MX2011007663A - Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2. - Google Patents

Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2.

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Publication number
MX2011007663A
MX2011007663A MX2011007663A MX2011007663A MX2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A
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MX
Mexico
Prior art keywords
saturated heterocyclic
substituted saturated
agonistic activity
sulfone compounds
receptor agonistic
Prior art date
Application number
MX2011007663A
Other languages
English (en)
Inventor
Kazuo Ando
Yasuhiro Iwata
Original Assignee
Raqualia Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raqualia Pharma Inc filed Critical Raqualia Pharma Inc
Publication of MX2011007663A publication Critical patent/MX2011007663A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Esta invención se refiere a compuestos de la fórmula (I) o una sal farmacéuticamente aceptable de éste, en donde, X, R1, R2, R3, R4, R5, R6, R7, k, m, n, p, q, r y s son cada una como se describe aquí, y las composiciones que contienen tales compuestos, y el uso de tales compuestos en el tratamiento de una condición mediada por la actividad del receptor de CB2. (ver fórmula (I)).
MX2011007663A 2009-01-22 2010-01-22 Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2. MX2011007663A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20203609P 2009-01-22 2009-01-22
US21397709P 2009-08-04 2009-08-04
PCT/JP2010/000377 WO2010084767A1 (en) 2009-01-22 2010-01-22 N-substituted saturated heterocyclic sulfone compounds with cb2 receptor agonistic activity

Publications (1)

Publication Number Publication Date
MX2011007663A true MX2011007663A (es) 2011-08-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011007663A MX2011007663A (es) 2009-01-22 2010-01-22 Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2.

Country Status (10)

Country Link
US (1) US8653063B2 (es)
EP (1) EP2379533A4 (es)
JP (1) JP5816883B2 (es)
KR (1) KR20110117146A (es)
CN (1) CN102292328A (es)
BR (1) BRPI1007202A2 (es)
CA (1) CA2747801A1 (es)
MX (1) MX2011007663A (es)
RU (1) RU2011134868A (es)
WO (1) WO2010084767A1 (es)

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US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
WO2012090179A2 (en) 2010-12-30 2012-07-05 Lupin Limited Isoquinoline derivatives as cannabinoid receptor modulators
WO2012090177A2 (en) 2010-12-30 2012-07-05 Lupin Limited Cannabinoid receptor modulators
CN102276511A (zh) * 2011-06-20 2011-12-14 兰州博实生化科技有限责任公司 1-叔丁氧羰基-3-碘氮杂环丁烷的合成方法
WO2013005168A2 (en) 2011-07-05 2013-01-10 Lupin Limited Cannabinoid receptor modulators
CN102432514B (zh) * 2011-12-26 2014-05-07 兰州博实生化科技有限责任公司 1-叔丁氧羰基-3-氟氮杂环丁烷的合成方法
US8633182B2 (en) 2012-05-30 2014-01-21 Boehringer Ingelheim International Gmbh Indanyloxyphenylcyclopropanecarboxylic acids
EP3563849A3 (en) 2012-10-25 2020-02-12 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
EP3060205A4 (en) 2013-10-22 2017-06-28 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
CA3033079A1 (en) 2016-08-31 2018-03-08 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
WO2019017995A1 (en) 2017-07-20 2019-01-24 Aztherapies, Inc. FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN
CN113038944A (zh) 2018-07-02 2021-06-25 通用医疗公司 色甘酸钠和α-乳糖的粉末化制剂
IL301333A (en) * 2020-11-12 2023-05-01 Askat Inc Stable salt and crystal forms of (2-[3-({1-[2-(dimethylamino)ethyl]-2-(2,2-dimethylpropyl)-H1-1,3-benzodiazol-5-yl}sulfonyl)aztidine- 1-Yil]Ethan-1-Wol

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FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
DE602005011844D1 (de) 2004-11-02 2009-01-29 Pfizer Sulfonylbenzimidazolderivate
JP2009536918A (ja) 2006-03-06 2009-10-22 ファイザー株式会社 スルホニルベンゾイミダゾール誘導体
MX2009000149A (es) * 2006-07-04 2009-01-23 Janssen Pharmaceutica Nv Agonistas de bencimidazol canabinoide que portan un grupo heterociclico sustituido.
EP2142531B1 (en) 2007-03-30 2015-07-08 Janssen Pharmaceutica N.V. Benzimidazole cannabinoid agonists
ES2574130T3 (es) * 2007-12-17 2016-06-15 Janssen Pharmaceutica, N.V. Bencimidazoles sustituidos con fluoroalquilo como agonistas cannabinoides

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Publication number Publication date
KR20110117146A (ko) 2011-10-26
BRPI1007202A2 (pt) 2016-02-23
US8653063B2 (en) 2014-02-18
EP2379533A1 (en) 2011-10-26
WO2010084767A1 (en) 2010-07-29
JP5816883B2 (ja) 2015-11-18
CN102292328A (zh) 2011-12-21
US20110281840A1 (en) 2011-11-17
CA2747801A1 (en) 2010-07-29
EP2379533A4 (en) 2012-07-04
RU2011134868A (ru) 2013-02-27
JP2012515712A (ja) 2012-07-12

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