MX2011007663A - Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2. - Google Patents

Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2.

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Publication number
MX2011007663A
MX2011007663A MX2011007663A MX2011007663A MX2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A MX 2011007663 A MX2011007663 A MX 2011007663A
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MX
Mexico
Prior art keywords
saturated heterocyclic
substituted saturated
agonistic activity
sulfone compounds
receptor agonistic
Prior art date
Application number
MX2011007663A
Other languages
English (en)
Inventor
Kazuo Ando
Yasuhiro Iwata
Original Assignee
Raqualia Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raqualia Pharma Inc filed Critical Raqualia Pharma Inc
Publication of MX2011007663A publication Critical patent/MX2011007663A/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)

Abstract

Esta invención se refiere a compuestos de la fórmula (I) o una sal farmacéuticamente aceptable de éste, en donde, X, R1, R2, R3, R4, R5, R6, R7, k, m, n, p, q, r y s son cada una como se describe aquí, y las composiciones que contienen tales compuestos, y el uso de tales compuestos en el tratamiento de una condición mediada por la actividad del receptor de CB2. (ver fórmula (I)).
MX2011007663A 2009-01-22 2010-01-22 Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2. MX2011007663A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20203609P 2009-01-22 2009-01-22
US21397709P 2009-08-04 2009-08-04
PCT/JP2010/000377 WO2010084767A1 (en) 2009-01-22 2010-01-22 N-substituted saturated heterocyclic sulfone compounds with cb2 receptor agonistic activity

Publications (1)

Publication Number Publication Date
MX2011007663A true MX2011007663A (es) 2011-08-15

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MX2011007663A MX2011007663A (es) 2009-01-22 2010-01-22 Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2.

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Country Link
US (1) US8653063B2 (es)
EP (1) EP2379533A4 (es)
JP (1) JP5816883B2 (es)
KR (1) KR20110117146A (es)
CN (1) CN102292328A (es)
BR (1) BRPI1007202A2 (es)
CA (1) CA2747801A1 (es)
MX (1) MX2011007663A (es)
RU (1) RU2011134868A (es)
WO (1) WO2010084767A1 (es)

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WO2012090177A2 (en) 2010-12-30 2012-07-05 Lupin Limited Cannabinoid receptor modulators
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WO2013005168A2 (en) 2011-07-05 2013-01-10 Lupin Limited Cannabinoid receptor modulators
CN102432514B (zh) * 2011-12-26 2014-05-07 兰州博实生化科技有限责任公司 1-叔丁氧羰基-3-氟氮杂环丁烷的合成方法
US8633182B2 (en) 2012-05-30 2014-01-21 Boehringer Ingelheim International Gmbh Indanyloxyphenylcyclopropanecarboxylic acids
EP2911664B1 (en) 2012-10-25 2019-05-08 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
AU2014340182B2 (en) * 2013-10-22 2019-05-23 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
CA3033079A1 (en) 2016-08-31 2018-03-08 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
KR20210070232A (ko) 2017-07-20 2021-06-14 아즈테라피즈 인코포레이티드 크로몰린 나트륨 및 이부프로펜의 분말화된 제형
CA3105392A1 (en) 2018-07-02 2020-01-09 The General Hospital Corporation Powdered formulations of cromolyn sodium and .alpha.-lactose
EP3893945A4 (en) 2018-12-10 2022-11-30 The General Hospital Corporation CROMOGLYC ESTERS AND THEIR USES
US12458622B2 (en) 2020-04-06 2025-11-04 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
AU2021380315B2 (en) * 2020-11-12 2023-04-13 Askat Inc. Stable salt and crystal forms of 2-(3-({1-(2-(dimethylamino)ethyl)-2-(2,2-dimethylpropyl)-1H-1,3-benzodiazol-5-yl}sulfonyl)azetidin-1-yl)ethan-1-ol

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GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
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CN102292328A (zh) 2011-12-21
CA2747801A1 (en) 2010-07-29
US8653063B2 (en) 2014-02-18
EP2379533A1 (en) 2011-10-26
RU2011134868A (ru) 2013-02-27
JP5816883B2 (ja) 2015-11-18
US20110281840A1 (en) 2011-11-17
JP2012515712A (ja) 2012-07-12
EP2379533A4 (en) 2012-07-04
WO2010084767A1 (en) 2010-07-29
BRPI1007202A2 (pt) 2016-02-23
KR20110117146A (ko) 2011-10-26

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