CL2010001333A1 - Metodo para cristalizar en estado solido particulas esfericas de una mezcla de dos o mas compuestos organicos alotropicos, obtenidas por fusion-pulverizacion y congelamiento, que incluye someter a dichas particulas a una atmosfera que contiene vapores de solvente (divisional de sol. 213-99). - Google Patents

Metodo para cristalizar en estado solido particulas esfericas de una mezcla de dos o mas compuestos organicos alotropicos, obtenidas por fusion-pulverizacion y congelamiento, que incluye someter a dichas particulas a una atmosfera que contiene vapores de solvente (divisional de sol. 213-99).

Info

Publication number
CL2010001333A1
CL2010001333A1 CL2010001333A CL2010001333A CL2010001333A1 CL 2010001333 A1 CL2010001333 A1 CL 2010001333A1 CL 2010001333 A CL2010001333 A CL 2010001333A CL 2010001333 A CL2010001333 A CL 2010001333A CL 2010001333 A1 CL2010001333 A1 CL 2010001333A1
Authority
CL
Chile
Prior art keywords
particles
crystallizing
freezing
spraying
melting
Prior art date
Application number
CL2010001333A
Other languages
English (en)
Inventor
De Gyves Aurelio
Gomez Abraham
Angeles Uribe Juan
Original Assignee
John Claude Savoir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21853984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010001333(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by John Claude Savoir filed Critical John Claude Savoir
Publication of CL2010001333A1 publication Critical patent/CL2010001333A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

).
CL2010001333A 1998-02-25 2010-12-02 Metodo para cristalizar en estado solido particulas esfericas de una mezcla de dos o mas compuestos organicos alotropicos, obtenidas por fusion-pulverizacion y congelamiento, que incluye someter a dichas particulas a una atmosfera que contiene vapores de solvente (divisional de sol. 213-99). CL2010001333A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/030,388 US6287693B1 (en) 1998-02-25 1998-02-25 Stable shaped particles of crystalline organic compounds

Publications (1)

Publication Number Publication Date
CL2010001333A1 true CL2010001333A1 (es) 2011-04-25

Family

ID=21853984

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010001333A CL2010001333A1 (es) 1998-02-25 2010-12-02 Metodo para cristalizar en estado solido particulas esfericas de una mezcla de dos o mas compuestos organicos alotropicos, obtenidas por fusion-pulverizacion y congelamiento, que incluye someter a dichas particulas a una atmosfera que contiene vapores de solvente (divisional de sol. 213-99).

Country Status (35)

Country Link
US (7) US6287693B1 (es)
EP (4) EP1056444B1 (es)
JP (2) JP4885357B2 (es)
KR (1) KR100726315B1 (es)
CN (2) CN1146407C (es)
AR (3) AR018107A1 (es)
AT (2) ATE427102T1 (es)
AU (1) AU747779B2 (es)
BR (1) BR9908156A (es)
CA (1) CA2319176C (es)
CL (1) CL2010001333A1 (es)
CY (1) CY1118522T1 (es)
CZ (1) CZ301042B6 (es)
DE (2) DE69934099T2 (es)
DK (3) DK2085075T3 (es)
EE (1) EE05019B1 (es)
ES (3) ES2609284T3 (es)
HK (2) HK1036017A1 (es)
HU (1) HUP0101271A3 (es)
ID (1) ID26523A (es)
IL (2) IL137970A0 (es)
MY (1) MY138375A (es)
NO (1) NO331804B1 (es)
NZ (1) NZ505987A (es)
PE (1) PE20000393A1 (es)
PL (1) PL196369B1 (es)
PT (1) PT2085075T (es)
RU (1) RU2225708C2 (es)
SA (1) SA99200098B1 (es)
TR (1) TR200002462T2 (es)
TW (1) TWI256308B (es)
UA (1) UA73470C2 (es)
UY (1) UY25404A1 (es)
WO (1) WO1999043304A1 (es)
ZA (1) ZA991058B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287693B1 (en) 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
PT2767539T (pt) 2002-05-16 2017-08-28 Janssen Sciences Ireland Uc Formas pseudopolimórficas de um inibidor de protease de hiv
US20040028746A1 (en) * 2002-08-06 2004-02-12 Sonke Svenson Crystalline drug particles prepared using a controlled precipitation (recrystallization) process
US20040028747A1 (en) * 2002-08-06 2004-02-12 Tucker Christopher J. Crystalline drug particles prepared using a controlled precipitation process
ATE454885T1 (de) * 2003-06-13 2010-01-15 Skendi Finance Ltd Mikrosphären von estradiol und cholesterol
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
EP1646354A4 (en) * 2003-07-22 2010-03-17 Baxter Int SMALL SPHERICAL PARTICLES OF LOW MOLECULAR WEIGHT MOLECULES AND PROCESSES FOR THEIR PREPARATION AND USE
RU2331410C2 (ru) * 2003-12-04 2008-08-20 Пфайзер Продактс Инк. Способ получения фармацевтических мультичастиц
SI2351555T1 (sl) * 2004-02-23 2017-01-31 Euro-Celtique S.A. Naprava za transdermalno dajanje opioida, varna pred zlorabo
RU2008100543A (ru) * 2005-06-17 2009-07-27 БАСФ Акциенгезельшафт (DE) Способ получения усилителей эффекта отбеливания
US20090246265A1 (en) * 2008-03-26 2009-10-01 Alltranz Inc. Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
WO2009128692A1 (es) * 2008-04-14 2009-10-22 Posi Visionary Solutions Llp Método y composición farmacéutica para lograr niveles plasmáticos de progesterona requeridos para diferentes indicaciones terapéuticas
FR2939326B1 (fr) * 2008-12-10 2011-04-01 Univ Joseph Fourier Procede et dispositif de controle d'une cristallisation.
BR112012008317A2 (pt) 2009-09-17 2016-03-22 Upsher Smith Lab Inc produto de liberação sustentada compreendendo uma combinação de uma amina não-opioide e uma droga anti-inflamatória não-esteroidal
UY33103A (es) * 2009-12-15 2011-07-29 Techsphere S A De C V Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico
KR101708528B1 (ko) * 2010-03-19 2017-02-20 다이이찌 산쿄 가부시키가이샤 디아민 유도체의 결정 및 그 제조 방법
US9351924B2 (en) 2011-03-11 2016-05-31 Snu R&Db Foundation Drug delivery system including laminated structure
KR101314126B1 (ko) 2011-03-11 2013-10-04 서울대학교산학협력단 다면체 형상의 약물 전달 시스템
MX365818B (es) 2011-11-23 2019-05-30 Therapeuticsmd Inc Formulaciones y terapias de reemplazo hormonal de combinacion naturales.
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
AU2014228175B2 (en) 2013-03-15 2018-05-31 Incyte Holdings Corporation Tricyclic heterocycles as BET protein inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
MX2016013851A (es) 2014-04-23 2017-07-14 Incyte Corp 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet).
US10206932B2 (en) 2014-05-22 2019-02-19 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
ITUB20153652A1 (it) * 2015-09-16 2017-03-16 Fatro Spa Microsfere contenenti lattoni macrociclici antielminitici
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
BR112018076486A2 (pt) 2016-06-20 2019-04-09 Incyte Corporation formas sólidas cristalinas de um inibidor de bet
PL236889B1 (pl) * 2017-10-03 2021-02-22 Univ Warszawski Medyczny Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie
EP3542786A1 (en) * 2018-03-21 2019-09-25 ITF Research Pharma, S.L.U. Progesterone intravaginal devices
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2447362A (en) 1945-11-01 1948-08-17 Rca Corp Production of crystals
US3800038A (en) * 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier
US4230621A (en) * 1978-05-01 1980-10-28 E. R. Squibb & Sons, Inc. Steroid derivatives and their use in radioimmunoassays
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
IL63968A (en) 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
JPS5799562A (en) 1980-12-12 1982-06-21 Nippon Shinyaku Co Ltd Preparation of microcrystal
DE3049196A1 (de) 1980-12-24 1982-07-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von granulaten aus organischen in form einer schmelze vorliegenden stoffen
US4447426A (en) * 1982-01-18 1984-05-08 E. R. Squibb & Sons, Inc. Steroid monohydrates, formulations containing same and method
JPS58143832A (ja) 1982-02-22 1983-08-26 Yoshiaki Kawashima 結晶性化学物質の球状化再結晶法
DE3213025C2 (de) 1982-04-02 1997-06-12 Fischer Karl Ind Gmbh Verfahren zur Nachkondensation von Polykondensaten
GB8618847D0 (en) * 1986-08-01 1986-09-10 Smith Kline French Lab Pharmaceutical formulations
JPH0714625B2 (ja) 1987-03-30 1995-02-22 呉羽化学工業株式会社 高結晶化ポリアリ−レンチオエ−テル成形物
US4897307A (en) 1987-08-11 1990-01-30 The Dow Chemical Company Process for the solvent-induced crystallization of amorphous poly(etheretherketone)-type polymers and the article formed thereby
DE3850384T2 (de) 1987-09-28 1995-02-23 Asahi Chemical Ind Verfahren zur herstellung von kristallinem aromatischem polykarbonat und so hergestellte aromatische polykarbonate.
US4919899A (en) 1988-02-29 1990-04-24 Herrmann Frederick T Crystal growth apparatus
YU120988A (en) * 1988-06-23 1990-06-30 Lek Tovarna Farmacevtskih Process for preparing new dispersion pills of cimetidine
IT1230566B (it) 1988-10-17 1991-10-28 Vectorpharma Int Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione
US5360478A (en) 1989-10-16 1994-11-01 Phasex Corporation Gas anti-solvent recrystallization process
FR2663224B1 (fr) * 1990-06-14 1995-01-20 Applicationes Farmaceuticas Sa Forme galenique parenterale.
FR2663223B1 (fr) * 1990-06-14 1994-12-02 Af Aplicaciones Far Lab Forme galenique parenterale.
JPH04305226A (ja) 1991-01-25 1992-10-28 Senichi Masuda ガス中窒素酸化物の低減方法
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5874063A (en) * 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
SE9101090D0 (sv) 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
US5391810A (en) 1991-05-23 1995-02-21 Ajinomoto Co., Inc. Method of crystallizing α-L-aspartyl-L-phenylalanine methyl ester
DE4130173A1 (de) 1991-09-11 1993-03-18 Bayer Ag Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters
DE4218929C1 (es) 1992-06-10 1993-09-09 Deutsche Bundesbahn, Vertreten Durch Das Bundesbahn-Zentralamt Minden (Westf.), 4950 Minden, De
US5290913A (en) 1992-10-08 1994-03-01 Carrier Vibrating Equipment, Inc. Method and apparatus for the heat treatment of material
US5558678A (en) 1992-11-13 1996-09-24 Karl Fischer Industrieanlagen Gmbh Process and apparatus for continuous crystallization of plastic granules
US5643595A (en) 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
WO1994020116A1 (en) * 1993-03-10 1994-09-15 University Of Alabama Research Foundation Artificial primers for glycogen synthesis
US5409605A (en) * 1993-08-05 1995-04-25 Chemical Lime Company Apparatus and method for treating waste sludge
JPH0757558A (ja) * 1993-08-09 1995-03-03 Showa Electric Wire & Cable Co Ltd 耐熱絶縁電線
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5849651A (en) * 1995-06-01 1998-12-15 Kabushiki Kaisha Toshiba Reversible thermal recording medium
JPH0957558A (ja) * 1995-08-18 1997-03-04 Nabeya Iron & Tool Works Ltd スライド装置
JPH09227558A (ja) * 1996-02-28 1997-09-02 Fujisawa Pharmaceut Co Ltd チアゾール化合物の安定な結晶およびその製造方法
US6287693B1 (en) * 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
JP2000143832A (ja) 1998-11-10 2000-05-26 Toppan Printing Co Ltd 高剛性を有するフィルムまたはシート

