CN114981295A - 多肽化合物及其应用 - Google Patents

多肽化合物及其应用 Download PDF

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Publication number
CN114981295A
CN114981295A CN202180009367.8A CN202180009367A CN114981295A CN 114981295 A CN114981295 A CN 114981295A CN 202180009367 A CN202180009367 A CN 202180009367A CN 114981295 A CN114981295 A CN 114981295A
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compound
γglu
aeeac
seq
aib
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CN202180009367.8A
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CN114981295B (zh
Inventor
黄亮
曹春来
邓慧兴
周翠
刘合栋
谢鑫
何秀仪
杨晓纯
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Zhuhai United Biopharmaceutical Co ltd
United Biotechnology Zhuhai Hengqin Co ltd
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Zhuhai United Biopharmaceutical Co ltd
United Biotechnology Zhuhai Hengqin Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

一种多肽化合物及其应用,激动胰高血糖素样肽‑1受体和任选地激动葡萄糖依赖性促胰岛素多肽受体及胰高血糖素受体的双重或三重激动剂多肽药物及其用于治疗代谢综合征的应用。

Description

PCT国内申请,说明书已公开。

Claims (17)

  1. PCT国内申请,权利要求书已公开。
CN202180009367.8A 2020-01-17 2021-01-15 多肽化合物及其应用 Active CN114981295B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/072768 2020-01-17
CN2020072768 2020-01-17
PCT/CN2021/072049 WO2021143810A1 (zh) 2020-01-17 2021-01-15 多肽化合物及其应用

Publications (2)

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CN114981295A true CN114981295A (zh) 2022-08-30
CN114981295B CN114981295B (zh) 2024-10-01

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CN (1) CN114981295B (zh)
WO (1) WO2021143810A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116327890A (zh) * 2023-05-29 2023-06-27 北京先为达生物科技有限公司 口服递送的组合物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102180963A (zh) * 2011-04-22 2011-09-14 中国药科大学 胰高血糖素样肽-1(glp-1)类似物及其应用
CN103087175A (zh) * 2012-11-30 2013-05-08 中国药科大学 新型长效化胰高血糖素样肽-1(glp-1)类似物及其应用
CN103458920A (zh) * 2010-12-22 2013-12-18 印第安那大学科技研究公司 表现出gip受体活性的胰高血糖素类似物
US20190175744A1 (en) * 2016-03-18 2019-06-13 Merck Sharp & Dohme Corp. Insulin-incretin conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11058775B2 (en) * 2016-04-26 2021-07-13 Merck Sharp & Dohme Corp. Insulin dimer-incretin conjugates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103458920A (zh) * 2010-12-22 2013-12-18 印第安那大学科技研究公司 表现出gip受体活性的胰高血糖素类似物
CN102180963A (zh) * 2011-04-22 2011-09-14 中国药科大学 胰高血糖素样肽-1(glp-1)类似物及其应用
CN103087175A (zh) * 2012-11-30 2013-05-08 中国药科大学 新型长效化胰高血糖素样肽-1(glp-1)类似物及其应用
US20190175744A1 (en) * 2016-03-18 2019-06-13 Merck Sharp & Dohme Corp. Insulin-incretin conjugates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116327890A (zh) * 2023-05-29 2023-06-27 北京先为达生物科技有限公司 口服递送的组合物及其应用
CN116327890B (zh) * 2023-05-29 2023-12-08 北京先为达生物科技有限公司 口服递送的组合物及其应用

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WO2021143810A1 (zh) 2021-07-22
CN114981295B (zh) 2024-10-01

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