO2008147945A1 (es)

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TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
US20100190826A1 (en) * 2007-07-24 2010-07-29 Akio Kakefuda Benzimidazole derivative
WO2012047538A1 (en) 2010-10-06 2012-04-12 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
RU2013136851A (ru) * 2011-01-07 2015-02-20 Таргасепт, Инк. Неконкурентные антагонисты никотиновых рецепторов
EP2705030B1 (en) 2011-05-06 2016-07-27 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
JP6169716B2 (ja) 2012-11-05 2017-07-26 ザフゲン，インコーポレイテッド 肝疾患を治療する方法
AU2015315177A1 (en) * 2014-09-10 2017-03-16 Epizyme, Inc. Substituted pyrrolidine carboxamide compounds

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US3933829A (en) * 1974-08-22 1976-01-20 John Wyeth & Brother Limited 4-Aminoquinoline derivatives
US4166853A (en) * 1978-05-05 1979-09-04 The Upjohn Company Antihypertensive 7-trifluoromethyl-4-aminoquinolones
US4159331A (en) * 1978-05-05 1979-06-26 The Upjohn Company Antihypertensive 4-aminoquinolines
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
AU686691B2 (en) * 1994-01-12 1998-02-12 F. Hoffmann-La Roche Ag Novel azepanes and homologs thereof
CA2187429A1 (en) * 1994-04-28 1995-11-09 Junya Ohmori N-(3-pyrrolidinyl)benzamide derivative
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
AU7270798A (en) * 1997-05-01 1998-11-24 Eli Lilly And Company Antithrombotic agents
US6576632B1 (en) * 1999-08-27 2003-06-10 Pfizer Inc Biaryl compounds useful as anticancer agents
US20030191279A1 (en) * 1999-08-27 2003-10-09 Goldstein Steven Wayne Urea derivatives useful as anticancer agents
ES2254772T3 (es) * 2001-12-04 2006-06-16 Actelion Pharmaceuticals Ltd. 4-(piperidil-y pirrolidil-alquil-ureido)-quinoleinas como receptores antagonistas de urotensina ii.
EA012112B1 (ru) * 2004-05-14 2009-08-28 Миллениум Фармасьютикалз, Инк. Соединения и способы для ингибирования митотической прогрессии
TW200602314A (en) * 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
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JP4942654B2 (ja) 2004-08-23 2012-05-30 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体薬剤、製剤及び治療的使用
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
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EP2601964B1 (en) * 2005-03-21 2018-07-25 The Trustees of Columbia University in the City of New York Balanol compounds for use in treating pain
JP2008537953A (ja) * 2005-04-15 2008-10-02 エラン ファーマシューティカルズ，インコーポレイテッド ブラジキニンｂ１受容体拮抗作用に有用な新規化合物
AU2007227681A1 (en) * 2006-03-15 2007-09-27 Wyeth N-substituted-azacyclylamines as histamine-3 antagonists
EP2007733B1 (en) * 2006-04-03 2016-05-25 MSD Italia S.r.l. Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors
US20070238718A1 (en) * 2006-04-06 2007-10-11 Matthias Grauert Thiazolyl-dihydro-indazole
PE20081152A1 (es) * 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3

Also Published As

Publication number Publication date
CN101778838A (zh) 2010-07-14
CA2688110A1 (en) 2008-12-04
TW200901983A (en) 2009-01-16
KR20100020487A (ko) 2010-02-22
IL202339A0 (en) 2010-06-30
CL2008001503A1 (es) 2008-07-04
AU2008256803A1 (en) 2008-12-04
US20080293771A1 (en) 2008-11-27
PE20090720A1 (es) 2009-06-11
WO2008147945A1 (en) 2008-12-04
AR066721A1 (es) 2009-09-09
EP2155719A1 (en) 2010-02-24
PA8781601A1 (es) 2008-12-18

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