Also Published As

Publication number Publication date
CN1146407C (zh) 2004-04-21
ES2275334T3 (es) 2007-06-01
DE69934099D1 (de) 2007-01-04
AU2293699A (en) 1999-09-15
UA73470C2 (uk) 2005-08-15
NO20004241D0 (no) 2000-08-24
ID26523A (id) 2001-01-11
RU2225708C2 (ru) 2004-03-20
CA2319176A1 (en) 1999-09-02
KR100726315B1 (ko) 2007-06-11
EP1772141A1 (en) 2007-04-11
MY138375A (en) 2009-05-29
HUP0101271A3 (en) 2002-10-28
DE69934099T2 (de) 2007-06-21
NO331804B1 (no) 2012-04-10
JP2011241220A (ja) 2011-12-01
AR077167A2 (es) 2011-08-10
US6737081B2 (en) 2004-05-18
CZ20003047A3 (cs) 2000-11-15
AU747779B2 (en) 2002-05-23
ES2609284T3 (es) 2017-04-19
US20020168395A1 (en) 2002-11-14
BR9908156A (pt) 2000-10-31
AR018107A1 (es) 2001-10-31
ES2324366T3 (es) 2009-08-05
ATE345779T1 (de) 2006-12-15
US6528094B1 (en) 2003-03-04
NZ505987A (en) 2003-07-25
EP2319497A1 (en) 2011-05-11
CY1118522T1 (el) 2017-07-12
EP1772141B1 (en) 2009-04-01
IL137970A (en) 2006-10-05
DK2085075T3 (en) 2017-01-23
PL196369B1 (pl) 2007-12-31
DK1056444T3 (da) 2007-03-12
ZA991058B (en) 1999-08-11
EP2319497B1 (en) 2012-08-22
TR200002462T2 (tr) 2000-11-21
HUP0101271A2 (hu) 2001-09-28
US6537580B1 (en) 2003-03-25
US6638536B2 (en) 2003-10-28
EP1056444B1 (en) 2006-11-22
DE69940684D1 (de) 2009-05-14
JP4885357B2 (ja) 2012-02-29
EE200000492A (et) 2002-02-15
US20040166164A1 (en) 2004-08-26
AR077168A2 (es) 2011-08-10
IL137970A0 (en) 2001-10-31
CN100528140C (zh) 2009-08-19
UY25404A1 (es) 1999-05-14
US20030147964A1 (en) 2003-08-07
ATE427102T1 (de) 2009-04-15
WO1999043304A1 (en) 1999-09-02
PL343170A1 (en) 2001-07-30
EP2085075A1 (en) 2009-08-05
JP2002504507A (ja) 2002-02-12
HK1036017A1 (en) 2001-12-21
CN1524608A (zh) 2004-09-01
CZ301042B6 (cs) 2009-10-21
KR20010034540A (ko) 2001-04-25
US6287693B1 (en) 2001-09-11
PE20000393A1 (es) 2000-05-04
NO20004241L (no) 2000-08-24
HK1155384A1 (en) 2012-05-18
EP2085075B1 (en) 2016-09-28
US20030191101A1 (en) 2003-10-09
CA2319176C (en) 2007-09-11
SA99200098B1 (ar) 2006-04-26
PT2085075T (pt) 2017-01-04
EP1056444A1 (en) 2000-12-06
CN1291887A (zh) 2001-04-18
US7427413B2 (en) 2008-09-23
EE05019B1 (et) 2008-06-16
US6663895B2 (en) 2003-12-16
DK1772141T3 (da) 2009-07-20
TWI256308B (en) 2006-06-11

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