AR061147A1 - Compuestos derivados de piperazina, un proceso para su preparacion y una composicion farmaceutica - Google Patents
Compuestos derivados de piperazina, un proceso para su preparacion y una composicion farmaceuticaInfo
- Publication number
- AR061147A1 AR061147A1 ARP070102364A ARP070102364A AR061147A1 AR 061147 A1 AR061147 A1 AR 061147A1 AR P070102364 A ARP070102364 A AR P070102364A AR P070102364 A ARP070102364 A AR P070102364A AR 061147 A1 AR061147 A1 AR 061147A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- pharmaceutical composition
- group
- piperazine
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto de formula (1) util en el tratamiento de un trastorno del sistema nervioso central relacionado con o afectado por el receptor 5-HT6, en la cual: X es O, S, SO1 o SO2; R1 es un grupo arilo o heteroarilo; R2 es H o un grupo alquilo, cicloalquilo o arilo; R3 y R4 son H o un grupo alquilo, R5 es H, halogeno, NR6R7, o un grupo alquilo, alcoxi, alquenilo, alquinilo o cicloalquilo, R6 es un grupo alquilo o cicloalquilo y R7 es H o un grupo alquilo o cicloalquilo; un estereoisomero o una sal aceptable farmacéuticamente de éstos. Proceso de preparacion del compuesto y una composicion farmacéutica que lo incluye.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80999606P | 2006-06-01 | 2006-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061147A1 true AR061147A1 (es) | 2008-08-06 |
Family
ID=38668755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102364A AR061147A1 (es) | 2006-06-01 | 2007-05-31 | Compuestos derivados de piperazina, un proceso para su preparacion y una composicion farmaceutica |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7501421B2 (es) |
| EP (1) | EP2024348A2 (es) |
| JP (1) | JP2009538909A (es) |
| KR (1) | KR20090023641A (es) |
| CN (1) | CN101490022A (es) |
| AR (1) | AR061147A1 (es) |
| AU (1) | AU2007255041A1 (es) |
| BR (1) | BRPI0712444A2 (es) |
| CA (1) | CA2659701A1 (es) |
| CR (1) | CR10474A (es) |
| EC (1) | ECSP088930A (es) |
| IL (1) | IL195590A0 (es) |
| MX (1) | MX2008015328A (es) |
| NO (1) | NO20085045L (es) |
| PE (1) | PE20080707A1 (es) |
| TW (1) | TW200804310A (es) |
| WO (1) | WO2007142904A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2414328B1 (en) * | 2009-04-02 | 2021-05-26 | Merck Serono S.A. | Dihydroorotate dehydrogenase inhibitors |
| KR101250606B1 (ko) * | 2011-01-24 | 2013-04-03 | 이화여자대학교 산학협력단 | 5-ｈｔ６ 수용체 억제 작용을 갖는 신규한 벤조티아졸 및 벤즈이소티아졸유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| EP3020718B1 (en) * | 2013-07-10 | 2018-12-26 | Meiji Seika Pharma Co., Ltd. | Novel pde4 inhibitor |
| SG11201610407QA (en) | 2014-07-08 | 2017-01-27 | Sunshine Lake Pharma Co Ltd | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
-
2007
- 2007-05-23 PE PE2007000635A patent/PE20080707A1/es not_active Application Discontinuation
- 2007-05-25 AU AU2007255041A patent/AU2007255041A1/en not_active Abandoned
- 2007-05-25 WO PCT/US2007/012569 patent/WO2007142904A2/en active Application Filing
- 2007-05-25 TW TW096118646A patent/TW200804310A/zh unknown
- 2007-05-25 CA CA002659701A patent/CA2659701A1/en not_active Abandoned
- 2007-05-25 CN CNA2007800261442A patent/CN101490022A/zh active Pending
- 2007-05-25 JP JP2009513221A patent/JP2009538909A/ja not_active Withdrawn
- 2007-05-25 BR BRPI0712444-9A patent/BRPI0712444A2/pt not_active Application Discontinuation
- 2007-05-25 MX MX2008015328A patent/MX2008015328A/es not_active Application Discontinuation
- 2007-05-25 KR KR1020087031621A patent/KR20090023641A/ko not_active Application Discontinuation
- 2007-05-25 EP EP07777299A patent/EP2024348A2/en not_active Withdrawn
- 2007-05-31 AR ARP070102364A patent/AR061147A1/es unknown
- 2007-05-31 US US11/809,424 patent/US7501421B2/en not_active Expired - Fee Related
-
2008
- 2008-11-27 IL IL195590A patent/IL195590A0/en unknown
- 2008-12-01 EC EC2008008930A patent/ECSP088930A/es unknown
- 2008-12-01 CR CR10474A patent/CR10474A/es not_active Application Discontinuation
- 2008-12-03 NO NO20085045A patent/NO20085045L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CR10474A (es) | 2009-01-07 |
| CA2659701A1 (en) | 2007-12-13 |
| JP2009538909A (ja) | 2009-11-12 |
| MX2008015328A (es) | 2008-12-12 |
| PE20080707A1 (es) | 2008-05-22 |
| ECSP088930A (es) | 2009-01-30 |
| AU2007255041A1 (en) | 2007-12-13 |
| WO2007142904A2 (en) | 2007-12-13 |
| US7501421B2 (en) | 2009-03-10 |
| NO20085045L (no) | 2008-12-12 |
| US20070281945A1 (en) | 2007-12-06 |
| BRPI0712444A2 (pt) | 2012-06-05 |
| KR20090023641A (ko) | 2009-03-05 |
| CN101490022A (zh) | 2009-07-22 |
| WO2007142904A3 (en) | 2008-02-07 |
| TW200804310A (en) | 2008-01-16 |
| IL195590A0 (en) | 2009-09-01 |
| EP2024348A2 (en) | 2009-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |